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compositionComposition:RIFAMPICIN-400MG
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Prescription Medicine
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Geno-Mix 400 Tablet 10's is used in combination with other medicines to treat tuberculosis (TB). It contains Rifampicin, which inhibits the growth of bacteria. In some cases, you may experience certain common side effects, such as drowsiness, dizziness, headache, weakness, muscle pain, heartburn, diarrhoea, gas, and numbness or tingling sensations. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.

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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Santoshini Reddy G , M Pharmacy
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More about the Product

Composition :

RIFAMPICIN-400MG

Manufacturer/Marketer :

Geno Pharmaceuticals Ltd

Consume Type :

Oral

Expires on or after :

Jan-28

Return Policy :

Not Returnable

About Geno-Mix 400 Tablet 10's

Geno-Mix 400 Tablet 10's is an oral antibiotic used to treat serious bacterial infections, primarily tuberculosis. It is also prescribed to eliminate bacteria from the nose and throat of individuals who may spread meningitis, even if they do not currently feel sick. This medicine is highly effective when used as part of a combination therapy plan to ensure the infection is completely cleared from your body.

For the best results, you must take Geno-Mix 400 Tablet 10's consistently and exactly as your doctor prescribes, typically once daily. It is best taken on an empty stomach, either one hour before or two hours after a meal, to ensure your body absorbs the maximum amount of medicine. Implementing a structured daily schedule can help you remain consistent with your doses and support your recovery.

While taking Geno-Mix 400 Tablet 10's, you will likely notice a harmless orange-red discolouration of your urine, sweat, and saliva. However, you should contact your doctor immediately if you experience severe side effects, such as persistent abdominal pain, unusual fatigue, or yellowing of your skin or eyes.

Do not take this if you have a known allergy to rifampicin antibiotics or have severe liver disease. Before starting, talk to your doctor if you have a history of liver problems, diabetes, or porphyria, as special monitoring may be required to keep you safe.

This medicine can interact significantly with other treatments, including hormonal birth control and blood thinners, reducing their effectiveness. If you are pregnant, breastfeeding, or an older adult, consult your healthcare provider to discuss the risks and benefits before taking this medication.

Uses of Geno-Mix 400 Tablet 10's

Geno-Mix 400 Tablet 10's is used to treat tuberculosis mainly. The detailed uses of Geno-Mix 400 Tablet 10's are as follows:

  • Tuberculosis: Geno-Mix 400 Tablet 10's helps by stopping the growth and replication of the bacteria causing this deep lung infection, usually in combination with other tuberculosis medications to prevent drug resistance.
  • Meningococcal carrier state: Geno-Mix 400 Tablet 10's helps by eliminating bacteria from the nose and throat of asymptomatic carriers, stopping the spread of bacterial meningitis to other people.
     

Key Benefits

Geno-Mix 400 Tablet 10's offers several key benefits for individuals fighting serious bacterial infections, providing a reliable path toward recovery and protecting those around them.

  • Deep-seated infection clearance: By aggressively targeting bacteria, it helps clear persistent pulmonary infections, allowing your lungs to heal and relieving chronic cough and fatigue.
  • Prevention of community spread: It quickly sanitises the respiratory tract of carriers, ensuring that dangerous, life-threatening pathogens are not passed to family members or close contacts.
  • Targeted therapeutic action: It works specifically on bacterial cells, minimising damage to healthy human tissue while delivering potent antibacterial effects.
     

Directions for Use

  • Take Geno-Mix 400 Tablet 10's 30 minutes before or 2 hours after food on an empty stomach.
  • Follow your doctor's instructions on the dosage and timing of this medication to ensure safety.
  • Swallow Geno-Mix 400 Tablet 10's as a whole with a glass of water.
  • Do not chew, crush or break it.

How Geno-Mix 400 Tablet 10's Works

Geno-Mix 400 Tablet 10's works by targeting the vital cellular machinery of bacteria. It specifically binds to and blocks a bacterial enzyme called RNA polymerase, which is responsible for copying genetic material and building essential proteins. Without this enzyme, the bacteria are unable to multiply, grow, or maintain their structure. Because human cells have a different structure and do not use this specific enzyme in the same way, Geno-Mix 400 Tablet 10's acts selectively on the bacteria. By halting bacterial reproduction, the medicine weakens the infection, allowing your body's natural immune system to easily target and eliminate the remaining bacteria.
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Alcohol

Caution

Geno-Mix 400 Tablet 10's intake is not recommended with alcohol. A patient is not advised to take alcohol with Geno-Mix 400 Tablet 10's as it may increase chances of liver damage.

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Pregnancy

Unsafe

Not recommended during pregnancy. Tell your doctor if you are pregnant or planning to become pregnant. Geno-Mix 400 Tablet 10's should not be taken during pregnancy as it can affect your unborn baby's growth and may cause complications to the mother and baby after birth.

