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compositionComposition:MIFEPRISTONE-25MG
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Prescription Medicine
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Written By Lakshmithulasi Yarragunta , PharmD (PB)
Reviewed By Veda Maddala , M Pharmacy
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More about the Product

Composition :

MIFEPRISTONE-25MG

Manufacturer/Marketer :

Jay Ell Healthcare Pvt Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Fibromif-25mg Tablet

Fibromif-25mg Tablet is an oral prescription medication used primarily for the medical termination of an early pregnancy (up to 70 days or 10 weeks of gestation) in combination with another medicine. It is also prescribed in specific cases to manage high blood sugar levels in adults with a condition called endogenous Cushing's syndrome who also have type 2 diabetes or glucose intolerance.

For ending an early pregnancy, this medication is typically taken as a single dose under clinical supervision, followed by a second medication a day or two later. When used for managing high blood sugar in Cushing's syndrome, it must be taken once daily with food at the exact same time every day to maintain consistent levels in your body. Making specific dietary adjustments, such as limiting sodium and eating potassium-rich foods, can help manage side effects during long-term treatment.

Common side effects include vaginal bleeding, cramping, nausea, headache, and physical weakness. While bleeding and cramping are expected parts of the pregnancy termination process, you must seek immediate medical attention if you experience extremely heavy bleeding, severe abdominal pain, or a fever that lasts more than 24 hours.

Do not take this if you have an intrauterine device (IUD) in place, a suspected pregnancy outside the womb (ectopic pregnancy), chronic adrenal failure, or bleeding disorders. It is crucial to discuss your complete medical history with your doctor before starting this medicine, especially if you have liver damage or kidney issues or are taking long-term steroid medications.

This medicine can interact with certain blood thinners, grapefruit juice, and medications processed by the liver, which can either increase your risk of severe side effects or make the treatment less effective. If you are breastfeeding, elderly, or have specific medical concerns, consult your healthcare provider to understand the unique risks and safety precautions required for your situation.

Uses of Fibromif-25mg Tablet

Fibromif-25mg Tablet is used primarily for the medical termination of an early pregnancy. The detailed uses of Fibromif-25mg Tablet are as follows:

  • Medical termination of early pregnancy: Fibromif-25mg Tablet helps end an intrauterine pregnancy of up to 10 weeks gestation by blocking the natural hormone needed to maintain and support the pregnancy.
  • Control of high blood sugar in Cushing's syndrome: Fibromif-25mg Tablet helps lower blood sugar levels in patients with Cushing's syndrome who have type 2 diabetes by blocking the effects of excess cortisol (the stress hormone) in the body.

Key Benefits

This medication provides critical therapeutic options for patients needing specialised endocrine or gynaecological care:

  • Non-surgical pregnancy option: It offers a highly effective, non-surgical alternative for ending an early pregnancy, allowing patients to complete the process in a familiar and private environment.
  • Targeted hormone blocking: By directly blocking progesterone, it reliably halts the supportive environment of the pregnancy, preparing the uterine lining for the final step of the medical regimen.
  • Blood sugar management: For those with Cushing's syndrome, it successfully lowers and stabilises blood sugar levels, helping to reduce the severe, long-term complications of high cortisol without requiring immediate invasive surgeries.
Side effects of Fibromif-25mg Tablet
  • Your doctor may reduce your medication dose gradually if you have too much cortisol, while still managing your condition.
  • Try hot baths, massages, and gentle exercises like water aerobics or tai chi to ease aches and pains.
  • Limit sodium and fatty foods to reduce health risks.
  • Consume foods rich in calcium, like dairy, leafy greens, fortified plant milk, and salmon, to support bone health.
  • Include sources of vitamin D in your meals, such as cod liver oil, egg yolks, fortified milk, and fatty fish like swordfish and salmon.
  • Make time for things you enjoy and set limits to avoid getting too tired.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
Here are the steps to Dry Mouth (xerostomia) caused by medication:
  • Inform your doctor about dry mouth symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Drink plenty of water throughout the day to help keep your mouth moist and alleviate dry mouth symptoms.
  • Chew sugar-free gum or candies to increase saliva production and keep your mouth moisturized.
  • Use saliva substitutes, such as mouthwashes or sprays, only if your doctor advises them to help moisturize your mouth and alleviate dry mouth symptoms.
  • Avoid consuming smoking, alcohol, spicy or acidic foods, and other irritants that may aggravate dry mouth symptoms.
  • Schedule regular dental check-ups to keep track of your oral health and handle any dry mouth issues as they arise.
  • Consume more protein-rich foods and healthy fats like beans, avocados, cheese, nuts and lean meats to minimize appetite.
  • Prefer foods high in fiber to help feel full for a long time.
  • If you have decreased appetite, eat only when you are hungry.
  • Eat several small meals or snacks all day.
  • Try to take only small sips of fluids while eating.
Here are the step-by-step strategies to manage the side effects of " Muscle Pain" caused by medication usage:
  • Report to Your Doctor: Inform your doctor about the muscle pain, as they may need to adjust your medication.
  • Stretch Regularly: Gentle stretching can help relieve muscle pain and stiffness.
  • Stay Hydrated: Adequate water intake supports muscle health by removing harmful substances and maintaining proper muscle function.
  • Warm or Cold Compresses: Apply cold or warm compresses to the affected area to reduce pain and inflammation.
  • Rest and Relaxation: Adequate rest helps alleviate muscle strain, while relaxation techniques like deep breathing and meditation can soothe muscle tightness, calm the mind, and promote relief from discomfort.
  • Gentle Exercise: Participate in low-impact activities, such as yoga or short walks, to improve flexibility, reduce muscle tension, and alleviate discomfort.
  • Consult a physician: If your symptoms don't improve or get worse, go to the doctor for help and guidance.

