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compositionComposition:DANAZOL-200MG
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Gonablok 200 Capsule is used to treat endometriosis and breast cysts. It contains Danazol which works by decreasing the amount of oestrogen in the body and shrinks the tissue or stops its growth. In some cases, this medicine may cause side effects such as sore throat, hoarse voice, hair loss, excessive hair growth on the body or face, and stomach pain. Inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.

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Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

DANAZOL-200MG

Manufacturer/Marketer :

Win Medicare Pvt Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Gonablok 200 Capsule

Gonablok 200 Capsule is a prescription medicine used to treat the painful symptoms of endometriosis, a condition where tissue similar to the lining of the uterus grows outside of it. It is also prescribed to relieve severe breast pain and tenderness caused by fibrocystic breast disease when other treatments do not work. Additionally, it helps prevent sudden swelling attacks in people with a rare genetic inflammatory condition called hereditary angioedema.

To get the best results, you must take this medicine exactly as your doctor tells you, keeping your doses consistent every single day. You can take this medicine either with food or without food, but you must choose one method and stick to it with every dose because food changes how your body absorbs it. Making certain dietary changes, such as reducing salt and caffeine, can also help minimise breast tenderness and fluid retention during your treatment.

While taking Gonablok 200 Capsule , you may notice some common side effects like mild acne, flushing, or small changes in your weight. However, you must contact your doctor immediately if you experience serious side effects, especially voice changes like hoarseness, yellowing of your skin or eyes, or severe abdominal pain. Your pharmacist or doctor can help you manage milder side effects while ensuring you remain safe during your treatment.

Before starting this medicine, tell your doctor about your complete medical history, especially if you have a history of seizures, migraines, or heart, liver, or kidney problems. Do not take this medicine if you are pregnant, breastfeeding, or if you have undiagnosed vaginal bleeding, severe liver damage, or a history of blood clots.
This medicine can interact with other substances; for instance, combining it with blood thinners or cholesterol medicines can cause serious health complications, and drinking alcohol can increase your risk of liver damage. If you belong to specific groups, such as the elderly or those with underlying medical conditions, you must talk to your doctor or pharmacist to weigh the risks and benefits before starting therapy.

Uses of Gonablok 200 Capsule

Gonablok 200 Capsule is used to manage hormone-dependent conditions and hereditary angioedema. It may be prescribed for:

  • Endometriosis: Gonablok 200 Capsule helps by shrinking abnormal endometrial tissue outside the uterus, which significantly reduces severe pelvic pain and painful menstrual periods.
  • Fibrocystic Breast Disease: It helps by lowering the swelling, pain, and physical nodularity in the breast tissue when non-hormonal therapies have failed.
  • Hereditary Angioedema: It helps prevent severe, painful swelling attacks in the face, airway, and extremities by increasing the production of protective proteins in your blood.

Key Benefits

Gonablok 200 Capsule is a synthetic hormone that helps manage certain hormone-dependent conditions by reducing the production of oestrogen and other hormones. It is used to treat endometriosis, fibrocystic breast disease, and hereditary angioedema.

