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compositionComposition:IMATINIB-400MG
prescription
Prescription Medicine
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Levin 400 Tablet is used to treat cancer. It contains Imatinib, which works by inhibiting the growth and spread of cancer cells. In some cases, this medicine may cause side effects such as nausea, vomiting, oedema, fatigue, muscle cramps, musculoskeletal pain, diarrhoea, rash, and abdominal pain. Inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.

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Written By Lakshmithulasi Yarragunta , PharmD (PB)
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

IMATINIB-400MG

Manufacturer/Marketer :

Dr Reddy's Laboratories Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Levin 400 Tablet

Levin 400 Tablet is an oral prescription medicine used to treat specific types of blood cancers, such as chronic myeloid leukemia, and certain gastrointestinal tumors. It works by targeting and blocking the signals that cause abnormal cells to grow and multiply. By stopping these signals, it helps control the spread of the disease and can help put it into remission.

For the best results, you must take Levin 400 Tablet consistently every day at the same time as prescribed by your doctor. It should be taken with a meal and a large glass of water to help prevent severe stomach irritation. Maintaining a balanced diet and staying well-hydrated can also help your body cope better with the treatment.

Some people may experience mild side effects, such as muscle cramps, mild nausea, or fluid retention while taking this medication. However, you must contact your doctor immediately if you experience rapid weight gain, severe shortness of breath, or signs of unusual bleeding. Your medical team will monitor you closely to manage these issues if they arise.

Before starting Levin 400 Tablet , talk to your doctor if you have a history of liver disease, kidney problems, or heart failure. Do not take this if you are pregnant, as the medication can cause severe harm to an unborn baby. Women of childbearing age must use highly effective birth control during treatment.

Levin 400 Tablet can interact with certain other prescriptions, over-the-counter remedies, and alcohol, which can increase the risk of liver damage. If you are breastfeeding, elderly, or have pre-existing heart conditions, consult your healthcare provider to discuss whether Levin 400 Tablet is safe for you.

Uses of Levin 400 Tablet

Levin 400 Tablet is used in the treatment of cancer. The detailed use of Levin 400 Tablet is as follows:

  • Chronic Myeloid Leukemia (CML): Levin 400 Tablet helps control the overproduction of abnormal white blood cells in the bone marrow, helping to bring blood cell counts back to safe, normal levels.
  • Acute Lymphoblastic Leukemia (ALL): It targets specific abnormal proteins to stop the rapid growth and spread of cancer cells in certain patients with this type of blood cancer.
  • Gastrointestinal Stromal Tumors (GIST): It prevents the growth and spread of non-cancerous or cancerous tumors within the walls of the stomach or intestines.
  • Dermatofibrosarcoma Protuberans (DFSP): It treats this rare type of skin tissue cancer when the tumor cannot be completely removed by surgery.

Key Benefits

Levin 400 Tablet helps treat certain types of cancer by slowing or stopping the growth of abnormal cells. By targeting specific proteins involved in cancer cell growth, it supports disease control and improves long-term treatment outcomes. Benefits may include:

  • Helps slow or stop the growth of certain cancer cells.
  • Supports long-term control of specific blood cancers and gastrointestinal stromal tumours (GIST).
  • May help shrink tumours before surgery or reduce the risk of recurrence after treatment.
  • Helps relieve symptoms caused by tumour growth and improve daily functioning.
  • Supports better treatment outcomes through targeted therapy.
  • Contributes to improved quality of life when used as part of a comprehensive cancer treatment plan.
Side effects of Levin 400 Tablet
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
  • Rest well; get enough sleep. This helps the body fight infection.
  • Keep yourself hydrated by drinking enough water and other fluids.
  • Wash your hands often and avoid touching your eyes, mouth or nose.
  • Wear a mask whilst going out.
  • Warm steam or a hot shower may help with nose secretions.
  • Avoid contact with others to prevent contamination.
  • Muscle cramps can be treated with regular exercise or yoga, which includes mild stretching, which helps strengthen the lower body.
  • Warm baths and gentle massage of the affected parts can help relieve cramps.
  • Avoid strenuous activity and take frequent breaks, as rest is critical.
  • Intake of nutritious food can help strengthen body and mind. A trained nutritionist can help design a balanced diet for strengthening muscles.
  • Speak to your doctor if the pain lasts an extended period. Medical help can be practical in finding a cure for cramps.
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
Managing Medication-Triggered Flushing (Reddening of the skin): A Step-by-Step Guide:
  • Consult your doctor if you experience skin redness, itching, or irritation after taking medication.
  • Your doctor may adjust your treatment plan by changing your medication or providing guidance on managing your erythema symptoms.
  • Your doctor may recommend or prescribe certain medications to help alleviate symptoms.
  • Apply cool compresses or calamine lotion to the affected skin area to reduce redness and itching.
  • Stay hydrated by drinking plenty of water to help alleviate symptoms and keep your skin hydrated.
  • Monitor your skin condition closely and promptly report any changes, worsening symptoms, or concerns to your healthcare provider.

