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  3. Glivec 400 mg Tablet 10's

Glivec 400 mg Tablet 10's, Pack of 10 TABLETS
Glivec 400 mg Tablet 10's, Pack of 10 TABLETS
Glivec 400 mg Tablet 10's, Pack of 10 TABLETS
Glivec 400 mg Tablet 10's, Pack of 10 TABLETS
Glivec 400 mg Tablet 10's, Pack of 10 TABLETS
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Composition :

IMATINIB-400MG

Manufacturer/Marketer :

Novartis India Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Glivec 400 mg Tablet

Glivec 400 mg Tablet belongs to a class of drugs known as 'anti-cancer medication', primarily used to treat various types of cancer. It is used to treat cancer of the blood (chronic myeloid leukaemia and acute lymphocytic leukaemia) and gastrointestinal stromal tumour. Cancer is a genetic change in which the cells divide uncontrollably and spread into surrounding tissues. There are more than 100 types of cancer, including blood cancer, lung cancer, breast cancer, etc.

Glivec 400 mg Tablet contains Imatinib, which is primarily used to treat cancer. It works by inhibiting an enzyme responsible for cancer cell proliferation and induces cell death (apoptosis). As a result, the growth and spread of cancer cells are stopped or slowed down.

You are advised to take Glivec 400 mg Tablet for as long as your doctor has prescribed it for you, depending upon your medical condition. In some cases, you may experience nausea, vomiting, oedema, fatigue, muscle cramps, musculoskeletal pain, diarrhoea, rash, and abdominal pain. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently. 

Do not take Glivec 400 mg Tablet if you are allergic to any of its ingredients. While taking Glivec 400 mg Tablet , you might become more sensitive to sunlight, so it is important to protect your skin with a high sun protection factor (SPF). Regular blood tests are required to monitor liver function and blood cells in the blood while taking Glivec 400 mg Tablet . Glivec 400 mg Tablet can cause swelling and water retention, so if you have unexpected rapid weight gain, please consult your doctor. If you ever had a hepatitis B infection, please tell your doctor before starting Glivec 400 mg Tablet as it can make hepatitis B active again. 

Uses of Glivec 400 mg Tablet

Treatment of Cancer

Directions for Use

Swallow the medicine as a whole with a glass of water. Do not crush, chew or break it.

Medicinal Benefits

Glivec 400 mg Tablet belongs to a class of drugs known as 'anti-cancer medication' containing Imatinib, primarily used to treat various cancer types. It is used to treat cancer of the blood (chronic myeloid leukaemia and acute lymphocytic leukaemia) and gastrointestinal stromal tumour. It works by inhibiting an enzyme responsible for cancer cell proliferation and induces cell death (apoptosis). As a result, the growth and spread of cancer cells are stopped or slowed down.

How Glivec 400 mg Tablet Works

Glivec 400 mg Tablet contains Imatinib, which is primarily used to treat cancer. It works by inhibiting an enzyme responsible for cancer cell proliferation and induces cell death (apoptosis). As a result, the growth and spread of cancer cells are stopped or slowed down.

Storage

Store in a cool and dry place away from sunlight
Side effects of Glivec 400 mg Tablet
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
  • Rest well; get enough sleep. This helps the body fight infection.
  • Keep yourself hydrated by drinking enough water and other fluids.
  • Wash your hands often and avoid touching your eyes, mouth or nose.
  • Wear a mask whilst going out.
  • Warm steam or a hot shower may help with nose secretions.
  • Avoid contact with others to prevent contamination.
  • Muscle cramps can be treated with regular exercise or yoga, which includes mild stretching, which helps strengthen the lower body.
  • Warm baths and gentle massage of the affected parts can help relieve cramps.
  • Avoid strenuous activity and take frequent breaks, as rest is critical.
  • Intake of nutritious food can help strengthen body and mind. A trained nutritionist can help design a balanced diet for strengthening muscles.
  • Speak to your doctor if the pain lasts an extended period. Medical help can be practical in finding a cure for cramps.
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
Managing Medication-Triggered Flushing (Reddening of the skin): A Step-by-Step Guide:
  • Consult your doctor if you experience skin redness, itching, or irritation after taking medication.
  • Your doctor may adjust your treatment plan by changing your medication or providing guidance on managing your erythema symptoms.
  • Your doctor may recommend or prescribe certain medications to help alleviate symptoms.
  • Apply cool compresses or calamine lotion to the affected skin area to reduce redness and itching.
  • Stay hydrated by drinking plenty of water to help alleviate symptoms and keep your skin hydrated.
  • Monitor your skin condition closely and promptly report any changes, worsening symptoms, or concerns to your healthcare provider.
  • High levels of liver enzymes need immediate medical attention.
  • Watch your diet and consume low-fat foods, like green leafy vegetables, fish, whole grains, nuts, etc.
  • Regularly do strengthening exercises to control your cholesterol levels.
  • Avoid drinking alcohol as it can affect your liver.
  • Focus on losing weight as it can help control cholesterol and maintain liver enzymes.
  • Practice yoga and meditation to improve liver functioning and overall health.
  • Avoid triggers like alcohol, caffeine, and energy drinks.
  • Try relaxation techniques such as yoga, meditation, or deep breathing.
  • Exercise regularly as it helps maintain heart health.
  • Follow a nutritious and balanced diet.

