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Glynase-MF Tablet 10's

Glynase-MF Tablet 10's

Prescription drug
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Manufacturer/Marketer

USV Pvt Ltd

Consume Type

ORAL

Return Policy

Not Returnable

Expires on or after

Jan-25

About Glynase-MF Tablet 10's

Glynase-MF Tablet 10's belongs to the class of anti-diabetic drugs. It is used in the treatment of type 2 diabetes mellitus. Diabetes mellitus is a metabolic disease that causes high blood sugar levels. It occurs when the insulin (a hormone produced by the beta cells of the pancreas) is resistant in breaking the glucose to produce energy (insulin resistance) or the pancreas (an organ behind the stomach) produces little or no insulin at all.

Glynase-MF Tablet 10's is composed of two medicines, namely Glipizide and Metformin. Glipizide belongs to the class of sulfonylureas. It promotes insulin secretion from the beta cells of the pancreas and reduces the glucose output from the liver.  It has the fastest absorption and onset of action compared to other sulfonylureas. Metformin belongs to the class of biguanides and is used to manage blood sugar levels, particularly in obese patients. It exhibits a non-pancreatic effect to reduce serum glucose levels without increasing insulin secretion. It is also known as an insulin sensitizer as it increases the effects of insulin.

Take Glynase-MF Tablet 10's with food at regular intervals as prescribed by your doctor to avoid stomach upset. Your doctor will decide the dosage form, and this may change timely depending on your blood sugar levels. The common side effects of Glynase-MF Tablet 10's include hypoglycemia (low blood sugar levels), nausea, diarrhoea, indigestion, headache, dizziness, blurred vision, weakness, cold sweats, stomach pain, weight gain, and oedema (swelling). Although not everyone experiences these side effects, if they occur, seek medical attention. Lactic acidosis, is a rare, but serious metabolic complication of excess lactic acid in the blood that is caused by metformin accumulation is reported. The risk of lactic acidosis is high in people with kidney, liver, and heart diseases.

Before starting Glynase-MF Tablet 10's, let your doctor know if you have any medical history of anaemia (low haemoglobin levels), seizures (fits), heart, kidney, and liver diseases. Also, speak to your doctor if you are on restricted food or fluid intake since Glynase-MF Tablet 10's causes dehydration, low blood sugar, and kidney damage. Do not take or stop this medicine, if the doctor did not advise you to do so.

Uses of Glynase-MF Tablet 10's

Treatment of Type 2 Diabetes mellitus.

Medicinal Benefits

Glynase-MF Tablet 10's is used to treat type 2 diabetes mellitus. It is a combination of Glipizide and Metformin. Glipizide is effective in treating low blood sugar levels when used as an adjunct to diet and exercise. It promotes insulin secretion from the beta cells of the pancreas and reduces the glucose output from the liver. It also exhibits an extrapancreatic effect by improving insulin sensitivity at peripheral sites like muscle, fat, or liver cells. Metformin shows a non-pancreatic effect to reduce serum glucose levels without increasing insulin secretion. It is also known as an insulin sensitizer as it increases the effects of insulin. It is considered to be a unique anti-diabetic drug since it does not lower blood sugar levels.

Directions for Use

Tablet: Swallow it as a whole with water; do not crush, break or chew it.Take Glynase-MF Tablet 10's preferably with a meal, since it lowers the blood sugar levels and causes gastrointestinal side effects. Your doctor may start the course with a low dose and gradually maintain an effective dose to achieve the required blood glucose control.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Glynase-MF Tablet 10's

Common side effects:

  • Hypoglycemia (low blood sugar levels)
  • Nausea
  • Diarrhoea
  • Indigestion
  • Headache
  • Blurred vision
  • Dizziness
  • Weakness
  • Cold sweats
  • Stomach pain
  • Weight gain
  • Oedema (swelling)

Rare side effects:

  • Lactic acidosis

Drug Warnings

Glynase-MF Tablet 10's can cause weight gain hence possible measures like eating healthy food and exercising are advised. It may also increase the risk of cardiovascular diseases and hypoglycemic conditions in renal and liver disease patients. Glynase-MF Tablet 10's sometimes causes impairment of vitamin b12 absorption and results in anaemia (low haemoglobin levels). Glynase-MF Tablet 10's has an increased risk of lactic acidosis. The risk of lactic acidosis is high in older people with kidney, liver and heart diseases. Hence, brief your medical history and take advice from your doctor before starting Glynase-MF Tablet 10's. Avoid consuming excessive alcohol as it can potentiate lactic acidosis.

