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compositionComposition:FULVESTRANT-250MG
prescription
Prescription Medicine
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Fulbreca 250 mg Injection 5 ml is used to treat breast cancer in postmenopausal women. It contains Fulvestrant, which works by inhibiting some of the actions of estrogen (female sex hormone which may help cancer cells grow in women with breast cancer) and reducing the amount that is in the body. Thus, it helps in reducing breast cancer tumour growth. In some cases, Fulbreca 250 mg Injection 5 ml may cause certain common side effects such as injection site reactions like pain and/or inflammation, weakness, nausea, tiredness, headache or joint and musculoskeletal pain.

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Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

FULVESTRANT-250MG

Manufacturer/Marketer :

RPG Life Sciences Ltd

Consume Type :

Parenteral

Expires on or after :

Dec-28

Return Policy :

Not Returnable

About Fulbreca 250 mg Injection 5 ml

Fulbreca 250 mg Injection 5 ml is a prescription hormonal therapy used to treat hormone receptor (HR)-positive, HER2-negative advanced or metastatic breast cancer. It works by blocking and breaking down estrogen receptors on breast cancer cells, slowing or stopping the growth of cancers that depend on estrogen to grow.

This medicine is administered as an intramuscular (IM) injection by a trained healthcare professional. Treatment is usually given once every month, with an additional dose two weeks after the first injection. Your doctor may prescribe Fulbreca 250 mg Injection 5 ml alone or in combination with other targeted anticancer medicines depending on your treatment plan.

During treatment, your doctor will monitor your response through regular medical check-ups and blood tests, including liver function tests when appropriate. Common side effects include injection-site pain, hot flushes, nausea, fatigue, and joint or muscle pain. Contact your healthcare provider immediately if you develop yellowing of the skin or eyes, severe allergic reactions, unusual bleeding or bruising, severe leg swelling, chest pain, or shortness of breath.

Before starting treatment, tell your doctor if you have liver disease, bleeding disorders, low platelet counts, or are taking blood-thinning medicines. Inform your healthcare provider about all prescription medicines, over-the-counter medicines, herbal products, and dietary supplements you use before receiving this medicine.

This medicine can harm an unborn baby and should not be used during pregnancy. Women who could become pregnant should use effective contraception during treatment and for 2 years after the final dose. Breastfeeding is not recommended during treatment or for 1 year after the last dose. Older adults generally do not require dose adjustment but may need closer monitoring depending on their overall health.

Uses of Fulbreca 250 mg Injection 5 ml

Your doctor may prescribe this medicine to help manage the following conditions:

  • HR-positive, HER2-negative advanced or metastatic breast cancer: Fulbreca 250 mg Injection 5 ml is used to treat hormone receptor-positive breast cancer that has spread beyond the breast or cannot be removed surgically in postmenopausal women and certain other eligible patients.
  • Combination therapy for advanced breast cancer: It is commonly used together with targeted medicines such as CDK4/6 inhibitors in patients whose hormone receptor-positive breast cancer has progressed or requires first-line treatment.

Key Benefits

When used as prescribed, Fulbreca 250 mg Injection 5 ml offers several important benefits in the treatment of hormone receptor-positive breast cancer.

