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compositionComposition:GLIMEPIRIDE-2MG+METFORMIN-500MG
prescriptionPrescription Medicine
Glipril MF Plus Tablet 10's

Glipril MF Plus Tablet is used to treat type 2 diabetes. It helps manage blood glucose levels in patients with diabetes and prevents diabetes-related complications like kidney damage, eye problems, and nerve issues.

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Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

GLIMEPIRIDE-2MG+METFORMIN-500MG

Manufacturer/Marketer :

Mefro Pharmaceuticals Pvt Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Glipril MF Plus Tablet

Glipril MF Plus Tablet belongs to a class of medicines called anti-diabetic drugs used in the treatment of type 2 diabetes, especially in patients whose blood sugar levels are not controlled by diet and exercise alone.

Glipril MF Plus Tablet contains Glimepiride and Metformin. Glimepiride helps the pancreas release more insulin, thereby lowering blood sugar levels. Metformin reduces the amount of sugar produced by the liver, slows down sugar absorption from food, and helps the body use insulin more effectively.

In some cases, Glipril MF Plus Tablet may cause side effects like stomach pain, nausea, diarrhoea, vomiting, headache or metallic taste. Most of these side effects of Glipril MF Plus Tablet do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

Do not take Glipril MF Plus Tablet if you are allergic to any of its components. Glipril MF Plus Tablet is not recommended during pregnancy, breastfeeding and in children. Avoid alcohol consumption with Glipril MF Plus Tablet as it may increase the risk of lactic acidosis (accumulation of lactic acid in the body).

Uses of Glipril MF Plus Tablet

Glipril MF Plus Tablet is used in the treatment of type 2 diabetes mellitus. The detailed uses of Glipril MF Plus Tablet are as follows:

  • Management of Type 2 Diabetes: Glipril MF Plus Tablet helps lower blood sugar levels in individuals diagnosed with type 2 diabetes.
  • Control of Blood Sugar Levels Post Meals: Glipril MF Plus Tablet assists in lowering postprandial blood sugar spikes, which is beneficial for overall diabetes management.

Key Benefits

  • Glipril MF Plus Tablet is indicated as an adjunct to diet and exercise to improve glycaemic control in patients with type 2 diabetes.
  • It helps manage blood glucose levels in patients with diabetes and prevents diabetes-related complications like kidney damage, eye problems, and nerve issues.
  • Glimepiride stimulates cells in the pancreas that produce insulin, which helps remove sugar from the blood.
  • Metformin reduces sugar production by cells in the liver and delays sugar absorption from the intestines. Additionally, it enhances the sensitivity of muscle cells to insulin, allowing these cells to remove sugar more effectively from the bloodstream.
Side effects of Glipril MF Plus Tablet
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
  • Drink water or other clear fluids.
  • To prevent worsening of pain, limit intake of tea, coffee, or alcohol.
  • Include bland foods like rice, toast, crackers, and rice in your diet.
  • Avoid lying down immediately after eating as it may cause indigestion or heartburn.
  • Avoid acidic and spicy food as it may cause indigestion.

Directions for Use

  • Glipril MF Plus Tablet can be taken with meals or as prescribed by the doctor.
  • Follow your doctor's instructions on the dosage and timing of this medication to ensure safety.
  • Swallow Glipril MF Plus Tablet as a whole with a glass of water.
  • Do not chew, crush or break it.

How Glipril MF Plus Tablet Works

Glipril MF Plus Tablet is a combination of two antidiabetic drugs, namely: Glimepiride and Metformin. Glimepiride works by stimulating beta cells in the pancreas that produce insulin. Thus, insulin helps to remove sugar from the blood. Metformin works by reducing the sugar production by cells in the liver and delays sugar absorption from the intestines. Also, it increases the sensitivity of muscle cells to insulin, which enables these cells to remove sugar more effectively from the blood.
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Alcohol

Unsafe

You are recommended to avoid consumption of alcohol with Glipril MF Plus Tablet as it may increase the risk of lactic acidosis (accumulation of lactic acid in the body).

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Pregnancy

Unsafe

Glipril MF Plus Tablet is not recommended for pregnant women as it may harm the unborn baby. Please consult a doctor if you are pregnant or planning for pregnancy.

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Breast Feeding

Unsafe

Avoid breastfeeding while taking Glipril MF Plus Tablet as it may be excreted in breastmilk and cause adverse effects in the baby. Therefore, please consult a doctor before using Glipril MF Plus Tablet if you are breastfeeding.

