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compositionComposition:METFORMIN-500MG+SAXAGLIPTIN-5MG
prescription
Prescription Medicine
info
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Glisaxapin M 5/500 Tablet 10's is used to treat type 2 diabetes. It contains Saxagliptin and Metformin which work by lowering the liver's glucose production, delaying glucose absorption from the intestines, and increasing the body's response to insulin. In some cases, this medicine may cause side effects such as low blood glucose levels, upper respiratory tract infection and headache. Inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.

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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

METFORMIN-500MG+SAXAGLIPTIN-5MG

Manufacturer/Marketer :

Steris Healthcare

Consume Type :

Oral

Expires on or after :

Jan-28

Return Policy :

Not Returnable

About Glisaxapin M 5/500 Tablet 10's

Glisaxapin M 5/500 Tablet 10's is a prescription oral medication used to manage high blood sugar levels in adults with type 2 diabetes. This medicine helps control glucose levels when diet and exercise alone are not enough to keep blood sugar within a safe range. It is not used for treating type 1 diabetes or diabetic ketoacidosis.

To get the best results, you must take Glisaxapin M 5/500 Tablet 10's consistently every day exactly as your healthcare provider prescribes. It is typically taken with meals to reduce the chance of getting an upset stomach. Combining this medication with healthy dietary choices and regular physical activity is essential to achieve long-term success.

While taking Glisaxapin M 5/500 Tablet 10's, some people may experience mild side effects, such as a stuffy nose or an upset stomach. However, you must seek medical care immediately if you experience severe symptoms, such as persistent, severe stomach pain that radiates to your back, as this can be a sign of a serious pancreas condition. Talk to your doctor if you notice any unusual symptoms that do not go away.

Before starting Glisaxapin M 5/500 Tablet 10's, talk to your doctor if you have a history of kidney disease, liver damage, or heart problems. Do not take this if you have severe kidney failure, acute metabolic acidosis, or if you are allergic to any of its components. Your doctor will evaluate your health history to ensure this treatment is safe for you.

This medicine can interact with alcohol, contrast dyes used in medical scans, and certain other medications, which may increase the risk of a rare but serious medical emergency called lactic acidosis. If you are pregnant, planning to become pregnant, breastfeeding, or are an older adult, consult your doctor or pharmacist to discuss if this medication is safe for you.

Uses of Glisaxapin M 5/500 Tablet 10's

Glisaxapin M 5/500 Tablet 10's is used to treat Type 2 diabetes mellitus. The detailed uses of Glisaxapin M 5/500 Tablet 10's are as follows:

  • Type 2 Diabetes Mellitus: Glisaxapin M 5/500 Tablet 10's is prescribed to lower blood sugar levels in adults whose glucose levels are not adequately controlled by diet, exercise, or other single-agent diabetes medications.

Key Benefits

Glisaxapin M 5/500 Tablet 10's helps manage type 2 diabetes by combining two complementary blood sugar-lowering medicines in a single tablet. With regular use, it supports consistent blood sugar control, simplifies your treatment routine, and helps protect against long-term diabetes-related complications.

  • Convenient Dual-Action Blood Sugar Control: By combining two different blood sugar-lowering mechanisms into one daily tablet, this medicine helps maintain blood sugar levels within the target range while reducing the need for multiple medications.
  • Supports Consistent Diabetes Management: This medicine provides effective day-to-day blood sugar control, helping you maintain better overall health and an active lifestyle.
  • Protection Against Long-Term Diabetes Complications: By keeping blood sugar levels under control over time, this medicine helps reduce the risk of nerve damage, kidney impairment, vision loss, and cardiovascular complications.

Directions for Use

  • Take Glisaxapin M 5/500 Tablet 10's with or without food as advised by your doctor.
  • It is advised to take Glisaxapin M 5/500 Tablet 10's once daily; however, follow your doctor's recommendation regarding the dosage and duration.
  • Swallow it as a whole with a glass of water.
  • Do not crush, chew or break it.

How Glisaxapin M 5/500 Tablet 10's Works

Glisaxapin M 5/500 Tablet 10's contains two active components that work in different, complementary ways to regulate your blood sugar levels. The first active component, saxagliptin, belongs to a class of medicines called DPP-4 inhibitors. It works by increasing the levels of natural hormones in your body called incretins. These hormones help your pancreas release more insulin when your blood sugar is high, especially after eating, and signal your liver to produce less sugar. The second active component, metformin, belongs to the biguanide class. It works primarily by reducing the amount of glucose that your liver makes and releases into your bloodstream. Additionally, it improves your body's sensitivity to insulin, allowing your cells to use sugar from your blood more effectively, and slows down the absorption of sugar from the food you eat.
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Alcohol

Unsafe

Glisaxapin M 5/500 Tablet 10's is not advised to be taken with alcohol as it causes bizarre interactions. Both hypoglycemia (low blood sugar) and hyperglycemia (high blood sugar) may occur, depending on how much and how often you drink.

