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compositionComposition:ESOMEPRAZOLE-20MG+NAPROXEN-500MG
prescription
Prescription Medicine
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Espra XN 500 Tablet is a painkiller medicine used to relieve pain. This combination medicine has anti-inflammatory properties which work by blocking the action of the body's cyclo-oxygenase (COX) enzyme to produce prostaglandins that cause pain and swelling. You may experience common side effects like indigestion, stomach pain, constipation, dizziness, nausea, and diarrhoea.

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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Veda Maddala , M Pharmacy
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More about the Product

Composition :

ESOMEPRAZOLE-20MG+NAPROXEN-500MG

Manufacturer/Marketer :

Zydus Cadila

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Espra XN 500 Tablet

Espra XN 500 Tablet is an oral medication prescribed to relieve pain, swelling, and joint stiffness caused by chronic inflammatory conditions like arthritis. By combining a pain reliever with a protective stomach coating, it helps manage long-term discomfort while shielding your digestive system from irritation. It is designed to target both joint inflammation and stomach protection in a single pill.

To get the best results, it is important to take this medicine consistently every day exactly as your doctor directs. It is best taken at least 30 minutes before a meal to ensure the protective component can work effectively. Making simple lifestyle adjustments, such as maintaining a healthy weight and doing gentle joint-friendly exercises, can also support your overall physical function.

While many people tolerate this medication well, some may experience mild side effects like an upset stomach, nausea, or a mild headache. If you notice any serious side effects, such as dark or tarry stools, severe stomach pain, or a sudden allergic reaction, seek medical help immediately. Always consult your doctor if you experience any unusual symptoms while taking this medicine.

Talk to your doctor before starting this medication if you have a history of high blood pressure, heart disease, or kidney problems. Do not take this if you have severe liver damage, advanced kidney disease, or if you have ever had an asthma attack or severe allergic reaction to aspirin or other pain relievers. Your doctor will help determine if this is the safest option for your condition.

This medicine can interact with certain blood thinners and blood pressure drugs, so it is vital to share a complete list of your current medications with your healthcare team. Drinking alcohol or smoking while using this drug can significantly increase your risk of stomach bleeding. Pregnant women, breastfeeding mothers, and elderly individuals should always consult their doctor before starting this treatment.

Uses of Espra XN 500 Tablet

This medicine is used to relieve pain, reduce inflammation, and help protect the stomach lining during treatment. The detailed uses of Espra XN 500 Tablet are as follows:

  • Osteoarthritis: Helps reduce joint pain, stiffness, and swelling in daily wear-and-tear arthritis, allowing for easier movement.
  • Rheumatoid Arthritis: Eases chronic joint inflammation, pain, and swelling caused by autoimmune joint disease.
  • Ankylosing Spondylitis: Relieves spinal pain and stiffness, helping to improve back mobility and comfort.
  • Stomach Ulcer Prevention: Specifically protects the stomach lining from painful sores and ulcers that can occur when taking long-term pain relievers.

Key Benefits

This medicine helps relieve pain and inflammation while protecting the stomach from irritation. Its benefits include:

  • Helps reduce joint pain, swelling, and stiffness.
  • Improves mobility and makes everyday activities more comfortable.
  • Provides long-lasting relief from pain and inflammation.
  • Helps protect the stomach lining and lowers the risk of stomach ulcers caused by long-term pain-reliever use.
  • Combines pain relief and stomach protection in a single medicine for added convenience.
  • Supports a more active and comfortable lifestyle by improving physical function.
Side effects of Espra XN 500 Tablet
Here are the step-by-step strategies to manage the side effects of "indigestion" caused by medication usage:
  • Take medications with food (if recommended): It can help prevent stomach distress and indigestion.
  • Eat smaller, more frequent meals: Divide daily food intake into smaller, more frequent meals to ease digestion.
  • Avoid trigger foods: Identify and avoid foods that trigger indigestion, such as spicy, fatty, or acidic foods.
  • Stay upright after eating: Sit or stand upright for at least 1-2 hours after eating to prevent stomach acid from flowing into the oesophagus.
  • Avoid carbonated drinks: Avoid drinking carbonated beverages, such as soda or beer, which can worsen indigestion.
  • Manage stress: To alleviate indigestion, engage in stress-reducing activities like deep breathing exercises or meditation.
  • Consult a doctor if needed: If indigestion worsens or persists, consult a healthcare professional to adjust the medication regimen or explore alternative treatments.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
  • You can take your medicine with meals to lower the chances of getting stomach pain.
  • Avoid foods that are acidic, spicy, sugary, or greasy.
  • Eat foods that are easily digestible such as rice, toast, and bananas.
  • Eat your meals in smaller amounts throughout the day to prevent strain on your stomach and digestion.
  • Drink water or fluids to stay hydrated and prevent stomach upset.
  • Use a heating pad or massage your stomach area.
  • Engage in mild physical activities such as yoga and walking.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.