  • Relieves Endometriosis Symptoms: Helps reduce pelvic pain, painful periods, and other symptoms associated with endometriosis by suppressing the growth of endometrial tissue.
  • Helps Manage Fibrocystic Breast Disease: May reduce breast pain, tenderness, and the size of benign breast cysts in appropriate patients.
  • Prevents Hereditary Angioedema Attacks: Helps reduce the frequency and severity of swelling episodes in people with hereditary angioedema.
  • Improves Daily Comfort: Better control of symptoms may help you perform daily activities with less pain, discomfort, and anxiety.
  • Supports Long-Term Disease Management: Regular use as prescribed helps reduce symptom recurrence and improve quality of life in eligible patients.
Side effects of Gonablok 200 Capsule
  • Keep your skin clean by gently washing your face two times daily and after sweating. Choose a mild and non-abrasive cleanser.
  • Use gentle alcohol-free skin care products. Avoid products that might irritate your skin such as exfoliants, astringents and toners.
  • Acne may also occur due to oil in the hair. Thus, if you have oily hair, shampoo more frequently than you do now and keep your hair away from face.
  • Keep your hands off your face as touching face throughout the day might worsen acne. Also, do not pick, squeeze or pop acne as it will prolong the healing process and increase the risk of dark spots and scarring.
  • Avoid tanning by applying a broad spectrum sunscreen and wearing sun-protective clothing when outdoors.
Managing Medication-Triggered Flushing (Reddening of the skin): A Step-by-Step Guide:
  • Consult your doctor if you experience skin redness, itching, or irritation after taking medication.
  • Your doctor may adjust your treatment plan by changing your medication or providing guidance on managing your erythema symptoms.
  • Your doctor may recommend or prescribe certain medications to help alleviate symptoms.
  • Apply cool compresses or calamine lotion to the affected skin area to reduce redness and itching.
  • Stay hydrated by drinking plenty of water to help alleviate symptoms and keep your skin hydrated.
  • Monitor your skin condition closely and promptly report any changes, worsening symptoms, or concerns to your healthcare provider.
Here are the steps to manage Joint Pain caused by medication usage:
  • Please inform your doctor about joint pain symptoms, as they may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Your doctor may prescribe common pain relievers if necessary to treat joint discomfort.
  • Maintaining a healthy lifestyle is key to relieving joint discomfort. Regular exercise, such as low-impact sports like walking, cycling, or swimming, should be combined with a well-balanced diet. Aim for 7-8 hours of sleep per night to assist your body in repairing and rebuilding tissue.
  • Applying heat or cold packs to the affected joint can help reduce pain and inflammation.
  • Please track when joint pain occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.
  • If your joint pain is severe or prolonged, consult a doctor to rule out any underlying disorders that may require treatment.
Managing Medication-Triggered Anxiety: A Comprehensive Approach:
  • Inform your doctor about your anxiety symptoms so that you doctor may explore potential drug interactions and alter your treatment plan.
  • Work with your doctor to adjust your medication regimen or dosage to minimize anxiety symptoms.
  • Reduce anxiety symptoms by practicing relaxation techniques like meditation, deep breathing, or yoga.
  • Regular self-care activities, such as exercise, healthy food, and adequate sleep, can assist control anxiety.
  • Surround yourself with a supportive network of friends, family, or a support group to help manage anxiety and stay motivated.
  • Regularly track anxiety symptoms and report any changes to your doctor to ensure your treatment plan is effective and adjusted as needed.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
  • To keep your vocal cords lubricated and hydrated, drink lots of water.
  • Suck on ice chips, popsicles, or lozenges to clear your throat and reduce hoarseness.
  • Your voice cords may be soothed and healed by honey's antibacterial and anti-inflammatory properties.
  • Gargle with salt water.
  • Using a steam humidifier or inhaling steam might help minimize hoarseness and release mucus.
  • Reduce salt intake to minimize fluid buildup.
  • Use compression stockings, sleeves, or gloves.
  • Gently massage the affected area towards the heart.
  • Protect the swollen area from injury and keep it clean.
  • Use lotion or cream to keep the skin moisturized.

Directions for Use

  • Gonablok 200 Capsule can be taken with or without food as prescribed by the doctor.
  • Follow your doctor's instructions on the dosage and timing of this medication to ensure safety.
  • Swallow Gonablok 200 Capsule as a whole with a glass of water.
  • Do not chew, crush, or break it.

How Gonablok 200 Capsule Works

Gonablok 200 Capsule contains danazol, which works by altering hormone levels in your body. It suppresses the release of specific hormones from the brain that normally signal the ovaries to produce oestrogen. By lowering oestrogen levels, Gonablok 200 Capsule causes abnormal endometrial tissue and inflamed breast tissue to shrink and quiet down, relieving pain and inflammation. For hereditary angioedema, Gonablok 200 Capsule works differently. It prompts your liver to increase the production of a specific protein called C1 esterase inhibitor. Having more of this protein prevents the biochemical chain reactions that cause blood vessels to leak fluid into surrounding tissues, thereby stopping sudden swelling before it starts.
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Alcohol

Unsafe

Avoid or limit alcohol consumption with Gonablok 200 Capsule as it may cause shortness of breath or make you feel sick.

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Pregnancy

Unsafe

Gonablok 200 Capsule is not recommended for pregnant women as it may cause birth defects. Please consult a doctor if you are pregnant or planning for pregnancy.