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Pregnancy

Caution

No harmful interaction has been reported in pregnant mothers, yet the patient is advised to consult a doctor before taking this drug during pregnancy.

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Breast Feeding

Caution

No harmful interaction has been reported in breastfeeding mothers, yet the patient is advised to consult a doctor before taking this drug.

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Driving

Caution

Caution is to be taken. If a patient feels dizzy while taking Glisaxapin M 5/500 Tablet 10's, do not drive or use any tools or machines. Hypoglycaemia may affect your ability to drive and use machines or work with a safe foothold, and there is a risk of hypoglycaemia after taking this medicine in combination with other medicines known to cause hypoglycaemia, such as insulin and sulphonylureas.

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Liver

Caution

It should be used with caution if you have liver conditions. Patients with severe liver problems are advised to take this drug with a doctor's consultation.

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Kidney

Caution

It should be used with caution if you have kidney problems. Patients with reduced kidney function are advised to consult with a doctor before taking Glisaxapin M 5/500 Tablet 10's as the doctor may decrease the dose as per his own judgment.

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Children

Caution

Glisaxapin M 5/500 Tablet 10's is not recommended for children and adolescents under 18 years. It is not known if this medicine is safe and effective when used in children and adolescents under 18 years of age. Consult your doctor for more information.

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Heart

Caution

Let your doctor know if you have any history of heart problems. Your doctor will weigh the benefits and potential risks before prescribing Glisaxapin M 5/500 Tablet 10's.

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Geriatrics

Caution

Glisaxapin M 5/500 Tablet 10's should be given to elderly patients only when prescribed by a doctor. If you have any concerns, please consult your doctor.

What if I have taken an overdose of Glisaxapin M 5/500 Tablet 10's

In case of an accidental overdose, you may experience severe low blood sugar, severe nausea, vomiting, or rapid breathing. Seek emergency medical attention immediately.

Diet & Lifestyle Advise

  • Monitor your carbohydrate intake: Focus on complex carbohydrates like whole grains, vegetables, and legumes, which release glucose slowly and help prevent sudden blood sugar spikes.
  • Stay active regularly: Aim for at least 150 minutes of moderate-intensity exercise, such as brisk walking or swimming, every week to help your muscles use insulin more efficiently.
  • Keep a regular meal schedule: Eating your meals at consistent times each day helps stabilise blood sugar levels and works in harmony with your medication.
  • Track your blood sugar levels: Monitor and log your glucose readings as recommended by your doctor to see how your body responds to the treatment.
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How Soon It Starts Working

The time required for Glisaxapin M 5/500 Tablet 10's to start to work: The time required for Glisaxapin M 5/500 Tablet 10's to show its action is unknown. The time for which the effects of Glisaxapin M 5/500 Tablet 10's last: The duration of action for Glisaxapin M 5/500 Tablet 10's is clinically unknown.

What if you forget to take Glisaxapin M 5/500 Tablet 10's

If you miss a dose of Glisaxapin M 5/500 Tablet 10's, take it as soon as you remember with food. However, if it is almost time for your next scheduled dose, skip the missed dose and resume your regular schedule. Do not take two doses at the same time to make up for a missed one. Talk to your doctor or pharmacist if you are unsure what to do.

Storage

• Store Glisaxapin M 5/500 Tablet 10's tablets at room temperature, ideally between 20°C and 25°C (68°F to 77°F). • Keep the tablets in their original packaging to protect them from moisture and direct light.

Drug Warnings

  • Check tablet appearance: Always inspect your tablets before taking them; do not use them if the packaging is damaged or if the tablets look discoloured or broken.
  • Monitor for lactic acidosis: Be aware of signs of lactic acidosis, such as unexplained muscle pain, fast breathing, or a slow heartbeat, and contact your doctor immediately if they occur.
  • Avoid excessive alcohol: Limit or avoid drinking alcohol while taking this medicine, as alcohol can significantly increase your risk of lactic acidosis and low blood sugar.
  • Pause before medical procedures: Tell your surgeon or dentist you are taking Glisaxapin M 5/500 Tablet 10's before any scheduled surgery, or if you need an imaging test using contrast dye, as you may need to temporarily stop taking this medication.
  • Check kidney function regularly: Ensure you attend your scheduled blood tests so your doctor can monitor your kidney health while you are on this medicine.

