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compositionComposition:GEFITINIB-250MG
prescription
Prescription Medicine
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Gefzest-250 Tablet 10's is used to treat non-small cell lung cancer. It contains Gefitinib which works by inhibiting the growth and multiplication of cancer cells. In some cases, this medicine may cause side effects such as itching or skin rash, acne, nail problems, vomiting, diarrhoea, and loss of appetite. Inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.

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Written By Lakshmithulasi Yarragunta , PharmD (PB)
Reviewed By Bayyarapu Mahesh Kumar , M Pharmacy
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More about the Product

Composition :

GEFITINIB-250MG

Manufacturer/Marketer :

Zee Laboratories Ltd

Consume Type :

Oral

Expires on or after :

Dec-28

Return Policy :

Not Returnable

About Gefzest-250 Tablet 10's

Gefzest-250 Tablet 10's is a prescription medication used to treat adults with non-small cell lung cancer that has spread to other parts of the body. It specifically targets cancer cells that have certain abnormal proteins or epidermal growth factor receptor (EGFR) mutations. By blocking these proteins, this medicine helps slow down or stop the growth and spread of cancer cells.

To get the most benefit, you must take Gefzest-250 Tablet 10's consistently at the same time every day as prescribed by your doctor. You can take this tablet with or without food, making it easy to fit into your daily routine. Staying well-hydrated and eating balanced, nutritious meals can also support your body during this treatment.

While taking Gefzest-250 Tablet 10's, you may experience common side effects such as skin rashes, diarrhoea, or dry skin. However, you must contact your doctor immediately if you develop severe or worsening shortness of breath, cough, fever, or severe eye irritation.

Before starting this medication, tell your doctor if you have a history of lung disease, liver damage, or kidney problems. Do not take this if you are allergic to any of the ingredients in this medicine.

Certain medicines, smoking, and alcohol can interfere with how this drug works, potentially reducing its effectiveness or increasing side effects. If you are pregnant, planning a pregnancy, breastfeeding, or are an older adult, talk to your doctor or pharmacist to discuss the risks and benefits before starting this therapy.
 

Uses of Gefzest-250 Tablet 10's

Here is the main condition where Gefzest-250 Tablet 10's is used to slow cancer growth and improve disease control:

  • Non-Small Cell Lung Cancer (NSCLC): Gefzest-250 Tablet 10's helps by targeting and blocking specific abnormal proteins on cancer cells, which stops the tumour from growing and spreading to other parts of the body.

 

Key Benefits

Gefzest-250 Tablet 10's offers several important benefits that help control lung cancer while allowing for more targeted treatment: 

  • Targeted Cancer Therapy: Unlike traditional chemotherapy which affects all rapidly dividing cells, Gefzest-250 Tablet 10's specifically targets cells with abnormal proteins. This helps limit damage to healthy cells, which can lead to fewer systemic side effects.
  • Slowing Tumour Growth: By blocking the signals that tell cancer cells to multiply, this medication helps keep the disease controlled, which can relieve symptoms like coughing and shortness of breath, helping you breathe easier.
  • Convenient At-Home Care: Since this is an oral tablet, you can take it in the comfort of your own home rather than travelling to a clinic for regular intravenous infusions, giving you more control over your daily schedule.
     
Side effects of Gefzest-250 Tablet
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
  • Increased protein levels indicate the body is dehydrated and when blood plasma is concentrated.
  • Consume water and stay hydrated. Talk to your doctor and take an oral rehydrating salt (ORS).
  • Sleep for 7-8 hours per night to assist your body in repairing and rebuilding hydration.
  • Manage your blood pressure by implementing changes in lifestyle like losing weight, reducing stress and exercising regularly.
  • Consume more protein-rich foods and healthy fats like beans, avocados, cheese, nuts and lean meats to minimize appetite.
  • Prefer foods high in fiber to help feel full for a long time.
  • If you have decreased appetite, eat only when you are hungry.
  • Eat several small meals or snacks all day.
  • Try to take only small sips of fluids while eating.
  • Rest well; get enough sleep.
  • Eat a balanced diet and drink enough water.
  • Manage stress with yoga and meditation.
  • Limit alcohol and caffeine.
  • Physical activities like walking or jogging might help boost energy and make you feel less tired.
  • Using a cold compress may help relieve itching and inflammation associated with conjunctivitis.
  • A warm compress and washing the eyes with water can help with crusting on the eyelids.
  • Avoid wearing contact lens until you feel better; use spectacles instead.
  • Do not rub the eyes.
  • Practise good hand hygiene and avoid touching the eyes to prevent the spread of infection.