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Breast Feeding

Unsafe

Gonablok 200 Capsule is contraindicated in breastfeeding women as small amounts of Gonablok 200 Capsule may be excreted in breast milk. Please consult a doctor if you are breastfeeding.

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Driving

Caution

Gonablok 200 Capsule may cause dizziness, vertigo (spinning feeling) or blurred vision. Therefore, avoid driving if you experience any of these symptoms after taking Gonablok 200 Capsule .

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Liver

Caution

Take Gonablok 200 Capsule with caution, especially if you have a history of Liver diseases/conditions. The dose may be adjusted by your doctor as required. Avoid taking Gonablok 200 Capsule if you have severe liver disease.

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Kidney

Caution

Take Gonablok 200 Capsule with caution, especially if you have a history of Kidney diseases/conditions. The dose may be adjusted by your doctor as required. Avoid taking Gonablok 200 Capsule if you have severe kidney disease.

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Children

Caution

Please consult a doctor regarding the use of Gonablok 200 Capsule in children.

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Heart

Caution

Gonablok 200 Capsule should be taken with caution in patients with heart problems. Please inform your doctor if you have any pre-existing heart problems before using Gonablok 200 Capsule .

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Geriatrics

Caution

Gonablok 200 Capsule should be given with caution in elderly patients due to an increased risk of side effects. If you have any concerns about the usage of Gonablok 200 Capsule in geriatrics, please consult your doctor.

What if I have taken an overdose of Gonablok 200 Capsule

In case of an accidental overdose, seek immediate medical attention or contact a poison control centre right away. Take the medicine container with you so the medical staff knows exactly what you have taken.

Diet & Lifestyle Advise

  • Limit caffeine and sodium: Reducing your intake of coffee, tea, chocolate, and salty foods can significantly decrease fluid retention and breast tenderness.
  • Use reliable non-hormonal birth control: Because this medicine can harm an unborn baby and hormonal birth control may not work effectively while taking it, you must use barrier methods (like condoms) to prevent pregnancy.
  • Eat a balanced, liver-friendly diet: Focus on whole foods, vegetables, and lean proteins, and avoid high-fat meals right before taking your dose unless you do so consistently, as fat greatly alters absorption.
  • Avoid alcohol completely: To minimise the risk of liver damage, do not drink alcoholic beverages while undergoing treatment with this medicine.
health query

Have a query?

How Soon It Starts Working

The time required for Gonablok 200 Capsule to start to work: The time required for Gonablok 200 Capsule to show its action is unknown. The time for which the effects of Gonablok 200 Capsule last: The effect of Gonablok 200 Capsule lasts for 24 hours.

What if you forget to take Gonablok 200 Capsule

If you miss a dose, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and resume your regular schedule. Do not take a double dose to make up for a missed one. Talk to your doctor or pharmacist if you miss multiple doses.

Storage

•Store Gonablok 200 Capsule at room temperature, ideally between 15°C and 30°C (59°F to 86°F). •Keep the medicine in its original container, tightly closed, and store it away from excess heat, moisture, and direct light—do not store it in the bathroom cabinet.

Drug Warnings

  • Monitor your voice: Check your voice daily. If you notice any hoarseness, cracking, or deepening, notify your doctor immediately, as these changes can become permanent if the medicine is not stopped.
  • Watch for signs of pregnancy: If you suspect you have become pregnant, stop taking the medicine immediately and call your doctor, as it can cause birth defects.
  • Keep your blood test appointments: Your doctor may schedule regular blood tests to monitor your liver function, cholesterol levels, and other health parameters during treatment. Do not skip these appointments.
  • Consistency is key: Do not alternate between taking this medicine with food on some days and on an empty stomach on other days, as this will cause the drug levels in your blood to fluctuate.

Drug-Drug Interactions

verifiedApollotooltip

Gonablok 200 Capsule may interact with certain medicines and alter their effects or increase the risk of side effects. Tell your doctor if you are taking:

  • Blood thinners (such as warfarin): Taking these with Gonablok 200 Capsule can increase your risk of bleeding. Your doctor may need to adjust your blood thinner dose.
  • Cholesterol medicines (statins): Combining these medicines can significantly increase your risk of severe muscle pain and damage.
  • Anti-seizure medications (such as carbamazepine): This medicine can raise the levels of anti-seizure drugs in your blood, increasing the risk of toxic side effects.
  • Immune system suppressants (such as cyclosporine): Gonablok 200 Capsule can increase the levels of these drugs in your system, potentially leading to kidney damage.

