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  3. Esperal Tablet 10's

Esperal Tablet 10's, Pack of 10 TABLETS
Esperal Tablet 10's, Pack of 10 TABLETS
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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Veda Maddala , M Pharmacy

Esperal Tablet is used to treat alcohol dependence or chronic alcoholism. It contains Disulfiram, which works by blocking an enzyme that breaks down alcohol in our body. This results in a higher level of acetaldehyde in the blood, causing discomfort and physical reactions. It can help alcohol-addicted people who have decided to quit alcohol drinking by deterring them from drinking again. So, it acts as a supportive agent in the treatment of alcoholism. It may cause common side effects such as drowsiness, tiredness, headache, acne, flushing (warmth, redness, or tingly feeling), sweating, increased thirst, swelling, rapid weight gain, nausea, severe vomiting, neck pain, throbbing headache, blurred vision, fast or pounding heartbeats or fluttering in your chest, confusion, weakness, spinning sensation, feeling unsteady, or and metallic/garlic-like taste in the mouth may occur as your body gets used to the medication. Do not take this medicine if you have consumed alcohol within the past 12 hours.

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Composition :

DISULFIRAM-250MG

Manufacturer/Marketer :

Torrent Pharmaceuticals Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Esperal Tablet

Esperal Tablet is used to treat alcohol dependence or chronic alcoholism. Heavy long-term use of alcohol can cause addiction in an individual, thereby making changes in your brain. Long-term alcohol intake can severely damage your liver and cause liver cirrhosis or fatty liver syndrome.

Esperal Tablet contains 'Disulfiram', which works by blocking an enzyme that breaks down alcohol in our body. When a patient drinks alcohol, it is changed into acetaldehyde, Esperal Tablet blocks the enzyme that breaks down acetaldehyde. This results in a higher level of acetaldehyde in the blood, causing discomfort and physical reactions. Esperal Tablet can help alcohol-addicted people who have decided to quit alcohol drinking by deterring them from drinking again. So, it acts as a supportive agent in the treatment of alcoholism. 

Esperal Tablet should be taken as prescribed by your doctor, with or without a meal, to avoid stomach upset and at fixed daily intervals for best results. The common side effects of Esperal Tablet include drowsiness, tiredness, headache, acne, flushing (warmth, redness, or tingly feeling), sweating, increased thirst, swelling, rapid weight gain, nausea, severe vomiting, neck pain, throbbing headache, blurred vision, fast or pounding heartbeats or fluttering in your chest, confusion, weakness, spinning sensation, feeling unsteady, or and metallic/garlic-like taste in the mouth may occur as your body gets used to the medication. Everyone need not experience the above side effects. If the Esperal Tablet causes any serious case of discomfort, speak with a doctor.

Before starting Esperal Tablet , do not take Esperal Tablet if you have consumed alcohol within the past 12 hours. Do not consume alcohol while taking Esperal Tablet and at least up to 14 days after you stop taking Esperal Tablet . If your doctor prescribes, Esperal Tablet is safe to use during pregnancy and breastfeeding. Unpleasant effects may occur after taking minimal amounts of alcohol used in cooking or even if rubbed into the skin. Avoid alcohol-containing aftershaves, perfumes/colognes, body lotions, vinegar, and alcohol-containing mouthwash and hand sanitiser. Even exposure to alcohol-based hand sanitisers in some people can trigger a serious side effect response. Hence, hand washing with water and soap is recommended instead.

Uses of Esperal Tablet

Esperal Tablet is used to treat alcohol addiction. The detailed uses of Esperal Tablet are as follows:

  • Alcohol dependence treatment: Esperal Tablet helps people stop drinking by causing an unpleasant reaction when they consume alcohol.
  • Behavioural therapy support: Often used alongside counselling and therapy to reinforce sobriety.

Directions for Use

• Esperal Tablet can be taken with or without food as advised by your doctor. • It should be taken once a day or as directed by the doctor. • Swallow Esperal Tablet as a whole with a glass of water. • If you have difficulty swallowing, crush them and mix with a liquid like water, milk, or juice.

