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compositionComposition:RIVAROXABAN-20MG
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Prescription Medicine
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Exafib 20 Tablet is used to prevent and treat blood clots in the legs (deep vein thrombosis) and lungs (pulmonary embolism). It contains Rivaroxaban, a blood thinner that works by blocking certain clotting factors in the blood, which helps to prevent clots from forming. By doing this, it reduces the risk of serious conditions, such as stroke or blocked blood vessels. You may experience some common side effects may including bleeding, low red blood cell count (anemia), and nausea. Before taking Exafib 20 Tablet , let your doctor know if you are allergic to any of its ingredients, if you are pregnant or breastfeeding, and about any other medicines you are taking or any health problems you have.

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Written By Lakshmithulasi Yarragunta , PharmD (PB)
Reviewed By Bayyarapu Mahesh Kumar , M Pharmacy
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More about the Product

Composition :

RIVAROXABAN-20MG

Manufacturer/Marketer :

Emcure Pharmaceuticals Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Exafib 20 Tablet

Exafib 20 Tablet is a prescription medicine used to treat and prevent harmful blood clots. It is commonly prescribed to protect people from strokes, deep vein thrombosis (clots in the legs), and pulmonary embolisms (clots in the lungs). By keeping your blood flowing smoothly, it lowers the risk of serious medical emergencies.

For this medicine to work effectively, you must take it consistently at the same time every day. Depending on the strength of your dose, your doctor may instruct you to take it with food to ensure your body absorbs it properly, or you may be able to take it with or without food. Making simple lifestyle adjustments, such as drinking enough water and staying active, can also support your treatment.

Like all medicines, Exafib 20 Tablet can cause side effects, with mild bleeding or easy bruising being the most common. However, if you experience serious symptoms like coughing up blood, severe dizziness, or bleeding that will not stop, you should contact your doctor immediately.

Do not take this if you have active, severe bleeding or severe liver damage. Before starting, it is crucial to talk to your doctor if you have kidney disease, a history of bleeding problems, or a prosthetic heart valve.

This medicine can interact with other drugs, including common pain relievers like aspirin or ibuprofen, which can increase your risk of bleeding. You should also limit alcohol consumption and consult your doctor if you are pregnant, breastfeeding, or managing health conditions as an older adult.

Uses of Exafib 20 Tablet

Exafib 20 Tablet may be prescribed for the following conditions related to blood clot prevention and treatment: 

  • Deep vein thrombosis (DVT): Exafib 20 Tablet helps by treating existing blood clots in the deep veins of your legs and preventing new ones from forming.
  • Pulmonary embolism (PE): This medicine treats blood clots that have travelled to your lungs and reduces the chance of them happening again.
  • Stroke prevention in atrial fibrillation: For people with an irregular heartbeat, Exafib 20 Tablet lowers the risk of a dangerous blood clot travelling to the brain and causing a stroke.
  • Blood clot prevention after surgery: It is used to protect you from developing blood clots in your veins after undergoing hip or knee replacement surgeries.
     

Key Benefits

Exafib 20 Tablet helps prevent and treat harmful blood clots by reducing the blood's ability to clot. It lowers the risk of serious complications while supporting a safer recovery in people at increased risk of clot formation.

  • Prevents Blood Clots: Helps prevent the formation of harmful blood clots in the legs, lungs, and other parts of the body.
  • Reduces Stroke Risk: Helps lower the risk of stroke in people with conditions such as non-valvular atrial fibrillation.
  • Supports Recovery After Surgery: Helps prevent blood clots following major hip or knee replacement surgery, supporting a safer recovery.
  • Treats Existing Blood Clots: Helps prevent existing clots from becoming larger while reducing the risk of new clots forming.
  • Provides Convenient Long-Term Protection: Regular use helps reduce the risk of recurrent clotting events without the routine blood monitoring required with some older anticoagulants.
     