Drug-Drug Interactions

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How does the drug interact with Gonablok 200 Capsule:
Combining Gonablok 200 Capsule and Simvastatin can increase the blood levels and effects of Simvastatin.

How to manage the interaction:
Taking Gonablok 200 Capsule and Simvastatin together is not recommended as it can lead to an interaction, but it can be taken if advised by your doctor. However, if you experience any symptoms like muscle pain, tenderness, or weakness, fever or dark colored urine, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, and yellowing of the skin or eyes, contact your doctor immediately. Do not discontinue any medications without consulting your doctor.
How does the drug interact with Gonablok 200 Capsule:
Using pimozide together with Gonablok 200 Capsule may significantly increase the blood levels of pimozide.

How to manage the interaction:
Taking Gonablok 200 Capsule with Pimozide is not recommended, please consult your doctor before taking it. You should seek immediate medical attention if you develop sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations. Do not stop using any medication without doctor's advice.
DanazolHalofantrine
Severe
How does the drug interact with Gonablok 200 Capsule:
Using Halofantrine together with Gonablok 200 Capsule may increase the blood levels of Halofantrine.

How to manage the interaction:
Although there is a possible interaction between Gonablok 200 Capsule and Halofantrine, you can take these medicines together if prescribed by your doctor. However, if you experience dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations, contact a doctor right away. Do not discontinue any medications without first consulting your doctor.
How does the drug interact with Gonablok 200 Capsule:
Combining Carfilzomib with Gonablok 200 Capsule may increase the risk of liver problems.

How to manage the interaction:
Although there is a possible interaction between Gonablok 200 Capsule and Carfilzomib, you can take these medicines together if prescribed by your doctor. However, if you experience chest pain; shortness of breath; difficulty breathing; coughing up blood; sudden loss of vision; pain, redness or swelling in an arm or leg; and numbness or weakness on one side of the body, contact a doctor right away. Do not discontinue any medications without first consulting your doctor.
DanazolLomitapide
Severe
How does the drug interact with Gonablok 200 Capsule:
Combining Lomitapide with Gonablok 200 Capsule can increase the blood levels of Lomitapide.

How to manage the interaction:
Co-administration of Gonablok 200 Capsule with Lomitapide can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you experience diarrhea, nausea, stomach pain, constipation, or any other discomfort, fever, joint pain, or skin rash consult a doctor. Do not stop using any medications without first talking to your doctor.
DanazolMipomersen
Severe
How does the drug interact with Gonablok 200 Capsule:
Combining Mipomersen with Gonablok 200 Capsule may increase the risk of liver problems.

How to manage the interaction:
Co-administration of Gonablok 200 Capsule with Mipomersen can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you experience fever, chills, joint pain, swelling, bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, abdominal pain, dark urine, bleeding, or liver damage contact a doctor right away. Do not stop using any medications without first talking to a doctor.
How does the drug interact with Gonablok 200 Capsule:
Using Lovastatin together with Gonablok 200 Capsule may significantly increase the blood levels of Lovastatin.

How to manage the interaction:
Although there is a possible interaction between Gonablok 200 Capsule and Lovastatin, you can take these medicines together if prescribed by your doctor. However, if you experience a muscle tenderness, muscle pain, weakness, fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, dark-colored urine, and/or yellowing of the skin or eyes contact a doctor right away. Do not discontinue any medications without first consulting your doctor.
How does the drug interact with Gonablok 200 Capsule:
Using atorvastatin together with Gonablok 200 Capsule may significantly increase the blood levels of atorvastatin.

How to manage the interaction:
Concomitant administration of atorvastatin along with Gonablok 200 Capsule can result in an interaction, it can be taken if a doctor has advised it. However, if you experience muscle pain, tenderness, or weakness, accompanied by fever or dark colored urine, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, dark colored urine, light colored stools, and/or yellowing of the skin or eyes, you should consult the doctor. Do not stop taking any medication without doctor's advice.
How does the drug interact with Gonablok 200 Capsule:
Combining Leflunomide with Gonablok 200 Capsule may increase the risk of liver problems.