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Breast Feeding

Unsafe

Not recommended while breastfeeding. A patient should not breast-feed while taking Geno-Mix 400 Tablet 10's. This is because a small amount of Geno-Mix 400 Tablet 10's may pass into the mother’s milk. So, if you are breastfeeding or planning to breastfeed, talk to your doctor.

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Driving

Caution

Caution should be maintained by a patient while driving a motor vehicle or doing hazardous work. A patient may experience dizziness, have problems with vision or have other side effects that could affect his ability to drive after taking this medicine. If this happens, do not drive.

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Liver

Caution

Not recommended to be taken in liver patients without a doctor's consultation as Geno-Mix 400 Tablet 10's has been found to affect liver function with raised ALT enzymes.

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Kidney

Caution

Not recommended for kidney patients without a doctor's consultation. Intake of Geno-Mix 400 Tablet 10's in these people may result in symptoms like blood in the urine, a change in the amount of urine passed and feeling drowsy or weak.

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Children

Safe if prescribed

Geno-Mix 400 Tablet 10's is safe to be prescribed in children below 12 years. Dose adjustments by the doctor are done according to age, weight, and severity of infection.

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Heart

Caution

Geno-Mix 400 Tablet 10's can be used in cardiac patients if prescribed by the physician. However caution should be exercised.

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Geriatrics

Caution

Geno-Mix 400 Tablet 10's should be used in elderly people only if prescribed by the physician. If recommended, careful monitoring of any side effects is advised.

What if I have taken an overdose of Geno-Mix 400 Tablet 10's

If you suspect an overdose or experience severe symptoms like extreme drowsiness, vomiting, or a pronounced orange-brown discolouration of the skin, seek immediate medical attention or call a poison control centre right away.

Diet & Lifestyle Advise

  • Avoid alcohol: Do not drink alcohol while taking this medicine. Both alcohol and the medication place stress on your liver, and combining them increases the risk of serious liver damage.
  • Skip contact lenses: Avoid wearing soft contact lenses during your treatment. The harmless reddish-orange tears caused by the medicine can permanently stain your lenses. Opt for glasses instead.
  • Eat nutrient-dense meals: Focus on a balanced diet rich in protein, vitamins, and minerals to support your body's immune system as it recovers from chronic infections like tuberculosis.
  • Maintain a hydration routine: Drink plenty of water throughout the day to support kidney function and help your body flush out bacterial waste products.
     
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How Soon It Starts Working

The time required for Geno-Mix 400 Tablet 10's to start to work: The time required for Geno-Mix 400 Tablet 10's to start to work is 1 to 3 hours after administration. The time for which the effects of Geno-Mix 400 Tablet 10's last: The effect of Geno-Mix 400 Tablet 10's lasts for 15 hours.

What if you forget to take Geno-Mix 400 Tablet 10's

If you miss a dose, take it as soon as you remember. If it is almost time for your next scheduled dose, skip the missed dose and resume your regular dosing schedule. Do not take two doses at the same time to make up for a missed one. If you miss multiple doses, talk to your doctor or pharmacist for advice.

Storage

•Store the medication at room temperature, ideally between 15°C and 30°C (59°F to 86°F).

Drug Warnings

  • Do not be alarmed if your urine, sweat, saliva, or tears turn a bright reddish-orange; this is a completely harmless, temporary effect of the medication.
  • Complete your full course of treatment exactly as prescribed, even if your symptoms disappear early, to prevent the bacteria from returning and becoming resistant to the antibiotic.
  • Monitor your skin and eyes daily for any signs of yellowing, and contact your healthcare provider immediately if you notice these changes.
  • Use a reliable, non-hormonal backup birth control method (such as condoms) during treatment, as this medicine makes hormonal contraceptives less effective.
  • Avoid wearing soft contact lenses to prevent permanent orange-red staining of the lens material.
     

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Drug-Drug Interactions

  • Hormonal Contraceptives: May significantly decrease the effectiveness of birth control pills, patches, rings, or implants, increasing the risk of unplanned pregnancy.
  • Blood Thinners (e.g., Warfarin): May reduce the thinning effect of these medications, requiring close monitoring and dosage adjustments of your blood thinner.
  • Antifungals and Antivirals: May lower the levels of these drugs in your bloodstream, making them less effective at treating other infections.


Drug-Food Interactions

  • Food: Taking this medicine with food dramatically reduces its absorption, making it less effective. Always take it on an empty stomach.


Drug-Disease Interactions

  • Liver Disease: May worsen existing liver impairment or accelerate liver damage. Regular liver function tests are highly recommended.
  • Porphyria: May trigger acute, painful attacks in patients who have this genetic blood disorder.

