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compositionComposition:FOLLITROPIN ALFA-450IU
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GONAL F 450IU PEN INJECTION 0.75ML is used to treat female infertility and hypogonadism in men. It contains Follitropin alfa which acts by inducing the ovulation procedure in women and sperm production in men. In some cases, this medicine may cause side effects such as headache, vomiting, diarrhoea, abdominal cramps, and injection site reactions. Inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.

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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Bayyarapu Mahesh Kumar , M Pharmacy
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More about the Product

Composition :

FOLLITROPIN ALFA-450IU

Manufacturer/Marketer :

Merck Ltd

Consume Type :

Parenteral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About GONAL F 450IU PEN INJECTION 0.75ML

GONAL F 450IU PEN INJECTION 0.75ML is an injectable hormonal medication used to treat infertility in individuals who are having difficulty conceiving. It provides a synthetic form of follicle-stimulating hormone, which is responsible for stimulating the ovaries to produce and mature healthy eggs. In certain cases, it is also prescribed to men to help stimulate the production of healthy sperm.

GONAL F 450IU PEN INJECTION 0.75ML is typically injected daily, and it is crucial to use it consistently at the same time each day to maintain stable hormone levels. Because it is given as an injection under the skin, food does not affect how well it works, meaning you can take it with or without meals. Making healthy lifestyle choices, such as maintaining a balanced weight and eating nutrient-dense foods, can further support the effectiveness of your treatment plan.

While taking GONAL F 450IU PEN INJECTION 0.75ML, you may experience mild, temporary reactions like headaches or irritation at the injection site. However, it is vital to contact your doctor immediately if you experience severe abdominal pain, sudden bloating, rapid weight gain, or shortness of breath. These symptoms can be warning signs of a serious condition affecting your ovaries that requires prompt medical evaluation.

Do not take this if you are already pregnant, have primary ovarian failure, or have untreated thyroid or adrenal gland disorders. It is also not suitable for individuals with tumors of the breast, uterus, ovaries, or brain structures like the hypothalamus or pituitary gland. Always talk to your doctor about your complete medical history before starting this medication to ensure it is safe for you.

This medication can interact with other fertility drugs, which may increase the risk of overstimulating your ovaries. It is recommended to avoid alcohol and smoking during treatment, as both can significantly lower your chances of a successful pregnancy. If you are breastfeeding, or have questions about how GONAL F 450IU PEN INJECTION 0.75ML affects specific age groups, talk to your doctor or pharmacist.

Uses of GONAL F 450IU PEN INJECTION 0.75ML

GONAL F 450IU PEN INJECTION 0.75ML is used in the treatment of Female infertility and hypogonadism in men. The detailed uses of GONAL F 450IU PEN INJECTION 0.75ML are as follows:

  • Female infertility: GONAL F 450IU PEN INJECTION 0.75ML helps by stimulating the ovaries to develop and release mature eggs in women who do not ovulate naturally.
  • Male hypogonadotropic hypogonadism: GONAL F 450IU PEN INJECTION 0.75ML helps by stimulating sperm production in men who have low levels of the natural hormones required for reproductive health.
  • Assisted Reproductive Technology (ART): GONAL F 450IU PEN INJECTION 0.75ML helps by encouraging the growth of multiple follicles (eggs) in women undergoing fertility procedures such as in vitro fertilization (IVF).

Key Benefits

GONAL F 450IU PEN INJECTION 0.75ML helps support fertility by stimulating normal reproductive processes in women and men with certain hormone-related fertility problems. By promoting egg or sperm development, it improves the chances of successful conception under specialist supervision.
Benefits may include:

  • Supports the growth and maturation of eggs in women undergoing fertility treatment.
  • May increase the chances of successful ovulation and pregnancy when used as prescribed.
  • Helps obtain multiple mature eggs during assisted reproductive procedures such as IVF.
  • Supports sperm production in men with certain hormone-related fertility disorders.
  • May improve sperm count and quality with appropriate treatment.
  • Supports family planning goals under the guidance of a fertility specialist.

Directions for Use

  • Your doctor will determine the dosage and timing of GONAL F 450IU PEN INJECTION 0.75ML based on your specific condition and response to treatment.
  • Your doctor or nurse will administer your first dose of GONAL F 450IU PEN INJECTION 0.75ML under the skin (subcutaneous) and may instruct you on self-administration.
  • If you are administering GONAL F 450IU PEN INJECTION 0.75ML to yourself, please follow the labelled instructions carefully.

