Grafotas-50 Capsule 5's
MRP ₹289
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About Grafotas-50 Capsule
Grafotas-50 Capsule belongs to a group of medications called 'immunosuppressants,' primarily used to prevent organ rejection after a transplant. It is also used to treat symptoms associated with psoriasis and rheumatoid arthritis.
Grafotas-50 Capsule contains 'cyclosporine,' which works by suppressing the immune system, thereby stopping your body from rejecting a new organ. It also reduces rapid skin cell growth and lowers pain and inflammation in the joints.
Grafotas-50 Capsule may cause side effects like headaches, vomiting, nausea, loss of appetite and diarrhoea. Most of these side effects do not require medical attention and resolve over time. However, consult your doctor if the side effects persist or worsen.
To treat your condition effectually, continue taking Grafotas-50 Capsule for as long as your doctor has prescribed. Inform your doctor about your health condition and any medications you are taking to help rule out any potential/unpleasant side effects.
Uses of Grafotas-50 Capsule
Grafotas-50 Capsule is used to prevent organ rejection and treat psoriasis and rheumatoid arthritis. The detailed uses of Grafotas-50 Capsule are as follows:
- Treatment of Organ Transplant Rejection: Grafotas-50 Capsule is used in the prevention of organ transplant rejection after liver, kidney, pancreas, lungs, heart, skin, and bone marrow transplants.
- Treatment of Psoriasis: Grafotas-50 Capsule is used in the treatment of psoriasis. It helps reduce rapid skin cell growth and inflammation caused by psoriasis.
- Treatment of Rheumatoid Arthritis: Grafotas-50 Capsule is used in the treatment of rheumatoid arthritis. It helps reduce pain and inflammation in the joints and slows down joint damage.
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Directions for Use
- Grafotas-50 Capsule can be taken with or without food as advised by your doctor.
- Follow your doctor's instructions on the dosage and timing of this medication to ensure safety.
- Check the label for directions and use as advised by your doctor.
- Measure the prescribed dose of Grafotas-50 Capsule using the dosing syringe. Mix it with apple or orange juice, stir well, and drink immediately.
- Do not store the prepared mixture for later use.
Key Benefits
- Grafotas-50 Capsule suppresses the immune system to prevent the rejection of transplanted organs (e.g., kidney, liver, heart).
- It is also used in bone marrow and stem cell transplantation to prevent graft rejection.
- Grafotas-50 Capsule helps control immune overactivity in various autoimmune conditions by blocking immune cells that attack the body’s own tissues.
- It reduces rapid skin cell growth and inflammation in severe psoriasis, leading to clearer skin and symptom relief.
- This medicine reduces joint pain, inflammation, and slows down joint damage in patients with active rheumatoid arthritis unresponsive to other therapies.
- It may also be used to treat severe atopic dermatitis, especially in patients who do not respond adequately to topical treatments.
- Helps manage severe inflammatory eye diseases that can threaten vision by reducing immune-mediated damage.
- It is used in certain cases of nephrotic syndrome (a kidney disorder causing excess protein loss in urine), especially when other treatments fail.
How Grafotas-50 Capsule Works
Storage
- Get plenty of fresh air.
- Take regular sips of a cold drink.
- Take ginger containing foods like ginger tea and ginger biscuits.
- Do not take heavy meals at a time, take small and frequent meals.
- Confusion is a major psychotic disorder that needs immediate medical attention.
- Acknowledge your experience and put effort to control confusion.
- Avoid smoking and alcohol intake as it can worsen the condition and increase your confusion.
- Practice meditation and yoga to avoid anxiety, which can be one of the leading causes.
- Talk to your dietician and consume food that can improve your mental health.
- Using a cold compress may help relieve itching and inflammation associated with conjunctivitis.
- A warm compress and washing the eyes with water can help with crusting on the eyelids.
- Avoid wearing contact lens until you feel better; use spectacles instead.
- Do not rub the eyes.
- Practise good hand hygiene and avoid touching the eyes to prevent the spread of infection.
