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compositionComposition:GLIMEPIRIDE-2MG+METFORMIN-500MG+VOGLIBOSE-0.2MG
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Prescription Medicine
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Gluconorm-VG 2 Tablet is used to treat type 2 diabetes mellitus. It acts by increasing the amount of insulin released by the pancreas. Thus, prevent the blood glucose levels from rising to very high levels and keeps your diabetes under control. It may cause certain common side effects such as hypoglycaemia (low blood glucose levels), taste change, nausea, diarrhoea, stomach pain, headache, and upper respiratory symptoms. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.

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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

GLIMEPIRIDE-2MG+METFORMIN-500MG+VOGLIBOSE-0.2MG

Manufacturer/Marketer :

Lupin Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Gluconorm-VG 2 Tablet

Gluconorm-VG 2 Tablet is a prescription tablet designed to help manage blood sugar levels in adults with type 2 diabetes. It is used when a single or double medication therapy, along with diet and exercise, is not enough to keep blood sugar within a safe range. By keeping glucose levels controlled, this medication helps prevent long-term health complications associated with diabetes. To get the best results, you must take Gluconorm-VG 2 Tablet consistently every day exactly as your doctor prescribes. It is typically taken shortly before or with your first main meal of the day to help control the rise in blood sugar that occurs after eating.

Combining this medication with a balanced, low-sugar diet and regular physical activity is essential for achieving optimal blood sugar control. While taking Gluconorm-VG 2 Tablet , some people may experience mild side effects like an upset stomach, mild diarrhea, or temporary low blood sugar. If you experience serious symptoms such as severe confusion, shakiness, extreme sleepiness, or yellowing of your skin or eyes, you must contact your doctor immediately. These symptoms can be signs of more serious complications that require medical attention.

Before starting Gluconorm-VG 2 Tablet , tell your doctor about your complete medical history, especially if you have heart problems or a history of low blood sugar. Do not take this if you have severe kidney disease, advanced liver damage, or if you are experiencing diabetic ketoacidosis.

Your doctor will evaluate your overall organ function to make sure this medicine is safe for you. This medication can interact with other substances, such as alcohol, which significantly increases your risk of dangerous blood sugar drops or a rare but severe metabolic condition. If you are pregnant, planning to become pregnant, breastfeeding, or are over the age of 65, talk to your doctor or pharmacist to determine if this is the right option for you.

Uses of Gluconorm-VG 2 Tablet

Gluconorm-VG 2 Tablet is used to treat Type 2 diabetes mellitus. The detailed uses of Gluconorm-VG 2 Tablet are as follows:

  • Type 2 Diabetes Mellitus: Gluconorm-VG 2 Tablet is prescribed to help lower high blood sugar levels in adults whose diabetes cannot be controlled by diet, exercise, and single-agent medications alone.

Key Benefits

Gluconorm-VG 2 Tablet provides reliable, daily support to help you manage your health and avoid the physical toll of fluctuating blood sugar levels. By keeping your blood sugar stable, this medicine brings several key health benefits:

  • Helps maintain healthy blood sugar control (glycemic control) throughout the day.
  • Reduces blood sugar spikes after meals.
  • Improves the body's ability to use insulin effectively.
  • Helps lower excess glucose production by the liver.
  • Reduces the risk of long-term diabetes-related complications, including nerve damage, kidney disease, vision problems, and cardiovascular complications when used as part of a comprehensive diabetes management plan.

Directions for Use

These are the following ways one can use Gluconorm-VG 2 Tablet :

  • Swallow the tablet whole with a glass of water. Do not crush, chew, or break the tablet, as this can interfere with how the medication is released into your body.
  • Take this medication exactly as prescribed by your doctor, usually right before or with your first main meal of the day.
  • Never adjust your dose or stop taking this medication without consulting your doctor first, even if your blood sugar readings improve.