How to manage the interaction:
Co-administration of Gonablok 200 Capsule with Teriflunomide can result in an interaction, but it can be taken if your doctor has advised it. If you have any of these symptoms fever, chills, joint pain, swelling, bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, abdominal pain, dark-colored urine, or unusual bleeding contact a doctor right away. Do not stop using any medications without a doctor's advice.
How does the drug interact with Gonablok 200 Capsule:
Using cisapride together with Gonablok 200 Capsule may significantly increase the blood levels of cisapride.

How to manage the interaction:
Although there is a possible interaction between Gonablok 200 Capsule and Cisapride, you can take these medicines together if prescribed by your doctor. However, if you experience dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations, contact a doctor right away. Do not discontinue any medications without first consulting your doctor.

Drug-Food Interactions

verifiedApollotooltip

Certain foods may affect how Gonablok 200 Capsule is absorbed. Follow your doctor's advice on taking it consistently with or without food.

  • High-fat meals: Eating a meal high in fat right before taking your dose significantly increases how much medicine your body absorbs, which can increase side effects. Always take your dose the same way every day.
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

No

Therapeutic Class

[SYNTHETIC ANABOLIC STEROID]

FAQs

Gonablok 200 Capsule contains Danazol that works by suppressing the activity of ovaries. Thus, it decreases the amount of oestrogen in the body and induces temporary menopause. Thereby, it shrinks the tissue outside the uterus or stops its growth.
No. You should avoid becoming pregnant while taking Gonablok 200 Capsule because it may harm an unborn baby. Hormonal contraceptives, including birth control pills, may be less effective during treatment. Use a reliable non-hormonal method of contraception, such as condoms, a copper intrauterine device (IUD), or another method recommended by your doctor, throughout treatment and for the period advised after stopping the medicine.
Gonablok 200 Capsule may be used to treat breast lumps when other treatments have not worked. Gonablok 200 Capsule inhibits the release of hormones in the body that cause breast pain and lumps.
Gonablok 200 Capsule may cause changes in blood sugar levels. Therefore, it is advised to regularly monitor blood sugar levels while taking Gonablok 200 Capsule and inform your doctor if you have diabetes before taking Gonablok 200 Capsule .
You are not recommended to take Gonablok 200 Capsule with simvastatin as it may increase the levels of simvastatin in the blood and increase the risk of liver damage and rhabdomyolysis (breakdown of skeletal muscle tissue). However, please consult a doctor before taking Gonablok 200 Capsule with other medicines.
Gonablok 200 Capsule is not recommended for patients suffering from severe liver disease as it may worsen the condition. Therefore, inform your doctor if you have any liver disease before taking Gonablok 200 Capsule .
Gonablok 200 Capsule is used to treat endometriosis (tissue lining the uterus grows outside the uterus) and breast cysts.
Gonablok 200 Capsule may cause side effects such as hoarse voice, sore throat, stomach pain, hair loss, skin rashes, chest pain and excessive hair growth on face or body. If these side effects persist or worsen, please consult your doctor.
Yes. Gonablok 200 Capsule may cause your periods to become irregular or stop while you are taking it. Your menstrual cycle usually returns within a few months after treatment ends, although symptoms of endometriosis may return in some people. Your doctor will discuss the best long-term treatment plan based on your condition.
It can cause voice deepening or hoarseness. If you notice any changes in your voice, you must tell your doctor immediately, as these changes can become permanent if the medication is continued. Talk to your doctor.
It is strongly recommended that you avoid alcohol while taking this medicine, as both alcohol and the medication put stress on your liver, increasing the risk of liver damage. Talk to your doctor.
Your doctor will order regular blood tests to monitor your liver function and check your cholesterol levels, ensuring the medicine is not causing underlying health issues. Talk to your doctor.
Yes, it is a synthetic hormone derived from an androgen (a male hormone). It works by suppressing female hormones to treat conditions like endometriosis and breast pain. Talk to your doctor.
You must seek immediate medical attention, as this medicine can occasionally cause a serious increase in pressure inside the skull, which requires prompt medical evaluation. Talk to your doctor.

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Country of origin

INDIA

Manufacturer/Marketer address

1309, 14th Floor, Madi Tower, 98, Nehru Place, New Delhi, Delhi 110019
Other Info - GON0004
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