What if I have taken an overdose of Glivec 400 mg Tablet

Take Glivec 400 mg Tablet only as prescribed by the physician. Avoid exceeding the recommended dose as it could lead to an overdose. Symptoms of overdose may include nausea, vomiting, diarrhoea, rash, swelling, extreme tiredness, muscle spasms/cramps, abdominal pain, headache, or loss of appetite. If you experience these symptoms or suspect you have taken an overdose, seek immediate medical attention.

Drug Warnings

Do not take Glivec 400 mg Tablet if you are allergic to any of its ingredients. Glivec 400 mg Tablet may cause blurry vision and dizziness, so do not drive or operate any machinery which requires concentration. While taking Glivec 400 mg Tablet , you might become more sensitive to sunlight, so it is important to protect your skin with a high sun protection factor (SPF) while going out, as it can lead to a skin rash if you are not using a strong SPF. Glivec 400 mg Tablet can cause leg swelling and water retention (oedema), so if you have unexpected rapid weight gain, please consult your doctor. If you ever had a hepatitis B infection, please tell your doctor before starting Glivec 400 mg Tablet as it can make hepatitis B active again. Glivec 400 mg Tablet may make you more susceptible to infections; consult your doctor if you develop any signs of infections, fever, sore throat, breathlessness, jaundice, unexplained bleeding or bruising.

Drug-Drug Interactions

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ImatinibNaloxegol
Critical
ImatinibCobimetinib
Critical

Drug-Drug Interactions

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ImatinibNaloxegol
Critical
How does the drug interact with Glivec 400 mg Tablet:
Taking Glivec 400 mg Tablet with Naloxegol may increase the level of naloxegol which may lead to side effects.

How to manage the interaction:
Taking Glivec 400 mg Tablet with Naloxegol is not recommended, it can be taken if prescribed by your doctor. However, if you experience any unusual symptoms, consult the consult.
ImatinibCobimetinib
Critical
How does the drug interact with Glivec 400 mg Tablet:
When Cobimetinib is taken with Glivec 400 mg Tablet, it can increase the risk of serious side effects.

How to manage the interaction:
Taking Glivec 400 mg Tablet with Cobimetinib is not recommended, but can be taken if prescribed by the doctor. However, if you experience any unusual symptoms, consult the doctor.
ImatinibEliglustat
Critical
How does the drug interact with Glivec 400 mg Tablet:
When Glivec 400 mg Tablet is taken with Eliglustat, Glivec 400 mg Tablet increases levels of eliglustat which may lead to side effects.

How to manage the interaction:
Taking Glivec 400 mg Tablet with Eliglustat is not recommended, it can be taken if prescribed by your doctor. However, if you experience any unusual symptoms, consult the doctor.
ImatinibRegorafenib
Critical
How does the drug interact with Glivec 400 mg Tablet:
When Regorafenib is taken with Glivec 400 mg Tablet, it may increase the level of Glivec 400 mg Tablet which may lead to side effects.

How to manage the interaction:
Taking Regorafenib with Glivec 400 mg Tablet is not recommended, it can be taken if prescribed by your doctor. However, if you experience any unusual symptoms, consult the doctor.
ImatinibDihydroergotamine
Critical
How does the drug interact with Glivec 400 mg Tablet:
When Dihydroergotamine is taken with Glivec 400 mg Tablet, it increases levels of dihydroergotamine leading to side effects.