Directions for Use

  • Gefzest-250 Tablet 10's should be taken on an empty stomach, at least 1 to 2 hours before a meal for effectiveness.
  • Follow your doctor’s recommendations on the dosage and timing of this medication to achieve optimal results.
  • Swallow it as a whole with a glass of water.
  • Do not crush, chew, or break it.

How Gefzest-250 Tablet 10's Works

Gefzest-250 Tablet 10's contains gefitinib, a targeted anticancer medicine that belongs to a class of medicines known as tyrosine kinase inhibitors. It is used to treat certain types of non-small cell lung cancer with specific genetic changes. Gefzest-250 Tablet 10's works by blocking the action of the Epidermal Growth Factor Receptor (EGFR), a protein that may be overactive in some lung cancer cells. EGFR normally sends signals that encourage cancer cells to grow and divide. By blocking these signals, Gefzest-250 Tablet 10's helps stop the growth and spread of cancer cells. Together, these actions help slow the progression of cancer, shrink or stabilise tumours, and improve disease control in people with EGFR-positive non-small cell lung cancer.
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Alcohol

Unsafe

You are recommended to avoid alcohol consumption with Gefzest-250 Tablet 10's as it may increase the risk of side effects such as dizziness, drowsiness, or difficulty in concentrating.

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Pregnancy

Unsafe

Gefzest-250 Tablet 10's is restricted to use in pregnancy. A woman needs to have a negative pregnancy test before starting treatment with this medicine. It is better to use effective birth control methods to prevent pregnancy while taking this medicine or at least 6 months after taking the last dose of Gefzest-250 Tablet 10's.

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Breast Feeding

Unsafe

Gefzest-250 Tablet 10's should not be taken by breastfeeding mothers as it passes into breast milk and may cause a possible risk to the infant.

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Driving

Caution

It is not known if Gefzest-250 Tablet 10's may affect your driving ability or not. Drive only if you are physically stable and mentally focussed. If you experience drowsiness after taking this medication, you should not drive or operate any machinery or vehicles.

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Liver

Caution

Gefzest-250 Tablet 10's should be taken with caution in patients dealing with liver disease. The doctor may adjust the dose according to the medical condition of the patient.

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Kidney

Caution

Gefzest-250 Tablet 10's is safe to take by patients dealing with kidney disease as prescribed by their doctor. The doctor may adjust the dose according to the medical condition of the patient.

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Children

Unsafe

Gefzest-250 Tablet 10's is not recommended for children below 18 years as the safety and effectiveness were not established.

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Heart

Consult your doctor

It is unknown whether Gefzest-250 Tablet 10's is safe for use in cardiac patients. Please consult your physician.

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Geriatrics

Safe if prescribed

Gefzest-250 Tablet 10's is safe for use in elderly patients if prescribed by the physician.

What if I have taken an overdose of Gefzest-250 Tablet 10's

If you suspect an overdose or have taken too much of this medication, seek immediate medical attention or call emergency services right away.

Diet & Lifestyle Advise

  • Monitor your breathing: Pay close attention to any sudden breathing changes or a new dry cough, as these can be signs of a serious lung condition.
  • Avoid grapefruit and grapefruit juice: This fruit can interfere with how your body breaks down Gefzest-250 Tablet 10's, potentially increasing the risk of side effects.
  • Limit alcohol and stop smoking: Smoking can significantly reduce the level of this medicine in your blood, making it less effective. Discuss smoking cessation options with your healthcare team.
  • Use reliable birth control: Both men and women taking this medicine should use effective contraception during treatment and for a specified time after the last dose to prevent pregnancy. Talk to your doctor for guidance.
  • Routine blood tests are necessary: Your doctor will need to perform regular blood tests to check your liver function while you are on this medication.
     
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Have a query?

How Soon It Starts Working

The time required for Gefzest-250 Tablet 10's to start to work: The time required for Gefzest-250 Tablet 10's to show its action is not clinically established. The time for which the effects of Gefzest-250 Tablet 10's last: The duration of action for Gefzest-250 Tablet 10's is not clinically established.

What if you forget to take Gefzest-250 Tablet 10's

If you miss a dose, take it as soon as you remember. However, if your next scheduled dose is less than 12 hours away, skip the missed dose and take your next dose at the regular time. Do not take two doses at the same time to make up for a missed one.

Storage

•Store Gefzest-250 Tablet 10's oral tablets at room temperature, ideally between 20°C to 25°C (68°F to 77°F).

