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compositionComposition:EVEROLIMUS-0.25MG
prescription
Prescription Medicine
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Evergraf 0.25 mg Tablet is used to treat cancer and to prevent organ rejection. It contains Everolimus which works by stopping cancer cells from reproducing and decreasing the activity of the immune system. In some cases, this medicine may cause side effects such as weakness, infection, cough, diarrhoea, fever, and fatigue. Inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.

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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

EVEROLIMUS-0.25MG

Manufacturer/Marketer :

Panacea Biotec Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Evergraf 0.25 mg Tablet

Evergraf 0.25 mg Tablet is an oral prescription medication primarily used to prevent your body from rejecting a newly transplanted kidney or liver. It is also prescribed to treat specific types of cancerous and non-cancerous tumours, including advanced breast cancer, kidney cancer, and tumours associated with tuberous sclerosis complex. By targeting abnormal cell growth and regulating your body's immune response, this medication helps protect your organs and control tumour progression.

To ensure this medication works effectively, you must take Evergraf 0.25 mg Tablet consistently at the same times every single day. You can take it either consistently with food or consistently without food, but you must not switch back and forth between these methods. Combining this treatment with a balanced diet, proper sun protection, and strict infection-prevention habits will help you achieve the best possible results.

While taking Evergraf 0.25 mg Tablet , you may experience common side effects such as mouth sores, unusual tiredness, skin rashes, and mild digestive upset. It is critical to monitor your health closely and contact your doctor immediately if you experience severe symptoms, such as a sudden high fever, a new or worsening cough, difficulty breathing, or yellowing of your skin or eyes.

Before starting this medication, tell your doctor if you have a history of diabetes, high cholesterol, lung problems, or liver damage. Do not take this if you have had a severe allergic reaction to this medication or any similar immunosuppressant medicines in the past.

This medicine can interact with several other drugs, alcohol, and tobacco, which can alter the medication levels in your blood and lead to severe side effects or reduced effectiveness. If you are pregnant, planning to become pregnant, breastfeeding, or are an elderly individual, you must consult your doctor before starting treatment, as special precautions or dosage adjustments will be necessary.

Uses of Evergraf 0.25 mg Tablet

Your doctor may prescribe this medicine to treat several conditions, including:

  • Organ Transplant Rejection: Evergraf 0.25 mg Tablet helps prevent your immune system from attacking and rejecting a newly transplanted kidney or liver, allowing the new organ to function safely.
  • Certain Types of Cancer: It helps slow down or stop the growth and spread of advanced breast cancer, kidney cancer, and neuroendocrine tumours of pancreatic, lung, or gastrointestinal origin.
  • Tuberous Sclerosis Complex (TSC) Tumours: It helps shrink non-cancerous tumours in the brain, kidneys, or lungs associated with TSC, and can help reduce the frequency of seizures in these patients.
     

Key Benefits

Evergraf 0.25 mg Tablet helps prevent organ transplant rejection and is also used to treat certain cancers and tumours by regulating immune activity and slowing abnormal cell growth. Key benefits include:

  • Prevents Organ Transplant Rejection: By suppressing the immune system, Evergraf 0.25 mg Tablet helps prevent the body from attacking a transplanted kidney or liver, supporting long-term transplant function and recovery.
  • Helps Treat Certain Cancers and Tumours: Evergraf 0.25 mg Tablet slows the growth and spread of abnormal cells, helping shrink certain cancers and non-cancerous tumours while reducing disease-related symptoms.
  • Manages Tuberous Sclerosis Complex: In people with tuberous sclerosis complex, Evergraf 0.25 mg Tablet helps reduce the size of certain tumours and may lower the frequency of seizures, improving disease management and quality of life.
     
