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  3. Fragmin 5000IU Injection 0.2 ml

Fragmin 5000IU Injection 0.2 ml, Pack of 1 INJECTION
Fragmin 5000IU Injection 0.2 ml, Pack of 1 INJECTION
Fragmin 5000IU Injection 0.2 ml, Pack of 1 INJECTION
Fragmin 5000IU Injection 0.2 ml, Pack of 1 INJECTION
Fragmin 5000IU Injection 0.2 ml, Pack of 1 INJECTION
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Written By Veda Maddala , M Pharmacy
Reviewed By Bayyarapu Mahesh Kumar , M Pharmacy
Fragmin 5000IU Injection is used to prevent deep vein thrombosis (blood clots in leg veins), pulmonary embolism (blood clots in the lung) and reduce the risk of getting clots in people who have undergone knee or hip replacement surgeries. Also, it helps to treat and prevent stroke risk, and heart attack in patients with atrial fibrillation (irregular heart rhythm). It contains Dalteparin which prevents the formation of blood clots by thinning the blood.
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Composition :

DALTEPARIN-5000IU

Manufacturer/Marketer :

Pfizer Ltd

Consume Type :

PARENTERAL

Return Policy :

Not Returnable

Expires on or after :

About Fragmin 5000IU Injection

Fragmin 5000IU Injection belongs to a class of drugs known as anticoagulants (blood thinner), primarily used to prevent and treat stroke risk, and heart attack in patients with atrial fibrillation (irregular heart rhythm), reducing blood clot formation. Besides this, it is also used to prevent deep vein thrombosis (blood clots in leg veins) and pulmonary embolism (blood clots in the lung) and reduces the risk of getting clots in people who have undergone knee or hip replacement surgeries. A blood clot can occur in any part of the body, leading to a heart attack, stroke and damage to organs (even coma or death). Blood clots can reach your arteries or veins in the organs like the brain, kidney, heart, lungs and limbs.

Fragmin 5000IU Injection contains ‘Dalteparin’ works by inhibiting the production of clotting factors Xa and thrombin. This prevents fibrinogen's conversion (soluble protein) to fibrin (insoluble protein), thereby preventing blood clot formation. It makes blood flow easily through your veins, making it less likely to form a serious blood clot. So, an intake of Fragmin 5000IU Injection helps prevent blood clots if you have an increased risk of having a heart attack or stroke.

Take Fragmin 5000IU Injection as prescribed by your doctor. You are advised to take Fragmin 5000IU Injection for as long as your doctor has prescribed it for you based on your medical condition. Some people may experience unusual bleeding, haematoma (blood clotting under the skin), thrombocytopenia (low number of platelets), pain and irritation at the injection site. Most of these side effects of Fragmin 5000IU Injection do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

If you are allergic to Fragmin 5000IU Injection or any other medicines, please tell your doctor. If you are pregnant or breastfeeding, it is advised to consult a doctor before using Fragmin 5000IU Injection . Fragmin 5000IU Injection should be used with caution in the elderly above 65 years of age as they may be at high risk of bleeding. Fragmin 5000IU Injection should be given to children only if prescribed by a doctor. Extra care must be taken while brushing your teeth or shaving to prevent bleeding. If you have a stomach ulcer, kidney or liver problems, high blood pressure or bleeding problems, inform your doctor before taking Fragmin 5000IU Injection . Try not to stop taking this medicine of your own. Stopping a sudden intake of Fragmin 5000IU Injection may worsen your condition and increase your risk of cardiovascular death, heart attack and stroke.

Uses of Fragmin 5000IU Injection

Treatment of Blood Clot

Directions for Use

Fragmin 5000IU Injection will be administered by a healthcare professional, do not self-administer. If you have kidney or liver problems, please inform your doctor before taking Fragmin 5000IU Injection so that the dose may be adjusted accordingly.

Medicinal Benefits

Fragmin 5000IU Injection belongs to a class of drugs known as anticoagulants or blood thinners. Fragmin 5000IU Injection contains ‘Dalteparin’ used to prevent clot formation in deep vein thrombosis (veins of the legs), pulmonary embolism (lungs), stroke (brain) and heart in patients with atrial fibrillation (irregular heart rhythm). Fragmin 5000IU Injection is primarily used to prevent and treat the risk of the acute coronary syndrome (sudden reduction or blockage of blood flow to the heart) and stroke by reducing blood clot formation. Besides this, it reduces the risk of clots in people who have undergone knee or hip replacement surgeries and abdominal surgery. Fragmin 5000IU Injection works by stopping the action of clotting factor Xa and thrombin (a protein that causes clotting). This prevents fibrinogen's conversion (soluble protein) to fibrin (insoluble protein), thereby preventing blood clot formation.