Directions for Use

  • Espra XN 500 Tablet should be taken on an empty stomach at least 30 minutes before a meal.
  • It is usually taken 2 times a day or as prescribed by your doctor.
  • Swallow Espra XN 500 Tablet as a whole with a glass of water.
  • Do not crush, chew, or break it.

How Espra XN 500 Tablet Works

Espra XN 500 Tablet contains Esomeprazole and Naproxen. Esomeprazole: It is a proton pump inhibitor (PPI) that reduces the amount of acid produced in the stomach. This helps protect the stomach lining and lowers the risk of ulcers caused by long-term use of pain-relieving medicines. Naproxen: It is a nonsteroidal anti-inflammatory drug (NSAID) that blocks the production of chemicals responsible for pain, inflammation, and swelling, helping relieve joint pain and stiffness.
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Alcohol

Unsafe

You are recommended to avoid alcohol consumption with Espra XN 500 Tablet as it may increase the risk of stomach bleeding and ulcer.

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Pregnancy

Caution

There is limited data on how Espra XN 500 Tablet affects pregnancy. Please consult your doctor if you are planning to become pregnant or already pregnant before starting Espra XN 500 Tablet .

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Breast Feeding

Caution

Espra XN 500 Tablet passes into the breast milk. However, no evidence of risk has been reported. Please consult your doctor before intake of Espra XN 500 Tablet . Your doctor will weigh the benefits and any potential risks before prescribing Espra XN 500 Tablet to you.

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Driving

Caution

Espra XN 500 Tablet may cause dizziness, tiredness, drowsiness or vision problems in some people. So, drive only if you are alert after taking Espra XN 500 Tablet .

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Liver

Caution

Espra XN 500 Tablet is to be used with caution in people having liver diseases. Dose adjustments may be necessary. So, you should use it only with your doctor's prescription.

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Kidney

Caution

Espra XN 500 Tablet is not recommended for use in patients with moderate to severe and severe renal impairment. The dose may be adjusted by your doctor as required. So, it should be used only when prescribed by your doctor.

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Children

Caution

Espra XN 500 Tablet should be used in children below 12 years of age only when prescribed by a child specialist.

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Heart

Caution

Espra XN 500 Tablet should be taken with caution in patients with heart problems. Please inform your doctor if you have any pre-existing heart problems.

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Geriatrics

Caution

Espra XN 500 Tablet should be given with caution in elderly patients due to an increased risk of side effects. Seek medical advice before using Espra XN 500 Tablet .

What if I have taken an overdose of Espra XN 500 Tablet

If you suspect an overdose or experience severe symptoms like extreme drowsiness, nausea, vomiting, or breathing difficulties after taking too much of this medication, seek immediate medical attention or call your local poison control center.

Diet & Lifestyle Advise

  • Avoid alcohol and tobacco: Avoid drinking alcohol and using tobacco products, as both can increase the risk of stomach ulcers and serious stomach bleeding while taking this medicine.
  • Stay hydrated: Drink plenty of water throughout the day to support healthy kidney function.
  • Exercise regularly: Include low-impact activities such as walking, swimming, or cycling to help keep your joints flexible and strong.
  • Maintain a healthy diet: Eat a balanced diet rich in calcium and vitamin D, as long-term use of acid-reducing medicines may affect the absorption of these nutrients.
health query

Have a query?

How Soon It Starts Working

The time required for Espra XN 500 Tablet to start to work: Espra XN 500 Tablet ideally shows its action within 1 hour after administration. The time for which the effects of Espra XN 500 Tablet last: The effect of Espra XN 500 Tablet lasts for 24 hours.

What if you forget to take Espra XN 500 Tablet

If you miss a dose, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed one and continue with your regular schedule. Do not take a double dose to make up for a missed tablet.

Storage

•Store Espra XN 500 Tablet tablets at room temperature, ideally between 68°F and 77°F (20°C to 25°C).

Drug Warnings

  • Monitor blood pressure: Check your blood pressure regularly, as this medicine may sometimes increase blood pressure.
  • Inform your healthcare provider: Tell your doctor, dentist, or surgeon that you are taking Espra XN 500 Tablet before any medical or surgical procedure.
  • Avoid other pain relievers: Do not take other over-the-counter pain relievers, such as ibuprofen or aspirin, unless your doctor advises you to.
  • Attend regular check-ups: If you use this medicine long term, your doctor may recommend regular blood tests or kidney function tests.
  • Seek immediate medical help: Stop taking this medicine and contact your doctor immediately if you develop persistent chest pain, shortness of breath, or slurred speech.