Side effects of Evergraf 0.25 Tablet
  • Eat more plant based foods like vegetables, fruits and whole grains.
  • Reduce intake of foods containing high fat such as dairy, oil and red meat.
  • Exercise for at least 30 minutes 5 days a week.
  • Aim for weight loss and maintain healthy weight.
  • Quit smoking.
  • Control blood sugar and blood pressure.
  • Stay hydrated by taking fluids like water, juices and soups etc.
  • Eat fruits and vegetables which contain vitamins.
  • Take iron rich food like dry fruits, green leafy vegetables and sea food etc.
  • Reduce intake of milk, cheese, yogurt, soy, chocolate, ice cream, Grapes, Popcorn, canned salmon, pomegranate.
  • Regular exercise like walking, jogging is helpful.
  • Rest well; get enough sleep.
  • Eat a balanced diet and drink enough water.
  • Manage stress with yoga and meditation.
  • Limit alcohol and caffeine.
  • Physical activities like walking or jogging might help boost energy and make you feel less tired.
  • Get plenty of rest and avoid activities that tire you out to allow your body fight the infection.
  • Drink lots of fluids to help loosen mucus in the lungs.
  • Use over-the-counter medications like paracetamol or ibuprofen to manage fever.
  • Use a humidifier as it helps soothe irritated airways.
  • Do not make changes to your medication schedule or take over-the-counter medicines without consulting your doctor.
  • Eat a healthy balanced diet.
  • Reduce stress with relaxation techniques such as yoga or meditation.
  • Keep track of your menstrual cycle any irregularities.
  • Have regular check ups to exclude other health problems.
  • Exercise but do not exercise to the extent of overheating.
  • Hydrate well, eat well (particularly iron and vitamins).
Here are the steps to manage Joint Pain caused by medication usage:
  • Please inform your doctor about joint pain symptoms, as they may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Your doctor may prescribe common pain relievers if necessary to treat joint discomfort.
  • Maintaining a healthy lifestyle is key to relieving joint discomfort. Regular exercise, such as low-impact sports like walking, cycling, or swimming, should be combined with a well-balanced diet. Aim for 7-8 hours of sleep per night to assist your body in repairing and rebuilding tissue.
  • Applying heat or cold packs to the affected joint can help reduce pain and inflammation.
  • Please track when joint pain occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.
  • If your joint pain is severe or prolonged, consult a doctor to rule out any underlying disorders that may require treatment.
Managing Medication-Triggered Epistaxis (Nosebleed): A Step-by-Step Guide:
  • If you experience nosebleeds or unusual bleeding after taking medication, seek medical attention right away and schedule an appointment to discuss your symptoms with your doctor.
  • Your doctor may adjust your treatment plan by changing the dosage, switching to a different medication, or stopping the medication.
  • If your doctor advises, take steps to manage bleeding and promote healing, such as applying pressure, using saline nasal sprays, or applying a cold compress, using humidifiers, avoiding blowing or picking your nose, and applying petroleum jelly to the nostrils.
  • Schedule follow-up appointments with your doctor to monitor progress, adjust treatment plans, and prevent future episodes.

Directions for Use

  • Evergraf 0.25 mg Tablet can be taken with or without food.
  • It is recommended to take Evergraf 0.25 mg Tablet once daily at the same time each day or as advised by your doctor.
  • Swallow Evergraf 0.25 mg Tablet as a whole with a glass of water.
  • Do not crush, break, or chew it.

How Evergraf 0.25 mg Tablet Works

Evergraf 0.25 mg Tablet works by targeting and blocking a specific protein in your body called mTOR (mammalian target of rapamycin). This protein acts as a master switch that controls cell growth, cell division, and the creation of blood vessels that feed tumours. By turning this switch off, the medication slows down the rapid growth of cancer cells and shrinks non-cancerous tumours. In transplant patients, blocking this same mTOR protein controls the activity of your immune system's white blood cells. This prevents these cells from multiplying and attacking your new kidney or liver, helping your body accept and integrate the transplanted organ.
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Alcohol

Caution

You are recommended to avoid alcohol consumption while taking Evergraf 0.25 mg Tablet to avoid unpleasant side-effects.

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Pregnancy

Unsafe

Evergraf 0.25 mg Tablet is belonging to pregnancy C category. It is not safe in pregnancy as it may causes harm to the unborn baby. Do not conceive a baby while taking Evergraf 0.25 mg Tablet .