Directions for Use

To ensure the medication is safe and effective, always follow these administration guidelines:

  • Swallow the tablet whole with a full glass of water. Do not crush, chew, or break the tablet, as this can affect how the medicine is absorbed in your body.
  • If you are taking this medication to end an early pregnancy, you will take the tablet as a single oral dose. Your doctor will provide you with a second, different medication to take 24 to 48 hours later.
  • If you are taking this daily for blood sugar control, take it with food at the same time each day to help prevent stomach upset and ensure a steady level of the medicine in your blood.
  • Always follow your doctor's exact instructions regarding the schedule and clinical follow-up appointments.

How Fibromif-25mg Tablet Works

The medication works by targeting specific hormone receptors in the body. Progesterone is a natural hormone that is absolutely essential for a pregnancy to continue because it prepares and maintains the lining of the womb. Fibromif-25mg Tablet acts as a progesterone blocker. By binding to progesterone receptors, it prevents the hormone from doing its job. This causes the lining of the womb to break down and shed, similar to what happens during a menstrual period. This action effectively stops the pregnancy from growing further. For its secondary use in managing Cushing's syndrome, the medicine blocks cortisol receptors instead. Cortisol is often called the stress hormone, and having too much of it causes high blood sugar and other health issues. By blocking cortisol from binding to its receptors, the medicine controls excess sugar production and helps bring your body's metabolism back into balance.
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Alcohol

Unsafe

Alcohol is known to cause excessive drowsiness if taken along with Fibromif-25mg Tablet and increase uterine bleeding.

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Pregnancy

Unsafe

Fibromif-25mg Tablet is used for medical abortion. If taken in pregnancy, it can lead to abortion.

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Breast Feeding

Caution

Let your doctor know if you are a nursing mother before prescribing Fibromif-25mg Tablet ; your doctor will decide whether Fibromif-25mg Tablet can be taken by breastfeeding mothers or not.

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Driving

Unsafe

Fibromif-25mg Tablet may reduce alertness or induce sleep and dizziness. If you experience these symptoms, don't drive or operate machinery.

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Liver

Caution

Fibromif-25mg Tablet to be taken with caution, especially if you have a history of Liver diseases/conditions. The dose may have to be adjusted by your doctor.

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Kidney

Caution

Fibromif-25mg Tablet to be taken with caution, especially if you have a history of Kidney diseases/conditions. The dose may have to be adjusted by your doctor.

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Children

Unsafe

Fibromif-25mg Tablet is not recommended for children below the age of 12. The safety and effectiveness of Fibromif-25mg Tablet have not been established in children due to limited testing of this drug on children by competent authorities worldwide. If necessary, your doctor will decide whether to give Fibromif-25mg Tablet or not.