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Driving

Caution

Glipril MF Plus Tablet may decrease alertness in some people. Therefore, drive only if you are alert after taking Glipril MF Plus Tablet .

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Liver

Caution

Take Glipril MF Plus Tablet with caution, especially if you have a history of liver diseases. The dose may be adjusted by your doctor as required.

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Kidney

Caution

Take Glipril MF Plus Tablet with caution, especially if you have a history of kidney diseases. The dose may be adjusted by your doctor as required.

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Children

Unsafe

Glipril MF Plus Tablet is not recommended for children as the safety and effectiveness were not established.

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Heart

Caution

Glipril MF Plus Tablet should be taken with caution in patients with heart problems. Please inform your doctor if you have any pre-existing heart problems before using Glipril MF Plus Tablet .

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Geriatrics

Caution

Glipril MF Plus Tablet should be given with caution in elderly patients due to an increased risk of side effects. If you have any concerns about the usage of Glipril MF Plus Tablet in geriatrics, please consult your doctor.

What if I have taken an overdose of Glipril MF Plus Tablet

Take Glipril MF Plus Tablet only as prescribed by the physician. Avoid exceeding the recommended dose as it could lead to an overdose. Symptoms of overdose may include hypoglycaemia (low blood sugar) and lactic acidosis (buildup of lactic acid in the blood). If you experience these symptoms or suspect you have taken an overdose, seek immediate medical attention.

Diet & Lifestyle Advise

  • Do regular exercise such as cycling, walking, jogging, dancing, or swimming for a minimum of 30 minutes per day. Invest at least 150 minutes of your week in exercise.
  • Maintain a healthy body weight, as obesity is also related to the onset of diabetes.
  • Maintain a low-fat and low-sugar diet. Replace carbohydrate-containing foods with whole grains, fruits, and vegetables, as carbohydrates turn to sugars, leading to high blood sugar.
  • Avoid the consumption of alcohol and quit smoking.

Have a query?

How Soon It Starts Working

The time required for Glipril MF Plus Tablet to start to work: Glipril MF Plus Tablet ideally shows its action within few hours after administration. 

The time for which the effects of Glipril MF Plus Tablet last: The duration of action for Glipril MF Plus Tablet is clinically unknown.

What if you forget to take Glipril MF Plus Tablet

If you miss a dose of Glipril MF Plus Tablet , take it as soon as you remember. If it is almost time for the next dose, skip the missed dose and continue with the regular dosing schedule. Do not take a double dose to make up for the missed dose.

Storage

• Store in a cool and dry place away from sunlight.• Keep Glipril MF Plus Tablet out of reach and sight of children.• Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.

Drug Warnings

  • Do not take Glipril MF Plus Tablet if you are allergic to any of its components, if you have type 1 diabetes mellitus, diabetic ketoacidosis or diabetic coma.
  • Inform the doctor if you have liver or kidney problems, low blood sugar, or circulation problems.
  • Glipril MF Plus Tablet is not recommended for pregnant women as it may harm the unborn baby. Please consult a doctor if you are pregnant or planning to become pregnant. This medicine may pass into breast milk; therefore, it should be avoided in nursing mothers.
  • Glipril MF Plus Tablet may decrease alertness in some people. Therefore, drive only if you are alert after taking Glipril MF Plus Tablet .
  • Avoid alcohol consumption with Glipril MF Plus Tablet as it may increase the risk of lactic acidosis (accumulation of lactic acid in the body).

Drug-Drug Interactions

verifiedApollotooltip

Drug-Drug Interaction: Glipril MF Plus Tablet may interact with certain medicines, potentially increasing side effects. Inform your doctor if you are taking any of the following:

  • Antibiotics (rifampicin, trimethoprim)
  • Calcium channel blockers (verapamil)
  • Antacids (cimetidine)
  • HIV/AIDS drugs (dolutegravir)
  • Heart-related medicine (ranolazine)
  • Anticancer drugs (vandetanib, crizotinib, olaparib)
  • Antifungals (fluconazole, miconazole)
  • Water pill (acetazolamide)
  • Antidiabetic drug (insulin)
  • Anticonvulsants (phenytoin)

Drug-Food Interaction: No interactions found.

Drug-Disease Interaction: If you have severe infections, uncontrolled diabetes, lactic acidosis or ketoacidosis (accumulation of ketone bodies in the blood), dehydration, or liver or kidney problems, inform your doctor before taking Glipril MF Plus Tablet .