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Breast Feeding

Unsafe

Evergraf 0.25 mg Tablet should not be taken by breastfeeding mothers as it may harm to the new-born baby.

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Driving

Caution

Evergraf 0.25 mg Tablet may cause tiredness (fatigue), do not drive or operate heavy machinery if you feel dizzy.

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Liver

Caution

Evergraf 0.25 mg Tablet should be taken with caution in patients dealing with liver disease. The doctor may adjust the dose according to the medical condition of the patient.

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Kidney

Caution

Evergraf 0.25 mg Tablet is likely unsafe in patients with severe kidney disease as it may cause kidney failure which can be dangerous, use Evergraf 0.25 mg Tablet only when prescribed by a doctor.

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Children

Unsafe

Evergraf 0.25 mg Tablet is not recommended for children below 18 years as the safety and effectiveness were not established.

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Heart

Consult your doctor

Please inform your doctor if you have a history of heart disease before using Evergraf 0.25 mg Tablet . Your doctor will prescribe it only if the benefits outweigh the risks.

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Geriatrics

Consult your doctor

Limited information available for use of Evergraf 0.25 mg Tablet in elderly patients. Please consult your doctor.

What if I have taken an overdose of Evergraf 0.25 mg Tablet

If you accidentally take more than your prescribed dose of Evergraf 0.25 mg Tablet , seek immediate emergency medical care or contact a poison control center right away, even if you do not feel sick or have any symptoms.

Diet & Lifestyle Advise

  • Avoid Grapefruit and Grapefruit Juice: Grapefruit contains natural compounds that block your body's ability to break down Evergraf 0.25 mg Tablet , which can cause the medicine to build up to dangerous levels in your blood.
  • Practice Gentle Oral Care: To manage or prevent mouth sores, use a soft-bristled toothbrush, rinse your mouth with water or alcohol-free mouthwash after meals, and avoid eating highly spicy, acidic, or very hot foods.
  • Protect Yourself from Infections: Wash your hands frequently with soap and water, avoid close contact with people who are actively sick, and speak with your doctor before scheduling any routine vaccinations.
  • Protect Your Skin from the Sun: This medicine can make your skin more sensitive to sunlight, increasing your risk of skin damage. Wear protective clothing, a wide-brimmed hat, and apply broad-spectrum sunscreen when outdoors.
     
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Have a query?

How Soon It Starts Working

The time required for Evergraf 0.25 mg Tablet to start to work: Evergraf 0.25 mg Tablet ideally shows its action within 1 to 2 hours after administration. The time for which the effects of Evergraf 0.25 mg Tablet last: The duration of action for Evergraf 0.25 mg Tablet is clinically unknown.

What if you forget to take Evergraf 0.25 mg Tablet

If you miss a dose of Evergraf 0.25 mg Tablet and it is within 6 hours of your scheduled time, take it as soon as you remember. If more than 6 hours have passed since your scheduled time, skip the missed dose entirely and take your next dose at your normal scheduled time. Do not take two doses at once to make up for a missed one.

Storage

•Store Evergraf 0.25 mg Tablet tablets in their original blister pack or container at room temperature, ideally between 20°C to 25°C (68°F to 77°F). •Keep the medicine in a dry place protected from direct heat, moisture, and light.

Drug Warnings

  • Attend All Scheduled Blood Tests: You will need frequent blood and urine tests so your doctor can monitor your kidney function, cholesterol, blood sugar, and the exact amount of medicine in your system.
  • Delay Dental or Surgical Procedures: Because Evergraf 0.25 mg Tablet can significantly slow down wound healing, you must inform your surgeon or dentist that you take this medicine, as you may need to pause treatment temporarily.
  • Avoid Live Vaccines: Do not receive any live vaccines (such as the nasal spray flu vaccine or yellow fever vaccine) while taking Evergraf 0.25 mg Tablet , as your weakened immune system may not protect you adequately.
  • Inspect Your Tablets Before Taking: Do not use any tablets that are broken, cracked, crumbling, or show signs of moisture damage inside the packaging.
  • Keep a Full List of Your Medicines: Inform every healthcare professional you visit that you are taking Evergraf 0.25 mg Tablet , as it interacts with many common prescription and over-the-counter drugs.
     