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Heart

Caution

Fibromif-25mg Tablet should be used under caution in cardiac patients as it can lead to QT prolongation.

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Geriatrics

Consult your doctor

Limited information is available for use in erderly patients. Please consult your doctor.

What if I have taken an overdose of Fibromif-25mg Tablet

Do not take more than the prescribed dose of Fibromif-25mg Tablet as it may cause overdose. The symptoms of overdose include severe vaginal bleeding. If you suspect you have taken overdose or notice signs of overdose, please consult a doctor immediately.

Diet & Lifestyle Advise

For pregnancy termination care:

  • Plan to rest in a comfortable environment for at least 24 to 48 hours after taking the second medication, as cramping and bleeding can be intense.
  • Use sanitary pads instead of tampons or menstrual cups during the bleeding process to monitor the amount of blood loss and lower the risk of uterine infection.
  • Stay hydrated by drinking plenty of water, clear broths, or electrolyte solutions to replace fluids lost through bleeding, vomiting, or diarrhoea.

For blood sugar management (Cushing's syndrome):

  • Limit your intake of grapefruit and grapefruit juice, as they can significantly alter how your body processes this medication, increasing the risk of side effects.
  • Eat potassium-rich foods like bananas, leafy greens, and potatoes, as long-term use of this medication can lower potassium levels in your blood.
  • Monitor your blood sugar levels regularly at home and keep a log to share with your healthcare provider at each visit.

Have a query?

How Soon It Starts Working

The time required for Fibromif-25mg Tablet to start to work: Fibromif-25mg Tablet ideally shows its action within 1 to 2 hours after administration. The time for which the effects of Fibromif-25mg Tablet last: The effect of Fibromif-25mg Tablet lasts for 7 to 10 days.

What if you forget to take Fibromif-25mg Tablet

If you missed to take a dose of Fibromif-25mg Tablet , please consult your doctor for advice.

Storage

•Store Fibromif-25mg Tablet tablets at controlled room temperature, ideally between 68°F and 77°F (20°C to 25°C). •Keep the tablets in their original blister pack or container to protect them from light and moisture.

Drug Warnings

  • Ensure a follow-up appointment is scheduled with your doctor 7 to 14 days after taking this medicine to confirm the pregnancy has been completely terminated.
  • Do not start any new medications, herbal supplements, or over-the-counter drugs without checking with your doctor or pharmacist first.
  • Avoid drinking alcohol during treatment, as it can worsen dizziness, drowsiness, and stomach discomfort and can mask signs of severe complications.
  • Be aware that vaginal bleeding is normal during this treatment, but it does not guarantee that the pregnancy has been fully terminated; only a medical exam can confirm this.
  • If you have a negative blood type (such as Rh-negative), ask your doctor if you need an injection of Rh immunoglobulin to protect future pregnancies.

Drug-Drug Interactions

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Drug-Drug Interactions

  • Corticosteroids: Fibromif-25mg Tablet blocks the action of steroids, making medications like prednisone or dexamethasone less effective.
  • Blood Thinners: Taking this medicine with anticoagulants (like warfarin) or antiplatelet drugs can significantly increase the risk of severe, life-threatening uterine bleeding.
  • CYP3A4 Inhibitors and Inducers: Medications like ketoconazole, erythromycin, and rifampin can alter how your liver breaks down this drug, either causing dangerous toxicity or reducing its effectiveness.

Drug-Food Interactions

  • Grapefruit and Grapefruit Juice: Can slow down the breakdown of this medication in the body, leading to higher drug levels and a greater risk of side effects.

Drug-Disease Interactions

  • Adrenal Insufficiency: Do not take this medication if you have chronic adrenal gland failure, as it can worsen this life-threatening condition.
  • Ectopic Pregnancy: This medicine is not effective for treating pregnancies outside the uterus and should not be used if an ectopic pregnancy is suspected.
  • Severe Anaemia: Use with extreme caution, as the expected blood loss during pregnancy termination can worsen severe anaemia.

Drug-Drug Interactions

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How does the drug interact with Fibromif-25mg Tablet:
Co-administration of Beclomethasone dipropionate with Fibromif-25mg Tablet may make it less effective as a therapy.