How Gluconorm-VG 2 Tablet Works

Gluconorm-VG 2 Tablet combines three distinct active medicines that work together in your body to lower blood sugar levels. Glimepiride (sulfonylurea, stimulates insulin secretion), Voglibose (alpha-glucosidase inhibitor, delays carbohydrate absorption), and Metformin (biguanide, reduces hepatic glucose output and improves insulin sensitivity). The insulin-stimulating component is part of the medicine that prompts your pancreas to release more insulin, which is the natural hormone your body uses to clear sugar out of the bloodstream and into your cells for energy. The slower carbohydrate absorption is the component that works directly in your digestive system to slow down the breakdown of complex carbohydrates from your food into simple sugars. This delays sugar absorption, preventing sharp blood sugar spikes after your meals. The liver and insulin-sensitivity helper part work in two ways, as it reduces the amount of excess sugar your liver makes and releases into your body, and it helps your muscles use your body's existing insulin much more efficiently.
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Alcohol

Unsafe

Taking Gluconorm-VG 2 Tablet with alcohol can cause hypoglycaemia and can also lead to a rare but life-threatening condition known as lactic acidosis. So, keep your doctor informed if you drink alcohol.

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Pregnancy

Consult your doctor

As the data around the use of Gluconorm-VG 2 Tablet in pregnant women is limited, the use of Gluconorm-VG 2 Tablet in pregnancy is unknown. Please consult your doctor for advice before using Gluconorm-VG 2 Tablet .

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Breast Feeding

Consult your doctor

The name is not recommended during breastfeeding. However, your doctor may prescribe it for you during breastfeeding if he/she feels that the benefit to you outweighs the risk. You should not take Gluconorm-VG 2 Tablet without a doctor's advice.

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Driving

Unsafe

Drive only if you are physically stable and mentally focussed, If you experience drowsiness after taking these medications you should not drive or operate any machinery or vehicles.

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Liver

Caution

Gluconorm-VG 2 Tablet to be taken with caution, especially if you have a history of liver disease.

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Kidney

Caution

Gluconorm-VG 2 Tablet to be taken with caution, especially if you have a history of Kidney disease

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Children

Unsafe

Gluconorm-VG 2 Tablet is not recommended for children below the age of 18 years as the safety and effectiveness of Gluconorm-VG 2 Tablet has not been established in children due to limited evidence.

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Heart

Consult your doctor

Gluconorm-VG 2 Tablet should be used with caution if you have any cardiac problems. This medicine is contraindicated in patients with severe heart failure.

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Geriatrics

Caution

Caution should be exercised in geriatric patients while taking Gluconorm-VG 2 Tablet .

What if I have taken an overdose of Gluconorm-VG 2 Tablet

If you take more than your prescribed dose, seek emergency medical attention or contact a poison control centre immediately. An overdose can cause dangerously low blood sugar or lactic acidosis, both of which require urgent medical treatment.

Diet & Lifestyle Advise

  • Count your carbohydrates: Learn to track your daily carbohydrate intake to maintain stable blood sugar levels and avoid sudden spikes or drops.
  • Eat consistent meals: Do not skip meals while taking this medication, as missing a meal can cause your blood sugar to drop dangerously low.
  • Carry fast-acting sugar: Always keep a source of fast-acting sugar with you, such as glucose tablets, fruit juice, or hard candy, to quickly treat sudden symptoms of low blood sugar.
  • Exercise regularly: Engage in moderate physical activity, like walking or cycling, for at least 150 minutes per week, as exercise helps your body use insulin more effectively.
health query

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How Soon It Starts Working

The time required for Gluconorm-VG 2 Tablet to start to work: The time required for Gluconorm-VG 2 Tablet to show its action is not clinically established. The time for which the effects of Gluconorm-VG 2 Tablet last: The duration of action for Gluconorm-VG 2 Tablet is not clinically established.

What if you forget to take Gluconorm-VG 2 Tablet

If you miss a dose, take it with your next main meal if that meal is coming up soon. However, if it is almost time for your next scheduled dose, skip the missed dose entirely and return to your regular schedule. Do not take two doses at the same time to make up for a missed one.

Storage

• Store Gluconorm-VG 2 Tablet at room temperature, ideally below 30°C (86°F), in a dry place. • Keep the tablets in their original blister packaging to protect them from direct sunlight, heat, and moisture.

Drug Warnings

  • Monitor your blood sugar levels regularly as advised by your doctor to ensure the medication is working safely and effectively.
  • Check your skin and feet daily for any cuts, sores, or infections, as diabetes can slow down your body's natural healing process.
  • Inform any surgeon, dentist, or medical specialist that you are taking Gluconorm-VG 2 Tablet , especially if you need to undergo surgery or a medical scan involving contrast dye.
  • Avoid drinking alcohol, as it can interfere with blood sugar control and significantly increase your risk of severe low blood sugar and lactic acidosis.
  • Gluconorm-VG 2 Tablet is not intended for use in children and adolescents unless specifically prescribed by a specialist. Its safety and effectiveness in pediatric patients have not been well established.
  • If you suspect an overdose, seek emergency medical attention immediately. Call or go to the nearest hospital emergency department. Symptoms may include severe low blood sugar, extreme weakness, confusion, loss of consciousness, or signs of lactic acidosis.