Side effects of Exafib 20 Tablet
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
Here are the steps to cope with constipation as a side effect of medication:
  • Inform your doctor about your constipation symptoms. They may adjust your medication or advise alternative treatments.
  • Stay hydrated by drinking sufficient of water (at least 8-10 glasses a day) to help soften stool and promote bowel movements.
  • Increase fibre intake by eating foods high in fibre, such as fruits, whole grains, vegetables and legumes, to help bulk up the stool.
  • Establish a bowel routine by trying to go to the bathroom at the same time each day to train your bowels.
  • Engaging in regular exercise, like walking or yoga, can support in bowel movement stimulation.
  • Consult your doctor if constipation persists, and discuss alternative treatments or adjustments to your medication.
Here are the 7 steps to manage Dizziness caused by medication:
  • Inform your doctor about dizziness symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Follow your doctor's instructions for taking medication, and take it at the same time every day to minimize dizziness.
  • When standing up, do so slowly and carefully to avoid sudden dizziness.
  • Avoid making sudden movements, such as turning or bending quickly, which can exacerbate dizziness.
  • Drink plenty of water throughout the day to stay hydrated and help alleviate dizziness symptoms.
  • If you're feeling dizzy, sit or lie down and rest until the dizziness passes.
  • Track when dizziness occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.
  • Regularly exercise and have a balanced diet to maintain a healthy weight.
  • Eat lot of fruits and vegetables (minimum 5 servings/day).
  • Include vitamin K-rich foods for stable anticoagulation control.
  • Limit red and processed meats.
  • Avoid smoking and consumption of alcohol.
  • Changes in kidney function need immediate medical attention.
  • Always monitor your blood pressure and inform your healthcare team if there are any sudden changes.
  • Take medicines as prescribed and eat a balanced diet suggested by your dietician for healthy kidney function.
  • Physical activity and exercise must be included in your daily routine to have proper kidney functioning and to maintain a healthy weight.
  • Get enough sleep to reduce the stress levels that have a direct impact on your kidney functioning.
  • Avoid massaging the bruise, as this might worsen the damage to the injured tissue.
  • Resting the affected area helps prevent more injury and aids healing.
  • Place a cloth-wrapped ice pack or cold compress on the affected area for 10 to 15 minutes.
  • If the bruise is extensive, severe, or accompanied by other symptoms like warmth, redness, or swelling, get medical help.

Directions for Use

  • Exafib 20 Tablet can be taken with or without food as advised by your doctor.
  • Follow your doctor's instructions on the dosage and timing of this medication to ensure safety.
  • Swallow Exafib 20 Tablet as a whole with a glass of water.
  • Do not chew, crush or break it.

How Exafib 20 Tablet Works

Exafib 20 Tablet contains rivaroxaban, which works by targeting a specific protein in your body called Factor Xa, which is essential for blood clotting. When you get a cut, your body uses these proteins to stick blood cells together to stop the bleeding. However, inside your blood vessels, unwanted clotting can block blood flow. By gently blocking the activity of Factor Xa, Exafib 20 Tablet slows down your body's clotting process. This keeps your blood thin and moving smoothly through your veins and arteries, which prevents new clots from forming and stops existing clots from growing larger.
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Alcohol

Unsafe

You are recommended to avoid consumption of alcohol with Exafib 20 Tablet as it may increase the risk of bleeding.

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Pregnancy

Consult your doctor

Tell your doctor before using Exafib 20 Tablet because it may cause harmful effects. So, only use in that condition when a doctor is prescribed.

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Breast Feeding

Consult your doctor

Exafib 20 Tablet may pass into breast milk. Therefore consult your doctor.

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Driving

Safe if prescribed

Exafib 20 Tablet usually does not affect your ability to drive or operate machinery.

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Liver

Caution

Take Exafib 20 Tablet with caution, especially if you have a history of Liver diseases/conditions. The dose may be adjusted by your doctor as required.

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Kidney

Caution

Take Exafib 20 Tablet with caution, especially if you have a history of Kidney diseases/conditions. The dose may be adjusted by your doctor as required.

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Children

Unsafe

Exafib 20 Tablet is not approved for children. Therefore Exafib 20 Tablet is not safe for children.

