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compositionComposition:FLUOROURACIL-500MG
prescription
Prescription Medicine
info
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Fivotop 500 Injection is used to treat breast, colon, rectum, pancreatic and stomach/gastric cancer. It contains Fluorouracil which works by preventing the cancer cells from multiplying and eventually kills them. In some cases, this medicine may cause side effects such as nausea, vomiting, weakness, loss of appetite, increased risk of infection, hair loss, diarrhoea, decreased blood cells, and mouth ulcers. Inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.

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Written By Lakshmithulasi Yarragunta , PharmD (PB)
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

FLUOROURACIL-500MG

Manufacturer/Marketer :

Axiommax Oncology Pvt Ltd

Consume Type :

Parenteral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Fivotop 500 Injection

Fivotop 500 Injection is a prescription medication given by injection or infusion to treat several types of cancer, including colon, breast, stomach, and pancreatic cancers. It works by targeting rapidly growing cells to stop them from multiplying, helping to control the spread of the disease. Your medical team will determine if this treatment is appropriate for your specific diagnosis.

Because Fivotop 500 Injection is given parenterally, your healthcare team will schedule your treatment in regular cycles. Staying consistent with these scheduled clinic appointments is vital for the treatment to work effectively. While undergoing treatment, making simple lifestyle adjustments—such as drinking plenty of water and eating soft, gentle foods—can help your body cope with the therapy.

While receiving Fivotop 500 Injection, you may experience some common side effects like mild nausea or fatigue. However, it can also cause serious issues such as severe diarrhea, mouth sores, or a significant drop in your white blood cell count. If you experience any severe symptoms, fever, or signs of an infection, you must contact your doctor immediately.

Do not take this if you have a complete deficiency of an enzyme called DPD (dihydropyrimidine dehydrogenase), as this can lead to severe, life-threatening side effects. Talk to your doctor before starting Fivotop 500 Injection if you have a history of bone marrow suppression, poor nutrition, or liver damage. Pregnant and breastfeeding women must not receive Fivotop 500 Injection, as it can harm the developing baby.

This treatment can interact with other medicines, such as certain blood thinners and vaccines, which can increase your risk of bleeding or cause severe infections. Elderly individuals may be more sensitive to the side effects of this medication and should be monitored closely during therapy. Always talk to your doctor or pharmacist about all the medications and supplements you are taking before starting treatment.

Uses of Fivotop 500 Injection

Fivotop 500 Injection is used in the treatment of breast, colon, rectum, pancreatic, and stomach/gastric cancer. The detailed uses of Fivotop 500 Injection are as follows:

  • Colorectal cancer: Fivotop 500 Injection helps by slowing down or stopping the growth of cancer cells in the colon and rectum, often used either alone or in combination with other chemotherapy drugs.
  • Breast cancer: It is used to target and destroy breast cancer cells, helping to reduce tumor size and prevent the cancer from returning after surgery.
  • Stomach cancer: Fivotop 500 Injection helps control the progression of advanced stomach cancer, easing symptoms and helping to manage the spread of the disease.
  • Pancreatic cancer: It is used in combination regimens to target pancreatic cancer cells, helping to slow tumor growth and manage symptoms.

Key Benefits

Fivotop 500 Injection helps treat certain types of cancer by slowing or stopping the growth of cancer cells. As part of a comprehensive cancer treatment plan, it helps control disease progression and supports improved treatment outcomes. Benefits may include:

  • Helps slow or stop the growth of cancer cells.
  • Supports the treatment of various cancers as prescribed by your doctor.
  • May help shrink tumours and limit the spread of cancer.
  • Helps relieve symptoms caused by tumour growth, such as pain or obstruction.
  • Supports better disease control and overall treatment effectiveness.
  • Contributes to improved quality of life when used as part of an appropriate cancer treatment plan.
Side effects of Fivotop 500 Injection 10 ml
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
  • If you experience symptoms such as mouth ulcers, redness, difficulty in swallowing or talking, abdominal pain, and painful bowel movements as a drug side effect, consult your doctor as they may adjust the dose if necessary or prescribe alternative medication.
  • Practice good hygiene, such as washing your hands regularly, to prevent infection.
  • Drink plenty of water to keep your mucous membranes hydrated and promote healing.
  • Avoid spicy or acidic foods, which can irritate the mucous membranes and exacerbate inflammation.
  • Increase your intake of omega-3 fatty acids, found in fatty fish, nuts, and seeds, to reduce inflammation.
  • Follow a soft food diet to reduce discomfort and promote healing.
  • Eat well-cooked food to minimize infection risk.
  • Practice good hand hygiene to prevent infections.
  • Avoid crowds and people with illnesses to reduce exposure.
  • Wear a mask when necessary to lower infection risk.
  • Rest adequately to support your body's healing process.
  • Stay hydrated by drinking plenty of water.
  • Regularly monitor blood cell counts for changes.
  • Seek immediate medical help if symptoms like fever, chills, or fatigue occur.
  • Consult your doctor right away if concerning symptoms arise.
  • Follow your doctor's guidance on managing myelosuppression and infection prevention.
  • Eat protein-rich foods like fish, poultry, eggs, and legumes.
  • Include foods with minerals and vitamins essential for hair health.
  • Join a support group to connect with others experiencing hair loss.
  • Openly discuss your feelings about hair loss.
  • Consider covering up with wigs, hats, or scarves.
  • Be patient and avoid seeking miracle cures.

Directions for Use

  • Follow your doctor's instructions on the dosage and timing of Fivotop 500 Injection to ensure safe and effective use.
  • Fivotop 500 Injection will be administered by a doctor or nurse in a hospital.
  • Do not self-administer it.

How Fivotop 500 Injection Works

Fivotop 500 Injection contains Fluorouracil, which belongs to a group of medicines known as antimetabolites. It is designed to mimic the natural building blocks that cells use to grow and divide. Once injected into the body, the medicine enters the cancer cells and interferes with the production of their DNA and RNA, which are essential for cell survival and multiplication. Because cancer cells divide much faster than most normal cells, they absorb more of Fivotop 500 Injection, leading to their self-destruction. This targeted action helps slow down or stop the growth of tumors throughout the body, though it can also affect some healthy, fast-growing cells, leading to temporary side effects.
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Alcohol

Unsafe

You are recommended to avoid alcohol consumption while on treatment with Fivotop 500 Injection to prevent unpleasant side effects. Alcohol intake, along with Fivotop 500 Injection, may cause increased drowsiness.

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Pregnancy

Unsafe

It is not recommended for pregnancy as it may harm your foetus. Hence, if you are pregnant or planning pregnancy, inform your doctor before receiving Fivotop 500 Injection.

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Breast Feeding

Unsafe

It is not recommended for breastfeeding as it may pass into breast milk and harm your infant. Hence, if you are breastfeeding, inform your doctor before receiving Fivotop 500 Injection. Your doctor may suggest you stop feeding while on treatment with this medicine.

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Driving

Safe if prescribed

Fivotop 500 Injection does not affect your driving ability.

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Liver

Consult your doctor

If you have a history of liver disease, inform your doctor before receiving Fivotop 500 Injection. Your doctor may adjust the dose of this medicine or prescribe a suitable alternative based on your condition.

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Kidney

Consult your doctor

If you have a history of kidney diseases, inform your doctor before receiving Fivotop 500 Injection. Your doctor may adjust the dose of this medicine or prescribe a suitable alternative based on your condition.

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Children

Unsafe

Fivotop 500 Injection is not recommended for children, as efficacy and safety have not been established.

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Heart

Consult your doctor

Please inform your doctor if you have a history of heart disease before using Fivotop 500 Injection. Your doctor will prescribe it only if the benefits outweigh the risks.

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Geriatrics

Consult your doctor

Limited information available for use of Fivotop 500 Injection in elderly patients. Please consult your doctor.

What if I have taken an overdose of Fivotop 500 Injection

Because this medication is administered by trained medical professionals in a clinical setting, an overdose is highly unlikely. However, if you suspect an error has occurred or experience sudden, severe side effects after a treatment session, seek immediate medical attention.