How GONAL F 450IU PEN INJECTION 0.75ML Works

GONAL F 450IU PEN INJECTION 0.75ML contains a highly purified form of recombinant follicle-stimulating hormone (FSH). In a typical reproductive system, the pituitary gland releases FSH to signal the ovaries to mature an egg. When injected, GONAL F 450IU PEN INJECTION 0.75ML acts just like your body's natural FSH, binding to receptors in the ovaries to trigger the growth and maturation of fluid-filled sacs called follicles, which contain the eggs. In men, FSH is essential for signaling the Sertoli cells within the testes. By injecting GONAL F 450IU PEN INJECTION 0.75ML, the testes are stimulated to begin and maintain spermatogenesis, which is the process of creating healthy, functional sperm. Because GONAL F 450IU PEN INJECTION 0.75ML acts directly on the target reproductive organs, it allows for precise medical control over follicle and sperm development.
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Alcohol

Consult your doctor

It is unknown whether GONAL F 450IU PEN INJECTION 0.75ML interacts with alcohol. Please consult your doctor.

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Pregnancy

Unsafe

Do not use GONAL F 450IU PEN INJECTION 0.75ML if you are pregnant. You may need to have a negative pregnancy test before starting this treatment.

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Breast Feeding

Unsafe

Do not use GONAL F 450IU PEN INJECTION 0.75ML if you are breastfeeding.

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Driving

Safe

GONAL F 450IU PEN INJECTION 0.75ML may not affect your ability to drive.

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Liver

Caution

If you have a pre-existing or a history of liver disease, inform your doctor before receiving GONAL F 450IU PEN INJECTION 0.75ML.

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Kidney

Caution

If you have a pre-existing or a history of kidney disease, inform your doctor before receiving GONAL F 450IU PEN INJECTION 0.75ML. Your doctor may adjust the dose of this medicine or prescribe a suitable alternative based on your condition.

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Children

Unsafe

GONAL F 450IU PEN INJECTION 0.75ML is not recommended for use in children.

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Heart

Consult your doctor

Please inform your doctor if you have a history of heart disease before using GONAL F 450IU PEN INJECTION 0.75ML. Your doctor will prescribe it only if the benefits outweigh the risks.

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Geriatrics

Consult your doctor

Limited information available for use of GONAL F 450IU PEN INJECTION 0.75ML in elderly patients. Please consult your doctor.

What if I have taken an overdose of GONAL F 450IU PEN INJECTION 0.75ML

If you accidentally inject more than your prescribed dose, seek immediate medical attention or contact a poison control center right away, as an overdose can increase your risk of severe ovarian complications.

Diet & Lifestyle Advise

  • Follow a nutrient-rich diet: Eat a balanced diet rich in antioxidants, leafy green vegetables, whole grains, and healthy fats such as avocados and olive oil to help support reproductive health.
  • Avoid smoking and limit alcohol: Do not smoke and limit alcohol consumption, as both can reduce egg and sperm quality and may lower the success of fertility treatment.
  • Stay physically active: Engage in gentle, low-impact activities such as walking or yoga, but avoid strenuous high-impact exercise during active ovarian stimulation unless advised by your doctor.
  • Stay well hydrated: Drink plenty of water throughout your treatment cycle to help manage mild bloating and support your body's normal functions.
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Have a query?

How Soon It Starts Working

The time required for GONAL F 450IU PEN INJECTION 0.75ML to start to work: The time required for GONAL F 450IU PEN INJECTION 0.75ML to show its action is unknown. The time for which the effects of GONAL F 450IU PEN INJECTION 0.75ML last: The duration of action for GONAL F 450IU PEN INJECTION 0.75ML is clinically unknown.

What if you forget to take GONAL F 450IU PEN INJECTION 0.75ML

If you miss a dose, do not inject a double dose to make up for the missed one. Contact your fertility clinic or pharmacist immediately for specific instructions on how to adjust your schedule.

Storage

• Store unopened GONAL F 450IU PEN INJECTION 0.75ML pens or vials in the refrigerator between 2°C and 8°C. • Do not freeze this medication, and discard any product that has been frozen.
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Keep Refrigerated. Do not freeze.Prepaid payment required.

Drug Warnings

  • Inspect the solution before use: Always check the solution before injecting. It should be completely clear and colorless. Do not use it if it appears discolored or contains visible particles.
  • Rotate injection sites regularly: Keep a record of your injection times, doses, and injection sites to help rotate sites properly and reduce the risk of skin irritation or bruising.
  • Do not reuse or share injection equipment: Never reuse needles or share your injection pen or syringe with anyone else, as this may increase the risk of infection and contamination.
  • Attend regular monitoring appointments: Keep all scheduled ultrasound scans and blood tests so your doctor can monitor your response to treatment and help prevent complications.