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Heart

Safe if prescribed

Exafib 20 Tablet is safe for use in heart patients if adminitered by the physician

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Geriatrics

Safe if prescribed

Exafib 20 Tablet can be safely used in elderly patients if prescribed by the physician. Close monitoring of the patient is needed.

What if I have taken an overdose of Exafib 20 Tablet

If you take too much of this medicine, seek emergency medical care immediately. An overdose can cause severe, dangerous bleeding.

Diet & Lifestyle Advise

  • Use Gentle Oral Care Products: Brush with a soft-bristled toothbrush and use waxed dental floss to help reduce the risk of bleeding gums.
  • Shave Safely: Use an electric razor instead of a manual blade to minimise cuts and bleeding.
  • Avoid High-Risk Activities: Avoid contact sports or activities with a high risk of falls, injuries, or bruising.
  • Maintain a Balanced Diet: Eat a healthy, consistent diet. Unlike some older blood thinners, Exafib 20 Tablet does not require you to avoid vitamin K-rich foods.
  • Stay Well-Hydrated: Drink adequate water throughout the day unless your doctor has advised you to restrict your fluid intake.
     

Have a query?

How Soon It Starts Working

  • The time required for Exafib 20 Tablet to start to work: The time required for Exafib 20 Tablet to start to work is 2 to 4 hours after administration.
  • The time for which the effects of Exafib 20 Tablet last: The effect of Exafib 20 Tablet lasts for 12 to 24 hours.

What if you forget to take Exafib 20 Tablet

If you miss a dose, take it as soon as you remember on that same day. If it is almost time for your next scheduled dose, skip the missed one and continue with your normal routine. Do not take a double dose to make up for a missed one. Talk to your doctor or pharmacist if you are unsure of what to do.

Storage

•Store Exafib 20 Tablet at room temperature, between 20°C and 25°C (68°F to 77°F). •Keep the tablets in their original packaging to protect them from light and moisture.

Drug Warnings

  • Inform Healthcare Providers: Tell your doctor, dentist, surgeon, or other healthcare professionals that you are taking Exafib 20 Tablet before any medical or dental procedure.
  • Carry Medical Identification: Wear a medical alert bracelet or carry a medical ID card stating that you are taking a blood thinner.
  • Watch for Unusual Bruising or Bleeding: Check for unexplained bruises, prolonged bleeding, blood in urine or stools, or other signs of bleeding, and seek medical advice if they occur.
  • Check Before Taking New Medicines: Consult your doctor or pharmacist before starting any prescription medicines, over-the-counter medicines, vitamins, or herbal supplements.
  • Seek Medical Attention After Head Injury: Contact your doctor immediately if you experience a fall or injury to your head, even if you feel well, as internal bleeding may occur.
     

Drug-Drug Interactions

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Drug-Drug Interactions

Inform your doctor if you are taking any of the following medicines, as they may interact with Exafib 20 Tablet : 

  • Nonsteroidal anti-inflammatory drugs (NSAIDs) like ibuprofen or naproxen: May significantly increase your risk of stomach or internal bleeding.
  • Other blood thinners (like aspirin, heparin, or warfarin): Can compound the blood-thinning effect and cause dangerous bleeding.
  • Certain antifungal medicines (like ketoconazole) or antiviral medicines: Can increase the levels of Exafib 20 Tablet in your body, raising the risk of side effects.

Drug-Food Interactions

Certain foods and beverages may affect the safety or effectiveness of Exafib 20 Tablet , including: 

  • Grapefruit or grapefruit juice: May interfere with how your body breaks down this medicine, potentially increasing the risk of bleeding.

Drug-Disease Interactions

Inform your doctor if you have any of the following medical conditions before taking Exafib 20 Tablet , as special precautions may be required:

  • Active major bleeding: Do not take this medicine if you have a condition causing active, uncontrolled bleeding.
  • Severe kidney or liver damage: May affect how your body processes and clears the medication, increasing the risk of buildup and bleeding.
     