  • Blocks estrogen-driven cancer growth: Fulvestrant blocks and destroys estrogen receptors, helping prevent estrogen from stimulating the growth of breast cancer cells.
  • Slows disease progression: By reducing estrogen signalling, this medicine helps slow the growth and spread of advanced breast cancer.
  • Works after previous hormonal therapy: Fulvestrant remains an effective treatment option for many patients whose cancer has progressed despite previous endocrine therapies.
  • Maintains quality of life: Because it specifically targets hormone receptors rather than rapidly dividing cells, many patients experience fewer systemic side effects than with traditional chemotherapy while maintaining daily activities.
Side effects of Fulbreca 250 mg Injection 5 ml
  • Rest well; get enough sleep.
  • Eat a balanced diet and drink enough water.
  • Manage stress with yoga and meditation.
  • Limit alcohol and caffeine.
  • Physical activities like walking or jogging might help boost energy and make you feel less tired.
  • Include iron-rich foods like dark leafy vegetables, lean red meat, legumes and fish in your diet.
  • Consume vitamin C-rich foods as they aid iron absorption.
  • Limit tea, cocoa, and coffee as these can slow iron absorption.
  • Exercise regularly; however, do not overdo it.
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
  • Managing a low platelet count (thrombocytopenia) caused by medication usage requires a multi-step approach. Here are some steps to help manage the condition:
  • Inform your doctor about your low platelet count and medication usage. They will assess the situation and guide the best course of action.
  • Your doctor may recommend adjusting or stopping the medication that is causing a low platelet count. This could involve switching to alternative medication or reducing the dosage.
  • Monitor your platelet count regularly through blood tests to track any changes. This will help the doctor determine the effectiveness of the treatment plan.
  • If an underlying condition, such as infection or inflammation, contributes to the low platelet count, your doctor will treat it.
  • In some cases, alternative treatments like platelet transfusions or medications that stimulate platelet production may be necessary.
  • Avoid risky activities and certain medications; eat a balanced diet with plenty of water to reduce bleeding risk and boost overall health.
  • If you experience severe bleeding or bruising, seek emergency medical attention immediately.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
Here's a comprehensive approach to managing medication-triggered fever:
  • Inform your doctor immediately if you experience a fever after starting a new medication.
  • Your doctor may adjust your medication regimen or dosage as needed to minimize fever symptoms.
  • Monitor your body temperature to monitor fever progression.
  • Drink plenty of fluids, such as water or electrolyte-rich beverages, to help your body regulate temperature.
  • Get plenty of rest and engage in relaxation techniques, such as deep breathing or meditation, to help manage fever symptoms.
  • Under the guidance of your doctor, consider taking medication, such as acetaminophen or ibuprofen, to help reduce fever.
  • If your fever is extremely high (over 103°F), or if you experience severe symptoms such as confusion, seizures, or difficulty breathing, seek immediate medical attention.

Directions for Use

  • Your doctor will decide the dosage and timing of Fulbreca 250 mg Injection 5 ml based on the stage of cancer and your body’s response to the treatment. Usually, it is given every two weeks for the first three doses, then once monthly.
  • Fulbreca 250 mg Injection 5 ml will be administered by a doctor or nurse in a medical facility.
  • Do not self-administer.

How Fulbreca 250 mg Injection 5 ml Works

Fulbreca 250 mg Injection 5 ml contains fulvestrant, a type of hormonal therapy known as a selective estrogen receptor degrader (SERD). Many breast cancers depend on the hormone estrogen to grow and multiply. Estrogen binds to receptors on cancer cells, sending signals that promote tumour growth. Fulvestrant binds to these estrogen receptors and blocks their activity. It also causes the receptors to be broken down and removed from the cancer cells, reducing the number of receptors available for estrogen to act on. By blocking and degrading estrogen receptors, fulvestrant slows or stops the growth of hormone receptor-positive breast cancer cells and helps control the progression of the disease.
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Alcohol

Caution

Avoid alcohol consumption while receiving this medicine. If you have any concerns, please discuss them with your doctor.

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Pregnancy

Unsafe

Fulbreca 250 mg Injection 5 ml is not recommended for use during pregnancy as it may harm the unborn baby. You are advised to use effective contraception while being treated with Fulbreca 250 mg Injection 5 ml and for two years after your last dose.

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Breast Feeding

Unsafe

Fulbreca 250 mg Injection 5 ml is contraindicated for use during lactation, or you are recommended to avoid breastfeeding while on treatment with Fulbreca 250 mg Injection 5 ml.

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Driving

Safe if prescribed

Fulbreca 250 mg Injection 5 ml usually does not affect your ability to drive or operate machinery. However, avoid driving or operating machinery if you feel tired or weak after receiving Fulbreca 250 mg Injection 5 ml.

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Liver

Caution

Fulbreca 250 mg Injection 5 ml is not recommended for patients with severe liver problems. Therefore, if you have liver problems, inform your doctor before receiving Fulbreca 250 mg Injection 5 ml.

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Kidney

Caution

If you have kidney problems, inform your doctor before receiving Fulbreca 250 mg Injection 5 ml.