How to manage the interaction:
Taking Beclomethasone with Fibromif-25mg Tablet is not recommended, but it can be taken if prescribed by the doctor. Do not discontinue any medication without consulting a doctor.
How does the drug interact with Fibromif-25mg Tablet:
Co-administration of Fluticasone with Fibromif-25mg Tablet may make Fluticasone less effective as a therapy.

How to manage the interaction:
Taking Fluticasone with Fibromif-25mg Tablet is not recommended, consult a doctor before taking it. Do not stop using any medications without talking to a doctor.
How does the drug interact with Fibromif-25mg Tablet:
Using Fibromif-25mg Tablet with Triamcinolone can significantly reduce the effects of triamcinolone.

How to manage the interaction:
Taking Triamcinolone with Fibromif-25mg Tablet is not recommended but can be taken if prescribed by a doctor. However, if you notice any unusual symptoms contact a doctor. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Fibromif-25mg Tablet:
Using Fibromif-25mg Tablet together with fondaparinux may increase the risk and/or severity of vaginal bleeding in women

How to manage the interaction:
Taking Fondaparinux with Fibromif-25mg Tablet together is not recommended as it can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience unusual symptoms contact a doctor immediately. Do not stop using any medications without talking to a doctor.
How does the drug interact with Fibromif-25mg Tablet:
When Fludrocortisone is taken with Fibromif-25mg Tablet, it can increase the risk of side effects.

How to manage the interaction:
Taking Fibromif-25mg Tablet with Fludrocortisone is not recommended, but it can be taken if prescribed by the doctor. Do not stop using any medication without consulting a doctor.
How does the drug interact with Fibromif-25mg Tablet:
Co-administration of Fibromif-25mg Tablet with Bivalirudin can increase the risk of negative side effects.

How to manage the interaction:
Taking Bivalirudin with Fibromif-25mg Tablet together is not generally recommended as it may lead to an interaction, but it can be taken if prescribed by a doctor. However, if you experience persistent, excessive bleeding, consult the doctor. Without consulting a doctor, never stop taking any medication.
How does the drug interact with Fibromif-25mg Tablet:
Taking fentanyl and Fibromif-25mg Tablet may significantly increase the blood levels of fentanyl, which may increase the risk of side effects.

How to manage the interaction:
Although there is an interaction between Fibromif-25mg Tablet and fentanyl, they can be taken together if advised by a doctor. Do not stop using any medications without talking to your doctor.
How does the drug interact with Fibromif-25mg Tablet:
Co-administration of Fibromif-25mg Tablet with Ticagrelor can increase the risk of vaginal bleeding in women.

How to manage the interaction:
Taking Ticagrelor with Fibromif-25mg Tablet is not recommended, but can be taken together if prescribed by a doctor. However, consult your doctor if you experience any symptoms like heavy period bleed for more than 7 days, weakness, tiredness, shortness of breath or paleness. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Fibromif-25mg Tablet:
When Fibromif-25mg Tablet is taken with Prednisolone, the effects of Prednisolone might be considerably reduced, which may be less effective in treating your condition.

How to manage the interaction:
Taking Prednisolone with Fibromif-25mg Tablet is not recommended, they can be taken together if advised by a doctor. Do not discontinue the medication without consulting a doctor.
How does the drug interact with Fibromif-25mg Tablet:
Coadministration of Lurasidone with Fibromif-25mg Tablet can increase the levels of Lurasidone which can increase the risk or severity of side effects.

How to manage the interaction:
Taking Lurasidone with Fibromif-25mg Tablet together is not recommended as it can result in an interaction, it can be taken if a doctor has advised it. However, if you notice any abnormal muscle movements, seizures(fits), high blood sugar, dizziness, lightheadedness, headache, flushing, fainting, and heart palpitations, you should contact a doctor immediately. Do not stop using any medications without talking to a doctor.

Drug-Food Interactions

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MIFEPRISTONE-25MGGrapefruit and Grapefruit Juice
Moderate

Drug-Food Interactions

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MIFEPRISTONE-25MGGrapefruit and Grapefruit Juice
Moderate
Common Foods to Avoid:
Grapefruit Juice

How to manage the interaction:
Grapefruit juice may increase the effects of Fibromif-25mg Tablet. Avoid consumption of grape juice while taking Fibromif-25mg Tablet. However, if you experience headache, dizziness, fatigue, nausea, vomiting, cramping, diarrhea, swelling, and high blood pressure, consult the doctor.