Drug-Drug Interactions

verifiedApollotooltip

Insulin or sulfonylureas: Combining these with Glisaxapin M 5/500 Tablet 10's may increase the risk of low blood sugar.

  • Strong CYP3A4/5 inhibitors (such as ketoconazole): Can increase the levels of certain components of Glisaxapin M 5/500 Tablet 10's in your blood, raising the risk of side effects.
  • Carbonic anhydrase inhibitors (such as topiramate): May increase the risk of developing lactic acidosis.
     
Saxagliptin + MetforminGatifloxacin
Critical
Saxagliptin + MetforminBexarotene
Severe

Drug-Drug Interactions

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Saxagliptin + MetforminGatifloxacin
Critical
How does the drug interact with Glisaxapin M 5/500 Tablet:
Co-administration of Saxagliptin and Metformin with Gatifloxacin can cause low and high blood glucose.

How to manage the interaction:
There is a possibility of interaction between Saxagliptin with Metformin and Gatifloxacin but they can be taken together if a doctor has prescribed them. Consult your doctor immediately if you experience symptoms like headache, weakness, sweating, palpitation, or fast heart rate. Do not discontinue without consulting a doctor.
Saxagliptin + MetforminBexarotene
Severe
How does the drug interact with Glisaxapin M 5/500 Tablet:
Coadministration of Bexarotene with Metformin and Saxagliptin can increase the risk of developing pancreatitis (inflammation of the pancreas).

How to manage the interaction:
Co-administration of Bexarotene and saxagliptin can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like persistent nausea, vomiting, abdominal tenderness, and upper abdominal pain, consult your doctor immediately. Do not discontinue any medications without first consulting your doctor.
Saxagliptin + MetforminAcetazolamide
Severe
How does the drug interact with Glisaxapin M 5/500 Tablet:
Co-administration of Metformin and Saxagliptin with Acetazolamide may increase Lactic acid levels.

How to manage the interaction:
Although there is a possible interaction between Metformin and Saxagliptin with Acetazolamide, you can take these medicines together if prescribed by a doctor. However, if you have symptoms such as weakness, muscle pain, or chest pain contact a doctor immediately. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

verifiedApollotooltip
  • Alcohol: Drinking alcohol can dangerously increase the risk of lactic acidosis and make blood sugar levels harder to control.
     
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[ANTIDIABETICS]

