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compositionComposition:FLUDARABINE-50MG
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Fludarither 50 Injection 2 ml is used to treat Chronic lymphocytic leukaemia. Fludarither 50 Injection 2 ml contains Fludarabine, which works by inhibiting DNA synthesis (responsible for DNA elongation, synthesis, and repair) in cancer cells by interfering with the ribonucleotide reductase and DNA polymerase enzymes. Thus, it slows or stops the growth of cancer cells in the body. Common side effects of this medicine may include fever, chills, hair loss, depression, fatigue, vomiting, nausea, headache, cough, constipation, oedema, weakness, and pain at the injection site.

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Written By Dr. Lakshmithulasi Yarragunta , PharmD (PB)
Reviewed By Santoshini Reddy G , M Pharmacy
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More about the Product

Composition :

FLUDARABINE-50MG

Manufacturer/Marketer :

Therdose Pharma Pvt Ltd

Consume Type :

Parenteral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Fludarither 50 Injection 2 ml

Fludarither 50 Injection 2 ml is a prescription cancer medicine used to treat chronic lymphocytic leukaemia (CLL), a type of cancer that affects your white blood cells. This medicine is designed to target and slow down the growth of these abnormal blood cells. It is given as an injection or slow drip into a vein, typically in a clinical setting under the supervision of a healthcare professional.

This medicine is usually given in cycles, meaning you will receive it daily for several days, followed by a rest period of a few weeks. Because it is injected directly into your bloodstream by a healthcare provider, you do not need to worry about taking it with or without food. To support your body during this treatment, your doctor may suggest simple lifestyle adjustments, such as drinking plenty of fluids and eating well-cooked, sterile meals to protect your digestive system.

Some of the common side effects you might experience include feeling very tired, mild nausea, and a temporary drop in your blood cell counts. If you experience severe side effects, such as signs of a serious infection like a high fever, severe breathing difficulties, or unusual bleeding, you must contact your doctor immediately.

Talk to your doctor before starting this treatment if you have a history of kidney disease or a weakened immune system. Do not receive this medicine if you have severe kidney damage or if you have had a severe allergic reaction to this medication in the past.

This medicine can interact with other treatments, including live vaccinations and drugs that suppress your immune system, which can increase your risk of severe infections. You should avoid drinking alcohol during treatment to prevent putting extra strain on your liver. If you are pregnant, planning a family, breastfeeding, or are an older adult, consult your doctor to weigh the risks and benefits of this medicine.

Uses of Fludarither 50 Injection 2 ml

Your doctor may prescribe Fludarither 50 Injection 2 ml to help manage the following conditions:

  • Chronic Lymphocytic Leukaemia (CLL): Fludarither 50 Injection 2 ml is used to treat CLL, particularly when other standard treatments have not successfully controlled the disease or have stopped working. It helps by stopping the rapid multiplication of abnormal white blood cells.
  • Other blood cancers: In certain cases, doctors may use this medicine to treat other types of slow-growing blood cancers, such as low-grade non-Hodgkin's lymphoma, to help manage symptoms and slow down disease progression.

Key Benefits

When treatment is effective, Fludarither 50 Injection 2 ml may help reduce problems caused by the buildup of abnormal blood cells.

