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FM Plus 80 mg/480 mg Tablet is used to treat and prevent malaria. It contains Artemether and Lumefantrine, which interfere with the Plasmodium parasite's growth in the red blood cells of the human body. It is a combination medicine used to treat non-severe malaria caused by a parasite called Plasmodium falciparum. It may cause common side effects, such as headache, dizziness, loss of appetite, weakness, fever, chills, tiredness, muscle or joint pain, nausea, vomiting, abdominal pain, cough, and trouble sleeping. Before using this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.

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Written By Veda Maddala , M Pharmacy
Reviewed By Bayyarapu Mahesh Kumar , M Pharmacy
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More about the Product

Manufacturer/Marketer :

Unicure Remedies Pvt Ltd

Consume Type :

Oral

Expires on or after :

Dec-28

Return Policy :

Not Returnable

About FM Plus 80 mg/480 mg Tablet

FM Plus 80 mg/480 mg Tablet is a prescription oral medication used to treat acute, uncomplicated malaria infections caused by parasites. This medicine is designed to clear the malaria parasite from your body, helping you recover from the infection. It is formulated specifically for oral intake and is highly effective when used correctly under medical supervision.

It is crucial to take FM Plus 80 mg/480 mg Tablet exactly as your doctor instructs and complete the full course of treatment, even if you start feeling better within a few hours. This medicine must always be taken with food, preferably a meal rich in fat (such as milk, cheese, or food cooked with oil), because fat significantly helps your body absorb the active medicine. Additionally, drinking plenty of clean fluids and getting plenty of physical rest are simple lifestyle steps that will support your body's recovery during treatment.

While taking FM Plus 80 mg/480 mg Tablet, you may experience common, mild side effects such as headaches, dizziness, or a temporary loss of appetite. However, you should contact your doctor immediately if you experience serious symptoms like a fast or irregular heartbeat, severe dizziness, or signs of liver damage, which include yellowing of your eyes or skin and dark urine.

Do not take this medicine if you have a history of severe heart rhythm abnormalities, a family history of sudden heart issues, or low levels of potassium or magnesium in your blood. Before starting treatment, talk to your doctor if you have liver damage, kidney disease, or any pre-existing heart conditions to ensure this medication is safe for you.

This medication can interact with other drugs, especially those that affect your heart rhythm, so it is important to share your full medication list with your healthcare provider. Avoid drinking alcohol during treatment, as it can worsen dizziness and put extra strain on your liver. If you are pregnant, breastfeeding, or an older adult, you must consult your doctor before taking this medicine.

Uses of FM Plus 80 mg/480 mg Tablet

FM Plus 80 mg/480 mg Tablet is used in the treatment of malaria. The detailed uses of FM Plus 80 mg/480 mg Tablet are as follows:

  • Acute uncomplicated malaria: FM Plus 80 mg/480 mg Tablet is prescribed to treat active, non-severe malaria infections caused by the Plasmodium falciparum parasite in adults, children, and infants weighing at least 5 kg.
  • Chloroquine-resistant malaria: This medicine is highly effective for treating malaria cases in which the parasite has developed resistance to older standard malaria treatments.

Key Benefits

FM Plus 80 mg/480 mg Tablet helps treat uncomplicated malaria, allowing you to recover more quickly from the infection.

Benefits may include:

  • Works quickly to clear malaria parasites from your bloodstream.
  • Helps reduce high fever, chills, body aches, and severe fatigue, with many patients starting to feel better within 24 to 48 hours of beginning treatment.
  • Combines two active ingredients that work together to effectively eliminate malaria parasites.
  • Helps prevent the infection from progressing to severe, life-threatening malaria when taken as prescribed.
  • Treatment is typically completed over just three days, making it simpler than many older malaria regimens.
  • The short treatment duration helps improve treatment completion and increases the likelihood of a successful recovery.

Directions for Use

  • Swallow the tablets whole with a glass of water. Do not crush or chew them unless instructed by your doctor.
  • For young children who cannot swallow tablets, the tablet may be crushed and mixed with a small amount of water or condensed milk immediately before taking.
  • Take each dose with food, milk, or a high-fat meal to ensure the medication is properly absorbed by your body.
  • If you vomit within one hour of taking your dose, you must take another dose immediately and contact your doctor.
  • Always follow your doctor's exact instructions regarding the timing and duration of your treatment.