How to manage the interaction:
Taking Glivec 400 mg Tablet with Dihydroergotamine is not recommended, it can be taken if advised by your doctor. However, if you experience any unusual symptoms, consult the doctor.
ImatinibConivaptan
Critical
How does the drug interact with Glivec 400 mg Tablet:
When Glivec 400 mg Tablet is taken with Conivaptan, it can cause increase in the blood levels of conivaptan leading to side effects.

How to manage the interaction:
Taking Glivec 400 mg Tablet with Conivaptan is not recommended, it can be taken if recommended by your doctor. However, if you experience any unusual symptoms, consult the doctor.
ImatinibCisapride
Critical
How does the drug interact with Glivec 400 mg Tablet:
When Glivec 400 mg Tablet is taken with Cisapride, it can increase the chance of a serious abnormal heart rhythm.

How to manage the interaction:
Taking Glivec 400 mg Tablet with Cisapride is not recommended, it can be taken if a doctor has prescribed this. However, if you experience sudden dizziness, lightheadedness, fainting, breathing difficulty, or rapid heartbeat, consult the doctor immediately. Do not discontinue the medication without consulting a doctor.
ImatinibLomitapide
Critical
How does the drug interact with Glivec 400 mg Tablet:
When Lomitapide is taken with Glivec 400 mg Tablet, it can increases levels of lomitapide which may lead to side effects.

How to manage the interaction:
Taking Glivec 400 mg Tablet with Lomitapide is not recommended, but it can be taken if prescribed by your doctor. However, if you experience any unusual symptoms, consult the doctor.
ImatinibIvabradine
Critical
How does the drug interact with Glivec 400 mg Tablet:
Coadministration of Ivabradine with Glivec 400 mg Tablet can increase the levels of Ivabradine in the body. This increases the risk or severity of side effects.

How to manage the interaction:
Taking Ivabradine with Bosutinib together is generally avoided as it can result in an interaction, it can be taken if your doctor has advised it. However, contact a doctor immediately if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, or memory loss. Do not discontinue any medications without consulting a doctor.
ImatinibLurasidone
Critical
How does the drug interact with Glivec 400 mg Tablet:
Using Lurasidone together with Glivec 400 mg Tablet may result in significantly higher Lurasidone blood levels. This may increase the possibility of negative effects like Parkinson's disease. (It is a brain disorder that produces uncontrollable movements.)

How to manage the interaction:
Taking Lurasidone with Glivec 400 mg Tablet is not recommended as it leads to an interaction, it can be used if prescribed by a doctor. Consult a doctor if you have any abnormal muscle activity, fits, high blood sugar, high sugars, high cholesterol, heat intolerance or heat stroke, dizziness, lightheadedness, headache, flushing, fainting, or heart palpitations. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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IMATINIB-400MGGrapefruit and Grapefruit Juice
Moderate

Drug-Food Interactions

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IMATINIB-400MGGrapefruit and Grapefruit Juice
Moderate
Common Foods to Avoid:
Grapefruit Juice, Grapefruit

How to manage the interaction:
Grapefruit or its juice may increase the blood levels of Glivec 400 mg Tablet which may lead to side effects. Avoid consuming Grapefruit and its juice during treatment with Glivec 400 mg Tablet.

Diet & Lifestyle Advise

  • Maintain a healthy weight by performing regular low-strain exercises and eating healthy food.
  • De-stress yourself by meditating, reading books, taking a warm bubble bath or listening to soothing music.
  • Eat food rich in antioxidants such as berries, spinach, kidney beans, dark chocolate and high fibre content. Also, eat small and frequent meals for a speedy recovery.
  • Avoid smoking and alcohol consumption. Also, avoid high fat and cholesterol diet.