Directions for Use

  • Levin 400 Tablet should be taken with a meal to prevent stomach discomfort and nausea.
  • It is usually taken 1-2 times daily based on the medical condition or as prescribed by your doctor.
  • Swallow Levin 400 Tablet as a whole with a glass of water. If you have difficulty swallowing it, you can dissolve it in water or apple juice.
  • Do not crush or chew it. If you accidentally touch a crushed tablet, wash the area thoroughly.

How Levin 400 Tablet Works

Levin 400 Tablet contains Imatinib, which belongs to a class of medications called tyrosine kinase inhibitors. In certain cancers, an abnormal gene creates a protein that continuously signals cells to divide and grow out of control. Levin 400 Tablet works by binding directly to this abnormal protein and switching off its signaling pathway. Without these continuous growth signals, the abnormal cells stop multiplying and eventually die off. This highly targeted mechanism helps control the disease without causing widespread damage to healthy, normal cells throughout your body.
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Alcohol

Unsafe

Avoid alcohol consumption while taking Levin 400 Tablet as it may increase drowsiness and lead to unpleasant side effects.

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Pregnancy

Unsafe

Levin 400 Tablet is a pregnancy category D drug. It should not be used in pregnancy as it is known to cause fetal damage. Also, maintain a gap of 6 months between the last dose of Levin 400 Tablet and your next pregnancy.

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Breast Feeding

Unsafe

Levin 400 Tablet is known to pass through breast milk, and it may cause harm to the baby. So, it is advised not to breastfeed while taking Levin 400 Tablet .

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Driving

Unsafe

Levin 400 Tablet may cause weakness, dizziness and drowsiness. Do not drive or operate machinery unless you are alert.

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Liver

Caution

Dose adjustment may be needed in patients with liver impairment. Please consult your doctor if you have a liver impairment or any concerns regarding this.

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Kidney

Caution

Dose adjustment may be needed in patients with kidney impairment. Please consult your doctor if you have kidney impairment or any concerns regarding this.

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Children

Caution

The safety and efficacy of Levin 400 Tablet are not known in children. It should be taken only if prescribed by a doctor.

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Heart

Safe if prescribed

Levin 400 Tablet can be used in heart patients if prescribed by the physician. Please consult your physician if you have any concerns.

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Geriatrics

Safe if prescribed

Levin 400 Tablet is safe for use in elderly patients if prescribed by the physician.

What if I have taken an overdose of Levin 400 Tablet

If you accidentally take too much Levin 400 Tablet , seek emergency medical attention or contact a poison control center immediately. Symptoms of an overdose may include severe stomach upset, extreme muscle pain, or severe skin rashes.

Diet & Lifestyle Advise

  • Avoid grapefruit and grapefruit juice: Grapefruit can interfere with how your body breaks down Levin 400 Tablet , leading to dangerously high levels of the medication in your blood.
  • Manage fluid retention: Keep a close eye on your daily weight. To help manage mild swelling, try to reduce your dietary salt intake and elevate your legs when sitting.
  • Protect yourself from infections: Because Levin 400 Tablet can lower your white blood cell count, wash your hands frequently, avoid close contact with sick individuals, and seek medical care at the first sign of a fever.
  • Stay hydrated: Drink plenty of fluids throughout the day to support kidney function and help manage mild diarrhoea or nausea.

Health Queries

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Levin 400 Tablet contains Imatinib and is used mainly as an anti-cancer medication to treat certain blood cancers and gastrointestinal stromal tumors by inhibiting cancer cell growth.

⚕️ About Levin 400 Tablet

  • It treats chronic myeloid leukemia, acute lymphocytic leukemia, and gastrointestinal stromal tumors.
  • Works by blocking an enzyme needed for cancer cell proliferation, slowing or stopping cancer growth.
  • Taken orally as prescribed by your doctor, usually over a prolonged period depending on your condition.