How FM Plus 80 mg/480 mg Tablet Works

FM Plus 80 mg/480 mg Tablet is a combination medicine containing two active ingredients that work together to kill the malaria parasite at different stages of its life cycle. • Artemether: It starts working rapidly after absorption. Inside the malaria parasite, it generates highly reactive free radicals (reactive oxygen species) that damage essential parasite proteins and membranes, rapidly killing most of the parasites. • Lumefantrine: It works more slowly but remains in your body for much longer. It interferes with the parasite's ability to detoxify toxic heme produced during haemoglobin digestion by inhibiting heme polymerisation, helping eliminate any remaining parasites and reducing the risk of the infection returning.
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Alcohol

Unsafe

Avoid alcohol while using FM Plus 80 mg/480 mg Tablet since it can worsen your side effects.

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Pregnancy

Unsafe

FM Plus 80 mg/480 mg Tablet is not recommended during the first three months of pregnancy. Your doctor may recommend other alternative medications. Please seek medical advice if you are pregnant or planning to conceive.

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Breast Feeding

Unsafe

FM Plus 80 mg/480 mg Tablet is not recommended during breastfeeding. Once you have completed the course, you should wait at least one week before starting to breastfeed again. Please consult your doctor before taking FM Plus 80 mg/480 mg Tablet.

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Driving

Unsafe

FM Plus 80 mg/480 mg Tablet may cause you to feel sleepy, dizzy, or generally weak. In such cases, do not drive or operate machinery.

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Liver

Caution

Close monitoring of patients with liver disease while they are treated with FM Plus 80 mg/480 mg Tablet is required. Let your doctor know if you have any history of liver disease before using FM Plus 80 mg/480 mg Tablet.

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Kidney

Caution

Therapy with FM Plus 80 mg/480 mg Tablet is to be cautiously administered in patients with renal impairment. Let your doctor know if you have any history of kidney disease before using FM Plus 80 mg/480 mg Tablet.

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Children

Caution

Your doctor will decide the dose based on your child's age and body weight.

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Heart

Unsafe

This medicine is not recommended in cardiac patients due to its adverse effects. However, if prescribed extreme caution should be exercised.

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Geriatrics

Caution

FM Plus 80 mg/480 mg Tablet can be given in elderly patients with caution and only if prescribed by the doctor.

What if I have taken an overdose of FM Plus 80 mg/480 mg Tablet

If you take more than your prescribed dose, or if you suspect an overdose, seek immediate emergency medical attention or contact a poison control centre. Overdose symptoms may include severe heart palpitations, extreme dizziness, or fainting.

Diet & Lifestyle Advise

  • Eat fat-rich foods: Always take each dose with foods high in fat, such as whole milk, cheese, yoghurt, eggs, or meals prepared with butter or oil, to ensure your body absorbs the medication effectively.
  • Stay hydrated: Drink plenty of clean water, broth, or oral rehydration solutions to replace fluids lost due to high fevers, sweating, or vomiting.
  • Prioritise rest: Give your body plenty of physical rest to help your immune system fight off the infection and recover your strength.
  • Eat small, frequent meals: If you suffer from a loss of appetite or nausea, try eating small, nutrient-dense snacks throughout the day instead of large meals.

Have a query?

How Soon It Starts Working

  • The time required for FM Plus 80 mg/480 mg Tablet to start to work: The time required for FM Plus 80 mg/480 mg Tablet to show its action is unknown.
  • The time for which the effects of FM Plus 80 mg/480 mg Tablet last: The duration of action for FM Plus 80 mg/480 mg Tablet is unknown.

What if you forget to take FM Plus 80 mg/480 mg Tablet

If you miss a dose, take it as soon as you remember, making sure to take it with a fat-rich meal or drink. However, if your next scheduled dose is only a few hours away, skip the missed dose and return to your regular schedule. Do not take a double dose to make up for a missed one.

Storage

• Store in a cool and dry place away from sunlight. • Keep out of sight and reach of children. • Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.