Medicinal Benefits

Esperal Tablet contains 'Disulfiram', which belongs to 'Antabuse' used to treat alcohol dependence. It works by blocking an enzyme (acetaldehyde) that helps break alcohol in the body. Esperal Tablet helps alcohol-dependent people who have decided to quit alcohol drinking by deterring them from drinking again.

How Esperal Tablet Works

Esperal Tablet contains 'Disulfiram', which works by blocking an enzyme that breaks down alcohol in our body. When a patient drinks alcohol, it is changed into acetaldehyde, Esperal Tablet blocks the enzyme that breaks down acetaldehyde. This results in a higher level of acetaldehyde in the blood, causing discomfort and physical reactions. Esperal Tablet can help alcohol-addicted people who have decided to quit alcohol drinking by deterring them from drinking again. So, it acts as a supportive agent in the treatment of alcoholism.

Storage

• Store in a cool and dry place away from sunlight. • Keep out of sight and reach of children. • Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.

What if I have taken an overdose of Esperal Tablet

Do not take more than the prescribed dose of Esperal Tablet as it may cause overdose. The symptoms of overdose include drowsiness, vomiting, loss of consciousness or loss of coordination. If you suspect you have taken overdose or notice signs of overdose, please consult a doctor immediately.

Drug Warnings

Before taking the Esperal Tablet , let your doctor know about all your medical conditions, sensitivities, and all medications you are using. Signs of an overdose of Esperal Tablet include feeling or being sick, stomach pain, diarrhoea, drowsiness, mental disorders, tiredness, rapid heartbeat, rapid breathing, high body temperature, low blood pressure, loss of muscle control, high blood sugar, changes in the blood (as seen in blood tests). Certain foods, liquid medicines, remedies, tonics, toiletries, perfumes, and sprays may contain enough alcohol to cause a disulfiram tablet-alcohol reaction. So avoid using any alcohol-containing drugs, hand wash, mouth wash or alcoholic beverages as it may lead to an 'aldehyde reaction'.

Drug-Drug Interactions

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DisulfiramAmprenavir
Critical
DisulfiramBenznidazole
Critical

Drug-Drug Interactions

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DisulfiramAmprenavir
Critical
How does the drug interact with Esperal Tablet:
Coadministration of Amprenavir and Esperal Tablet can increase the risk of side effects.

How to manage the interaction:
Taking Amprenavir and Esperal Tablet together is generally avoided as it can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like difficulty breathing, vomiting, sweating, palpitation, or dizziness, contact your doctor immediately. Do not discontinue any medications without first consulting your doctor.
DisulfiramBenznidazole
Critical
How does the drug interact with Esperal Tablet:
Coadministration of Esperal Tablet with Benznidazole can increase the risk of side effects.

How to manage the interaction:
Taking benznidazole and Esperal Tablet together is advised as it can lead to an interaction, it can be taken if advised by your doctor. However, if you experience sudden dizziness, weakness, shortness of breath, or palpitations, contact your doctor immediately.
DisulfiramMetronidazole
Critical
How does the drug interact with Esperal Tablet:
Coadministration of Esperal Tablet with Metronidazole can increase the risk of side effects.

How to manage the interaction:
Taking Metronidazole and Esperal Tablet together is generally avoided as it can lead to an interaction, it can be taken if advised by your doctor. However, if you experience sudden dizziness, confusion, weakness, shortness of breath, or palpitations, contact your doctor. Do not discontinue any medications without consulting a doctor.
DisulfiramParaldehyde
Critical
How does the drug interact with Esperal Tablet:
Coadministration of Paraldehyde and Esperal Tablet can increase the risk of side effects.