Drug-Drug Interactions

verifiedApollotooltip

Inform your doctor if you are taking any of the following medicines, as they may interact.

  • Beta-blockers: May mask the warning signs of low blood sugar, such as a rapid heart rate.
  • Water pills (diuretics) and steroids: May raise your blood sugar levels, reducing the effectiveness of Gluconorm-VG 2 Tablet .
  • Pain relievers (NSAIDs) and certain blood pressure medications (ACE inhibitors): May increase the risk of low blood sugar or affect kidney function when taken together.
Glimepiride + Metformin + VogliboseIopromide
Critical
Glimepiride + Metformin + VogliboseGatifloxacin
Critical

Drug-Drug Interactions

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Glimepiride + Metformin + VogliboseIopromide
Critical
How does the drug interact with Gluconorm-VG 2 Tablet:
Co-administration of Iopromide with Metformin can increase the risk of lactic acidosis (a medical condition characterized by a build-up of lactate in the body).

How to manage the interaction:
Taking Iopromide with Metformin is not recommended, consult a doctor before taking it. Do not stop using any medications without talking to a doctor.
Glimepiride + Metformin + VogliboseGatifloxacin
Critical
How does the drug interact with Gluconorm-VG 2 Tablet:
Taking Glimepiride with Gatifloxacin may affect both low blood glucose and, less frequently, high blood glucose have been reported.

How to manage the interaction:
Gatifloxacin is not recommended for patients with diabetes, however, it can be taken if advised by a doctor. Consult the prescriber if you experience symptoms such as nervousness, confusion, headache, dizziness, drowsiness, tremors, nausea, hunger, weakness, perspiration, palpitation, rapid heartbeat, increased urination, increased thirst, and increased hunger. Do not discontinue the medications without consulting a doctor.
Glimepiride + Metformin + VogliboseIomeprol
Critical
How does the drug interact with Gluconorm-VG 2 Tablet:
Co-administration of Iomeprol with Metformin can increase the risk of lactic acidosis (a medical condition characterized by a build-up of lactate in the body).

How to manage the interaction:
Taking Metformin with Iomeprol is not recommended, consult a doctor before taking it. Do not stop using any medications without talking to a doctor.
Glimepiride + Metformin + VogliboseIodamide
Critical
How does the drug interact with Gluconorm-VG 2 Tablet:
Co-administration of Metformin and Iodamide can increase the risk of lactic acidosis (when the body produces too much lactic acid).

How to manage the interaction:
Taking Metformin with Iodamide is generally avoided as it can result in an interaction, consult a doctor before taking it. Do not stop using any medications without talking to a doctor.
Glimepiride + Metformin + VogliboseMetrizamide
Critical
How does the drug interact with Gluconorm-VG 2 Tablet:
Co-administration of Metformin and Metrizamide together can cause the risk of lactic acidosis (when the body produces too much lactic acid ).

How to manage the interaction:
Taking Metformin with Metrizamide is generally avoided as it can result in an interaction, it can be taken if a doctor has advised it. However, if you experience headaches, nausea, vomiting, diarrhea, muscle cramps or pain, body weakness, extreme fatigue, and visual disturbances, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
Glimepiride + Metformin + VogliboseIopamidol
Critical
How does the drug interact with Gluconorm-VG 2 Tablet:
Co-administration of Iopamidol with Metformin can increase the risk of lactic acidosis (a medical condition characterized by a build-up of lactate in the body).

How to manage the interaction:
Taking Metformin with Iopamidol is not recommended, consult a doctor before taking it. Do not stop using any medications without talking to a doctor.
Glimepiride + Metformin + VogliboseIodixanol
Critical
How does the drug interact with Gluconorm-VG 2 Tablet:
Co-administration of Iodixanol with Metformin can increase the risk of lactic acidosis (a medical condition characterized by a build-up of lactate in the body).

How to manage the interaction:
Taking Metformin with Iodixanol is not recommended, consult a doctor before taking it. Do not stop using any medications without talking to a doctor.
Glimepiride + Metformin + VogliboseGrepafloxacin
Severe
How does the drug interact with Gluconorm-VG 2 Tablet:
Co-administration of Glimepiride with Grepafloxacin can cause both hyperglycemia (high blood glucose) and, less frequently, hypoglycemia (low blood glucose).