🩺 Common Side Effects

  • Possible nausea, vomiting, swelling (edema), fatigue, muscle cramps, diarrhea, rash, and abdominal pain.
  • Usually mild and improve over time; persistent symptoms should be discussed with your doctor.

⚠️ Important Precautions

  • Avoid if allergic to any ingredients.
  • Can cause increased sensitivity to sunlight—use strong sun protection.
  • Regular blood tests to monitor liver function and blood cells are essential during treatment.
  • Inform your doctor if you had hepatitis B, as the medication may reactivate the infection.
  • Report rapid unexpected weight gain promptly due to possible fluid retention.

Consult your oncologist or hematologist for personalized guidance and monitoring while using Levin 400 Tablet.

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How Soon It Starts Working

  • The time required for Levin 400 Tablet to start to work: Levin 400 Tablet ideally shows its action within 2 to 4 hours after administration.
  • The time for which the effects of Levin 400 Tablet last: The effect of Levin 400 Tablet lasts for 18 hours.

What if you forget to take Levin 400 Tablet

If you miss a dose, take it as soon as you remember, provided you can take it with food. However, if it is almost time for your next scheduled dose, skip the missed dose and return to your regular schedule. Do not take a double dose to make up for a missed one.

Storage

• Store in a cool and dry place away from sunlight.• Keep Levin 400 Tablet out of the sight and reach of children. • Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.

Drug Warnings

  • Monitor your blood counts: You will need regular blood tests to check your liver function, kidney function, and blood cell levels while taking Levin 400 Tablet .
  • Watch for sudden weight gain: Weigh yourself daily; a rapid increase in weight can indicate dangerous fluid retention in your lungs or heart.
  • Protect your skin: Levin 400 Tablet can make your skin more sensitive to sunlight, so apply broad-spectrum sunscreen and wear protective clothing when outdoors.
  • Use reliable birth control: Both men and women taking Levin 400 Tablet should use highly effective birth control during treatment to prevent pregnancy, as Levin 400 Tablet can cause severe birth defects.
  • Do not crush or split tablets routinely: Avoid breathing in any dust from broken tablets, especially if you are pregnant or planning a family.

Drug-Drug Interactions

verifiedApollotooltip
  • Anti-seizure medicines (e.g., carbamazepine, phenytoin): These medicines may reduce the effectiveness of Levin 400 Tablet by increasing its breakdown in the body.
  • Certain antifungal medicines (e.g., ketoconazole) and antibiotics (e.g., clarithromycin): These medicines may increase the amount of Levin 400 Tablet in the body, raising the risk of serious side effects.
  • Blood thinners (e.g., warfarin): Taking these medicines alongside Levin 400 Tablet may increase the risk of serious bleeding and require closer monitoring.
ImatinibLurasidone
Critical
ImatinibDihydroergotamine
Critical

Drug-Drug Interactions

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ImatinibLurasidone
Critical
How does the drug interact with Levin 400 Tablet:
Using Lurasidone together with Levin 400 Tablet may result in significantly higher Lurasidone blood levels. This may increase the possibility of negative effects like Parkinson's disease. (It is a brain disorder that produces uncontrollable movements.)

How to manage the interaction:
Taking Lurasidone with Levin 400 Tablet is not recommended as it leads to an interaction, it can be used if prescribed by a doctor. Consult a doctor if you have any abnormal muscle activity, fits, high blood sugar, high sugars, high cholesterol, heat intolerance or heat stroke, dizziness, lightheadedness, headache, flushing, fainting, or heart palpitations. Do not discontinue any medications without consulting a doctor.
ImatinibDihydroergotamine
Critical
How does the drug interact with Levin 400 Tablet:
When Dihydroergotamine is taken with Levin 400 Tablet, it increases levels of dihydroergotamine leading to side effects.

How to manage the interaction:
Taking Levin 400 Tablet with Dihydroergotamine is not recommended, it can be taken if advised by your doctor. However, if you experience any unusual symptoms, consult the doctor.
ImatinibIvabradine
Critical
How does the drug interact with Levin 400 Tablet:
Coadministration of Ivabradine with Levin 400 Tablet can increase the levels of Ivabradine in the body. This increases the risk or severity of side effects.

How to manage the interaction:
Taking Ivabradine with Bosutinib together is generally avoided as it can result in an interaction, it can be taken if your doctor has advised it. However, contact a doctor immediately if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, or memory loss. Do not discontinue any medications without consulting a doctor.
ImatinibFlibanserin
Critical
How does the drug interact with Levin 400 Tablet:
Taking Levin 400 Tablet with Flibanserin may increase the level of flibanserin in body leading to side effects.