RivaroxabanCobicistat
Severe

Drug-Drug Interactions

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How does the drug interact with Exafib 20 Tablet:
Co-administration of Exafib 20 Tablet together with Diclofenac may increase the risk of unsual bleeding.

How to manage the interaction:
Co-administration of Diclofenac and Exafib 20 Tablet can lead to an interaction; it can be taken if advised by your doctor. However, if you experience any symptoms like unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult your doctor immediately. Do not stop using any medications without a doctor's advice.
RivaroxabanCobicistat
Severe
How does the drug interact with Exafib 20 Tablet:
Co-administration of Cobicistat and Exafib 20 Tablet can increase the blood levels of Exafib 20 Tablet and increase the risk of bleeding complications.

How to manage the interaction:
Co-administration of Clobicistat and Exafib 20 Tablet can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, or severe headache, and weakness, consult the doctor immediately. Do not stop using any medications without a doctor's advice.
How does the drug interact with Exafib 20 Tablet:
Co-administration of Etodolac and Exafib 20 Tablet can increase the risk of bleeding problems, including severe hemorrhage.

How to manage the interaction:
Co-administration of Etodolac and Exafib 20 Tablet can lead to an interaction, it can be taken if advised by a doctor. However, if you experience any symptoms like unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult the doctor immediately. Do not stop using any medications without a doctor's advice.
How does the drug interact with Exafib 20 Tablet:
Co-administration of enoxaparin and Exafib 20 Tablet can increase the risk of bleeding problems.

How to manage the interaction:
Co-administration of enoxaparin and Exafib 20 Tablet can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood, severe headache, and weakness, consult the doctor immediately. Do not stop using any medications without a doctor's advice.
How does the drug interact with Exafib 20 Tablet:
Taking ticagrelor with Exafib 20 Tablet can increase the risk or severity of bleeding problems.

How to manage the interaction:
Taking Exafib 20 Tablet with Ticagrelor together can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you notice any unusual bleeding or bruising, dizziness, lightheadedness, red or black tarry stools, coughing up or vomiting blood, severe headache, and weakness, you should contact your doctor immediately. Do not stop using any medications without consulting your doctor.
How does the drug interact with Exafib 20 Tablet:
Coadministration of Naproxen and Exafib 20 Tablet may increase the risk or severity of bleeding problems.

How to manage the interaction:
There may be a possible interaction between Naproxen and Exafib 20 Tablet, but they can be taken together if they are prescribed by doctor. However, if you experience unusual bleeding or bruising, or have other signs and symptoms of bleeding such as dizziness; lightheadedness; red or black, stools; coughing up or vomiting fresh or dried blood that looks like coffee grounds; severe headache; and weakness, consult the doctor. Do not discontinue any medication without a doctor's advice.
How does the drug interact with Exafib 20 Tablet:
Co-administration of Dabigatran etexilate and Exafib 20 Tablet can increase the risk of bleeding, including severe blood loss.

How to manage the interaction:
Co-administration of Dabigatran etexilate and Exafib 20 Tablet can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like unusual bleeding, dizziness, tarry stools, coughing up or vomiting blood, or severe headache, consult the doctor immediately. Do not stop using any medications without a doctor's advice.
How does the drug interact with Exafib 20 Tablet:
Co-administration of primidone and Exafib 20 Tablet may reduce the blood levels of Exafib 20 Tablet, which may increase the risk or severity of bleeding problems.

How to manage the interaction:
Although there is an interaction between primidone and Exafib 20 Tablet, it can be taken if advised by a doctor. However, if you experience any unusual symptoms, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Exafib 20 Tablet:
Coadministration of Exafib 20 Tablet together with ketorolac may increase the risk of bleeding problems.

How to manage the interaction:
Although taking Ketorolac and Exafib 20 Tablet together can possibly result in an interaction, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience any unusual bleeding, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Exafib 20 Tablet:
Co-administration of Exafib 20 Tablet and Ibuprofen can increase the risk of bleeding problems.