How Fragmin 5000IU Injection Works

Fragmin 5000IU Injection contains ‘Dalteparin’ works by inhibiting the production of clotting factors Xa and thrombin. This prevents fibrinogen's conversion (soluble protein) to fibrin (insoluble protein), thereby preventing blood clot formation. It makes blood flow easily through your veins, making it less likely to form a serious blood clot.

Storage

Store in a cool and dry place away from sunlight
Side effects of Fragmin 5000IU Injection 0.2 ml
  • Increase iron intake through iron-rich foods like red meat, spinach, and beans.
  • Boost vitamin C intake through foods like citrus fruits, bell peppers, and broccoli.
  • Consume foods high in antioxidants, such as berries, leafy greens, and nuts, to help protect against oxidative stress.
  • Stay hydrated by drinking plenty of water.
  • Rest and recover from surgery and transfusion.
  • Avoid strenuous activities like heavy lifting, bending, or exercise.
  • Practice stress-reducing techniques, including meditation, yoga, and deep breathing exercises to help cope with stress and promote relaxation.
  • Follow medical advice and attend follow-up appointments.
  • Focus on consuming a variety of nutrient-dense foods, including plenty of colorful fruits and vegetables, along with whole grains for optimal nutrition.
  • Avoid excessive sugar, salt, and unhealthy fats.
  • Consider increasing foods high in antioxidants, such as berries and leafy greens.
  • Abstain from alcohol or significantly reduce consumption.
  • Achieve and maintain a healthy weight by balancing a nutritious diet with regular physical activity.
  • Engage in moderate exercise, such as brisk walking, most days of the week.
  • Find calm and reduce stress by practicing relaxation methods like mindfulness, meditation, or slow, deliberate breathing.
  • Review medications and supplements with your doctor to ensure they are not contributing to elevated liver enzymes.
  • Reduce saturated fat and sugar intake by limiting processed foods, sugary drinks, and fried foods.
  • Increase fiber intake through plenty of fruits, vegetables, and whole grains.
  • Focus on liver-friendly foods like garlic, turmeric, leafy greens, cruciferous vegetables, and berries.
  • Consider a low-sodium diet by monitoring salt intake.
  • Limit alcohol consumption as even moderate intake can elevate liver enzymes.
  • Engage in regular exercise with moderate-intensity activity most days of the week.
  • Manage weight, as losing a small amount can improve liver health.
  • Quit smoking to prevent worsening liver damage.
  • Practice stress management through relaxation techniques like yoga or meditation.
  • Consult a doctor if your AST and ALT levels are significantly elevated or if you experience symptoms such as fatigue, abdominal pain, jaundice, or loss of appetite.
  • Apply pressure for 5-10 minutes to reduce bleeding.
  • Apply cold compresses or ice packs for 15-20 minutes, repeat every few hours.
  • Consult the doctor and use antihistamines if advised to minimise injection site reaction.
  • Use pain relief medication, like acetaminophen if recommended by the doctor, but avoid NSAIDs if bleeding is a concern.
  • Rotate injection sites and use proper needle size and technique if you are self-administering the medication.
  • Monitor signs such as increased pain, redness, warmth, or pus, and seek medical attention if symptoms worsen.
  • Managing a low platelet count (thrombocytopenia) caused by medication usage requires a multi-step approach. Here are some steps to help manage the condition:
  • Inform your doctor about your low platelet count and medication usage. They will assess the situation and guide the best course of action.
  • Your doctor may recommend adjusting or stopping the medication that is causing a low platelet count. This could involve switching to alternative medication or reducing the dosage.
  • Monitor your platelet count regularly through blood tests to track any changes. This will help the doctor determine the effectiveness of the treatment plan.
  • If an underlying condition, such as infection or inflammation, contributes to the low platelet count, your doctor will treat it.
  • In some cases, alternative treatments like platelet transfusions or medications that stimulate platelet production may be necessary.
  • Avoid risky activities and certain medications; eat a balanced diet with plenty of water to reduce bleeding risk and boost overall health.
  • If you experience severe bleeding or bruising, seek emergency medical attention immediately.
  • Staying hydrated helps prevent hematuria by increasing urine production. You should drink about eight glasses of fluid per day, and more in hot weather.
  • Avoiding smoking as it is linked to urinary tract cancers.
  • Eat berries like Cranberries, blueberries, and raspberries can help promote urinary tract health and protect against infection.
  • Taking Vitamin C can help treat urinary tract infections.
  • Avoid irritants that can contribute to hematuria.
  • Empty the bladder regularly, as it can helps in preventing hematuria.