How to manage the interaction:
Taking Levin 400 Tablet with Flibanserin is not recommended, but it can be taken if prescribed by your doctor. However, if you experience any unusual symptoms, consult the doctor.
ImatinibNaloxegol
Critical
How does the drug interact with Levin 400 Tablet:
Taking Levin 400 Tablet with Naloxegol may increase the level of naloxegol which may lead to side effects.

How to manage the interaction:
Taking Levin 400 Tablet with Naloxegol is not recommended, it can be taken if prescribed by your doctor. However, if you experience any unusual symptoms, consult the consult.
ImatinibCobimetinib
Critical
How does the drug interact with Levin 400 Tablet:
When Cobimetinib is taken with Levin 400 Tablet, it can increase the risk of serious side effects.

How to manage the interaction:
Taking Levin 400 Tablet with Cobimetinib is not recommended, but can be taken if prescribed by the doctor. However, if you experience any unusual symptoms, consult the doctor.
ImatinibCisapride
Critical
How does the drug interact with Levin 400 Tablet:
When Levin 400 Tablet is taken with Cisapride, it can increase the chance of a serious abnormal heart rhythm.

How to manage the interaction:
Taking Levin 400 Tablet with Cisapride is not recommended, it can be taken if a doctor has prescribed this. However, if you experience sudden dizziness, lightheadedness, fainting, breathing difficulty, or rapid heartbeat, consult the doctor immediately. Do not discontinue the medication without consulting a doctor.
ImatinibLomitapide
Critical
How does the drug interact with Levin 400 Tablet:
When Lomitapide is taken with Levin 400 Tablet, it can increases levels of lomitapide which may lead to side effects.

How to manage the interaction:
Taking Levin 400 Tablet with Lomitapide is not recommended, but it can be taken if prescribed by your doctor. However, if you experience any unusual symptoms, consult the doctor.
ImatinibVenetoclax
Critical
How does the drug interact with Levin 400 Tablet:
When Venetoclax is taken with Levin 400 Tablet, Levin 400 Tablet may increase the level of venetoclax which may lead to side effects.

How to manage the interaction:
Taking Levin 400 Tablet with Venetoclax is not recommended, it can be taken if prescribed by your doctor. However, if you experience any unusual symptoms, consult the doctor.
ImatinibEliglustat
Critical
How does the drug interact with Levin 400 Tablet:
When Levin 400 Tablet is taken with Eliglustat, Levin 400 Tablet increases levels of eliglustat which may lead to side effects.

How to manage the interaction:
Taking Levin 400 Tablet with Eliglustat is not recommended, it can be taken if prescribed by your doctor. However, if you experience any unusual symptoms, consult the doctor.

Drug-Food Interactions

verifiedApollotooltip
  • Grapefruit and grapefruit juice: Avoid consuming grapefruit products while taking Levin 400 Tablet , as they can increase the amount of the medicine in your bloodstream and raise the risk of side effects.
IMATINIB-400MGGrapefruit and Grapefruit Juice
Moderate

Drug-Food Interactions

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IMATINIB-400MGGrapefruit and Grapefruit Juice
Moderate
Common Foods to Avoid:
Grapefruit Juice, Grapefruit

How to manage the interaction:
Grapefruit or its juice may increase the blood levels of Levin 400 Tablet which may lead to side effects. Avoid consuming Grapefruit and its juice during treatment with Levin 400 Tablet.

All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[ANTINEOPLASTIC]