How to manage the interaction:
Although there is a possible interaction between Glimepiride and Grepafloxacin, you can take these medicines together if prescribed by a doctor. If you experience headache, dizziness, sleepiness, confusion, shaking, feeling hungry, weak, heart racing, high blood sugar, low blood sugar, serious infections, bleeding, feeling anxious, feeling sick or very thirsty - make sure to call a doctor right away. Do not stop using any medications without talking to a doctor.
Glimepiride + Metformin + VogliboseOfloxacin
Severe
How does the drug interact with Gluconorm-VG 2 Tablet:
Co-administration of Ofloxacin and Glimepiride can cause both hyperglycemia (high blood glucose) and, hypoglycemia (low blood glucose).

How to manage the interaction:
Although combining Ofloxacin and Glimepiride can lead to an interaction, they can be taken on a doctor's advice. If you experience any symptoms of hypoglycemia (headache, dizziness, sleepiness, nervousness, confusion, shaking, nausea, hunger, weakness, sweat, palpitation, and rapid heartbeat) or hyperglycemia (increased thirst, hunger, and urination), consult a doctor. Keep an eye on your blood glucose level. Do not discontinue any medications without consulting a doctor.
Glimepiride + Metformin + VogliboseVoriconazole
Severe
How does the drug interact with Gluconorm-VG 2 Tablet:
Co-administration of Glimepiride with Voriconazole may increase the blood levels and effects of Glimepiride.

How to manage the interaction:
Although there is a possible interaction, glimepiride can be taken with voriconazole if prescribed by the doctor. Consult the prescriber if you experience symptoms of low blood sugar such as headache, dizziness, drowsiness, nervousness, confusion, tremors, nausea, hunger, weakness, perspiration, palpitation, and rapid heartbeat. Do not discontinue the medications without consulting a doctor.

Drug-Food Interactions

verifiedApollotooltip
  • Alcohol: Increases the risk of dangerous low blood sugar and a serious metabolic condition called lactic acidosis.
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

No

Therapeutic Class

[ANTIDIABETICS]