  • May ease disease-related symptoms: As the number of abnormal cells decreases, symptoms such as tiredness, night sweats, or unintentional weight loss may improve.
  • May reduce discomfort from enlarged lymph nodes or spleen: Treatment may shrink enlarged lymph nodes or an enlarged spleen, helping relieve swelling, fullness, or abdominal discomfort.
  • May help you feel and function better: Improvement in disease-related symptoms may make everyday activities more manageable and improve overall well-being.
  • May provide a period of remission: Some people respond well enough that the signs and symptoms of their cancer become significantly reduced for a period of time. The response and duration of benefit vary between individuals.
Side effects of Fludarither 50 Injection 2 ml
  • Eat well-cooked food to minimize infection risk.
  • Practice good hand hygiene to prevent infections.
  • Avoid crowds and people with illnesses to reduce exposure.
  • Wear a mask when necessary to lower infection risk.
  • Rest adequately to support your body's healing process.
  • Stay hydrated by drinking plenty of water.
  • Regularly monitor blood cell counts for changes.
  • Seek immediate medical help if symptoms like fever, chills, or fatigue occur.
  • Consult your doctor right away if concerning symptoms arise.
  • Follow your doctor's guidance on managing myelosuppression and infection prevention.
Here's a comprehensive approach to managing medication-triggered fever:
  • Inform your doctor immediately if you experience a fever after starting a new medication.
  • Your doctor may adjust your medication regimen or dosage as needed to minimize fever symptoms.
  • Monitor your body temperature to monitor fever progression.
  • Drink plenty of fluids, such as water or electrolyte-rich beverages, to help your body regulate temperature.
  • Get plenty of rest and engage in relaxation techniques, such as deep breathing or meditation, to help manage fever symptoms.
  • Under the guidance of your doctor, consider taking medication, such as acetaminophen or ibuprofen, to help reduce fever.
  • If your fever is extremely high (over 103°F), or if you experience severe symptoms such as confusion, seizures, or difficulty breathing, seek immediate medical attention.
  • Rest well; get enough sleep.
  • Wear comfortable layers of clothes and get to a warm place.
  • Drink warm fluids like coffee, tea or hot chocolate.
  • Warm up using a blanket or heating pad.
  • Rest well; get enough sleep.
  • Eat a balanced diet and drink enough water.
  • Manage stress with yoga and meditation.
  • Limit alcohol and caffeine.
  • Physical activities like walking or jogging might help boost energy and make you feel less tired.
  • Rest well; get enough sleep.
  • Eat a balanced diet and drink enough water.
  • Manage stress with yoga and meditation.
  • Limit alcohol and caffeine.
  • Physical activities like walking or jogging might help boost energy and make you feel less tired.
  • Wash your hands regularly with soap and water or use a hand sanitizer to prevent the spread of infections.
  • Wear masks, gloves and other protective clothing.
  • Cover sneezes and coughs with a medical mask or tissue or your elbow.
  • Take vaccinations to enhance your immunity to specific diseases.
  • Clean your utensils, linen and surfaces regularly.
Here are the steps to manage the medication-triggered Cough:
  • Tell your doctor about the cough symptoms you're experiencing, which may be triggered by your medication.
  • Your doctor may adjust your treatment plan by changing your medication, adding new medications, or providing guidance on managing your cough symptoms.
  • Practice good hygiene, including frequent handwashing, avoiding close contact with others, and avoiding sharing utensils or personal items.
  • Stay hydrated by drinking plenty of fluids, such as water, tea, or soup, to help thin out mucus and soothe your throat.
  • Get plenty of rest and engage in stress-reducing activities to help your body recover. If your cough persists or worsens, consult your doctor for further guidance.

Directions for Use

  • Follow your doctor’s instructions on the dosage and timing of this medication to ensure safety.
  • Fludarither 50 Injection 2 ml will be administered by the doctor or healthcare professional.
  • Do not self-administer.

How Fludarither 50 Injection 2 ml Works

Fludarither 50 Injection 2 ml contains fludarabine, a cancer medicine that belongs to a group called purine analogues. After fludarabine enters the body, it is converted into an active form inside cells. This active form interferes with enzymes needed to make and repair DNA, the genetic material cells need to function and multiply. By disrupting DNA production and repair, fludarabine prevents susceptible cancer cells from multiplying and can cause them to die. This helps reduce the number of abnormal blood cells and control the cancer. Fludarabine can also affect healthy blood-forming and immune cells. This is why blood cell counts and other aspects of your health are monitored closely during treatment.
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Alcohol

Caution

It is not known if alcohol interacts with Fludarither 50 Injection 2 ml. Please consult the doctor.