- Reduce salt intake to minimize fluid buildup.
- Use compression stockings, sleeves, or gloves.
- Gently massage the affected area towards the heart.
- Protect the swollen area from injury and keep it clean.
- Use lotion or cream to keep the skin moisturized.
- Increase protein intake by eating protein-rich foods like eggs, fish, lean meat, beans, and nuts to support nail strength.
- Include biotin-rich foods like salmon, avocado, bananas, almonds, and whole grains in your diet to promote nail health.
- Boost iron intake by consuming iron-rich foods like spinach, red meat, lentils, and fortified cereals to prevent iron deficiency.
- Moisturize your nails and cuticles regularly by applying cuticle oil or hand cream multiple times a day.
- Keep your nails short to reduce the risk of breakage and snagging.
- Avoid biting your nails, as it can cause significant damage to your nails and cuticles.
- Consider taking biotin supplements after consulting your doctor, as they may help strengthen brittle nails.
What if I have taken an overdose of Grafotas-50 Capsule
Drug Warnings
- Do not take Grafotas-50 Capsule if you are allergic to any of the components.
- Let your doctor know before using Grafotas-50 Capsule if you have/had liver or kidney problems, epilepsy, high blood pressure, low levels of magnesium, high levels of potassium, cancer, or infection.
- Grafotas-50 Capsule may make you more susceptible to infections; consult your doctor if you develop any signs of severe conditions such as fever, sore throat, breathlessness, jaundice, unexplained bleeding, or bruising.
- Before taking Grafotas-50 Capsule, inform your doctor if you have any type of cancer.
- Consult your doctor before taking Grafotas-50 Capsule if you are pregnant or planning for pregnancy.
- Grafotas-50 Capsule should not be taken by breastfeeding mothers as it passes into breast milk.
- Inform your doctor about your health condition and medicines to rule out any unpleasant side effects.
Drug-Drug Interactions
Drug-Drug Interactions
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Taking cyclosporine with cidofovir can increase the risk of kidney problems.
How to manage the interaction:
Taking Grafotas-50 Capsule with Cidofovir is not recommended, but can be taken be together if prescribed by a doctor. However, if you experience nausea, vomiting, loss of hunger, increased or decreased urination, sudden weight gain or weight loss, swelling, shortness of breath, bone pain, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm, contact the doctor immediately. Do not discontinue any medications without consulting a doctor
When Bosentan is taken with Cyclosporine, it may increase the risk of side effects.
How to manage the interaction:
Taking Grafotas-50 Capsule with Bosentan is not recommended, but it can be taken if prescribed by the doctor. However, if you experience any symptoms like severe headache, nausea, or an increased heart rate, consult the doctor immediately. Do not stop using any medications without talking to a doctor.
Co-administration of Baricitinib with Cyclosporine can increase the risk of infections as well as some cancers.
How to manage the interaction:
Taking Grafotas-50 Capsule with Baricitinib is not recommended as it can cause an interaction, but it can be taken together if prescribed by a doctor. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning sensation when you urinate, consult a doctor. Do not stop using any medications without a doctor's advice.
Combining Grafotas-50 Capsule and Simvastatin can increase the blood levels and effects of Simvastatin. This can increase the risk of side effects such as liver damage and rhabdomyolysis(involves the breakdown of skeletal muscle tissue).
How to manage the interaction:
Taking Grafotas-50 Capsule and Simvastatin together is not recommended as it can lead to an interaction, but it can be taken if advised by your doctor. However, if you experience any symptoms like muscle pain, tenderness, or weakness, fever or dark colored urine, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of hunger, weakness, nausea, vomiting, and yellowing of the skin or eyes, contact the doctor immediately. Do not discontinue any medications without consulting your doctor.
Coadministration of pitavastatin with Grafotas-50 Capsule may significantly increase the blood levels of pitavastatin which can increase the risk of side effects such as liver problems and rhabdomyolysis(involves the breakdown of skeletal muscle tissue).