FAQs

Gluconorm-VG 2 Tablet is a combination of anti-diabetic drugs used to treat type 2 diabetes mellitus.
If you have symptoms like increased hunger, increased thirst, frequent urination (usually at night), unexplained weight loss, fatigue, blurred vision, slow wound/sores healing and frequent infections, contact doctor as it can be a condition of type 2 diabetes.
Hypoglycaemia refers to low blood sugar levels. The symptoms of hypoglycaemia include nausea, headache, irritability, hunger, sweating, dizziness. Gluconorm-VG 2 Tablet can cause hypoglycaemia. Hypoglycaemia can occur if you miss or delay your food, drink alcohol, over-exercise or take other anti-diabetic medicine along with Gluconorm-VG 2 Tablet . Diabetics are advised to keep a quick source of sugar like glucose tablets, honey or fruit juice with them.
Gluconorm-VG 2 Tablet should be avoided in patients who are allergic to any of the components or excipients of this medicine. It should be avoided in patients suffering from moderate to severe kidney disease and in patients with underlying metabolic acidosis including diabetic ketoacidosis.
If you feel thirsty after taking Gluconorm-VG 2 Tablet , it may be because of dehydration as Gluconorm-VG 2 Tablet can lead to loss of fluids. Increase intake of fluids, if even then you feel thirsty please consult your doctor.
If you have been affected with diabetes, you should have a test of HbA1c once in three months.
Yes, long-term usage of Gluconorm-VG 2 Tablet can cause vitamin B12 deficiency as it interferes with the absorption of vitamin B12 in the stomach. The symptoms can be managed by taking Vitamin B12 supplements as advised by your doctor.
No. Till date there is no clinical evidence that states that Gluconorm-VG 2 Tablet affects fertility in either men or women.
Lactic acidosis is rare but life threatening condition when, there is too much of lactic acid build up in the bloodstream. Long term intake of Gluconorm-VG 2 Tablet may lead to lactic acidosis when cells get deprived of the oxygen levels. Symptoms of lactic acidoisis includes burning sensation of muscle, muscle ache, fast breathing, nausea and stomach pain. Immediately contact doctor if you experience any of these symptoms when on Gluconorm-VG 2 Tablet .
If you feel shaky, sweaty, or dizzy, immediately consume 15 to 20 grams of fast-acting sugar, such as a half-cup of fruit juice, glucose tablets or plain sugar. Check your sugar again in 15 minutes, and if it is still low, repeat the treatment. Talk to your doctor if this happens frequently.
Follow a diet rich in fibre, low in fat with sufficient carbohydrates, protein, vitamins and minerals. Maintain the regular meal timings and try to have 2-3 healthy snacks between meals such as salads and soups. Use edible oils moderately and drink at least 8-10 glasses of water every day.
You are recommended to avoid white bread, maida, poori, naan, noodles, biryani, fried rice, carrot juice, soups, deep-fried vegetables, creams and vegetable curries with excess oil. Also, avoid mango, seetaphal, jack fruit, fruit salads with ice cream, and fruit-based desserts. Avoid overeating. Avoid shopping when you are hungry. You could be tempted to purchase oil and fried food.
Gluconorm-VG 2 Tablet acts by encouraging insulin secretion from the β-cells of the pancreas and increase the amount of insulin released by the pancreas. Also, it helps to restore the body's proper response to the insulin it naturally produces.
Store Gluconorm-VG 2 Tablet at room temperature. Protect from light and moisture. Keep it out of reach of children.
Gluconorm-VG 2 Tablet may cause side effects such as hypoglycemia (low blood sugar level), taste change, stomach pain, nausea, diarrhea, and headache. If these side effects persist or worsen, please consult your doctor.
No, you should avoid alcohol. Drinking alcohol while taking this medicine significantly increases your risk of severe low blood sugar and a rare but dangerous condition called lactic acidosis. Talk to your doctor for more information.
It is usually best to take this medication right before your first main meal of the day, or exactly as your doctor has instructed. Taking it with your meal helps prevent post-meal blood sugar spikes and reduces stomach upset.
Some components of this medicine are generally weight-neutral or may support mild weight loss, while others can occasionally cause slight weight gain due to increased insulin action. Talk to your doctor or pharmacist about what to expect.
No, you should never stop taking your medication without consulting your doctor. Normal blood sugar readings mean the medication is working as intended, and stopping it suddenly can cause your blood sugar to rise rapidly again.
This medication is generally not recommended during pregnancy or breastfeeding. Insulin is typically preferred to manage blood sugar during these times. Talk to your doctor for safe alternatives.
This medication is cleared from your body through your kidneys. While it does not directly damage healthy kidneys, patients with significantly reduced kidney function (eGFR below 45 or 30) may need dose adjustments or discontinuation, as per standard guidelines. Metformin should be used with caution between eGFR 30–45 and is contraindicated below eGFR 30; and glimepiride also requires caution in renal impairment due to hypoglycemia risk. Your doctor will perform routine blood tests to monitor your kidney function and ensure it remains safe for you to take.
No, you must swallow the tablet whole. Crushing, chewing, or breaking the tablet can cause too much of the medication to release into your body at once, which increases the risk of side effects and low blood sugar. Talk to your doctor if you have trouble swallowing.

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Reference

  1. National Center for Biotechnology Information (NCBI). Pmc3919386 Scientific Research Publication. Bethesda, MD: NLM; 2025. [Accessed on 02 Jun. 2026]Check here
  2. Electronic Medicines Compendium (EMC). Pil.594 Patient Information Leaflet (PIL). Cheshire, UK: Datapharm; 2025. [Accessed on 02 Jun. 2026]Check here
  3. Electronic Medicines Compendium (EMC). Pil.6048 Patient Information Leaflet (PIL). Cheshire, UK: Datapharm; 2025. [Accessed on 02 Jun. 2026]Check here
  4. Metformin Hydrochloride (Prolonged Release), Voglibose & Glimepiride [Patient Information Sheet]. 2015. [Accessed on 28th Sept. 2023]Check here
  5. Central Drugs Standard Control Organisation [Internet]. Cdscoonline.gov.in. 2024 [Accessed on 17 July 2025]Check here
  6. Glimepiride+Metformin+Voglibose [Product Monograph]. 2018. [Accessed on 25 Oct. 2021]Check here

Country of origin

India

Manufacturer/Marketer address

Lupin Ltd, 3rd floor Kalpataru Inspire, Off. W E Highway, Santacruz (East), Mumbai 400 055. India Country of Origin: India
Other Info - GLU0341
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