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Pregnancy

Unsafe

Fludarither 50 Injection 2 ml is not recommended for use in pregnancy as it may harm the foetus. Hence, if you are pregnant or planning pregnancy, inform your doctor before receiving Fludarither 50 Injection 2 ml. You should not become pregnant while on treatment with Fludarither 50 Injection 2 ml.

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Breast Feeding

Unsafe

Fludarither 50 Injection 2 ml is not recommended for use in breastfeeding as it may pass into breast milk and harm your infant. If you are breastfeeding, inform your doctor before receiving Fludarither 50 Injection 2 ml. Your doctor may suggest you stop feeding while on treatment with this medicine.

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Driving

Caution

Fludarither 50 Injection 2 ml will be administered in a hospital setting. Hence, driving is not recommended.

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Liver

Caution

If you have a pre-existing or a history of liver disease, inform your doctor before receiving Fludarither 50 Injection 2 ml.

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Kidney

Caution

If you have a pre-existing or a history of kidney disease, inform your doctor before receiving Fludarither 50 Injection 2 ml. Your doctor may adjust the dose of this medicine or prescribe a suitable alternative based on your condition.

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Children

Consult your doctor

It is unknown whether Fludarither 50 Injection 2 ml can be given to children or not. Therefore, consult your paediatrician if needed.

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Heart

Consult your doctor

Please consult your doctor before receiving Fludarither 50 Injection 2 ml if you have pre-existing heart problems. Your doctor will prescribe Fludarither 50 Injection 2 ml if the benefits outweigh the risks.

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Geriatrics

Consult your doctor

Please consult a doctor before administering Fludarither 50 Injection 2 ml to geriatric patients. Your doctor will prescribe Fludarither 50 Injection 2 ml if the benefits outweigh the risks.

What if I have taken an overdose of Fludarither 50 Injection 2 ml

Since this medicine is prepared and given by trained healthcare providers, an overdose is extremely rare. If you suspect an error has occurred or experience sudden, severe side effects during or shortly after your injection, tell your medical team right away or seek emergency medical care.

Diet & Lifestyle Advise

  • Eat fully cooked foods: Because your white blood cell count will drop during treatment, your body cannot fight off infections easily. Avoid raw meats, raw seafood, unwashed raw vegetables, and unpasteurised dairy products to reduce the risk of food poisoning.
  • Stay well-hydrated: Drink plenty of water and clear broths, especially on the days you receive your treatment. This helps your kidneys process and flush out the waste products left behind when cancer cells are destroyed.
  • Avoid crowds and sick people: Wash your hands frequently with soap and water, carry hand sanitiser, and consider wearing a mask in crowded indoor spaces to protect yourself from viruses and bacteria.
  • Protect your gums and skin: Your blood may take longer to clot during treatment. Use a soft-bristled toothbrush to prevent bleeding gums and use an electric razor instead of a manual blade to avoid cuts.
health query

Have a query?

How Soon It Starts Working

The time required for Fludarither 50 Injection 2 ml to start to work: The exact onset time of Fludarither 50 Injection 2 ml has not been clinically established. The time for which the effects of Fludarither 50 Injection 2 ml last: The duration of Fludarither 50 Injection 2 ml’s effect is clinically not established.

What if you forget to take Fludarither 50 Injection 2 ml

Because this medicine is given to you by medical professionals in a clinic, it is highly unlikely that you will miss a dose. However, if you miss a scheduled appointment, contact your clinic or doctor immediately to reschedule your treatment as soon as possible.

Storage

• This medicine is stored, prepared, and disposed of by healthcare professionals at the clinic or hospital.
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Keep Refrigerated. Do not freeze.