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Habit Forming

No

Therapeutic Class

[ANTI- TUBERCULOSIS]

FAQs

Geno-Mix 400 Tablet 10's belongs to the group of medicines called macrolide antibiotics, primarily used to treat tuberculosis (TB).
Geno-Mix 400 Tablet 10's is a bactericidal drug, which means it kills bacteria. It acts by blocking the activity of a bacterial enzyme called DNA-dependent RNA polymerase, which is essential for bacterial survival, thereby killing the bacteria.
Geno-Mix 400 Tablet 10's has no known serious drug interaction with ibuprofen or aspirin. Inform your doctor about all the medications you are currently taking to avoid harmful interactions that may reduce treatment effectiveness.
Yes, in some cases, a headache can be caused as a side effect of Geno-Mix 400 Tablet 10's. A patient must consult a doctor if it progresses over time.
Geno-Mix 400 Tablet 10's is safe when used at prescribed doses for the prescribed duration. Constant monitoring of liver function is important while on treatment with Geno-Mix 400 Tablet 10's. Please consult your doctor if you have any liver problems before taking Geno-Mix 400 Tablet 10's as it may worsen the situation. However, prolonged use of Geno-Mix 400 Tablet 10's can cause raised ALT (liver enzyme), and the person taking the treatment can develop jaundice symptoms like yellowing of the eyes, skin, etc. In this case, stop taking Geno-Mix 400 Tablet 10's and immediately contact a doctor.
No, Geno-Mix 400 Tablet 10's is not a penicillin, amoxicillin, or sulfa drug. It is an antibiotic in the rifamycin class, combined with other medicines to treat tuberculosis.
Geno-Mix 400 Tablet 10's is an inducer (increases enzyme activity) of cytochrome P450 enzymes.
Geno-Mix 400 Tablet 10's may lead to side effects like weight loss, hair loss, and yeast infections, though constipation is less common. Consult your doctor if you experience any of these effects.
Geno-Mix 400 Tablet 10's causes side effects such as drowsiness, dizziness, headache, muscle pain, weakness, heartburn, diarrhoea, gas, and numbness or tingling sensation. Most of these are temporary and do not require any medical attention, as they will gradually reduce over time. Please contact a doctor if these persist for longer periods.
This is a harmless, expected side effect. The medicine naturally has a red-brown colour that temporarily stains bodily fluids like urine, sweat, saliva, and tears. Your fluids will return to their normal colour after you finish your treatment. Talk to your doctor or pharmacist if you have concerns.
No, you should avoid alcohol entirely. Combining alcohol with this medicine increases the stress on your liver and significantly raises your risk of experiencing severe liver damage. Talk to your doctor if you need support with avoiding alcohol.
Yes, it can make hormonal birth control, including pills, patches, vaginal rings, and implants, less effective. You must use a reliable non-hormonal barrier method (like condoms) during your treatment and for at least 28 days after stopping. Talk to your doctor to discuss your birth control options.
No, you should take this medicine on an empty stomach, either 1 hour before a meal or 2 hours after. Taking it with food reduces how much of the drug your body absorbs, which can make it less effective at clearing your infection. Talk to your doctor or pharmacist if you experience stomach discomfort.
You should avoid wearing soft contact lenses while taking this medicine. The reddish-orange tears caused by the medication can permanently stain and damage soft lenses. Use glasses instead. Talk to your doctor or eye care specialist for more advice.
Take the missed dose as soon as you remember. If it is almost time for your next scheduled dose, skip the missed one and continue with your regular schedule. Do not double the dose to make up for a missed one. Talk to your doctor if you miss several doses.
The duration of your treatment depends on the specific infection being treated and your body's response. For tuberculosis, treatment usually lasts for several months. You must finish the entire course, even if you feel completely better. Talk to your doctor about your specific timeline.
This medicine is only prescribed during pregnancy or breastfeeding if the benefits outweigh the potential risks, as it can cross the placenta and enter breast milk. It may also affect blood clotting in newborns. Talk to your doctor to discuss the safest treatment plan for you and your baby.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Reference

  1. Electronic Medicines Compendium (EMC). Pil.8789 Patient Information Leaflet (PIL). Cheshire, UK: Datapharm; 2025. [Accessed on 02 Jun. 2026]Check here
  2. MedlinePlus. A682403 Patient Information Monograph. Bethesda, MD: U.S. National Library of Medicine (NLM); 2025. [Accessed on 02 Jun. 2026]Check here
  3. National Center for Biotechnology Information (NCBI). Nbk557488 Scientific Research Publication. Bethesda, MD: NLM; 2025. [Accessed on 02 Jun. 2026]Check here
  4. MIMS Drug Reference Compendium. Rifampicin Monograph. Singapore: MIMS; 2025. [Accessed on 02 Jun. 2026]Check here
  5. Ema. Rifampicin. [[Accessed on 21 Aug].2019]Check here
  6. Webmd. Rifampicin. [[Accessed on 21 Aug].2019]Check here
  7. Chaves RG, Lamounier JA Breastfeeding and maternal medications. J Pediatr (Rio J). 2004;80(5 Suppl):S189-S198Check here

Country of origin

India

Manufacturer/Marketer address

Geno Pharmaceuticals Pvt. Ltd., Pharmaceutical Complex, Tivim Industrial Estate, Karaswada, Mapusa, Goa - 403 526
Other Info - GEN0644
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