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compositionComposition:ANTITHYMOCYTE IMMUNOGLOBULIN-20MG
prescriptionPrescription Medicine
Grafalon 5Ml Inj

Grafalon 5Ml Inj is used to prevent and treat acute rejection in patients receiving a kidney transplant. It may also treat aplastic anaemia in patients unsuitable for bone marrow transplantation. It contains Antithymocyte immunoglobulin, which lowers specific cells within the immune system that are likely to attack the transplanted kidney. It helps to stop the body's immune system from rejecting the new kidney.

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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

ANTITHYMOCYTE IMMUNOGLOBULIN-20MG

Manufacturer/Marketer :

Cadila Healthcare Ltd

Consume Type :

Parenteral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Grafalon 5Ml Inj

Grafalon 5Ml Inj belongs to the group of medicines called immunosuppressants indicated for the prevention and treatment of acute rejection in patients receiving a kidney transplant. It may also be used to treat aplastic anaemia in patients unsuitable for bone marrow transplantation.

Grafalon 5Ml Inj contains antithymocyte immunoglobulin, which works by preventing the white blood cells within the immune system that are likely to attack the transplanted kidney. It helps to stop the body's immune system from rejecting the new kidney.

In some cases, Grafalon 5Ml Inj may cause side effects such as fever, chills, low white blood cell count, low platelet count, blood clotting problems, and skin rash. Do not be reluctant to talk with your doctor if any of the side effects persist or worsen.

Let the doctor know if you are allergic to any of the components in Grafalon 5Ml Inj. Consult the doctor Grafalon 5Ml Inj if you are pregnant. Avoid breastfeeding during treatment. Keep the doctor informed about your health condition and medications to rule out any side effects/interactions.

Uses of Grafalon 5Ml Inj

Grafalon 5Ml Inj is used in the prevention and treatment of Kidney transplant rejection and aplastic anaemia. The detailed uses of Grafalon 5Ml Inj are as follows:

  • Prevent kidney transplant rejection: Grafalon 5Ml Inj is used to prevent and treat acute rejection episodes in patients who have undergone a renal (kidney) transplant, especially when other treatments are not effective.
  • Treat moderate to severe aplastic anemia: Grafalon 5Ml Inj is prescribed for patients with aplastic anemia who are not suitable candidates for a bone marrow transplant. It helps by suppressing the immune system’s attack on bone marrow cells.
  • Immunosuppressive therapy: Grafalon 5Ml Inj reduces the number of active T-cells in the body. This makes it useful in conditions where immune suppression is required to protect transplanted organs or manage autoimmune condition.

Key Benefits

Grafalon 5Ml Inj belongs to the group of medicines called immunosuppressants indicated for preventing and treating acute rejection in patients receiving a kidney transplant. It may also be used to treat aplastic anaemia in patients unsuitable for bone marrow transplantation. Grafalon 5Ml Inj contains Antithymocyte immunoglobulin, which lowers certain cells within the immune system that are likely to attack the transplanted kidney. It helps to stop the body's immune system from rejecting the new kidney.

