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Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Grandem Syrup is used to prevent nausea and vomiting caused by chemotherapy or radiation therapy in children. It contains Granisetron, which works by blocking a natural substance (serotonin) in the body that causes nausea and vomiting. This medicine may sometimes cause side effects such as diarrhoea, constipation, stomach pain, weakness, headache, fever, dizziness, and drowsiness. Inform your doctor if your child is allergic to Grandem Syrup. Also, let your doctor know your child's complete medication history and medical history before taking Grandem Syrup. This medicine is not recommended for use in pregnant and breastfeeding mothers.

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Whats That

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Composition :

GRANISETRON-1MG

Manufacturer/Marketer :

Aristo Pharmaceuticals Pvt Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Grandem Syrup

Grandem Syrup belongs to the class of ‘anti-emetic’ drugs, primarily used to treat nausea and vomiting caused by medical treatments, such as chemotherapy or radiation treatment for cancer in children. Nausea is defined as stomach discomfort and the sensation of an urge to vomit. Vomiting is the forcible, voluntary, or involuntary emptying of the contents of the stomach through the mouth.

Grandem Syrup contains an anti-emetic (eases vomiting symptoms) medicine, 'Granisetron', that belongs to the class of serotonin receptor antagonists or serotonin blockers. It works by blocking the activity of serotonin (chemical messenger) in the brain that triggers nausea and vomiting during cancer treatment (chemotherapy or radiation therapy) or after surgery.

Your paediatrician will decide the dose and duration based on the severity of your child's medical condition. Common side effects of Grandem Syrup include diarrhoea, constipation, stomach pain, weakness, headache, fever, dizziness, drowsiness, trouble sleeping, and anxiety. These side effects are not familiar to everyone and vary from person to person. If you notice any bothersome or unmanageable side effects, please consult your doctor.

Let your doctor know if your child has any liver, kidney, or heart diseases, stomach/intestinal problems, allergic reactions, or low levels of potassium and magnesium in the blood before starting Grandem Syrup. This medicine is not recommended for use in pregnant and breastfeeding women. 

Uses of Grandem Syrup

Grandem Syrup is an antiemetic medication used primarily to prevent and treat nausea and vomiting, especially those caused by chemotherapy, radiation therapy, or surgery. The detailed uses of Grandem Syrup are as follows:<br/>• Chemotherapy-Induced Nausea and Vomiting (CINV): Given before and sometimes after chemotherapy to prevent severe nausea and vomiting. Often used in combination with other antiemetics for a more effective result. <br/>• Radiation-Induced Nausea and Vomiting (RINV): Prevents nausea associated with radiation therapy, especially to the abdomen or whole body.<br/>• Postoperative Nausea and Vomiting (PONV): Used to prevent or treat nausea and vomiting after surgery under general anesthesia.

Directions for Use

  • Grandem Syrup can be given with or without food, or as the doctor advises.
  • Follow your doctor's instructions on the dosage and timing of this medication.
  • Measure the prescribed dose using a measuring cup to get an accurate dose and administer it orally.
  • Avoid using regular household spoons, as they may not measure the dose correctly. Shake well before use.

Medicinal Benefits

Grandem Syrup contains an anti-emetic drug, Granisetron, that treats nausea and vomiting caused by cancer treatment (chemotherapy or radiation therapy) or after surgery, etc. Granisetron belongs to the class of 5-HT3 receptor antagonists, also known as serotonin receptor antagonists or serotonin blockers. When the cells lining the gastrointestinal tract are damaged by chemotherapy or radiation therapy, they release a natural substance called serotonin (5HT3, 5-hydroxytryptamine). This serotonin binds to serotonin receptors on nerves that induce nausea and vomiting. Grandem Syrup works by blocking the activity of serotonin in the brain and preventing postoperative nausea and vomiting.

How Grandem Syrup Works

Grandem Syrup contains an anti-emetic (eases vomiting symptoms) medicine, 'Granisetron', that belongs to the class of serotonin receptor antagonists or serotonin blockers. It works by blocking the activity of serotonin (chemical messenger) in the brain that triggers nausea and vomiting during cancer treatment (chemotherapy or radiation therapy) or after surgery.