How to manage the interaction:
Taking Paraldehyde and Esperal Tablet together is not recommended as it can lead to an interaction, it can be taken if advised by your doctor. However, if you experience palpitations, difficulty breathing, vomiting, sweating, chest pain, dizziness, or blurred vision contact your doctor immediately. Do not discontinue any medications without first consulting your doctor.
DisulfiramTipranavir
Severe
How does the drug interact with Esperal Tablet:
Co-administration of Tipranavir with Esperal Tablet can increase the risk of side effects.

How to manage the interaction:
Co-administration of Tipranavir with Esperal Tablet can lead to an interaction, it can be taken if your doctor advises. However, consult the doctor immediately if you experience any symptoms like palpitations, excessive sweating, chest pain, or ringing of the ears. Do not stop using any medications without a doctor's advice.
DisulfiramMipomersen
Severe
How does the drug interact with Esperal Tablet:
Co-administration of Esperal Tablet and Mipomersen can increase the risk of liver problems.

How to manage the interaction:
Co-administration of Esperal Tablet and Mipomersen can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like fever, weakness, vomiting, stomach pain, dark urine, pale stools, and yellowing of the skin or eyes, consult the doctor immediately. Do not stop using any medications without a doctor's advice.
DisulfiramRitonavir
Severe
How does the drug interact with Esperal Tablet:
Co-administration of Ritonavir with Esperal Tablet can increase the risk or severity of side effects.

How to manage the interaction:
Co-administration of Esperal Tablet with ritonavir can lead to an interaction, but it can be taken if advised by your doctor. However, consult your doctor if you experience headaches, difficulty breathing, vomiting, excessive sweating, chest pain, palpitations, dizziness, or blurred vision. Do not stop using any medications without a doctor's advice.
DisulfiramTeriflunomide
Severe
How does the drug interact with Esperal Tablet:
Co-administration of Esperal Tablet and Teriflunomide can increase the risk of liver problems.

How to manage the interaction:
Co-administration of Esperal Tablet and Teriflunomide can lead to an interaction, but it can be taken if advised by your doctor. However, if you experience dizziness, fever, joint pain, vomiting, stomach pain, dark urine, pale stools, and yellowing of the skin or eyes, consult the doctor immediately. Do not stop using any medications without a doctor's advice.
DisulfiramSertraline
Severe
How does the drug interact with Esperal Tablet:
Co-administration of Esperal Tablet and Sertraline can increase the risk of developing side effects.

How to manage the interaction:
Co-administration of Esperal Tablet with Sertraline can lead to an interaction, it can be taken if advised by your doctor. However, consult the doctor immediately if you experience headache, vomiting, excessive sweating, or thirst. Do not stop using any medications without a doctor's advice.
DisulfiramEthanol
Severe
How does the drug interact with Esperal Tablet:
Co-administration of Ethanol with Esperal Tablet can increase the risk of developing side effects.

How to manage the interaction:
Co-administration of Ethanol with Esperal Tablet can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any vomiting, blurred vision, shortness of breath, or palpitations, consult the doctor immediately. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • A patient is advised to have a diet that increases serotonin levels which makes a person feel good & involves eating foods high in carbohydrates, especially the complex carbohydrates present in starchy food items like legumes (e.g., beans, lentils and peas), root vegetables (e.g., potatoes and carrots), pasta and bread. Eating such foods in combination with protein in meals will benefit.

  • Deficiencies in B-complex vitamins such as thiamine, folate or folic acid, and B12 are common with alcoholism, and inadequate stores of other B vitamins and vitamin C frequently occur. A patient should take supplements and vitamins on consulting a doctor.

  • Malnutrition is common during alcohol consumption and is revealed slowly and gradually. The patient becomes tired and develops a weaker immune system—which means they are more susceptible to infections. These problems need to be identified and treated during the recovery process—ideally by a team of healthcare professionals.

  • The patient should change his drinking priorities and prefer drinks like apple cider, vanilla shake, mixing juice or lemonade with sparkling water etc.

Habit Forming

No

Therapeutic Class

ANTI-ALCOHOLIC AGENT

Esperal Tablet Substitute

Substitutes safety advice

Product Substitutes

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Alcohol

Unsafe

Not recommended for alcoholism as Esperal Tablet and alcohol causes severe 'aldehyde reaction' causing life-threatening conditions.