Side effects of Grafalon 5Ml Inj
Managing Medication-Triggered UTIs: A Comprehensive Approach:
  • Inform your doctor about the medication you're taking and the UTI symptoms you're experiencing.
  • Your doctor may adjust your medication regimen or consider alternative medications or dosages that may reduce the risk of UTIs.
  • Drink plenty of water (at least 8-10 glasses a day) to help flush out bacteria. Avoid sugary drinks and caffeine, which can exacerbate UTI symptoms.
  • Urinate when you feel the need rather than holding it in. This can help prevent bacterial growth and reduce the risk of UTIs.
  • Consider cranberry supplements: Cranberry supplements may help prevent UTIs by preventing bacterial adhesion.
  • Monitor UTI symptoms and report any changes to your doctor.
  • If antibiotics are prescribed, take them as directed and complete the full course.
  • Drink water or other clear fluids.
  • To prevent worsening of pain, limit intake of tea, coffee, or alcohol.
  • Include bland foods like rice, toast, crackers, and rice in your diet.
  • Avoid lying down immediately after eating as it may cause indigestion or heartburn.
  • Avoid acidic and spicy food as it may cause indigestion.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
Here are the seven steps to manage medication-triggered Dyspnea (Difficulty Breathing or Shortness of Breath):
  • Tell your doctor immediately if you experience shortness of breath after taking medication.
  • Your doctor may adjust the medication regimen or dosage or give alternative medical procedures to minimize the symptoms of shortness of breath.
  • Monitor your oxygen levels and breathing rate regularly to track changes and potential side effects.
  • For controlling stress and anxiety, try relaxation techniques like deep breathing exercises, meditation, or yoga.
  • Make lifestyle changes, such as quitting smoking, exercising regularly, and maintaining a healthy weight.
  • Seek emergency medical attention if you experience severe shortness of breath, chest pain, or difficulty speaking.
  • Follow up regularly with your doctor to monitor progress, adjust treatment plans, and address any concerns or questions.
Here's a comprehensive approach to managing medication-triggered fever:
  • Inform your doctor immediately if you experience a fever after starting a new medication.
  • Your doctor may adjust your medication regimen or dosage as needed to minimize fever symptoms.
  • Monitor your body temperature to monitor fever progression.
  • Drink plenty of fluids, such as water or electrolyte-rich beverages, to help your body regulate temperature.
  • Get plenty of rest and engage in relaxation techniques, such as deep breathing or meditation, to help manage fever symptoms.
  • Under the guidance of your doctor, consider taking medication, such as acetaminophen or ibuprofen, to help reduce fever.
  • If your fever is extremely high (over 103°F), or if you experience severe symptoms such as confusion, seizures, or difficulty breathing, seek immediate medical attention.
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
Managing Medication-Triggered Anxiety: A Comprehensive Approach:
  • Inform your doctor about your anxiety symptoms so that you doctor may explore potential drug interactions and alter your treatment plan.
  • Work with your doctor to adjust your medication regimen or dosage to minimize anxiety symptoms.
  • Reduce anxiety symptoms by practicing relaxation techniques like meditation, deep breathing, or yoga.
  • Regular self-care activities, such as exercise, healthy food, and adequate sleep, can assist control anxiety.
  • Surround yourself with a supportive network of friends, family, or a support group to help manage anxiety and stay motivated.
  • Regularly track anxiety symptoms and report any changes to your doctor to ensure your treatment plan is effective and adjusted as needed.

Directions for Use

  • Follow your doctor's instructions on the dosage and timing of this medication.
  • Grafalon 5Ml Inj will be administered by a healthcare professional.
  • Do not self-administer it.

How Grafalon 5Ml Inj Works

Grafalon 5Ml Inj contains antithymocyte immunoglobulin, which works by preventing the white blood cells within the immune system that are likely to attack the transplanted kidney. It helps to stop the body's immune system from rejecting the new kidney.
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Alcohol

Consult your doctor

It is not known if alcohol affects Grafalon 5Ml Inj. Please consult your doctor.

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Pregnancy

Caution

Consult the doctor if you are pregnant, think you may be pregnant or are planning for pregnancy. Your doctor will prescribe only if the benefits outweigh the risks.

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Breast Feeding

Unsafe

Avoid breastfeeding whilst on treatment with Grafalon 5Ml Inj. Seek medical advice before taking this medicine if you want to breastfeed your child.

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Driving

Caution

Do not drive or operate heavy machinery after the treatment with Grafalon 5Ml Inj as it may cause side effects. ask your doctor for more information.

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Liver

Consult your doctor

If you have a pre-existing or a history of liver disease, inform your doctor before receiving Grafalon 5Ml Inj.

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Kidney

Consult your doctor

If you have a pre-existing or a history of kidney disease, inform your doctor before receiving Grafalon 5Ml Inj.

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Children

Consult your doctor

Information about the use of Grafalon 5Ml Inj in children is limited. Consult the doctor if you have any concerns.

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Heart

Consult your doctor

Please inform your doctor if you have any pre-existing heart problems before using Grafalon 5Ml Inj. Your doctor will prescribe Grafalon 5Ml Inj if the benefits outweigh the risk.

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Geriatrics

Consult your doctor

Please consult a doctor before administering Grafalon 5Ml Inj to geriatric patients, as limited safety data is available for this age group.

What if I have taken an overdose of Grafalon 5Ml Inj

As Grafalon 5Ml Inj is a parenteral formulation, the chance of overdose may be less. If you think there has been an overdose or experiencing any adverse events, get medical care right away.

Diet & Lifestyle Advise

  • Eat a healthy diet and exercise regularly to maintain proper weight.
  • Avoid smoking and alcohol consumption.
  • Avoid fast food, fried food, processed meats, refined carbs and added sugar.
  • Get optimal sleep; rest well.

Have a query?

How Soon It Starts Working

The time required for Grafalon 5Ml Inj to start to work: Grafalon 5Ml Inj ideally shows its action within 24 hours after administration. The time for which the effects of Grafalon 5Ml Inj last: The effect of Grafalon 5Ml Inj lasts for 1 year.