Habit Forming

No

Therapeutic Class

ANTINEOPLASTIC

Glivec 400 mg Tablet Substitute

Substitutes safety advice

Product Substitutes

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Alcohol

Unsafe

Avoid alcohol consumption while taking Glivec 400 mg Tablet as it may increase drowsiness and lead to unpleasant side effects.

bannner image

Pregnancy

Unsafe

Glivec 400 mg Tablet is a pregnancy category D drug. It should not be used in pregnancy as it is known to cause fetal damage. Also, maintain a gap of 6 months between the last dose of Glivec 400 mg Tablet and your next pregnancy.

bannner image

Breast Feeding

Unsafe

Glivec 400 mg Tablet is known to pass through breast milk, and it may cause harm to the baby. So, it is advised not to breastfeed while taking Glivec 400 mg Tablet .

bannner image

Driving

Unsafe

Glivec 400 mg Tablet may cause weakness, dizziness and drowsiness. Do not drive or operate machinery unless you are alert.

bannner image

Liver

Caution

Dose adjustment may be needed in patients with liver impairment. Please consult your doctor if you have a liver impairment or any concerns regarding this.

bannner image

Kidney

Caution

Dose adjustment may be needed in patients with kidney impairment. Please consult your doctor if you have kidney impairment or any concerns regarding this.

bannner image

Children

Caution

The safety and efficacy of Glivec 400 mg Tablet are not known in children. It should be taken only if prescribed by a doctor.

Have a query?

FAQs

Glivec 400 mg Tablet is used to treat chronic myeloid leukaemia (cancer that begins in the bone marrow), acute lymphocytic leukaemia (cancer of the blood and bone marrow) and gastrointestinal stromal tumour (tumour that occurs in the gastrointestinal tract).

Glivec 400 mg Tablet contains Imatinib, an anti-cancer medication that works by inhibiting an enzyme responsible for the proliferation of cancer cells and hence induces cell death (apoptosis). As a result, the growth and spread of cancer cells are stopped or slowed down.

Regular monitoring of blood and urine tests and weight checks are required. An effective way of contraception should be used by both men and women while taking Glivec 400 mg Tablet .

Yes, you might become more sensitive to sunlight while taking Glivec 400 mg Tablet , so it is important to protect your skin with a high sun protection factor (SPF) while going out, as it can lead to a skin rash if you are not using a strong SPF.

In elderly patients taking Glivec 400 mg Tablet , the risk of side effects is more. For the elderly, dose adjustment might be required, or your doctor might prescribe any other medication safe for the elderly.

If you are having surgery, including dental surgery, please inform your doctor if you are taking Glivec 400 mg Tablet as your doctor might stop Glivec 400 mg Tablet before undergoing surgery.

Glivec 400 mg Tablet can make you more likely to get infections or may worsen any current infections. Avoid contact with people with infections that may spread to others (such as chickenpox, measles, or flu). Consult your doctor if you have been exposed to an infection or for more details.

Glivec 400 mg Tablet contains Imatinib, an anti-cancer medication.

Glivec 400 mg Tablet can be taken along with food as it helps prevent nausea.

Glivec 400 mg Tablet may cause weakness, dizziness and drowsiness. Do not drive or operate machinery until you know how the medicine affects you.

Glivec 400 mg Tablet may cause foetal harm, therefore let the doctor know if you are pregnant, planning for pregnancy or think you may be pregnant. Regular monitoring of weight and blood count is advised. Inform the doctor if you have liver, heart, kidney or thyroid problems.

Glivec 400 mg Tablet can cause sensitivity to sunlight leading to itching and rashes when exposed to the sun. Wear protective clothing, hat and use sunscreen whilst going out.

Glivec 400 mg Tablet might cause liver damage and taking paracetamol with Glivec 400 mg Tablet might increase that risk. Therefore, consult the doctor before taking paracetamol or any other medicine with Glivec 400 mg Tablet to prevent any interactions.

Taking Glivec 400 mg Tablet regularly as advised by the doctor helps improve the outcome of patients with chronic myeloid leukaemia (CML). Please consult the doctor if you have any concerns.

Side effects of Glivec 400 mg Tablet are nausea, vomiting, oedema, fatigue, muscle cramps, musculoskeletal pain, diarrhoea, rash, and abdominal pain. Talk to your doctor if you experience these side effects persistently.

Country of origin

Switzerland

Manufacturer/Marketer address

Sandoz House, Shiv Sagar Estate, Worli Mumbai -400 018, India
Other Info - GLI0316

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Author Details

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jan 1, 2025 | 2:48 PM IST

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Reference

  1. https://www.medicines.org.uk/emc/files/pil.2330.pdf
  2. https://www.accessdata.fda.gov/drugsatfda_docs/label/2008/021588s024lbl.pdf
  3. https://www.drugs.com/cdi/imatinib.html
  4. https://medlineplus.gov/druginfo/meds/a606018.html

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