Drug Warnings

  • Watch closely for infections: Fludarabine can significantly weaken your immune system. Consult your doctor right away if you develop fever, chills, a persistent cough, sore throat, or other signs of infection.
  • Take infection-prevention medicines as prescribed: Your doctor may prescribe medicines to help prevent certain infections, such as Pneumocystis jirovecii pneumonia (PJP) or herpes infections, depending on your treatment and individual risk. Take them exactly as directed.
  • Stay hydrated and attend monitoring appointments: Fludarabine can sometimes cause tumour lysis syndrome, particularly when many cancer cells break down quickly. Drink fluids as advised by your healthcare team and attend all scheduled blood tests and check-ups so changes in kidney function and blood salts can be detected early.
  • Tell your healthcare team before receiving a blood transfusion: If you need a transfusion, inform your doctors and blood bank staff that you are receiving or have previously received fludarabine. Blood products should be appropriately irradiated to reduce the risk of transfusion-associated graft-versus-host disease (TA-GvHD), a rare but potentially fatal complication.
  • Avoid live vaccines: Do not receive live vaccines during treatment unless your oncology team specifically advises otherwise. Fludarabine suppresses the immune system, which can make live vaccines unsafe.
  • Discuss pregnancy prevention with your oncology team: Fludarabine can harm an unborn baby. Follow your doctor's recommendations about effective contraception during treatment and for the required period afterwards, as recommendations may vary by product and patient circumstances.

Drug-Drug Interactions

verifiedApollotooltip
  • Pentostatin: Do not receive this medicine alongside pentostatin. Combining these two medications can cause severe, life-threatening damage to your lungs.
  • Immunosuppressive medicines: Taking other medicines that weaken your immune system, such as high-dose corticosteroids or other chemotherapies, can severely lower your white blood cell count and increase your risk of dangerous infections.
FludarabineCladribine
Severe
FludarabineBaricitinib
Severe

Drug-Drug Interactions

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FludarabineCladribine
Severe
How does the drug interact with Fludarither 50 Injection 2 ml:
Taking Cladribine with Fludarither 50 Injection 2 ml can increase the risk of developing serious infections.

How to manage the interaction:
Co-administration of Fludarither 50 Injection 2 ml with Cladribine can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning sensation when you urinate, consult a doctor. Do not stop using any medications without a doctor's advice.
FludarabineBaricitinib
Severe
How does the drug interact with Fludarither 50 Injection 2 ml:
Coadministration of baricitinib and Fludarither 50 Injection 2 ml can raise the risk of developing serious infections.

How to manage the interaction:
Although there is an interaction, baricitinib can be taken with Fludarither 50 Injection 2 ml if prescribed by the doctor. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, red or irritated skin, body sores, and discomfort or burning when you urinate, consult a doctor. Do not discontinue any medication without consulting a doctor.
FludarabineInfliximab
Severe
How does the drug interact with Fludarither 50 Injection 2 ml:
Combining Infliximab with Fludarither 50 Injection 2 ml can increase the risk or severity of developing serious infections.

How to manage the interaction:
There may be a possibility of interaction between Fludarither 50 Injection 2 ml and Infliximab, but it can be taken if prescribed by a doctor. If you have any of these symptoms like fever, chills, diarrhea, sore throat, muscle pain, difficulty breathing, losing weight, and pain or burning when you pee, it's important to contact a doctor right away. Do not stop using any medications without a doctor's advice.
FludarabineClozapine
Severe
How does the drug interact with Fludarither 50 Injection 2 ml:
Co-administration of Fludarither 50 Injection 2 ml with Clozapine can increase the risk of neutropenia (low levels of neutrophils in blood).

How to manage the interaction:
There may be a possibility of interaction between Fludarither 50 Injection 2 ml and Clozapine, but it can be taken if prescribed by a doctor. If you experience any symptoms such as infection, fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, weight loss, or pain or burning during urination, it is important to contact a doctor right away. Do not stop using any medications without a doctor's advice.
FludarabineThalidomide
Severe
How does the drug interact with Fludarither 50 Injection 2 ml:
Taking thalidomide together with Fludarither 50 Injection 2 ml may increase the risk of blood clots and other complications.