Storage

• Store in a cool and dry place away from sunlight.
• Keep Grandem Syrup out of the sight and reach of children.
• Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.

What if I have taken an overdose of Grandem Syrup

Take Grandem Syrup only as prescribed by the physician. Avoid exceeding the recommended dose as it could lead to an overdose. Symptoms of overdose may include a headache. If you experience these symptoms or suspect you have taken an overdose, seek immediate medical attention.

Drug Warnings

Grandem Syrup is intended for paediatric use only. It is suggested to seek medical advice if you are using any prescription or non-prescription medicines. Inform your doctor if your child have a history of stomach/intestinal problems like stomachache, wind, feeling or being sick, and difficulty passing stools; heart problems, electrolyte imbalance (potassium, sodium or calcium), and liver or kidney diseases before starting Grandem Syrup. Grandem Syrup is not recommended in children below two years of age. This medicine is also not recommended for use in pregnant and breastfeeding mothers.

Drug-Drug Interactions

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GranisetronSaquinavir
Critical

Drug-Drug Interactions

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GranisetronSaquinavir
Critical
How does the drug interact with Grandem Syrup 10 ml:
When Grandem Syrup 10 ml is taken with Saquinavir, can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Taking Grandem Syrup 10 ml with Saquinavir is not recommended as it can result in an interaction, it can be taken if a doctor has advised it. However, if you experience abrupt dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations while taking any of these drugs, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.
How does the drug interact with Grandem Syrup 10 ml:
Taking Grandem Syrup 10 ml with Ziprasidone can increase the risk of abnormal heart rhythm.

How to manage the interaction:
Taking Grandem Syrup 10 ml with Ziprasidone is not recommended, as it can result in an interaction, it can be taken if a doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, breathing difficulty, or rapid heartbeat, consult the doctor immediately. Do not stop using any medications without talking to a doctor.
How does the drug interact with Grandem Syrup 10 ml:
Taking Grandem Syrup 10 ml with Sparfloxacin can increase the chance of a serious abnormal heart rhythm.

How to manage the interaction:
Taking Grandem Syrup 10 ml with Sparfloxacin is not recommended as it can result in an interaction, it can be taken if a doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, breathing difficulty, or rapid heartbeat, consult the doctor immediately. Do not stop using any medications without talking to a doctor.
GranisetronMesoridazine
Critical
How does the drug interact with Grandem Syrup 10 ml:
Taking Grandem Syrup 10 ml with mesoridazine can increase the risk of an irregular heart rhythm. I

How to manage the interaction:
Taking Mesoridazine with Grandem Syrup 10 ml is not recommended as it can result in an interaction, it can be taken if a doctor has advised it. However, if you experience abrupt dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations while taking any of these drugs, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.
How does the drug interact with Grandem Syrup 10 ml:
Taking Grandem Syrup 10 ml with Thioridazine can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Taking Grandem Syrup 10 ml with Thioridazine is not recommended as it can result in an interaction, it can be taken if a doctor has advised it. However, if you experience abrupt dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations while taking any of these drugs, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.
How does the drug interact with Grandem Syrup 10 ml:
Taking Grandem Syrup 10 ml with Dronedarone can increase the risk of irregular heart rhythm.