Diet & Lifestyle Advise

  • Practice gentle mouth care: Use a soft-bristled toothbrush and rinse your mouth regularly with a mixture of salt and baking soda in warm water to prevent painful mouth sores. Avoid alcohol-based mouthwashes.
  • Eat small, frequent meals: To manage nausea and loss of appetite, eat five to six small, bland meals throughout the day instead of three large ones. Avoid spicy, greasy, or highly acidic foods.
  • Stay well-hydrated: Drink plenty of fluids, such as water, clear broths, or decaffeinated teas, especially if you are experiencing diarrhea or nausea.
  • Avoid raw or undercooked foods: Because your immune system may be weakened during treatment, eat only fully cooked foods and wash fruits and vegetables thoroughly to reduce the risk of foodborne infections.
  • Protect your skin from the sun: Fivotop 500 Injection can make your skin highly sensitive to sunlight. Wear protective clothing, a wide-brimmed hat, and apply a broad-spectrum sunscreen with SPF 30 or higher when outdoors.
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Have a query?

How Soon It Starts Working

  • The time required for Fivotop 500 Injection to start to work: The time required for Fivotop 500 Injection to show its action is unknown.
  • The time for which the effects of Fivotop 500 Injection last: The duration of action for Fivotop 500 Injection is clinically unknown.

What if you forget to take Fivotop 500 Injection

If you miss an appointment for your injection or infusion, contact your clinic or oncologist immediately to reschedule. Keeping your treatment cycles on schedule is very important for the medication to be effective.

Storage

• Store in a cool and dry place away from sunlight.• Keep Fivotop 500 Injection out of the sight and reach of children. • Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.

Drug Warnings

  • Inspect the infusion setup: If you are using a portable pump at home, regularly check the solution bag; it should be clear and colourless. If you notice any cloudiness, particles, or leaking, call your clinic immediately.
  • Monitor your injection site: Tell your nurse right away if you feel any burning, stinging, redness, or swelling around your IV line or port during or after the injection.
  • Avoid live vaccines: Do not receive any live vaccines (such as the measles, mumps, or shingles vaccines) while using Fivotop 500 Injection, as your weakened immune system may not be able to handle them safely.
  • Use reliable birth control: Both men and women must use highly effective birth control during treatment and for several months afterwards to prevent pregnancy, as Fivotop 500 Injection can cause severe birth defects.
  • Keep up with regular blood tests: Your doctor will order frequent blood tests to check your liver function and monitor your white and red blood cell counts during your treatment cycles.

Drug-Drug Interactions

verifiedApollotooltip
  • Blood thinners (e.g., warfarin): Taking these medicines alongside Fivotop 500 Injection may increase the risk of serious bleeding. Your doctor may monitor your blood clotting more closely and adjust the dose if needed.
  • Anti-seizure medicines (e.g., phenytoin): Combining these with Fivotop 500 Injection may increase phenytoin levels in the blood, raising the risk of side effects and toxicity.
  • Live vaccines: Do not receive live vaccines while taking Fivotop 500 Injection, as the medicine can weaken your immune system and increase the risk of serious infections.
FluorouracilMitomycin
Severe
FluorouracilThalidomide
Severe

Drug-Drug Interactions

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FluorouracilMitomycin
Severe
How does the drug interact with Fivotop 500 Injection 10 ml:
Taking Fivotop 500 Injection 10 ml with mitomycin has been associated with a condition known as hemolytic uremic syndrome (HUS) and using it with Fivotop 500 Injection 10 ml may increase that risk.

How to manage the interaction:
Although taking Mitomycin and Fivotop 500 Injection 10 ml together can cause an interaction, it can be taken if your doctor has suggested it. Do not discontinue any medications without first consulting a doctor.
FluorouracilThalidomide
Severe
How does the drug interact with Fivotop 500 Injection 10 ml:
Taking thalidomide together with Fivotop 500 Injection 10 ml may increase the risk of blood clots and that may lead to serious complications.

How to manage the interaction:
Although taking thalidomide and Fivotop 500 Injection 10 ml together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as chest pain, shortness of breath, difficulty breathing, coughing up blood, sudden loss of vision, pain, redness or swelling in an arm or leg, and numbness or weakness on one side of the body. Do not discontinue any medications without consulting a doctor.
FluorouracilCladribine
Severe
How does the drug interact with Fivotop 500 Injection 10 ml:
Combining Cladribine with Fivotop 500 Injection 10 ml can increase the risk of side effects.