Drug Warnings

  • Complete the full course: Take every dose exactly as prescribed, even if you start feeling better after the first day. Stopping treatment too soon may allow the infection to return.
  • Check the packaging: Inspect the blister pack before taking your medicine. Do not use it if the foil is torn, punctured, or damaged.
  • Use only for treatment: Take this medicine only to treat a confirmed malaria infection. Do not use it to prevent malaria unless your doctor specifically advises you to do so.
  • Be careful when driving: Avoid driving, riding a bicycle, or operating heavy machinery until you know how this medicine affects you, as it may cause dizziness in some patients.
  • Watch for heart symptoms: Contact your doctor immediately if you notice a fast or irregular heartbeat, a fluttering feeling in your chest, or feel faint or lightheaded during treatment.

Drug-Drug Interactions

verifiedApollotooltip
  • Heart rhythm medications (e.g., amiodarone, quinidine): Taking these medicines alongside FM Plus 80 mg/480 mg Tablet may increase the risk of serious irregular heartbeats and may require closer monitoring.
  • Antipsychotic or Antidepressant Medicines (e.g., haloperidol, citalopram): Taking these medicines alongside FM Plus 80 mg/480 mg Tablet may increase the risk of abnormal heart rhythms.
  • Other antimalarial drugs (e.g., quinine, mefloquine): Taking FM Plus 80 mg/480 mg Tablet alongside certain other antimalarial medicines may increase the risk of heart rhythm problems (QT prolongation) and other side effects. Only combine antimalarial treatments if specifically instructed by your doctor.

Drug-Drug Interactions

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How does the drug interact with FM Plus 80 mg/480 mg Tablet:
Using Carbamazepine with Artemether may decrease the blood levels of Artemether.

How to manage the interaction:
Taking Carbamazepine with Artemether is not recommended, but can be taken if prescribed by the doctor. However, if you experience any unusual symptoms, consult the doctor. Do not discontinue any medications without consulting a doctor.
How does the drug interact with FM Plus 80 mg/480 mg Tablet:
Taking lumefantrine together with Cisapride can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Taking lumefantrine together with Cisapride can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations, consult the doctor immediately. Do not stop using any medications without a doctor's advice.
Critical
How does the drug interact with FM Plus 80 mg/480 mg Tablet:
Taking artemether together with fosphenytoin can reduce the blood levels of artemether, which may make the medication less effective in treating malaria.

How to manage the interaction:
The combined use of artemether and fosphenytoin is not recommended as it can lead to an interaction, it can be taken if advised by your doctor. If you experience any symptoms, consult the doctor immediately. Do not stop using any medications without a doctor's advice.
Critical
How does the drug interact with FM Plus 80 mg/480 mg Tablet:
Taking lumefantrine together with Enzalutamide can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Taking lumefantrine together with Enzalutamide can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations, consult the doctor immediately. Do not stop using any medications without a doctor's advice.
How does the drug interact with FM Plus 80 mg/480 mg Tablet:
Taking lumefantrine together with Disopyramide can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Taking lumefantrine together with Disopyramide can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations, consult the doctor immediately. Do not stop using any medications without a doctor's advice.
How does the drug interact with FM Plus 80 mg/480 mg Tablet:
Taking lumefantrine together with Degarelix can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Taking lumefantrine together with Degarelix can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations, consult the doctor immediately. Do not stop using any medications without a doctor's advice.
How does the drug interact with FM Plus 80 mg/480 mg Tablet:
Taking lumefantrine together with Clarithromycin can increase the blood levels of artemether and increase the risk of an irregular heart rhythm.

How to manage the interaction:
Taking lumefantrine together with Clarithromycin can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations, consult the doctor immediately. Do not stop using any medications without a doctor's advice.
How does the drug interact with FM Plus 80 mg/480 mg Tablet:
Taking Artemether together with abarelix can increase the blood levels of artemether and increase the risk of an irregular heart rhythm.

How to manage the interaction:
Taking Artemether together with abarelix can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations, consult the doctor immediately. Do not stop using any medications without a doctor's advice.
How does the drug interact with FM Plus 80 mg/480 mg Tablet:
Taking lumefantrine together with Gatifloxacin can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Taking lumefantrine together with Gatifloxacin can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations, consult the doctor immediately. Do not stop using any medications without a doctor's advice.
Severe
How does the drug interact with FM Plus 80 mg/480 mg Tablet:
Taking lumefantrine together with Desipramine can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Taking lumefantrine together with Desipramine can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations, consult the doctor immediately. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

verifiedApollotooltip
  • Grapefruit juice: Drinking grapefruit juice while taking this medicine may increase the amount of the drug in your body, raising the risk of severe side effects.
  • Low-fat meals: Taking this medicine on an empty stomach or with a completely fat-free meal will drastically reduce its absorption, making the treatment ineffective.
ARTEMETHER-80MG+LUMEFANTRINE-480MGGrapefruit and Grapefruit Juice
Moderate