Glimepiride + MetforminIopromide
Critical
Glimepiride + MetforminGatifloxacin
Critical

Drug-Drug Interactions

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Glimepiride + MetforminIopromide
Critical
How does the drug interact with Glipril MF Plus Tablet:
Co-administration of Iopromide with Metformin can increase the risk of lactic acidosis (a medical condition characterized by a build-up of lactate in the body).

How to manage the interaction:
Taking Iopromide with Metformin is not recommended, consult a doctor before taking it. Do not stop using any medications without talking to a doctor.
Glimepiride + MetforminGatifloxacin
Critical
How does the drug interact with Glipril MF Plus Tablet:
Taking Glimepiride with Gatifloxacin may cause both low blood glucose and high blood glucose have been reported.

How to manage the interaction:
Gatifloxacin is not recommended for patients with diabetes, however, it can be taken if advised by a doctor. Consult the prescriber if you experience symptoms such as nervousness, confusion, headache, dizziness, drowsiness, tremors, nausea, hunger, weakness, perspiration, palpitation, rapid heartbeat, increased urination, increased thirst, and increased hunger. Do not discontinue the medications without consulting a doctor.
Glimepiride + MetforminIodamide
Critical
How does the drug interact with Glipril MF Plus Tablet:
Co-administration of Metformin and Iodamide can increase the risk of lactic acidosis (when the body produces too much lactic acid).

How to manage the interaction:
Taking Metformin with Iodamide is generally avoided as it can result in an interaction, consult a doctor before taking it. Do not stop using any medications without talking to a doctor.
Glimepiride + MetforminIopamidol
Critical
How does the drug interact with Glipril MF Plus Tablet:
Co-administration of Iopamidol with Metformin can increase the risk of lactic acidosis (a medical condition characterized by a build-up of lactate in the body).

How to manage the interaction:
Taking Metformin with Iopamidol is not recommended, consult a doctor before taking it. Do not stop using any medications without talking to a doctor.
Glimepiride + MetforminMetrizamide
Critical
How does the drug interact with Glipril MF Plus Tablet:
Co-administration of Metformin and Metrizamide together can cause the risk of lactic acidosis (when the body produces too much lactic acid ).

How to manage the interaction:
Taking Metformin with Metrizamide is generally avoided as it can result in an interaction, it can be taken if a doctor has advised it. However, if you experience headaches, nausea, vomiting, diarrhea, muscle cramps or pain, body weakness, extreme fatigue, and visual disturbances, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
Glimepiride + MetforminIomeprol
Critical
How does the drug interact with Glipril MF Plus Tablet:
Co-administration of Iomeprol with Metformin can increase the risk of lactic acidosis (a medical condition characterized by a build-up of lactate in the body).

How to manage the interaction:
Taking Metformin with Iomeprol is not recommended, consult a doctor before taking it. Do not stop using any medications without talking to a doctor.
Glimepiride + MetforminIodixanol
Critical
How does the drug interact with Glipril MF Plus Tablet:
Co-administration of Iodixanol with Metformin can increase the risk of lactic acidosis (a medical condition characterized by a build-up of lactate in the body).

How to manage the interaction:
Taking Metformin with Iodixanol is not recommended, consult a doctor before taking it. Do not stop using any medications without talking to a doctor.
Glimepiride + MetforminNalidixic acid
Severe
How does the drug interact with Glipril MF Plus Tablet:
When Glimepiride is taken with Nalidixic acid, can cause both hyperglycemia (high blood glucose) and hypoglycemia (low blood glucose).

How to manage the interaction:
There may be a possibility of interaction between Glimepiride and Nalidixic acid, but it can be taken if prescribed by a doctor. Contact a doctor headache, dizziness, drowsiness, nervousness, confusion, tremor, nausea, hunger, weakness, perspiration, palpitation, and rapid heartbeat, increased thirst, increased hunger, and increased urination. Do not discontinue any medications without consulting a doctor.
Glimepiride + MetforminTrovafloxacin
Severe
How does the drug interact with Glipril MF Plus Tablet:
When Glimepiride is taken with Trovafloxacin, it can affect blood glucose levels either hypoglycemia or hyperglycemia.

How to manage the interaction:
Taking Glimepiride with Trovafloxacin together can result in an interaction, but it can be taken if a doctor has advised it. Contact a doctor if you experience headache, dizziness, drowsiness, nervousness, confusion, tremor, nausea, hunger, weakness, perspiration, palpitation, and rapid heartbeat, increased thirst, increased hunger, and increased urination. Do not stop using any medications without a doctor's advice.
Glimepiride + MetforminTopiramate
Severe
How does the drug interact with Glipril MF Plus Tablet:
The combined use of Metformin and Topiramate may increase the risk of Lactic acidosis (excessive lactic acid production in the blood).