How to manage the interaction:
Taking Cladribine with Fivotop 500 Injection 10 ml together can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning sensation when you urinate, consult a doctor. Do not stop using any medications without a doctor's advice.
FluorouracilTofacitinib
Severe
How does the drug interact with Fivotop 500 Injection 10 ml:
Using tofacitinib together with Fivotop 500 Injection 10 ml may increase the risk of serious infections.

How to manage the interaction:
Although there is a interaction between tofacitinib and Fivotop 500 Injection 10 ml but can be taken if advised by a doctor. However, consult the doctor immediately if you experience symptoms such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination. Do not stop using any medications without consulting doctor.
FluorouracilWarfarin
Severe
How does the drug interact with Fivotop 500 Injection 10 ml:
Taking Warfarin together with Fivotop 500 Injection 10 ml may increase the risk of bleeding.

How to manage the interaction:
Although taking Warfarin and Fivotop 500 Injection 10 ml together can result in an interaction, it can be taken if a doctor has prescribed it. However, consult a doctor immediately if you experience symptoms such as unusual bleeding or bruising, vomiting, blood in your urine or stools, headache, dizziness, or weakness. Do not stop using any medications without consulting a doctor.
FluorouracilInfliximab
Severe
How does the drug interact with Fivotop 500 Injection 10 ml:
Using Infliximab together with Fivotop 500 Injection 10 ml can increase the risk or severity of developing serious infections.

How to manage the interaction:
Taking Infliximab together with Fivotop 500 Injection 10 ml together can result in an interaction, it can be taken if your doctor has advised it. However, if you experience fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
FluorouracilClozapine
Severe
How does the drug interact with Fivotop 500 Injection 10 ml:
Co-administration of Fivotop 500 Injection 10 ml with Clozapine can increase the risk of neutropenia (low levels of neutrophils in blood).

How to manage the interaction:
There may be a possibility of interaction between Fivotop 500 Injection 10 ml and Clozapine, but it can be taken if prescribed by a doctor. If you experience any symptoms such as infection, fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, weight loss, or pain or burning during urination, it is important to contact a doctor right away. Do not stop using any medications without a doctor's advice.
FluorouracilFolic acid
Severe
How does the drug interact with Fivotop 500 Injection 10 ml:
Coadministration of Folic acid and Fivotop 500 Injection 10 ml may increase the effects of Fivotop 500 Injection 10 ml and increase the risk of serious side effects such as bleeding problems, anaemia (lack of blood), infections, and nerve damage.

How to manage the interaction:
Although there is a possible interaction between Folic acid and Fivotop 500 Injection 10 ml, you can take these medicines together if prescribed by your doctor. However, if you experience diarrhoea, paleness of skin, severe nausea and vomiting, over-tiredness, dizziness, fainting, blood in the stools, unusual bleeding or bruising, fever, chills, body pains, flu-like symptoms, skin reactions, mouth ulcers or sores, and/or numbness, burning or tingling in your hands and feet, contact your doctor.

Drug-Food Interactions

verifiedApollotooltip
  • No interactions found
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[ANTIMETABOLITES]

FAQs

Fivotop 500 Injection is used to treat breast, colon, rectum, pancreatic and stomach/gastric cancer.
Fivotop 500 Injection works by interfering with the growth of genetic material (DNA and RNA) of the cancer cells. This slows the growth of cancer cells and eventually kills them.
Yes, Fivotop 500 Injection affects the hair by making it thin, which further causes hair loss. However, it is not very common. Hair reduction possibly happens due to the estrogen-lowering effect of Fivotop 500 Injection. These effects are not long-lasting and may return after some time. If it matters to you, then consult your doctor for further advice.
Yes, Fivotop 500 Injection may change the results of blood tests and other laboratory tests. Inform the person doing the tests that you are taking Fivotop 500 Injection.
$nanme might affect fertility (ability to have children) in both men and women. You may not be able to become pregnant or father a child after treatment with Fivotop 500 Injection. However, it is essential to talk to your doctor before starting treatment with Fivotop 500 Injection if you think you may want to have a baby in the future.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Country of origin

India

Manufacturer/Marketer address

A/303, Atrium -1, Andheri - Kurla Road, Mumbai 400 059 India
Other Info - FIV0020
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