What if I have taken an overdose of Fragmin 5000IU Injection

The overdose of Fragmin 5000IU Injection is unlikely as it is administered by a doctor. However, Fragmin 5000IU Injection overdose may lead to hemorrhagic (bleeding) complications.Therefore, if you suspect any adverse reactions or unusual symptoms while on treatment with Fragmin 5000IU Injection , please inform your doctor immediately.

Drug Warnings

  • If you are known to be allergic to Fragmin 5000IU Injection or any other medicines, please tell your doctor.

  • If you are pregnant or breastfeeding, it is advised to consult a doctor before using Fragmin 5000IU Injection .

  • Fragmin 5000IU Injection should be given to children only if prescribed by a doctor.

  • Do not use multiple-dose formulations of Fragmin 5000IU Injection in neonates and infants as they contain benzyl alcohol that may harm a newborn.

  • Fragmin 5000IU Injection should be used with caution in the elderly above 65 years of age as they may be at high risk of bleeding. 

  • If you have diabetes, high blood pressure, congestive heart failure,  blood cell disorder (low platelets or low red blood cells), bleeding in the stomach or intestines, had a stroke, kidney, liver or bleeding problems, stomach ulcer, inform your doctor before taking Fragmin 5000IU Injection .

  • Do not stop taking Fragmin 5000IU Injection of your own. Stopping a sudden intake of Fragmin 5000IU Injection may worsen your condition and increase your risk of cardiovascular death, heart attack and stroke. Hence, you should consult a doctor before stopping the dose of Fragmin 5000IU Injection .

  • You should inform the doctor that you are taking Fragmin 5000IU Injection before any surgery is scheduled. 

  • Fragmin 5000IU Injection can cause a serious blood clot around your spinal cord if you undergo a spinal tap or receive spinal anaesthesia (epidural).

  • Avoid consumption of alcohol while taking Fragmin 5000IU Injection as it may increase the risk of stomach bleeding.

  • Extra care must be taken while brushing your teeth or shaving to prevent bleeding.

Drug-Drug Interactions

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DalteparinDipyridamole
Critical
DalteparinDefibrotide
Critical

Drug-Drug Interactions

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DalteparinDipyridamole
Critical
How does the drug interact with Fragmin 5000IU Injection 0.2 ml:
Combining Dipyridamole with Fragmin 5000IU Injection 0.2 ml can increase the risk of bleeding.

How to manage the interaction:
Although taking Fragmin 5000IU Injection 0.2 ml with Dipyridamole may possibly lead to an interaction, they can be taken if a doctor prescribes it. Consult a doctor if you have any symptoms including dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that resembles coffee grounds, severe headache, and weakness. Without consulting a doctor, never stop taking any medication.
DalteparinDefibrotide
Critical
How does the drug interact with Fragmin 5000IU Injection 0.2 ml:
Combining Defibrotide with Fragmin 5000IU Injection 0.2 ml can increase the risk of bleeding.

How to manage the interaction:
Although taking Fragmin 5000IU Injection 0.2 ml with Defibrotide may possibly lead to an interaction, they can be taken if a doctor prescribes it. Consult a doctor if you have any symptoms including dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that resembles coffee grounds, severe headache, and weakness. Without consulting a doctor, never stop taking any medication.
DalteparinMifepristone
Critical
How does the drug interact with Fragmin 5000IU Injection 0.2 ml:
Combining Mifepristone with Fragmin 5000IU Injection 0.2 ml can increase the risk of vaginal bleeding in women.

How to manage the interaction:
Although taking Fragmin 5000IU Injection 0.2 ml with Mifepristone may possibly lead to an interaction, they can be taken if a doctor prescribes it. Emergency medical attention may be needed for persistent, excessive bleeding. Without consulting a doctor. Do not stop using any medications without talking to a doctor.
DalteparinCefdinir
Severe
How does the drug interact with Fragmin 5000IU Injection 0.2 ml:
Taking cefdinir with Fragmin 5000IU Injection 0.2 ml together may decrease the therapeutic effects of Fragmin 5000IU Injection 0.2 ml.

How to manage the interaction:
Although taking Cefdinir and Fragmin 5000IU Injection 0.2 ml can evidently cause an interaction, it can be taken if your doctor has suggested it. In case you experience aby unusual effects like lightheadedness, dizziness, unusual bruising, bleeding tendencies, blood in stools or urine, consult a doctor. Do not stop using any medications without a doctor's advice.
DalteparinPiroxicam
Severe
How does the drug interact with Fragmin 5000IU Injection 0.2 ml:
Coadministration of Piroxicam with Fragmin 5000IU Injection 0.2 ml can increase the risk of bleeding.