Drug Interactions

Drug-Drug Interaction: Glynase-MF Tablet 10's may interact with pain killers (aspirin), anti-diabetics (glipizide, sitagliptin, insulin glargine), drugs that treat fluid retention (furosemide), medicines used to treat high blood pressure (metoprolol), and thyroid hormones (levothyroxine). Please check the instruction leaflet that comes with the medication before you take Glynase-MF Tablet 10's.

Drug-Food Interaction: Limit alcohol intake since it affects blood sugar levels. Avoid fatty foods and include healthy carbohydrates in your diet.

Drug-Disease Interaction: Tell your doctor before taking Glynase-MF Tablet 10's if you have a medical history of allergic reactions to medicines, renal dysfunction, liver disease, congestive heart failure, diabetic ketoacidosis, and gastrointestinal obstruction (GI narrowing).

Drug-Drug Interactions Checker List

  • ASPIRIN
  • GLIPIZIDE
  • SITAGLIPTIN
  • INSULIN GLARGINE
  • FUROSEMIDE
  • METOPROLOL
  • LEVOTHYROXINE SODIUM

Habit Forming

No

Diet & Lifestyle Advise

  • Maintain a fiber-rich diet and include healthy carbohydrates from fruits, vegetables and whole grains to maintain your blood glucose levels.
  • Eat at regular intervals
  • Keep a check on your weight and exercise regularly to keep your heart healthy.
  • Your doctor also guides you on how to notice and manage the early symptoms of high/low blood sugar levels.
  • Gastrointestinal side effects can be managed with simple modifications in your lifestyle. These include cutting down on sugars and fatty foods, and avoiding carbonated drinks and foods that cause gas.

Special Advise

Regular blood tests are recommended while taking Glynase-MF Tablet 10's to monitor blood sugar levels.

Disease/Condition Glossary

Diabetes mellitus, also known as adult-onset diabetes, is a metabolic disease that causes high blood sugar levels. It is a type 2 diabetes and occurs when the insulin (a hormone produced by the beta cells of the pancreas) is resistant in breaking the glucose to produce energy (insulin resistance) or the pancreas (an organ behind the stomach) produces little or no insulin at all. This disease mostly occurs in people aged above 40 years, but can also occur in childhood based on the risk factors. The treatment includes oral glucose-lowering medicines and insulin shots.

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Alcohol

Caution

You are recommended to avoid consumption of alcohol with Glynase-MF Tablet 10's as it may increase the risk of lactic acidosis (accumulation of lactic acid in the body).

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Pregnancy

Caution

Glynase-MF Tablet 10's may affect the fetus during pregnancy. Please consult your doctor before starting Glynase-MF Tablet 10's.

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Breast Feeding

Caution

There is no sufficient data on how Glynase-MF Tablet 10's affects breastfeeding. It is safe to seek medical advice before you start Glynase-MF Tablet 10's if you are lactating.

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Driving

Caution

Your driving may be affected if your blood sugar levels are too high or too low. Do not drive or operate machinery if may experience dizziness or drowsiness.

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Liver

Caution

Let your doctor know if you have any history of liver diseases or hepatic impairment when you are prescribed Glynase-MF Tablet 10's.

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Kidney

Caution

Let your doctor know if you have any history of kidney diseases when you are prescribed Glynase-MF Tablet 10's.

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Children

Caution

Please seek advice from a doctor before giving Glynase-MF Tablet 10's to a child.

Country of origin

India

Manufacturer/Marketer address

Arvind Vithal Gandhi Chowk, BSD Marg, Station Road, Govandi East, Mumbai - 400 088. , India.
Other Info -

FAQs

Glynase-MF Tablet 10's contains two antidiabetic drugs, namely: Glipizide and Metformin. Glipizide promotes insulin secretion from the beta cells of the pancreas and reduces the glucose output from the liver. Metformin works by reducing the sugar production by cells in the liver and delays sugar absorption from the intestines.
Glynase-MF Tablet 10's may increase the risk of low blood sugar levels, especially with alcohol intake, exercise more than usual, delay or missing snacks or meals. However, if you experience any signs of low blood pressure such as dizziness, nausea, light-headedness, dehydration or fainting, please consult a doctor.
You are not recommended to stop taking Glynase-MF Tablet 10's on your own as discontinuing Glynase-MF Tablet 10's suddenly may cause recurring symptoms or worsen the condition. However, if you experience any difficulty while taking Glynase-MF Tablet 10's, please consult your doctor so that alternative medicine may be prescribed.
In type 1 diabetes, the body doesn’t produce insulin as the islet cells (insulin-producing cells) in the pancreas are destroyed completed. In type 2 diabetes, though islet cells are working, the body doesn’t respond to insulin as the body becomes resistant to insulin.

Author Details

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