Drug-Drug Interactions

verifiedApollotooltip
  • Antifungal medications (such as ketoconazole or itraconazole): Can raise the amount of Evergraf 0.25 mg Tablet in your blood to dangerously high levels, increasing the risk of severe side effects.
  • Certain antibiotics (such as clarithromycin or erythromycin): May block the breakdown of Evergraf 0.25 mg Tablet , leading to an unsafe build-up of the drug in your body.
  • Seizure medications (such as carbamazepine, phenobarbital, or phenytoin): Can lower the effectiveness of Evergraf 0.25 mg Tablet by speeding up how quickly your body clears the medicine.
  • St. John's Wort: This herbal supplement can significantly lower the levels of Evergraf 0.25 mg Tablet in your system, making your treatment less effective.
     
EverolimusGentamicin
Severe
EverolimusItraconazole
Severe

Drug-Drug Interactions

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EverolimusGentamicin
Severe
How does the drug interact with Evergraf 0.25 Tablet:
Evergraf 0.25 Tablet may cause kidney problems, and combining it with gentamicin may increase that risk.

How to manage the interaction:
Although there is a possible interaction, gentamicin can be taken with Evergraf 0.25 Tablet if prescribed by the doctor. Consult the doctor if you experience symptoms of kidney damage such as nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or weight loss, fluid retention, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm.
EverolimusItraconazole
Severe
How does the drug interact with Evergraf 0.25 Tablet:
Co-administration of Evergraf 0.25 Tablet and itraconazole can increase the blood levels of Evergraf 0.25 Tablet leading to serious side effects (pneumonitis - inflammation of the lungs, infection, mouth ulcers, anemia, or bleeding).

How to manage the interaction:
Itraconazole and Evergraf 0.25 Tablet may interact, but if a doctor prescribes them, you can still take them. If you have an infection, oral ulcers, pale skin, or bleeding, consult a doctor right once. Never discontinue taking a medication without consulting a doctor.
EverolimusMeloxicam
Severe
How does the drug interact with Evergraf 0.25 Tablet:
Co-administration of Evergraf 0.25 Tablet with Meloxicam can increase the risk of kidney problems.

How to manage the interaction:
Although taking Evergraf 0.25 Tablet and Meloxicam together can cause an interaction, it can be taken if a doctor has suggested it. However, if you experience things like nausea, vomiting, loss of appetite, weight loss, swelling, muscle cramps, weakness, dizziness, confusion, or an irregular heartbeat, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
EverolimusMefenamic acid
Severe
How does the drug interact with Evergraf 0.25 Tablet:
Coadministration of Mefenamic acid with Evergraf 0.25 Tablet can increase the risk or severity of kidney disease.

How to manage the interaction:
Taking Mefenamic acid with Evergraf 0.25 Tablet together can result in an interaction, it can be taken if a doctor has advised it. However, if you notice any symptoms of nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or weight loss, fluid retention, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm you should contact a doctor immediately. Do not stop using any medications without talking to a doctor.
EverolimusGriseofulvin
Severe
How does the drug interact with Evergraf 0.25 Tablet:
When Evergraf 0.25 Tablet is taken with Griseofulvin, it may decrease the blood levels of Evergraf 0.25 Tablet, which may make Evergraf 0.25 Tablet less effective in treating the condition.

How to manage the interaction:
There may be a possibility of interaction between Evergraf 0.25 Tablet and Griseofulvin, but it can be taken if prescribed by a doctor. Do not stop using any medications without talking to a doctor.
EverolimusFlurbiprofen
Severe
How does the drug interact with Evergraf 0.25 Tablet:
Using Evergraf 0.25 Tablet and Flurbiprofen can increase the risk of kidney problems.