Drug Warnings

Tell your doctor if you have liver or kidney disease, vision problems, breathing problems or taking any blood thinner like warfarin. Before undergoing any surgery, it is advised to tell the medical professional who performs the procedure about all the medicines you are taking. Some persons may experience diarrhoea as a side effect of Gefzest-250 Tablet 10's, so it is advised to drink a lot of water and tell your doctor in such a case. Inform your doctor if you notice any severe side effects of Gefzest-250 Tablet 10's, including shortness of breath, worsening cough, and other vision problems. You need to go to regular blood tests to check if this medicine is working fine for you.  Avoid high-fibre foods, raw fruits, cereals, vegetables, and drink lots of water as Gefzest-250 Tablet 10's may cause diarrhoea. 

Drug-Drug Interactions

verifiedApollotooltip

Here are the medicines that may interact with Gefzest-250 Tablet 10's and affect its safety or effectiveness:

  • Acid-reducing medications (such as proton pump inhibitors, H2 blockers, or antacids): These can lower the absorption of Gefzest-250 Tablet 10's by reducing stomach acid, making the treatment less effective.
  • Strong CYP3A4 inducers (like rifampicin, phenytoin, or carbamazepine): These can speed up how your body processes the medicine, lowering its levels in your blood.
  • Blood thinners (like warfarin): Taking this medicine with blood thinners may increase your risk of bleeding. Your doctor may need to monitor your blood clotting times more closely.

 

GefitinibThioridazine
Critical
GefitinibDexlansoprazole
Severe

Drug-Drug Interactions

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GefitinibThioridazine
Critical
How does the drug interact with Gefzest-250 Tablet:
When Gefzest-250 Tablet is taken with Thioridazine it can increase the levels of Thioridazine in the body. This increases the risk or severity of side effects in the body.

How to manage the interaction:
Co-administration of Gefzest-250 Tablet with Thioridazine is not recommended as it can possibly result in an interaction, but it can be taken if your doctor has advised it. If you notice any symptoms, such as sudden dizziness, lightheadedness, fainting, trouble breathing, or experiencing heart palpitations, consult the doctor immediately. Do not stop using any medications without talking to a doctor.
GefitinibDexlansoprazole
Severe
How does the drug interact with Gefzest-250 Tablet:
Co-administration of Dexlansoprazole may interfere with the absorption of Gefzest-250 Tablet into the bloodstream and reduce its effectiveness.

How to manage the interaction:
Although there is a possible interaction, dexlansoprazole can be taken with Gefzest-250 Tablet if advised by a doctor. Do not stop using any medications without talking to a doctor.
GefitinibAminolevulinic acid
Severe
How does the drug interact with Gefzest-250 Tablet:
Coadministration of Gefzest-250 Tablet with Aminolevulinic acid can increase the risk or severity of skin reactions like severe sunburn.

How to manage the interaction:
Taking Gefzest-250 Tablet with Aminolevulinic acid together can result in an interaction, but it can be taken if your doctor has advised it. However, if you notice any redness and inflammation on the skin, Skin feels hot or tight, Pain or tenderness, or Peeling skin you should contact your doctor immediately. Avoid or limit exposure of the eyes and skin to sunlight or bright indoor lights. Do not stop using any medications without talking to a doctor.
GefitinibCalcium carbonate
Severe
How does the drug interact with Gefzest-250 Tablet:
Co-administration of Calcium carbonate may interfere with the absorption of Gefzest-250 Tablet and reduce its effectiveness.

How to manage the interaction:
Although there is an interaction, Calcium carbonate can be taken with Gefzest-250 Tablet if prescribed by the doctor. However, Gefzest-250 Tablet and Calcium carbonate should not be taken orally at the same time. Maintain a gap of 2-6 hours between both medicines. Do not discontinue using any medications without consulting a doctor.
GefitinibMagnesium carbonate
Severe
How does the drug interact with Gefzest-250 Tablet:
Magnesium carbonate can make Gefzest-250 Tablet less effective by reducing its absorption and lowering its concentration in the blood.

How to manage the interaction:
Although there is a possible interaction between Gefzest-250 Tablet and Magnesium carbonate, you can take these medicines together if prescribed by your doctor. It's important to keep an eye on how well your treatment is working. Your doctor can help you find other options that won't interfere with your current medication. Do not discontinue any medications without consulting a doctor.
GefitinibRifampicin
Severe
How does the drug interact with Gefzest-250 Tablet:
Coadministration of Gefzest-250 Tablet with Rifampicin can decrease the blood levels of Gefzest-250 Tablet, which may make the medication less effective.

How to manage the interaction:
Although there is an interaction between Gefzest-250 Tablet and rifampicin, they can be taken together if prescribed by a doctor. Do not discontinue any medications without consulting a doctor.
GefitinibLeflunomide
Severe
How does the drug interact with Gefzest-250 Tablet:
Gefzest-250 Tablet can cause higher levels of Leflunomide in the blood by reducing its excretion rate. This can increase the risk or severity of liver damage.