How to manage the interaction:
Taking Pitavastatin with Grafotas-50 Capsule is not recommended, as it can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience symptoms like unexpected bruising or bleeding, skin rash, itching, tiredness, nausea, vomiting, yellowing of the skin or eyes, unexplained muscular pain, tenderness, or weakness, fever, dark urine, chills, joint pain, or swelling, consult a doctor. Do not discontinue any medications without a doctor's advice.
Taking cyclosporine and hydroxychloroquine can increases the blood levels of ciclosporine.
How to manage the interaction:
Co-administration of cyclosporine and hydroxychloroquine can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any unusual symptoms contact your doctor immediately. Do not stop using any medications without first talking to your doctor.
The combined use of aliskiren and Grafotas-50 Capsule can significantly increase the blood levels and effects of aliskiren, which may lead to low blood pressure, hyperkalemia (high potassium levels) in the body. High potassium levels can cause hyperkalemia, which can lead to kidney failure, muscular paralysis, abnormal heart rhythms. If you are elderly, dehydrated, or have kidney disease, diabetes, or severe heart failure, you are more prone to develop hyperkalemia while taking these medications.
How to manage the interaction:
Taking aliskiren and Grafotas-50 Capsule will lead to an interaction, they can be taken together if your doctor has prescribed them. However, consult the doctor if you experience nausea, vomiting, weakness, disorientation, tingling in your hands and feet, feelings of heaviness in your legs, a weak pulse, or a slow or irregular heartbeat. It is important to maintain proper fluid intake while taking these medications. It is advised to reduce intake of potassium-rich foods such as tomatoes, raisins, figs, potatoes, lima beans, bananas, plantains, papayas, pears, cantaloupes, mangoes, and potassium-containing salt substitutes.
Coadministration of adefovir dipivoxil with Grafotas-50 Capsule may significantly increase the negative effect of kidneys.
How to manage the interaction:
Although there is a possible interaction between adefovir dipivoxil and Grafotas-50 Capsule, they can be taken together if your doctor has prescribed them. However, contact your doctor if experience any symptoms such as nausea, vomiting, loss of hunger, increased or decreased urination, sudden weight gain or weight loss, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, or irregular heart rhythm, contact a doctor immediately. Do not stop using any medications without talking to a doctor.
Coadministration of deferasirox with Grafotas-50 Capsule may increase the risk of kidney problems.
How to manage the interaction:
Although there is a possible interaction between deferasirox and Grafotas-50 Capsule, they can be taken together if your doctor has prescribed them. However, contact your doctor immediately if experience nausea, vomiting, loss of hunger, increased or decreased urination, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, or irregular heart rhythm. Do not stop using any medications without talking to a doctor.
Taking Triamterene with Cyclosporine can increase the risk of hyperkalemia(high levels of potassium in blood).
How to manage the interaction:
Taking Grafotas-50 Capsule with Triamterene together can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you experience slow, fast, or uneven heartbeat, rapid breathing, numbness or tingly feeling, and muscle pain or weakness contact your doctor right away. Do not discontinue any medications without first consulting your doctor.
Drug-Food Interactions
Drug-Food Interactions
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Grapefruit Juice, Grapefruit
How to manage the interaction:
Consuming grapefruit and grapefruit juice while taking Grafotas-50 Capsule can increase the effects of Grafotas-50 Capsule. Avoid consuming grapefruit and grapefruit juice while taking Grafotas-50 Capsule.
Diet & Lifestyle Advise
- Eat foods rich in quercetin (a flavonoid) such as apples, cherries, broccoli, spinach, and blueberries.
- Consuming food rich in probiotics helps in developing the immune system against allergies.
- Limit intake of food that might trigger allergies, such as dairy products, soy, eggs, and nuts.
- Avoid consumption of foods with excess sugar to prevent flare-up inflammation.
- Include fruits, vegetables, whole grains, healthy fats and fish in your diet.
- Reducing stress and maintaining a regular sleep pattern would be helpful.
- Avoid getting in contact with harsh soaps, detergents, and rough fabrics.