All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[ANTIPROGESTERONE]

FAQs

Fibromif-25mg Tablet is used in combination with Misoprostol to induce a medical abortion. Fibromif-25mg Tablet is primarily used to end an early pregnancy (lasting up to 70 days or less than this) or an unwanted pregnancy with medication help.

If you miss a dose of Fibromif-25mg Tablet , take the missed dose as soon as you remember it. However, if it's almost time for the next dose, do not take a double dose to make up for a missed one.

Some of the common side effects of Fibromif-25mg Tablet are nausea, weakness, fever/chills, vomiting, headache, diarrhoea, and dizziness.

Fibromif-25mg Tablet contains Mifepristone, which works by blocking the effect of progesterone (female hormone), which is needed to sustain a pregnancy. In the absence of progesterone, the lining of the uterus breaks down as it does every month during the menstrual cycle, and the development of the pregnancy is stopped.

No, taking more than the prescribed dose of Fibromif-25mg Tablet will not make it more effective and could be dangerous. Please follow the dosage as prescribed by your doctor to avoid potential side effects or complications.

Please inform your doctor if you have a history of liver disease before using Fibromif-25mg Tablet . The dosage may need to be adjusted by your doctor, as liver impairment can affect how the drug is metabolized.

Swallow Fibromif-25mg Tablet as a whole with water; do not crush or chew it. The doctor will determine the dose based on your condition.

After taking Fibromif-25mg Tablet , you may experience cramping or bleeding in the uterus as the medication works to block the hormone progesterone and prepare your body for the next step in the abortion process. Typically, bleeding begins within 24-48 hours after taking Fibromif-25mg Tablet . It is common to experience other side effects such as nausea, vomiting, diarrhoea, dizziness, or infection following the abortion. Follow-up with your doctor is essential to ensure that the process is complete.

For pregnancy termination, the medicine starts blocking hormones within a few hours of taking it, though you may not experience significant bleeding or cramping until you take the second medication 24 to 48 hours later. If you are taking it daily for Cushing's syndrome, it may take several weeks to see a steady improvement in your blood sugar levels. Talk to your doctor if you have questions about what to expect.

This medicine can pass into breast milk, but the amount is typically low. However, because its effects on infants are not fully known, it is recommended to discuss breastfeeding with your healthcare provider. Some women choose to pump and discard breast milk for a few days after taking the medication. Talk to your doctor to make a safe plan for your baby.

If you vomit within 1 hour of taking the tablet, the medicine may not have been fully absorbed, and you may need to take another dose. Do not take an extra tablet on your own; instead, contact your healthcare provider or clinic immediately for instructions on what to do.

There is no medical evidence to suggest that a single, uncomplicated use of this medicine for medical abortion affects your future fertility or ability to have a healthy pregnancy. However, you can become pregnant again very quickly after the procedure, so you should discuss birth control options with your healthcare provider. Talk to your doctor for personalised advice.

This medicine can cause side effects like dizziness, fatigue, and physical weakness, especially when combined with cramping or blood loss. It is safest to avoid driving or operating machinery until you know how the medicine affects you and you feel physically strong enough. Talk to your doctor if you are unsure.

Heavy bleeding and the passage of tissue are signs that the medicine is working, but the only way to confirm a complete and successful termination is to have a follow-up medical examination, ultrasound, or blood test 7 to 14 days later. Skipping this follow-up can lead to serious health complications. Talk to your doctor to schedule this vital appointment.

No, it is highly recommended to use sanitary pads instead of tampons or menstrual cups during the entire bleeding process. Pads make it easier to monitor how much blood you are losing and significantly reduce the risk of introducing bacteria that could cause a uterine infection. Talk to your doctor or pharmacist if you need advice on post-treatment care.

It is highly recommended to avoid alcohol while taking this medicine. Alcohol can worsen side effects like dizziness, nausea, and dehydration, and it may mask important warning signs of complications, such as heavy bleeding or infection. Talk to your doctor before consuming any alcohol during your treatment.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Country of origin

INDIA

Manufacturer/Marketer address

SCO 43, Sector 82, Mohali, Punjab-140306, India
Other Info - FIB0103
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