How to manage the interaction:
Although taking Fragmin 5000IU Injection 0.2 ml with Piroxicam may lead to an interaction, they can be taken if a doctor prescribes it. However, consult a doctor if you have any symptoms including dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that resembles coffee grounds, severe headache, and weakness. Without consulting a doctor, never stop taking any medication.
DalteparinTinzaparin
Severe
How does the drug interact with Fragmin 5000IU Injection 0.2 ml:
Combining Tinzaparin with Fragmin 5000IU Injection 0.2 ml can increase the risk of bleeding.

How to manage the interaction:
Although taking Tinzaparin with Defibrotide may possibly lead to an interaction, they can be taken if a doctor prescribes it. Consult a doctor if you have any symptoms including dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that resembles coffee grounds, severe headache, and weakness. Without consulting a doctor, never stop taking any medication.
DalteparinStreptokinase
Severe
How does the drug interact with Fragmin 5000IU Injection 0.2 ml:
Using streptokinase together with Fragmin 5000IU Injection 0.2 ml may increase the risk of bleeding.

How to manage the interaction:
Although taking Fragmin 5000IU Injection 0.2 ml with Streptokinase may possibly lead to an interaction, they can be taken if a doctor prescribes it. Consult a doctor if you have any symptoms including dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that resembles coffee grounds, severe headache, and weakness. Without consulting a doctor, never stop taking any medication.
DalteparinAbciximab
Severe
How does the drug interact with Fragmin 5000IU Injection 0.2 ml:
The combined use of Abciximab with Fragmin 5000IU Injection 0.2 ml can increase the risk of bleeding.

How to manage the interaction:
Taking Abciximab with Fragmin 5000IU Injection 0.2 ml together can possibly result in an interaction, but it can be taken if your doctor has advised it. However, contact a doctor immediately if you experience any symptoms such as bleeding, severe bleeding, bruising, dark or black stools, severe headache, weakness, bleeding, or vomiting. Do not discontinue any medications without consulting a doctor.
DalteparinEtodolac
Severe
How does the drug interact with Fragmin 5000IU Injection 0.2 ml:
Taking Etodolac with Fragmin 5000IU Injection 0.2 ml can increase the risk of bleeding and hemorrhage.

How to manage the interaction:
Although there is a possible interaction between Etodolac and Fragmin 5000IU Injection 0.2 ml, you can take these medicines together if prescribed by a doctor. However, if you experience unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult the doctor. Do not stop using any medications without a doctor's advice.
DalteparinArgatroban
Severe
How does the drug interact with Fragmin 5000IU Injection 0.2 ml:
Combining Argatroban with Fragmin 5000IU Injection 0.2 ml can increase the risk of bleeding.

How to manage the interaction:
Although taking Fragmin 5000IU Injection 0.2 ml with Argatroban may possibly lead to an interaction, they can be taken if a doctor prescribes it. Consult a doctor if you have any symptoms including dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that resembles coffee grounds, severe headache, and weakness. Without consulting a doctor, never stop taking any medication.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Do not make any changes in your diet without first talking to your doctor.
  • Avoid vitamin K-rich foods such as coriander, cabbage, spinach, broccoli, collard greens, kale (leaf cabbage), black liquorice, turnip greens, avocados, and Brussels sprouts as they may decrease the effectiveness of Fragmin 5000IU Injection .
  • Avoid cranberry juice, grapefruit juice, noni juice, pomegranate juice and green tea as they may interact with Fragmin 5000IU Injection and lead to unwanted side effects.
  • Do the regular exercise as it helps to dissolve blood clots, especially in obese people.
  • Avoid the consumption of alcohol as it may increase the risk of bleeding.
  • Take the medication as directed by the doctor and at regular intervals. Do not use other over-the-counter medications, herbal or vitamin supplements without informing your pharmacist or doctor when you take Fragmin 5000IU Injection .
  • Keep your cholesterol and triglyceride levels under control.
  • Eat at regular intervals and maintain a healthy diet that includes fresh fruits and vegetables.
  • Limit alcohol intake since it raises blood pressure and increases the risk of heart disease.
  • Keep a check on your weight and exercise regularly to keep your heart healthy.
  • Your doctor also guides you on how to notice and manage the early symptoms of detecting heart diseases. 