What if you forget to take Grafalon 5Ml Inj

Grafalon 5Ml Inj is typically administered by a doctor or nurse, so missed doses are unlikely. If you think you've missed a dose, inform your doctor or nurse immediately. For further questions, consult your doctor or nurse.

Storage

• Store in a cool and dry place away from sunlight. • Keep Grafalon 5Ml Inj out of reach and sight of children. • Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.
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Keep Refrigerated. Do not freeze.Prepaid payment required.

Drug Warnings

Do not use Grafalon 5Ml Inj if you are allergic to any of its components. Inform the doctor if you have any active infection. Consult the doctor if you are pregnant or think you may be pregnant. Avoid/discontinue breastfeeding during treatment with Grafalon 5Ml Inj. Seek medical attention if you experience symptoms of cytokine release syndrome (fever, chills, headache, chest pain, low blood pressure, shortness of breath, fast breathing, and swelling), infusion-associated reactions (generalised rash, fast heart rate, shortness of breath, and low blood pressure), or serum sickness (rash, joint pain, fever, chills, and pain). Let the doctor know if you are taking any other medicines, including supplements and herbal products.

Drug-Drug Interactions

verifiedApollotooltip

Drug-Drug Interactions: No interactions found/established.

Drug-Food Interactions: No interactions found/established.

Drug-Disease Interactions: No interactions found/established.

Antithymocyte GlobulinClozapine
Severe
Antithymocyte GlobulinBaricitinib
Severe

Drug-Drug Interactions

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Antithymocyte GlobulinClozapine
Severe
How does the drug interact with Grafalon 5Ml Inj:
Co-administration of Antithymocyte Globulin and Clozapine may increase the effect of neutropenia.

How to manage the interaction:
Although taking Antithymocyte Globulin and Clozapine together can evidently cause an interaction, it can be taken if your doctor has suggested it. If you notice any signs of infection like fever, chills, or sore throat, or if you have any other symptoms like diarrhea or muscle aches, make sure to contact your doctor right away. Do not stop using any medications without first talking to your doctor.
Antithymocyte GlobulinBaricitinib
Severe
How does the drug interact with Grafalon 5Ml Inj:
Taking Antithymocyte Globulin with Baricitinib can increase the risk of developing serious infections as well as some cancers over time.

How to manage the interaction:
Taking Antithymocyte Globulin with Baricitinib together can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, red or irritated skin, body sores, and discomfort or burning when you urinate, consult a doctor. Do not stop using any medications without a doctor's advice.
Antithymocyte GlobulinEtanercept
Severe
How does the drug interact with Grafalon 5Ml Inj:
When Etanercept is used with Antithymocyte Globulin, the likelihood or severity of infection may increase.

How to manage the interaction:
Although there is a possible interaction between Antithymocyte Globulin and Etanercept, you can take these medicines together if prescribed by a doctor. However, if you develop fever, chills, diarrhea, sore throat, muscular pains, shortness of breath, blood in phlegm, weight loss, red or irritated skin, body sores, or discomfort or burning during urination, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.
Antithymocyte GlobulinTofacitinib
Severe
How does the drug interact with Grafalon 5Ml Inj:
Using tofacitinib together with antithymocyte globulin can increase the risk of serious infections.

How to manage the interaction:
Taking Antithymocyte Globulin with Tofacitinib together can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you experience fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, weight loss, pain or burning during urination contact your doctor. Do not discontinue any medications without consulting your doctor.

Drug-Food Interactions

verifiedApollotooltip
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

No

Therapeutic Class

[IMMUNOSUPPRESSANTS]

FAQs

Grafalon 5Ml Inj is used to prevent and treat acute rejection in patients receiving a kidney transplant. It may also treat aplastic anaemia in patients unsuitable for bone marrow transplantation.

Grafalon 5Ml Inj helps to stop your body's immune system from rejecting the new kidney.

Due to immunosuppressive effects, infections have been reported during treatment with Grafalon 5Ml Inj. Careful patient monitoring and appropriate anti-infective prophylaxis are recommended. Consult the doctor immediately if you notice signs of infections such as fever, chills, pale skin, shortness of breath, tiredness, or mouth sores.

Concomitant use of Grafalon 5Ml Inj with live vaccines is not advised, as live vaccines may interfere with Grafalon 5Ml Inj treatment. Talk to the doctor if you are undergoing any vaccination.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Country of origin

India

Manufacturer/Marketer address

Sarkhej-Dholka Road, Bhat, Ahmedabad-382 210, INDIA.
Other Info - GRA0243

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