How to manage the interaction:
Taking Grandem Syrup 10 ml with Dronedarone is not recommended as it can result in an interaction, it can be taken if a doctor has advised it. However, if you experience abrupt dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations while taking any of these drugs, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.
How does the drug interact with Grandem Syrup 10 ml:
Taking Grandem Syrup 10 ml with Cisapride can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Taking Grandem Syrup 10 ml with Cisapride is not recommended as it can result in an interaction, it can be taken if a doctor has advised it. However, if you experience abrupt dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations while taking any of these drugs, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.
How does the drug interact with Grandem Syrup 10 ml:
Taking Grandem Syrup 10 ml with Pimozide can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Taking Grandem Syrup 10 ml with Pimozide is not recommended as it can result in an interaction, it can be taken if a doctor has advised it. However, if you experience abrupt dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations while taking any of these drugs, consult a doctor immediately. Do not stop using any medications without talking to a doctor.
How does the drug interact with Grandem Syrup 10 ml:
Using Grandem Syrup 10 ml together with Imipramine can increase the risk of a serious condition called serotonin syndrome (A condition resulting from the accumulation of high levels of serotonin in the body. Serotonin is a mood stabilizer).

How to manage the interaction:
There may be a possibility of interaction between Grandem Syrup 10 ml and Imipramine, but it can be taken if prescribed by a doctor. However, if you notice any of the following symptoms - confusion, hallucination, seizure, increased heart rate, fever, excessive sweating, blurred vision, muscle spasm, stomach cramp, nausea, vomiting, diarrhea, dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations consult a doctor immediately. Do not discontinue any medications without consulting a doctor.
GranisetronProcainamide
Severe
How does the drug interact with Grandem Syrup 10 ml:
Taking Grandem Syrup 10 ml with procainamide increases the risk of an abnormal heart rhythm.

How to manage the interaction:
Although taking Grandem Syrup 10 ml and Procainamide together can cause an interaction, it can be taken if a doctor has suggested it. However, if you experience abrupt dizziness, lightheadedness, fainting, shortness of breath, or rapid heartbeat, consult a doctor immediately. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Avoid chocolates, junk food, cheese, and processed food.
  • You can try increasing your mindfulness by doing meditation and stress reduction techniques.
  • Make your child drink enough water to stay hydrated.
  • Include a diet rich in whole grains, vegetables, and fruits. This is a healthier option than eating a lot of simple carbohydrates found in processed foods.
  • You can incorporate antioxidants into your daily diet, such as ashwagandha, omega-3 fatty acids, green tea, and lemon balm.

Habit Forming

No

Therapeutic Class

ANTIEMETICS
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Alcohol

Not applicable

Grandem Syrup is for paediatric use.

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Pregnancy

Not applicable

Grandem Syrup is not recommended for use in pregnant women.

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Breast Feeding

Not applicable

Grandem Syrup is intended for use in paediatrics.

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Driving

Not applicable

Grandem Syrup is for paediatric use.

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Liver

Caution

Grandem Syrup should be cautiously used by patients with liver diseases. Please consult your paediatrician if you have a history of liver impairment before starting Grandem Syrup.

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Kidney

Caution

Grandem Syrup should be cautiously used by patients with kidney problems. Please consult your doctor if you have a history of kidney impairment/kidney disease.

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Children

Safe if prescribed

Grandem Syrup is safe for use in children as prescribed by your doctor. The paediatrician will decide the dose based on the age and body weight of the child.

Have a query?

FAQs

Grandem Syrup is used to treat nausea and vomiting caused by medical treatments.

Grandem Syrup contains Granisetron, an anti-emetic drug. It is a serotonin blocker that blocks the activity of serotonin, a chemical messenger that induces nausea and vomiting after treatments like chemotherapy and radiation therapy. Thus, Grandem Syrup relieves symptoms of post-operative nausea and vomiting.

You are advised to complete the course prescribed by your doctor. Please do not stop giving this medicine unless advised by your doctor, since it may lead to recurrent episodes of nausea and vomiting.

Take Grandem Syrup as soon as possible. However, if it's time for the next dose, skip the missed dose and return to your regular dosing schedule. Do not double the dose.

Grandem Syrup may cause constipation as a side effect. You can avoid it by including high-fibre foods in your diet, which improves your digestion. Limit the intake of alcohol to manage your constipation.

Country of origin

India

Manufacturer/Marketer address

Mercantile Chamber, 3rd Floor, 12, J.N. Heredia Marg, Ballard Estate, Mumbai – 400 001, India.
Other Info - GRA0020

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