How to manage the interaction:
Taking Leflunomide with Gefzest-250 Tablet together can result in an interaction, but it can be taken if your doctor has advised it. If you have any of these symptoms like fever, chills, joint pain, swelling, bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, abdominal pain, dark-colored urine, liver damage, or bleeding, make sure to contact a doctor right away. Do not stop using any medications without a doctor's advice.
GefitinibCimetidine
Severe
How does the drug interact with Gefzest-250 Tablet:
Coadministration of Gefzest-250 Tablet with Cimetidine can reduce Gefzest-250 Tablet absorption and reduce its levels in the body. This can lead to low treatment outcomes.

How to manage the interaction:
Taking Gefzest-250 Tablet with Cimetidine together can possibly result in an interaction, it can be taken if your doctor has advised it. Do not stop using any medications without talking to a doctor.
GefitinibEnzalutamide
Severe
How does the drug interact with Gefzest-250 Tablet:
Coadministration of Gefzest-250 Tablet with Enzalutamide can alter the blood levels of Gefzest-250 Tablet which can lead to poor treatment outcomes.

How to manage the interaction:
Taking Gefzest-250 Tablet with Enzalutamide together can possibly result in an interaction, it can be taken if your doctor has advised it. Do not stop using any medications without talking to a doctor.
GefitinibMagaldrate
Severe
How does the drug interact with Gefzest-250 Tablet:
Magaldrate can make Gefzest-250 Tablet less effective by reducing its absorption and lowering its concentration in the blood.

How to manage the interaction:
Taking Gefzest-250 Tablet with Magaldrate together can result in an interaction, but it can be taken if your doctor has advised it. it is recommended that you take Gefzest-250 Tablet 6 hours before or 6 hours after magaldrate to help minimize the interaction. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

verifiedApollotooltip

Here are the important food and drink considerations while taking Gefzest-250 Tablet 10's:

  • Grapefruit and grapefruit juice: Avoid consuming these as they can block the enzymes that break down the medication, leading to high levels of the drug in your body and increasing side effects.

 

No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[ANTINEOPLASTIC]

FAQs

Gefzest-250 Tablet 10's is used to treat non-small cell lung cancer.
Gefzest-250 Tablet 10's works by stopping the action of an abnormal protein that causes the multiplication of cancerous cells. Thereby, it prevents the spread of cancerous cells.
The most common sign of lung cancer is a cough that lasts long and gets worse with time. Sometimes, a patient may notice blood in the cough. Chest pain is also a sign of lung cancer followed by coughing.
It is suggested to avoid taking an antacid or stomach acid-reducing medicine within 6 hours after taking Gefzest-250 Tablet 10's as it may make the medicine less effective if taken simultaneously.
Gefzest-250 Tablet 10's is safe to be taken by a diabetic person. However, take Gefzest-250 Tablet 10's only after asking a doctor as they may adjust the dosing according to the patient's condition.
Antacids and other acid-reducing medicines can reduce the absorption of Gefzest-250 Tablet 10's, making it less effective. If you need to take an antacid, take it at least 2 hours before or 2 hours after your dose of this medicine. Talk to your doctor or pharmacist for a safe schedule.
Mild skin rashes are a common side effect. You can manage them by using gentle, fragrance-free moisturisers and avoiding hot showers. However, if the rash is severe, painful, or blistering, do not self-treat. Talk to your doctor immediately.
Yes, smoking can significantly lower the levels of Gefzest-250 Tablet 10's in your blood, which can make the treatment much less effective. It is highly recommended to stop smoking while taking this medication. Talk to your doctor for help with quitting.
It is best to limit or avoid alcohol while taking this medicine. Alcohol can increase the risk of liver damage and worsen stomach irritation or dehydration. Talk to your doctor or pharmacist about what is safe for you.
This medication is typically taken for as long as your disease remains controlled and you do not experience severe side effects. Your doctor will regularly evaluate your progress to decide how long you should continue treatment. Talk to your doctor if you have concerns.
No, this medicine can harm an unborn baby. Both men and women should use highly effective birth control while taking this medicine and for some time after stopping it. Talk to your doctor immediately if you are planning a family or suspect a pregnancy.
You should generally swallow the tablet whole. If you have severe trouble swallowing, the tablet can be dispersed in half a glass of non-carbonated drinking water. Stir well until it disperses and drink immediately. Talk to your doctor or pharmacist for precise instructions on how to do this safely.
Watch for signs of liver damage such as yellowing of your skin or the whites of your eyes, unusually dark urine, severe fatigue, or pain in the upper right side of your stomach. If you notice any of these, call your doctor right away.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Country of origin

India

Manufacturer/Marketer address

Uchani, G.T. Road, Karnal-132001 Haryana (INDIA).
Other Info - GEF0060
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