FAQs

Glisaxapin M 5/500 Tablet 10's is used in the treatment of type 2 diabetes in adults. It is prescribed for the condition of type 2 diabetes when diet and exercise alone cannot control blood sugar levels.
Yes, Glisaxapin M 5/500 Tablet 10's is known to cause stomach upset, indigestion, nausea, and diarrhoea. To avoid these side effects, please take Glisaxapin M 5/500 Tablet 10's with a meal. Also, Glisaxapin M 5/500 Tablet 10's should be taken at evenly spaced intervals to avoid any unpleasant side effects and for best results.
Glisaxapin M 5/500 Tablet 10's has been reported to increase blood cholesterol levels in a normal patient and thus not recommended in patients with hyperlipidemia.
The patient is advised to take the missed dose as soon as possible; otherwise, jump to the next dose. A patient should never take a double dose to compensate for the missed dose. It may aggravate harmful side effects.
According to American Diabetes Association, most of the studies carried out on Glisaxapin M 5/500 Tablet 10's and its ability to cause cancer resulted in a conclusion that Glisaxapin M 5/500 Tablet 10's is not associated with any form of cancer & hence is safe to use.
A patient who accidentally takes an overdose of Glisaxapin M 5/500 Tablet 10's may experience collapse, seizure attack, and troubled breathing. In such a case, without any delay, emergency health services must be contacted, and medical help should be sought.
Before taking Glisaxapin M 5/500 Tablet 10's inform your doctor if you have any kidney or liver problems, a history of pancreatitis (swollen pancreas), heart disease, alcohol use, or if you are pregnant or breastfeeding. Also, mention any other medications you are taking, especially those for diabetes.
Glisaxapin M 5/500 Tablet 10's is not advised to be used in individuals with a history of severe allergic reactions such as difficulty breathing, or serious skin conditions. Glisaxapin M 5/500 Tablet 10's is also not recommended for those with renal dysfunction (kidney problems), pancreatitis, or pancreatic disease. Glisaxapin M 5/500 Tablet 10's is also contraindicated in pregnant or breastfeeding women. Therefore, always consult a healthcare provider before use.
Glisaxapin M 5/500 Tablet 10's is not usually associated with significant weight gain. However, some people may experience mild weight changes. It is important to monitor any changes with your healthcare provider.
Glisaxapin M 5/500 Tablet 10's may not be suitable for individuals with kidney problems, as it can impact kidney function. Glisaxapin M 5/500 Tablet 10's should be used with caution or avoided in those with renal issues (kidney problems). Always, consult a physician if you have kidney concerns.
Yes, it is essential to maintain a healthy diet and exercise routine while taking Glisaxapin M 5/500 Tablet 10's. Although Glisaxapin M 5/500 Tablet 10's helps control blood sugar, proper diet and regular physical activity are crucial for managing diabetes and supporting overall health. Your healthcare provider can offer guidance in best manner on how to include these habits in your treatment plan.
You are recommended to take Glisaxapin M 5/500 Tablet 10's for as long as it is advised by your doctor for effective results. If your symptoms continue or worsen, seek further advice from your doctor.
Glisaxapin M 5/500 Tablet 10's, can be safe for the long-term if taken as advised by your doctor. However, potential risks include acute pancreatitis (swollen pancreas), kidney problems, and hypoglycaemia (low blood sugar). Regular check-ups are essential to assess your health, especially if you have a history of kidney, liver, or heart issues. Always, follow your doctor's recommendations to manage any risks and ensure safe long-term use.
Glisaxapin M 5/500 Tablet 10's causes side effects such as dizziness, sweating, palpitations, dry mouth and skin and hypoglycaemia (low blood glucose levels). Please, contact a doctor if these side effects or any other concerns persist for longer durations.
It is best to take Glisaxapin M 5/500 Tablet 10's with meals. Taking it with food reduces the chances of experiencing a mild upset stomach, nausea, or diarrhoea. Talk to your doctor if you have persistent stomach discomfort.
Although Glisaxapin M 5/500 Tablet 10's rarely causes low blood sugar on its own, it can happen if you take it with other diabetes medicines. If you feel shaky, sweaty, or dizzy, consume a fast-acting sugar source like fruit juice or hard candy, then talk to your doctor.
No, it is not recommended to drink large amounts of alcohol while taking Glisaxapin M 5/500 Tablet 10's. Alcohol can increase the risk of a rare but serious condition called lactic acidosis and can also cause unstable blood sugar levels. Talk to your doctor about safe alcohol consumption.
Glisaxapin M 5/500 Tablet 10's is not prescribed for weight loss, though some patients may experience slight weight loss or a stable weight while taking it. Its primary goal is to manage blood sugar levels. Talk to your doctor for advice on healthy weight management.
You should not stop taking Glisaxapin M 5/500 Tablet 10's without consulting your healthcare provider, even if your blood sugar levels improve. Stopping the medication suddenly can cause your blood sugar to spike again. Talk to your doctor before making any changes.
It is generally not recommended to take Glisaxapin M 5/500 Tablet 10's during pregnancy or while breastfeeding. Your doctor will likely suggest alternative ways to manage your blood sugar during this time. Talk to your doctor to discuss your options.
Signs of lactic acidosis include unusual muscle pain, trouble breathing, deep and rapid breathing, severe tiredness, dizziness, or a sudden slow heartbeat. This is a medical emergency that requires immediate medical help. Talk to your doctor if you have any concerns.

Disclaimer

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Reference

  1. Electronic Medicines Compendium (EMC). Pil.6675 Patient Information Leaflet (PIL). Cheshire, UK: Datapharm; 2025. [Accessed on 02 Jun. 2026]Check here
  2. National Center for Biotechnology Information (NCBI). Pmc4821002 Scientific Research Publication. Bethesda, MD: NLM; 2025. [Accessed on 02 Jun. 2026]Check here
  3. MIMS Drug Reference Compendium. Onglyza Monograph. Singapore: MIMS; 2025. [Accessed on 02 Jun. 2026]Check here
  4. WebMD Medical Reference Review Board. Details Drug and Treatment Monograph. Atlanta, GA: WebMD; 2026. [Accessed on 02 Jun. 2026]Check here
  5. Saxagliptin/metformin [EMC Label]. 2017. [Accessed on 28 Jan. 2019]Check here
  6. Metformin hydrochloride + saxagliptin hydrochloride [EMC Label]. 2011. [Accessed on 08 Apr. 2019]Check here
  7. Saxagliptin and metformin [Product Information]. 2023. [Accessed on 28th Sept. 2023]Check here

Country of origin

India

Manufacturer/Marketer address

A.O. : 328-A, Tanaji Chowk, New Mill Road, Kurla (West), Mumbai 400070.
Other Info - GLI2577
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