How to manage the interaction:
Co-administration of Exafib 20 Tablet and Ibuprofen can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult the doctor immediately. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[ANTICOAGULANT/ANTITHROMBOTIC]

FAQs

Exafib 20 Tablet is used to prevent and treat deep vein thrombosis (blood clots in leg veins) and pulmonary embolism (blood clots in the lung) by reducing blood clot formation.
No, Exafib 20 Tablet is not expected to cause weight gain. If you notice unexpected weight gain and think it is because of this Exafib 20 Tablet , immediately consult your doctor and inform him about it.
Exafib 20 Tablet has many beneficial effects, but it has the ability to make you bleed more than normal. Even with minor injuries as it decreases your ability to blood clotting. Sometimes Exafib 20 Tablet may cause severe bleeding that may be dangerous and may require urgent medical care. This risk may be increased in people taking Exafib 20 Tablet along with other blood thinner medicines.
While taking Exafib 20 Tablet , avoid grapefruit and grapefruit juice because they may increase the level of the medicine in your body and raise the risk of bleeding. Unlike warfarin, Exafib 20 Tablet is not affected by vitamin K-rich foods, so foods such as spinach, broccoli, Brussels sprouts, and other green leafy vegetables do not usually need to be restricted. If you have questions about your diet, consult your doctor or pharmacist.
It is not known that Exafib 20 Tablet causes hair loss. Kindly contact your doctor.
Exafib 20 Tablet is a type of medicine known as an anticoagulant. Exafib 20 Tablet works by stopping a clotting factor called factor Xa from working. This thins your blood, so it takes longer to clot.
You should take Exafib 20 Tablet just after a meal or snack, or as advised by the doctor. It is important to take it with food to help your body absorb the entire dose.
The side effects of Exafib 20 Tablet include bleeding, nausea and anemia (lack of blood). If these side effects persist or worsen, please consult your doctor.
Yes, Exafib 20 Tablet is a blood thinner. It prevents the blood from clotting inside the blood vessels and also prevents the blood clots from recurring in the blood vessels.
No. Do not stop taking Exafib 20 Tablet without consulting your doctor, even if you feel better. Stopping this medicine suddenly can increase your risk of developing a blood clot or having a stroke. Continue taking it for as long as your doctor has prescribed and speak to your doctor before making any changes to your treatment.
Unlike some older blood thinners, Exafib 20 Tablet does not usually require routine blood monitoring to check its thinness level. However, your doctor may perform occasional blood tests to check how your kidneys and liver are working. Talk to your doctor for personalised advice.
You should avoid taking pain relievers like ibuprofen, naproxen, or aspirin while on this medicine unless specifically directed by your doctor. These drugs can increase your risk of stomach and internal bleeding. Talk to your doctor or pharmacist about safer pain relief alternatives like acetaminophen.
For minor cuts, apply firm, direct pressure with a clean cloth for at least 5 to 10 minutes. If the bleeding does not stop after applying pressure, or if the cut is deep, seek emergency medical attention immediately. Talk to your doctor if you experience frequent nosebleeds or bruising.
It is best to limit or avoid alcohol while taking this medicine. Alcohol can increase your risk of stomach bleeding and also make you more prone to falls, which can lead to dangerous internal bleeding. Talk to your doctor about what is safe for you.
Whether you need to take Exafib 20 Tablet with food depends entirely on the dose your doctor has prescribed. Some strengths must be taken with a full meal to be properly absorbed, while others can be taken with or without food. Talk to your pharmacist or check your prescription label for exact instructions.
No, this medicine is generally not recommended during pregnancy as it may cause bleeding complications for both the mother and the unborn baby. If you are planning to become pregnant or find out you are pregnant, contact your doctor immediately to discuss alternative treatments. Talk to your doctor for guidance.
Yes, but you must inform your dentist that you are taking this medicine before any procedure is performed. They will coordinate with your doctor to decide if your treatment needs to be temporarily paused or if special precautions are necessary. Talk to your doctor before making any changes.

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Country of origin

India

Manufacturer/Marketer address

255/2, Hinjawadi, Pune - 411057, India
Other Info - EXA0055
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