FAQs

Levin 400 Tablet is used to treat chronic myeloid leukaemia (cancer that begins in the bone marrow), acute lymphocytic leukaemia (cancer of the blood and bone marrow) and gastrointestinal stromal tumour (tumour that occurs in the gastrointestinal tract).
Levin 400 Tablet contains Imatinib, an anti-cancer medication that works by inhibiting an enzyme responsible for the proliferation of cancer cells and hence induces cell death (apoptosis). As a result, the growth and spread of cancer cells are stopped or slowed down.
Regular monitoring of blood and urine tests and weight checks are required. An effective way of contraception should be used by both men and women while taking Levin 400 Tablet .
Yes, you might become more sensitive to sunlight while taking Levin 400 Tablet , so it is important to protect your skin with a high sun protection factor (SPF) while going out, as it can lead to a skin rash if you are not using a strong SPF.
In elderly patients taking Levin 400 Tablet , the risk of side effects is more. For the elderly, dose adjustment might be required, or your doctor might prescribe any other medication safe for the elderly.
If you are having surgery, including dental surgery, please inform your doctor if you are taking Levin 400 Tablet as your doctor might stop Levin 400 Tablet before undergoing surgery.
Levin 400 Tablet can make you more likely to get infections or may worsen any current infections. Avoid contact with people with infections that may spread to others (such as chickenpox, measles, or flu). Consult your doctor if you have been exposed to an infection or for more details.
Levin 400 Tablet contains Imatinib, an anti-cancer medication.
Levin 400 Tablet can be taken along with food as it helps prevent nausea.
Levin 400 Tablet may cause weakness, dizziness and drowsiness. Do not drive or operate machinery until you know how the medicine affects you.
Levin 400 Tablet may cause foetal harm, therefore let the doctor know if you are pregnant, planning for pregnancy or think you may be pregnant. Regular monitoring of weight and blood count is advised. Inform the doctor if you have liver, heart, kidney or thyroid problems.
Levin 400 Tablet can cause sensitivity to sunlight leading to itching and rashes when exposed to the sun. Wear protective clothing, hat and use sunscreen whilst going out.
Levin 400 Tablet might cause liver damage and taking paracetamol with Levin 400 Tablet might increase that risk. Therefore, consult the doctor before taking paracetamol or any other medicine with Levin 400 Tablet to prevent any interactions.
Taking Levin 400 Tablet regularly as advised by the doctor helps improve the outcome of patients with chronic myeloid leukaemia (CML). Please consult the doctor if you have any concerns.
Side effects of Levin 400 Tablet are nausea, vomiting, oedema, fatigue, muscle cramps, musculoskeletal pain, diarrhoea, rash, and abdominal pain. Talk to your doctor if you experience these side effects persistently.
Muscle cramps are a common side effect. Ensure you are drinking enough fluids and ask your doctor if mineral supplements like calcium or magnesium are safe for you. Talk to your doctor before starting any new supplements.
You should avoid live vaccines during treatment because Levin 400 Tablet can weaken your immune system. Always talk to your doctor or pharmacist before getting any vaccine.
In some cases, Levin 400 Tablet can cause fluid retention that puts extra strain on your heart, or it may directly affect heart function. If you notice swelling, shortness of breath, or rapid weight gain, talk to your doctor immediately.
Avoid using paracetamol (acetaminophen) in high doses as it can stress your liver, and avoid NSAIDs like ibuprofen if you are at risk of bleeding. Talk to your doctor or pharmacist for a safe pain relief recommendation.
If you vomit after taking your dose, do not take an extra tablet to replace it. Wait and take your next scheduled dose the following day. Talk to your doctor if vomiting becomes a regular issue.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Reference

  1. Electronic Medicines Compendium (EMC). Pil.2330 Patient Information Leaflet (PIL). Cheshire, UK: Datapharm; 2025. [Accessed on 02 Jun. 2026]Check here
  2. U.S. Food and Drug Administration (FDA). 021588S024Lbl [FDA Prescribing Information]. Silver Spring, MD: FDA; 2024. [Accessed on 02 Jun. 2026]Check here
  3. Drugs.com Clinical Review Team. Imatinib Clinical Drug Monograph. Auckland, NZ: Drugs.com; 2026. [Accessed on 02 Jun. 2026]Check here
  4. MedlinePlus. A606018 Patient Information Monograph. Bethesda, MD: U.S. National Library of Medicine (NLM); 2025. [Accessed on 02 Jun. 2026]Check here
  5. Imatinib film-coated tablets - Summary of Product Characteristics (SmPC) - (emc) [Internet]. Medicines.org.uk. 2025 [Accessed on 29 Aug 2025]Check here
  6. Imatinib film-coated tablets - Patient Information Leaflet (PIL) - (emc) [Internet]. Medicines.org.uk. 2025 [Accessed on 29 Aug 2025]Check here
  7. Nida Iqbal and Naveed Iqbal. Imatinib: A Breakthrough of Targeted Therapy in Cancer. Journal of chemotherapy research and practice. May 2014. [Accessed on 19th November 2022]Check here

Country of origin

India

Manufacturer/Marketer address

Dr. Reddy's Laboratories Ltd., 8-2-337, Road No. 3, Banjara Hills, Hyderabad, Telangana 500034, INDIA
Other Info - LEV0179
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