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Alcohol
Safe if prescribed
You are recommended to avoid alcohol consumption while taking Grafotas-50 Capsule. It could lead to increased dizziness.
Pregnancy
Consult your doctor
Grafotas-50 Capsule belongs to pregnancy category C. Consult your doctor before taking Grafotas-50 Capsule if you are pregnant or planning for pregnancy.
Breast Feeding
Consult your doctor
Grafotas-50 Capsule passes into breast milk. Avoid breastfeeding while taking Grafotas-50 Capsule.
Driving
Safe if prescribed
Grafotas-50 Capsule may cause dizziness. Drive or operate machinery only if you are alert.
Liver
Consult your doctor
Dose adjustment may be needed. Please consult your doctor if you have a liver impairment or any concerns regarding this.
Kidney
Consult your doctor
Dose adjustment may be needed. Please consult your doctor if you have kidney impairment or any concerns regarding this.
Children
Safe if prescribed
Grafotas-50 Capsule is not recommended for children as efficacy and safety have not been established.
Heart
Please inform your doctor if you have any pre-existing heart problems
Geriatrics
Consult your doctor
Grafotas-50 Capsule should be given to elderly patients only if prescribed by a doctor. If you have any concerns, please consult your doctor.
FAQs
Grafotas-50 Capsule is used to prevent organ rejection after a transplant. Also, it helps to reduce the pain/inflammation in rheumatoid arthritis conditions and in the treatment of psoriasis.
Grafotas-50 Capsule acts as an immunosuppressant, which helps in reducing inflammation and preventing joint stiffness, thereby providing relief from rheumatoid arthritis.
If you miss a dose of Grafotas-50 Capsule, take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and take the scheduled dose instead.
Diarrhoea might be a side effect of Grafotas-50 Capsule. Drink lots of fluids and eat non-spicy food if you experience diarrhoea. If you find blood in stools (tarry stools) or if you experience severe diarrhoea, consult your doctor. Do not take anti-diarrheal medicine on your own.
Yes, the use of Grafotas-50 Capsule may cause abnormal facial and body hair growth as a common side effect. Please consult your doctor if you have any concerns.
Grafotas-50 Capsule is known to suppress the immune system. As a result, it increases the risk of infections and developing cancers, especially of the skin. Therefore, avoid prolonged exposure to sunlight by wearing suitable protective clothing and using sunscreen regularly.
Grafotas-50 Capsule may cause high blood pressure. Therefore, consult the doctor before taking Grafotas-50 Capsule if you have high blood pressure.
No, Grafotas-50 Capsule is not a steroid. It is an immunosuppressant.
Grafotas-50 Capsule may cause weight gain. Follow a healthy diet and exercise regularly to maintain proper weight. Consult your doctor if you have any concerns.
Grafotas-50 Capsule may cause fatigue. Eat a healthy diet, get regular exercise, manage stress, improve sleep habits, and quit smoking. Doing these may help cope with fatigue.
Yes, your doctor will recommend certain tests to check your body’s response to Grafotas-50 Capsule.
Grafotas-50 Capsule may cause side effects like headache, vomiting nausea, high blood pressure, loss of appetite (feeling unwell and upset stomach), and diarrhoea. Talk to your doctor if you experience these side effects persistently.
Use the measuring cup/dosing syringe provided with the pack to measure the prescribed dose of Grafotas-50 Capsule. Mix the solution/suspension in a glass of milk or orange juice, stir well, and consume immediately. Do not store the prepared mixture for later use.
You are advised to take Grafotas-50 Capsule for the duration prescribed by the doctor. The duration of treatment will depend upon your condition and response to the treatment.
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Reference
- https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/050715s035,050716s038lbl.pdf
- https://www.drugs.com/disease-interactions/cyclosporine.html
- https://www.medicines.org.uk/emc/files/pil.5300.pdf
- https://www.medicines.org.uk/emc/files/pil.1034.pdf
- https://www.webmd.com/drugs/2/drug-5645-9108/cyclosporine-oral/cyclosporine-oral/details