Drug-Drug Interactions

verifiedApollotooltip
  • Other ovulation-inducing medicines (e.g., hCG, clomiphene): Taking these medicines alongside GONAL F 450IU PEN INJECTION 0.75ML may overstimulate the ovaries and increase the risk of ovarian hyperstimulation syndrome (OHSS).
No Drug - Drug interactions found in our data. We may lack specific data on this medicine and are actively working to update our database. Consult your doctor for personalized advice

Drug-Drug Interactions

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Drug-Food Interactions

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No clinically significant food interactions are known with GONAL F 450IU PEN INJECTION 0.75ML when used as directed.

No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

No

Therapeutic Class

[FERTILITY DRUG]

FAQs

GONAL F 450IU PEN INJECTION 0.75ML is used to treat female infertility.
GONAL F 450IU PEN INJECTION 0.75ML contains ‘Follitropin alfa’, which develops and ripens several follicles (containing an egg) and induces the ovulation procedure (releasing an egg from the ovary). An egg must be released from the ovary to get fertilized by a sperm cell to get pregnant.
If you undergo a blood or urine test to detect pregnancy within 10 days of using GONAL F 450IU PEN INJECTION 0.75ML, there may be a chance of false-positive test results.
The common side effects of GONAL F 450IU PEN INJECTION 0.75ML are headache, pain, and redness at the injection site. These side effects are usually mild and temporary. However, immediately inform your doctor if any of these side effects persist or worsen.
GONAL F 450IU PEN INJECTION 0.75ML should not be used in patients who have a tumor in the pituitary gland or hypothalamus (parts of the brain), ovarian cysts (fluid-filled sacs in ovaries), unexplained vaginal bleeding, cancer of ovaries, womb, or breast, blood clotting problems, menopause, premature ovarian failure (early menopause or dysfunction of sexual organs).
In most cases, female infertility can be cured by medicines, surgery, or assisted reproductive technology (ART), such as in-vitro fertilization (IVF) or a combination of these treatments. The doctor will suggest a suitable treatment depending on the cause of infertility.
GONAL F 450IU PEN INJECTION 0.75ML is given by a healthcare professional such as doctor or a nurse as a subcutaneous (under the skin) injection. The dosage of GONAL F 450IU PEN INJECTION 0.75ML will be determined by your doctor based on your specific condition and response to therapy. Do not self-administer.
If you miss a dose of GONAL F 450IU PEN INJECTION 0.75ML, contact your doctor as soon as possible. They will advise you on the best course of action, which may include rescheduling the missed dose or adjusting your treatment plan.
Severe stomach pain, especially when accompanied by rapid weight gain or nausea, can be a sign of Ovarian Hyperstimulation Syndrome (OHSS). Stop using the medication and call your doctor or seek emergency medical care immediately. Talk to your doctor if you feel any unusual discomfort.
Yes, because GONAL F 450IU PEN INJECTION 0.75ML stimulates your ovaries to mature multiple eggs, the risk of a multiple pregnancy (such as twins, triplets, or more) is significantly higher than with natural conception. Talk to your doctor to understand the risks and monitoring steps involved.
No, GONAL F 450IU PEN INJECTION 0.75ML is not safe to use during pregnancy. If you find out you are pregnant or suspect you might be, stop taking the medication immediately. Talk to your doctor for guidance.
A typical treatment cycle of daily injections usually lasts between 7 to 14 days, depending on how quickly your follicles develop. Your doctor will monitor your progress with frequent blood tests and ultrasounds. Talk to your doctor for a personalized timeline.
It is highly recommended to avoid or strictly limit alcohol while undergoing fertility treatments. While alcohol does not directly stop the medicine from working, it can negatively impact egg quality and overall reproductive success. Talk to your doctor for specific advice.
The most common and comfortable areas to inject GONAL F 450IU PEN INJECTION 0.75ML are the fatty tissue of the lower abdomen (avoiding the immediate area around your belly button) or the front of your thigh. Remember to rotate your injection site daily. Talk to your doctor or nurse if you are unsure where to inject.
In men, this hormone therapy is used to stimulate the cells in the testes responsible for producing healthy, active sperm. It is typically prescribed to men who have low hormone levels causing fertility issues. Talk to your doctor to see if this treatment is suitable for you.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Country of origin

INDIA

Manufacturer/Marketer address

L-2, J.R. Complex, Gate No. 4, Village Mandoli, Delhi-110 093, India
Other Info - GON0009
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