How to manage the interaction:
Although taking thalidomide and Fludarither 50 Injection 2 ml together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as chest pain, shortness of breath, difficulty breathing, coughing up blood, sudden loss of vision, pain, redness or swelling in an arm or leg, and numbness or weakness on one side of the body. Do not discontinue any medications without consulting a doctor.
FludarabineEtanercept
Severe
How does the drug interact with Fludarither 50 Injection 2 ml:
When Etanercept is used with Fludarither 50 Injection 2 ml, the likelihood or severity of infection may increase.

How to manage the interaction:
Co-administration of Etanercept with Fludarither 50 Injection 2 ml can result in an interaction, but it can be taken if a doctor has advised it. However, if you develop fever, chills, diarrhea, sore throat, muscular pains, shortness of breath, blood in phlegm, weight loss, red or irritated skin, body sores, or discomfort or burning during urination, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.

Drug-Food Interactions

verifiedApollotooltip
  • There are no known direct interactions between this medicine and specific foods. However, you should strictly avoid raw, unpasteurised, or potentially unhygienic foods to prevent infections while your immune system is weak.
     
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[ANTINEOPLASTIC]

FAQs

Fludarither 50 Injection 2 ml is used to treat Chronic lymphocytic leukemia.
Fludarither 50 Injection 2 ml contains Fludarabine, which works by inhibiting the production of genetic material (DNA) in cancer cells by interfering with the ribonucleotide reductase and DNA polymerase enzymes.
If you are about to receive any vaccinations, it is advised to inform your doctor that you are on treatment with Fludarither 50 Injection 2 ml as it may cause infections.
Fludarither 50 Injection 2 ml may interfere with the normal menstrual cycle in women and may stop sperm production in men. Therefore, please consult a doctor if you plan to have a baby.
Fludarither 50 Injection 2 ml is primarily used to treat chronic lymphocytic leukaemia (CLL), a slow-growing type of blood cancer that affects white blood cells. It is typically prescribed when other treatments have not worked. Talk to your doctor to understand your specific treatment plan.
It is given as an injection or a slow drip into a vein (intravenously) by a trained healthcare professional in a clinic, oncology office, or hospital. It is not available as a pill to take at home. Talk to your doctor for details about your infusion sessions.
While hair loss is not a highly common side effect of this medicine, some patients may experience mild hair thinning. If you are concerned about hair loss or other changes to your appearance, talk to your doctor.
This medicine can make you feel extremely tired, dizzy, or confused. It is highly recommended that you arrange for a family member or friend to drive you home after your treatment sessions. Talk to your doctor if you feel unsafe or have questions about driving.
This medicine temporarily lowers the number of white blood cells in your body, which are responsible for fighting off illnesses. This means you will be more susceptible to catching infections during and shortly after your treatment. Talk to your doctor or pharmacist about how to stay safe.
A fever of 100.4°F (38°C) or higher is considered a medical emergency when you are receiving this treatment. Contact your doctor immediately or go to the nearest emergency room, as it could indicate a serious infection. Talk to your doctor right away.
You must avoid "live" vaccines during treatment and for several months afterward, as they can cause severe, life-threatening infections. Other vaccines may be safe, but they might not work as well. Talk to your doctor before receiving any vaccine.
No, this medicine can cause severe harm to an unborn baby. You must use effective birth control during treatment and for at least six months after your last dose. If you suspect you are pregnant, talk to your doctor immediately.

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Country of origin

India

Manufacturer/Marketer address

Plot No'S : 118 - 120, Road No.6, Aleap Ie, Pragathi Nagar, Gajularamaram Village, Kukatpally, Hyderabad ,Telangana - 500 072, India.
Other Info - FLU0869
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