Drug-Drug Interactions

verifiedApollotooltip
  • Blood thinners: May increase the risk of severe stomach bleeding when taken with medications like warfarin or aspirin.
  • Blood pressure medications: Can reduce the effectiveness of certain blood pressure drugs, such as ACE inhibitors or beta-blockers.
  • Certain immune-modifying drugs: May increase the risk of kidney toxicity when combined with medications like methotrexate or cyclosporine.
No Drug - Drug interactions found in our data. We may lack specific data on this medicine and are actively working to update our database. Consult your doctor for personalized advice

Drug-Drug Interactions

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Drug-Food Interactions

verifiedApollotooltip
  • High-fat meals: Taking this medication with a high-fat meal can delay how quickly your body absorbs the active ingredients, which is why it is recommended to take it on an empty stomach.
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[NON-STEROIDAL DRUG]

FAQs

Espra XN 500 Tablet belongs to a group of medicines called Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) or painkillers used to reduce and relieve pain.
Espra XN 500 Tablet contains Naproxen (NSAID or pain reliever) and esomeprazole (antacid). Naproxen works by blocking the release of certain chemical messengers (prostaglandins) that cause pain and inflammation (redness and swelling). Esomeprazole works by blocking the action of the enzyme known as the gastric proton pump that is responsible for the production of acid. This helps reduce the amount of acid produced, heals the ulcers and prevents the formation of new ulcers.
You are not recommended to take Espra XN 500 Tablet with clopidogrel as co-administration of these two medicines may increase the risk of bleeding more easily. However, please consult a doctor immediately if you notice blood in urine or stools, dizziness, unusual bleeding or bruising, vomiting, weakness or headache. If you are supposed to use these medicines together, you are advised to contact your doctor to adjust the dose appropriately to use safely.
Yes, Espra XN 500 Tablet can alter specific medical tests like neuroendocrine tumors (secretin stimulation test) and urine screening tests for tetrahydrocannabinol (THC). So before undergoing such diagnostics test, contact your doctor.
Naproxen in Espra XN 500 Tablet may increase the risk of heart problems such as heart attack and stroke especially when used in high doses or for a prolonged duration. It is advised to inform your doctor if you have any of these conditions or have a history of heart problems or stroke before taking Espra XN 500 Tablet . However, it is recommended to take Espra XN 500 Tablet in the dose and for the duration as prescribed by your doctor. It should be not used by the patient who had recent heart bypass surgery (coronary artery bypass graft - CABG).
Espra XN 500 Tablet does not cure arthritis but relieves symptoms of arthritis-like joint pain, swelling and stiffness. Arthritis is a chronic condition of joints with pain and inflammation.
Espra XN 500 Tablet is a pregnancy Category C medicine so, it is advisable to tell your doctor before its intake. It may inhibit ovulation (release of an egg from the ovary) and decrease the levels of progesterone leading to infertility in women. However, this effect is temporary and ovulation returns to normal mostly after one month of stopping Espra XN 500 Tablet . However, if you are planning for pregnancy or have difficulties becoming pregnant, please inform your doctor before taking Espra XN 500 Tablet .
It is highly recommended to take Espra XN 500 Tablet on an empty stomach, at least 30 minutes before a meal, to allow the protective coating to work properly. If you experience severe stomach upset, talk to your doctor.
It is best to avoid alcohol while taking this medicine, as combining them significantly increases your risk of developing stomach ulcers or internal bleeding. Talk to your doctor if you have concerns about this.
No, you should not take other nonsteroidal anti-inflammatory drugs (NSAIDs) while taking this medicine, as doing so greatly increases your risk of serious stomach side effects. Talk to your doctor or pharmacist before taking any new medications.
This medication is generally not recommended during pregnancy, especially during the last three months, as it can cause complications for the baby and during delivery. Talk to your doctor for safer alternatives.
Some people may experience mild dizziness or drowsiness while taking this medication. Avoid driving or operating machinery until you know how this medicine affects you, and talk to your doctor if these symptoms persist.
This medication is typically prescribed for chronic joint conditions like arthritis and is not meant for short-term, occasional pain like a simple headache. Talk to your doctor for guidance on appropriate headache treatments.
If your symptoms do not improve after a few weeks of consistent use, do not increase your dose on your own. Talk to your doctor to re-evaluate your treatment plan and discuss alternative options.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Country of origin

India

Manufacturer/Marketer address

Sarkhej-Dholka Road, Bhat, Ahmedabad-382 210, India.
Other Info - ESP0062

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