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Children

Unsafe

Fulbreca 250 mg Injection 5 ml is not recommended for children and adolescents below 18 years of age.

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Heart

Consult your doctor

Please inform your doctor if you have any pre-existing heart problems before using Fulbreca 250 mg Injection 5 ml. Your doctor will prescribe Fulbreca 250 mg Injection 5 ml if the benefits outweigh the risk.

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Geriatrics

Safe if prescribed

Fulbreca 250 mg Injection 5 ml is generally considered safe when used under medical supervision in geriatric patients; however, significant precautions should be taken due to age-related sensitivities.

What if I have taken an overdose of Fulbreca 250 mg Injection 5 ml

Because this medicine is administered by trained healthcare professionals, an overdose is unlikely. If an overdose is suspected, you will be monitored closely and treated for any symptoms that develop.

Diet & Lifestyle Advise

  • Eat a balanced diet: Include plenty of fruits, vegetables, whole grains, and lean protein to help maintain your strength during cancer treatment.
  • Support bone health: Your doctor may recommend adequate calcium and vitamin D intake, along with weight-bearing exercise, especially if you are at risk of osteoporosis.
  • Stay physically active: Gentle activities such as walking or stretching may help reduce joint stiffness, improve energy levels, and maintain muscle strength.
  • Limit alcohol intake: Alcohol may increase the risk of liver problems. Discuss alcohol consumption with your doctor during treatment.
  • Maintain a healthy weight: Achieving and maintaining a healthy body weight may support your overall health during breast cancer treatment.
  • Attend regular follow-up appointments: Routine medical reviews help monitor your response to treatment and detect side effects early.
health query

Have a query?

How Soon It Starts Working

The time required for Fulbreca 250 mg Injection 5 ml to start to work: The time required for Fulbreca 250 mg Injection 5 ml to show its action is not clinically established. The time for which the effects of Fulbreca 250 mg Injection 5 ml last: The duration of action for Fulbreca 250 mg Injection 5 ml is not clinically established.

What if you forget to take Fulbreca 250 mg Injection 5 ml

If you miss your scheduled injection appointment, contact your healthcare provider immediately to arrange another appointment. Receiving your injections on time helps maintain consistent treatment.

Storage

•Store prefilled syringes in a refrigerator between 2°C and 8°C (36°F and 46°F).

Keep Refrigerated. Do not freeze.

Drug Warnings

  • Attend all scheduled injections: Receiving your injections on time helps maintain consistent estrogen receptor blockade and improves treatment effectiveness.
  • Tell your doctor if you take blood thinners: Medicines such as warfarin or other anticoagulants may increase the risk of bleeding or bruising following the intramuscular injection.
  • Report persistent injection-site pain: Inform your healthcare provider if you develop severe pain, swelling, numbness, tingling, or weakness in your buttock or leg after the injection.
  • Monitor your liver function: Regular blood tests may be required during treatment, particularly if you have a history of liver disease.
  • Pregnancy warning: This medicine can harm an unborn baby. Use effective contraception during treatment and for at least 2 years after your final dose if you could become pregnant. Do not breastfeed during treatment.
  • Inform every healthcare provider that you are receiving hormonal therapy: This is especially important before starting new medicines or undergoing surgical procedures.
  • Do not stop treatment without medical advice: Continue receiving your injections for as long as your doctor recommends, even if you feel well.
  • When to seek urgent medical care: Seek immediate medical attention if you develop severe allergic reactions, yellowing of the skin or eyes, sudden chest pain, shortness of breath, or symptoms of a blood clot.

Drug-Drug Interactions

verifiedApollotooltip
  • Anticoagulants (such as warfarin): Fulvestrant should be used cautiously with blood-thinning medicines because intramuscular injections may increase the risk of bleeding or large injection-site haematomas.
  • Other anticancer medicines: Fulvestrant is commonly used with targeted therapies such as CDK4/6 inhibitors. Your healthcare team will monitor you closely for side effects during combination treatment.
FulvestrantFluoroestradiol (18f)
Severe

Drug-Drug Interactions

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FulvestrantFluoroestradiol (18f)
Severe
How does the drug interact with Fulbreca 250 mg Injection 5 ml:
Coadministration of Fulbreca 250 mg Injection 5 ml with Fluoroestradiol (18f) can reduce the action of Fluoroestradiol (18f) in detecting cancer.