Drug-Food Interactions

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ARTEMETHER-80MG+LUMEFANTRINE-480MGGrapefruit and Grapefruit Juice
Moderate
Common Foods to Avoid:
Grapefruit, Grapefruit Juice

How to manage the interaction:
Coadministration with grapefruit juice may increase the plasma concentrations of artemether and lumefantrine. Avoid consumption of grapefruit juice and grape fruit.

All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[ANTI- MALARIALS]

FAQs

FM Plus 80 mg/480 mg Tablet belongs to the class of anti-malarial drugs, used to treat and prevent malaria.
FM Plus 80 mg/480 mg Tablet contains a combination of anti-malarial drugs, Artemether and Lumefantrine. It treats malaria by interfering with Plasmodium parasite's growth in the red blood cells of the human body.
FM Plus 80 mg/480 mg Tablet may affect the heart rhythm and cause QT prolongation (heart muscle takes longer than usual to recharge between beats). This QT prolongation can cause serious fast/irregular heartbeat. Hence it is advised to inform your doctor if you have any heart-related problems like heart failure, slow heartbeat, QT prolongation in EKG or ECG (electrocardiogram) and a family history of heart diseases.
FM Plus 80 mg/480 mg Tablet is not recommended in cases of any liver or kidney problems, malarial infection of the brain, lungs or kidneys, severe heart diseases and electrolyte imbalance. Also, let your doctor know if you have recently undergone treatment with other anti-malarial drugs.
Take the missed dose as soon as possible. However, if it is time for the next dose, skip the missed dose and go back to your regular dosing schedule.
FM Plus 80 mg/480 mg Tablet should be swallowed as a whole with water; do not crush or chew it.
FM Plus 80 mg/480 mg Tablet is not recommended during the first three months of pregnancy. Your doctor may recommend other alternative medications. Please seek medical advice if you are pregnant or planning to conceive.
FM Plus 80 mg/480 mg Tablet is contraindicated if you are allergic to any of its components.
Store FM Plus 80 mg/480 mg Tablet at room temperature, in a dry place. Keep it out of sight and reach of children.
FM Plus 80 mg/480 mg Tablet should be taken with food as it aids in better absorption of the medicine.
Take another dose of FM Plus 80 mg/480 mg Tablet if you have vomited within 1-2 hours of taking the medicine.
FM Plus 80 mg/480 mg Tablet may cause side effects such as headache, dizziness, loss of appetite, weakness, fever, chills, tiredness, muscle or joint pain, nausea, vomiting, abdominal pain, cough, and trouble sleeping. These side effects are not familiar to everyone and vary from person to person. If you notice any side effects that are not manageable, please consult your doctor.
Do not discontinue FM Plus 80 mg/480 mg Tablet without consulting your doctor. To treat your condition effectively, keep taking FM Plus 80 mg/480 mg Tablet for the prescribed duration.
No, FM Plus 80 mg/480 mg Tablet is not approved for malaria prevention. It is exclusively used to treat active, confirmed malaria infections. Your doctor can recommend a suitable medicine to help prevent malaria before you travel.
Fatty foods, such as milk, eggs, or cheese, act as a carrier that helps your digestive system absorb the active ingredients in FM Plus 80 mg/480 mg Tablet. Without fat, the medicine will not enter your bloodstream in sufficient amounts to clear the infection. Your doctor or pharmacist can also suggest suitable foods or drinks to take with each dose.
Yes, FM Plus 80 mg/480 mg Tablet can be used in children and infants weighing at least 5 kg, but the dosage must be carefully calculated based on the child's body weight. It is not recommended for infants weighing less than 5 kg because its safety and effectiveness have not been adequately established. Your child's healthcare provider will determine the correct dose based on body weight.
It is highly advised to avoid alcohol while taking FM Plus 80 mg/480 mg Tablet. Alcohol can worsen common side effects like dizziness and headaches, and it can also place unnecessary stress on your liver. If you are unsure whether alcohol is safe for you, ask your healthcare provider for advice.

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Country of origin

India
Other Info - FM27768
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