How to manage the interaction:
Although taking Evergraf 0.25 Tablet and Flurbiprofen together can cause an interaction, it can be taken if a doctor has suggested it. Do not stop using any medications without talking to a doctor.
EverolimusFosphenytoin
Severe
How does the drug interact with Evergraf 0.25 Tablet:
Taking Evergraf 0.25 Tablet and Fosphenytoin may reduce the blood levels of Evergraf 0.25 Tablet, which may make it less effective in treating the condition.

How to manage the interaction:
Although there is a possible interaction between Evergraf 0.25 Tablet and Fosphenytoin, you can take these medicines together if prescribed by a doctor. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, or rapid heartbeat, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
EverolimusAnakinra
Severe
How does the drug interact with Evergraf 0.25 Tablet:
When Evergraf 0.25 Tablet is coupled with Anakinra, the breakdown of it can be enhanced.

How to manage the interaction:
Although there is a possible interaction between Anakinra and Evergraf 0.25 Tablet, you can take these medicines together if prescribed by a doctor. Do not discontinue any medications without a doctor's advice.
EverolimusRifapentine
Severe
How does the drug interact with Evergraf 0.25 Tablet:
When Evergraf 0.25 Tablet is taken with Rifapentine, it may lower Evergraf 0.25 Tablet blood levels, making it less effective in treating the illness.

How to manage the interaction:
Taking Evergraf 0.25 Tablet with Rifapentine together can result in an interaction, but it can be taken if a doctor has advised it. Do not stop using any medications without a doctor's advice.
EverolimusMiconazole
Severe
How does the drug interact with Evergraf 0.25 Tablet:
Coadministration of miconazole and Evergraf 0.25 Tablet may increase the effect of miconazole. This can increase the risk or severity of side effects.

How to manage the interaction:
Although there is a possible interaction between miconazole and Evergraf 0.25 Tablet, you can take these medicines together if prescribed by a doctor. Do not stop using medications without a doctor's advice.

Drug-Food Interactions

verifiedApollotooltip
  • Grapefruit and Grapefruit Juice: Prevents your liver from processing the medicine properly, which can lead to toxic levels of Evergraf 0.25 mg Tablet in your blood.
     
EVEROLIMUS-0.25MGGrapefruit and Grapefruit Juice
Moderate

Drug-Food Interactions

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EVEROLIMUS-0.25MGGrapefruit and Grapefruit Juice
Moderate
Common Foods to Avoid:
Grapefruit Juice

How to manage the interaction:
Taking Evergraf 0.25 Tablet with grapefruit juice can raise blood levels and enhance the effects of Evergraf 0.25 Tablet. Since the co-administration of Evergraf 0.25 Tablet along with grapefruit juice can lead to an interaction, You should not consume grapefruit juice or eat grapefruits while taking Evergraf 0.25 Tablet.

All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[ANTINEOPLASTIC]