How to manage the interaction:
Taking Fulbreca 250 mg Injection 5 ml with Fluoroestradiol (18f) together can possibly result in an interaction, it can be taken if your doctor has advised it. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

verifiedApollotooltip
  • There are no known clinically significant food interactions with fulvestrant. You may continue your usual diet unless your doctor recommends otherwise.
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[ANTINEOPLASTIC]

FAQs

Fulbreca 250 mg Injection 5 ml is used to treat Breast cancer in postmenopausal women.
Fulbreca 250 mg Injection 5 ml contains Fulvestrant which works by inhibiting some of the actions of estrogen (female sex hormone) and reducing the amount that is in the body. Thus, it helps in reducing breast cancer tumour growth.
Fulbreca 250 mg Injection 5 ml is not recommended for patients with severe liver problems. Therefore, if you have any liver problems, inform your doctor before receiving Fulbreca 250 mg Injection 5 ml.
Fulbreca 250 mg Injection 5 ml may cause weakness or tiredness as a common side effect. However, if weakness persists or worsens, please consult your doctor.
Fulbreca 250 mg Injection 5 ml contains Fulvestrant, which belongs to a class of medications called estrogen receptor antagonists. It helps to slow or stop the growth of specific breast tumours that depend on estrogen (a female sex hormone) to grow.
Fulbreca 250 mg Injection 5 ml is administered as a liquid injection into a muscle in the buttocks by a doctor in a medical setting. It is typically injected slowly over 1 to 2 minutes. For the first three doses, you will receive an injection every two weeks (on days 1, 15, and 29). After that, it is usually given once a month. Your doctor will determine the exact schedule based on your condition and how you respond to the medication. The injection will be given as two separate shots (one in each buttock). Please do not self-administer it.
Fulbreca 250 mg Injection 5 ml may cause common side effects, such as injection site reactions like pain and inflammation, weakness, nausea, tiredness, headache, or joint and musculoskeletal pain in some individuals. Most of these side effects of Fulbreca 250 mg Injection 5 ml do not require medical attention and gradually resolve over time. However, if these side effects persist or worsen, please consult your doctor.
Fulbreca 250 mg Injection 5 ml is given as an injection directly into the muscle of your buttocks. It is administered slowly by a trained healthcare professional in a clinic or doctor's office. Talk to your doctor if you have questions about the injection process.
Fulbreca 250 mg Injection 5 ml is specifically approved for women who are postmenopausal. If you are premenopausal, your doctor may only consider this treatment if it is combined with other medications that suppress ovarian function. Talk to your doctor to see if this treatment is right for you.
While hair thinning can sometimes occur with hormone therapies, complete hair loss is not a common side effect of Fulbreca 250 mg Injection 5 ml. If you are concerned about hair thinning, talk to your doctor or pharmacist for supportive care options.
Because Fulbreca 250 mg Injection 5 ml lowers the effect of estrogen in your body, it can potentially affect your bone density over time. Your doctor may recommend regular bone density scans or suggest calcium and Vitamin D supplements to help protect your bones. Talk to your doctor about your bone health.
No, Fulbreca 250 mg Injection 5 ml is not chemotherapy. It is a hormone therapy (specifically, an estrogen receptor downregulator) that selectively targets hormone-sensitive cancer cells, which generally results in a different side effect profile than traditional chemotherapy. Talk to your doctor for more details.
Most people can drive safely after receiving their injection, as it does not typically cause drowsiness. However, if you feel dizzy, weak, or experience pain at the injection site that affects your movement, avoid driving and talk to your doctor.
It is very important to get your injections on time to keep the treatment working. If you miss an appointment, contact your healthcare provider right away to schedule a make-up injection. Talk to your doctor or pharmacist if you need help tracking your schedule.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Country of origin

India

Manufacturer/Marketer address

463, 4 Th Floor, Rpg House, Dr. Annie Besant Road, Worli, Mumbai 400 030. Maharashtra, India
Other Info - FUL0233
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