How to manage the interaction:
Coadministration Metformin and Topiramate can lead to an interaction, it can be taken if prescribed by a doctor. However, if you experience symptoms such as weakness, muscle pain, respiratory distress, fatigue, loss of appetite, slow or irregular heartbeat, breathing difficulty, or chills consult the doctor immediately. Do not stop using any medication without a doctor's advice.

Drug-Food Interactions

verifiedApollotooltip
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[ANTIDIABETICS]

FAQs

Glipril MF Plus Tablet is indicated in the treatment of type 2 diabetes mellitus.

Glipril MF Plus Tablet works by decreasing the amount of glucose absorbed from the food and the amount of glucose made by the liver. It helps the pancreas to produce insulin and helps the body use insulin efficiently.

Glipril MF Plus Tablet may increase the risk of low blood sugar levels, especially with alcohol intake, exercise more than usual, delay or miss snacks or meals. However, if you experience any signs of low blood pressure, such as dizziness, nausea, light-headedness, dehydration or fainting, please consult a doctor.

In type 1 diabetes, the body does not produce insulin as the islet cells (insulin-producing cells) in the pancreas are destroyed completely. In type 2 diabetes, though islet cells are working, the body doesn't respond to insulin as the body becomes resistant to it.

You are not recommended to stop taking Glipril MF Plus Tablet on your own as discontinuing Glipril MF Plus Tablet suddenly may cause recurring symptoms or worsen the condition. However, if you experience any difficulty while taking Glipril MF Plus Tablet , please consult your doctor so that alternative medicine may be prescribed.

You are not recommended to take Glipril MF Plus Tablet with phenytoin as it may reduce the effect of Glipril MF Plus Tablet and increase blood sugar levels. However, please consult a doctor before using Glipril MF Plus Tablet with other medicines.

Include a diet rich in fruits, vegetables and whole grains like brown rice, whole wheat, oats, barley, and quinoa. Non-fat or low-fat dairy and proteins like chicken, lean meats, nuts, beans, tofu, lentils, eggs, fish, and turkey can also be included.

Cut back on foods high in sodium, alcohol, fried foods, and high-carb food and drinks like sugary drinks, drinks with added sugar, white rice and starchy vegetables.

You are advised to take Glipril MF Plus Tablet for the duration recommended by the doctor.

Store Glipril MF Plus Tablet at room temperature, in a dry place. Keep out of sight and reach of children.

Glipril MF Plus Tablet may cause lactic acidosis (builds up of lactic acid in the blood). Consult the doctor if you notice symptoms of lactic acidosis like abdominal pain, vomiting, muscle cramps, difficulty breathing, reduced body temperature and heartbeat, and severe tiredness.

Glipril MF Plus Tablet is an anti-diabetic medicine used to treat type 2 diabetes mellitus, also known as noninsulin-dependent diabetes mellitus.

Side effects of Glipril MF Plus Tablet are stomach pain, nausea, diarrhoea, vomiting, headache or metallic taste. Most of these side effects may not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

Long-term use of Glipril MF Plus Tablet may lead to vitamin B12 deficiency. Regular monitoring of vitamin B12 levels is recommended.

You are recommended to avoid consumption of alcohol with Glipril MF Plus Tablet as it may increase the risk of lactic acidosis (accumulation of lactic acid in the body).

Glipril MF Plus Tablet should be swallowed as a whole with water; do not crush, break or chew it.

Regularly monitor blood glucose levels. Have your meals regularly and never miss a meal. Always carry a source of sugar and consume it if you experience low blood sugar. If you are due to undergo any tests or surgery, inform the doctor that you are taking Glipril MF Plus Tablet . Avoid drinking alcohol.

Other medicines should be taken with Glipril MF Plus Tablet only if prescribed by the doctor. To prevent any interactions it is advised to consult the doctor before taking other medicines during treatment with Glipril MF Plus Tablet .

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Author Details

Veda MaddalaDoctor badge

Written By

  • Veda Maddala

    M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

  • Dr Aneela Siddabathuni

    MPharma., PhD

Last Updated

Doctor imageWe provide you with authentic, trustworthy and relevant information

Country of origin

India
Other Info - GLI1800

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