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Pregnancy

Caution

Not enough data available but Esperal Tablet is not given in pregnant females unless recommended in a doctor.

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Breast Feeding

Unsafe

Not recommended as such, as not enough data is available. Breastfeeding mothers should consult a doctor before taking the Esperal Tablet .

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Driving

Caution

Not recommended before driving. Esperal Tablet has been found to cause drowsiness in the patient. Hence, taking Esperal Tablet before driving or performing hazardous tasks is not recommended.

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Liver

Caution

Not recommended in liver patients. Esperal Tablet has been found to cause liver damage in patients & hence not recommended to be taken without doctors consultation.

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Kidney

Caution

Not recommended in kidney patients. Esperal Tablet should be taken by kidney patients only on doctors consultation.

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Children

Unsafe

Strictly not recommended in children. it may result in neurological interactions resulting in harmful symptoms.

Have a query?

FAQs

Esperal Tablet is used to treat alcohol dependence or chronic alcoholism.

Esperal Tablet contains 'Disulfiram', which belongs to 'Antabuse' used to treat alcohol dependence. It works by blocking an enzyme (acetaldehyde) that helps break alcohol in the body. Esperal Tablet helps alcohol-dependent people who have decided to quit alcohol drinking by deterring them from drinking again.

An asthmatic patient, if already on cough-suppressing medications like diphenhydramine, is not recommended to take Esperal Tablet . Esperal Tablet and diphenhydramine are contraindicated and may result in harmful implications.

Not recommended in patients taking blood thinners like warfarin to prevent blood clot formation inside heart/brain vessels. Warfarin (blood thinner) and Esperal Tablet are contraindicated and should not be taken together.

Yes, Esperal Tablet has been implicated in altering the results of tests done for adrenal tumours & hence not recommended to be taken before any diagnostic test is done.

The common side effects of Esperal Tablet are usually temporary, including headaches, nausea, a metallic taste in the mouth and feeling tired.

Take the missed dose as soon as you remember. Take the rest of the day's doses at evenly spaced intervals unless otherwise directed by your doctor.

Esperal Tablet  is safe if taken in the dose and duration prescribed by the doctor.

Esperal Tablet is not an over-the-counter medicine. It can be taken only when prescribed by the doctor.

Esperal Tablet is not addictive. It does not have habit-forming tendencies.

Esperal Tablet will not work for everyone. It is used to help people with an alcohol addiction who have already stopped drinking and are maintaining their ability to no longer drink alcohol. Esperal Tablet is not recommended for people with heart failure or coronary artery disease.

Esperal Tablet does not stop cravings. It is a medicine used along with social support and counselling, to help people recover from alcohol use disorder and to avoid having the urge to drink alcohol again. It causes sudden, undesirable effects when mixed with alcohol to help you refrain from alcohol, even if you are dependent on alcohol.

Esperal Tablet takes 1-2 hours to start working. For the full benefits, keep taking Esperal Tablet for the prescribed duration.

Country of origin

India

Manufacturer/Marketer address

Off. Ashram Road, Ahmedabad - 380 009., Gujarat, India
Other Info - ESP0023

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Author Details

Bayyarapu Mahesh KumarDoctor badge

Written By

Bayyarapu Mahesh Kumar

M Pharmacy

Veda MaddalaDoctor badge

Reviewed By

Veda Maddala

M Pharmacy

Last Updated

Aug 5, 2025 | 9:00 AM IST

Doctor imageWe provide you with authentic, trustworthy and relevant information

Reference

  1. https://www.medicines.org.uk/emc/files/pil.11168.pdf
  2. https://www.mims.com/india/drug/info/disulfiram?type=full&mtype=generic
  3. https://www.drugs.com/mtm/disulfiram.html
  4. https://www.webmd.com/drugs/2/drug-1446/disulfiram-oral/details

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