FAQs

Evergraf 0.25 mg Tablet is used to treat breast cancer, pancreatic cancer, lung cancer and kidney cancer.
Evergraf 0.25 mg Tablet is an anticancer medicine. It belongs to a group of medicines known as a kinase inhibitor. It works by lowering the blood supply to the tumor, which reduces the growth and spread of cancer cells.
There is no specific duration of treatment with Evergraf 0.25 mg Tablet . Evergraf 0.25 mg Tablet is continued till benefit is seen or undesirable toxicity or side effects occur.
Evergraf 0.25 mg Tablet can lead to serious side effects that consist of severe allergic reactions, angioedema (painless swelling under the skin) and kidney failure which can be dangerous and can lead to death. It is possible that you may develop an infection or problems associated to lungs like breathing problems.
It usually takes three to six months for most types of lung cancer to double their size. It will take a long time for lung cancer to reach a size that could be diagnosed in X-Ray.
Evergraf 0.25 mg Tablet contains Everolimus, which belongs to the group of medicines known as kinase inhibitors.
Regular monitoring is essential when using Evergraf 0.25 mg Tablet . Your doctor may check your blood tests, blood sugar, blood pressure, and kidney function. They may also adjust your dose based on your response to treatment or any side effects that occur. It's essential to report any changes or concerns to your doctor to ensure safe and effective treatment.
While taking Evergraf 0.25 mg Tablet , avoiding certain things is essential to ensure your safety. Avoid consuming grapefruit juice and products and St. John's Wort, as they can interact with the medication. Certain antibiotics, antifungals, and medications can also interact with Everolimus, so consult your doctor before taking any new medications. Additionally, consult your doctor before receiving any vaccinations and avoid high-risk activities that may increase the risk of infections and bleeding. It's also important to avoid getting pregnant or fathering a child while taking Everolimus, as well as breastfeeding. Finally, limit your sun exposure to avoid increasing the risk of skin cancer. Always consult your doctor or pharmacist for a comprehensive list of medications and activities to avoid while taking Everolimus.
Evergraf 0.25 mg Tablet is administered orally in the form of a tablet. Take Everolimus with or without food, as advised by your doctor. Swallow the tablet whole with water; do not crush, break, or chew it. Note: It's important to follow your doctor's instructions and take Evergraf 0.25 mg Tablet exactly as prescribed
By regularly monitoring your progress through brain scans and other evaluations, your doctor can determine if Evergraf 0.25 mg Tablet is effectively shrinking your brain tumor.
Evergraf 0.25 mg Tablet is indeed considered a cytotoxic medication, but it's a targeted therapy that specifically targets cancer cells and inhibits their growth. It's not a traditional chemotherapy medication, but it can still have side effects and be harmful to healthy cells to some extent. If you have any concerns or questions, please consult your doctor or healthcare team to discuss potential risks and benefits and manage any side effects.
Common side effects of Evergraf 0.25 mg Tablet may include weakness, infection, sinus inflammation, cough, diarrhoea, fever, fatigue, otitis media (infection of the ear), stomatitis (Inflammation of the mouth) and upper respiratory tract infection. Most of these side effects of Evergraf 0.25 mg Tablet do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.
No, Evergraf 0.25 mg Tablet can cause serious harm or birth defects to an unborn baby. Women who are able to get pregnant must use highly effective birth control during treatment and for several weeks after stopping the medicine. Talk to your doctor if you are planning a pregnancy.
Your doctor needs to check the level of the medicine in your blood to ensure it stays in a safe and effective range. These tests also monitor your kidney function, liver health, blood sugar, and cholesterol. Talk to your doctor to understand your testing schedule.
Mouth sores are a common side effect of Evergraf 0.25 mg Tablet . You can manage them by brushing gently with a soft toothbrush, using an alcohol-free mouthwash, and avoiding spicy or acidic foods. If they become very painful or prevent you from eating, talk to your doctor.
You can safely receive an inactive (dead) flu shot, but you must completely avoid live vaccines (such as the nasal spray flu vaccine) while taking Evergraf 0.25 mg Tablet because your immune system is suppressed. Talk to your doctor before receiving any vaccine.
Some patients taking Evergraf 0.25 mg Tablet may experience mild hair thinning or hair loss. This is typically temporary and usually improves after you finish your treatment. If you are concerned about hair thinning, talk to your doctor.
Evergraf 0.25 mg Tablet can increase blood glucose levels, which is especially important to monitor if you already have diabetes. Your doctor will check your blood sugar levels regularly during treatment. Talk to your doctor if you experience extreme thirst or frequent urination.
It is highly recommended to limit or avoid alcohol while taking Evergraf 0.25 mg Tablet , as alcohol can increase your risk of liver damage and worsen side effects like dizziness or fatigue. Talk to your doctor about what is safe for you.
Evergraf 0.25 mg Tablet can slow down wound healing and increase your risk of infection after surgery. You must notify your surgeon and your prescribing doctor well in advance, as you may need to temporarily stop taking Evergraf 0.25 mg Tablet before and after your procedure. Talk to your doctor for a personalized plan.

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Country of origin

India

Manufacturer/Marketer address

Off. Ashram Road, Ahmedabad - 380 009., Gujarat, India
Other Info - EVE0183
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