Habit Forming

No

Therapeutic Class

ANTICOAGULANT/ANTITHROMBOTIC

Fragmin 5000IU Injection Substitute

Substitutes safety advice

  • Daltepin 5000 IU Injection 0.2ml

    by Others

    ₹90.00per tablet

  • Daltehep 5000 IU Injection 2 ml

    by Others

    ₹136.13per tablet

  • Daltehep-G 5000IU Injection 0.2 ml

    by Others

    ₹688.50per tablet

  • Dalpin 5000IU Injection

    by Others

    ₹359.10per tablet

Product Substitutes

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Alcohol

Unsafe

Avoid alcohol consumption while on treatment with Fragmin 5000IU Injection as it may increase the risk of bleeding.

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Pregnancy

Caution

Fragmin 5000IU Injection is a Category C pregnancy drug and is given to pregnant women only if clearly needed and has more benefits than risks. Preservative-free forms are preferred in pregnant women as preservatives such as benzyl alcohol may cross the placenta.

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Breast Feeding

Caution

Fragmin 5000IU Injection is not recommended for use in breastfeeding. If you are breastfeeding, inform your doctor before receiving Fragmin 5000IU Injection .

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Driving

Caution

Fragmin 5000IU Injection usually does not affect your ability to drive or operate machinery.

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Liver

Caution

Inform your doctor if you have any pre-existing or a history of liver disease. Your doctor will weigh the benefits and potential risks before prescribing Fragmin 5000IU Injection . However, it is not recommended for patients with severe liver diseases.

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Kidney

Caution

Inform your doctor if you have any pre-existing or a history of kidney diseases. Your doctor will weigh the benefits and potential risks before prescribing Fragmin 5000IU Injection . However, it is not recommended in patients with severe kidney diseases.

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Children

Caution

Fragmin 5000IU Injection should be given to children only if prescribed by a doctor.

FAQs

Fragmin 5000IU Injection is used to prevent the risk of stroke, and heart attack in patients with atrial fibrillation (irregular heart rhythm) by reducing blood clot formation. Besides this, it is also used to prevent deep vein thrombosis (blood clots in leg veins) and pulmonary embolism (blood clots in the lung) and reduces the risk of getting clots in people who have undergone knee or hip replacement surgeries.

Fragmin 5000IU Injection contains Dalteparin, an anticoagulant (blood thinner) that inhibits the production of clotting factors Xa (a protein that causes clotting). It prevents the conversion of fibrinogen to fibrin (a protein that binds platelets together and forms a clot) and helps prevent blood clot formation.

No, you are not recommended to take clopidogrel with Fragmin 5000IU Injection as co-administration of these two medicines may increase the risk of bleeding more easily. However, if you notice blood in urine or stools, dizziness, unusual bleeding or bruising, vomiting, weakness or headache, please consult a doctor immediately. If you are supposed to use these medicines together, you are advised to contact your doctor so that the dose may be adjusted appropriately to use safely.

It is recommended to avoid taking grapefruit and grapefruit juice while taking Fragmin 5000IU Injection . It contains compounds that slow down the metabolism of Fragmin 5000IU Injection and increase the activity leading to bleeding.

Do not stop taking Fragmin 5000IU Injection without consulting your doctor to worsen the condition. Therefore, take Fragmin 5000IU Injection for as long as your doctor has prescribed it.

Yes, Fragmin 5000IU Injection may increase potassium levels in the blood (hyperkalaemia), especially when given for a long period. Therefore, it is advised to inform your doctor if you are taking any medicines that increase potassium levels in the blood.

Yes, Fragmin 5000IU Injection consists of Dalteparin is a blood-thinning agent and can increase the risk of bleeding. It is advised to be cautious during your daily activities like shaving, cutting fingernails or using sharp objects. Also, please consult your doctor beforehand if you undergo any surgery.

Country of origin

Belgium

Manufacturer/Marketer address

The Capital, 1802, 18th Floor , Plot No. C-70, ‘G’ Block , Bandra Kurla Complex, Bandra East , Mumbai – 400051.
Other Info - FRA0004

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Author Details

Doctor imageDoctor badge

Written By

Veda Maddala

M Pharmacy

Doctor imageDoctor badge

Reviewed By

Bayyarapu Mahesh Kumar

M Pharmacy

Last Updated

Jan 1, 2025 | 2:48 PM IST

Doctor imageWe provide you with authentic, trustworthy and relevant information

Reference

  1. https://www.drugs.com/drug-interactions/dalteparin-index.html
  2. https://www.medicines.org.uk/emc/files/pil.4247.pdf
  3. https://www.accessdata.fda.gov/drugsatfda_docs/label/2010/020287s050lbl.pdf
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