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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Granicip Syrup is used to prevent nausea and vomiting caused by chemotherapy or radiation therapy. It contains Granisetron, which works by blocking a natural substance (serotonin) in the body that causes nausea and vomiting. This medicine may sometimes cause side effects such as diarrhoea, constipation, stomach pain, weakness, headache, fever, dizziness, and drowsiness. Inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.

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Composition :

GRANISETRON-1MG

Manufacturer/Marketer :

Cipla Ltd

Consume Type :

Oral

Expires on or after :

Return Policy :

Not Returnable

About Granicip Syrup

Granicip Syrup belongs to the class of ‘anti-emetic’ drugs, primarily used to treat nausea and vomiting caused by medical treatments, such as chemotherapy or radiation treatment for cancer. Nausea is defined as stomach discomfort and the sensation of an urge to vomit. Vomiting is the forcible, voluntary, or involuntary emptying of the contents of the stomach through the mouth.

Granicip Syrup contains an anti-emetic (eases vomiting symptoms) medicine, 'Granisetron', that belongs to the serotonin receptor antagonists or serotonin blockers class. It works by blocking the activity of serotonin (chemical messenger) in the brain that triggers nausea and vomiting during cancer treatment (chemotherapy or radiation therapy) or after surgery.

Your doctor will decide the dose and duration based on the severity of your medical condition. Common side effects of Granicip Syrup include diarrhoea, constipation, stomach pain, weakness, headache, fever, dizziness, drowsiness, trouble sleeping, and anxiety. These side effects are not familiar to everyone and vary individually. If you notice any side effects that are not manageable, please consult your doctor.

If you use other prescription or non-prescription medicines, inform your doctor before using Granicip Syrup. Let your doctor know if you have any liver, kidney, or heart diseases, stomach/intestinal problems, allergic reactions, or low potassium and magnesium levels in the blood before starting Granicip Syrup. Granicip Syrup may make you dizzy or drowsy, hence avoid driving if you are not mentally alert. Consult your doctor before taking Granicip Syrup if you are pregnant, planning for pregnancy, or breastfeeding. Avoid consuming alcohol along with Granicip Syrup as it could lead to increased drowsiness.

Uses of Granicip Syrup

Granicip Syrup is an antiemetic medication used primarily to prevent and treat nausea and vomiting, especially those caused by chemotherapy, radiation therapy, or surgery. The detailed uses of Granicip Syrup are as follows:

  • Chemotherapy-Induced Nausea and Vomiting (CINV): Given before and sometimes after chemotherapy to prevent severe nausea and vomiting. Often used in combination with other antiemetics for a more effective result.
  • Radiation-Induced Nausea and Vomiting (RINV): Prevents nausea associated with radiation therapy, especially to the abdomen or whole body.
  • Postoperative Nausea and Vomiting (PONV): Used to prevent or treat nausea and vomiting after surgery under general anaesthesia.

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Directions for Use

  • Granicip Syrup can be taken with or without food, or as your doctor advises.
  • Follow your doctor's instructions on the dosage and timing of this medication.
  • Swallow Granicip Syrup as a whole with a glass of water.
  • Do not crush, break, or chew it.

Key Benefits

Granicip Syrup contains an anti-emetic drug, 'Granisetron', that treats nausea and vomiting caused by cancer treatment (chemotherapy or radiation therapy) or after surgery, etc. Granisetron belongs to the class of 5-HT3 receptor antagonists (also called serotonin receptor antagonists or serotonin blockers). When the cells lining the gastrointestinal tract are damaged by chemotherapy or radiation therapy, they release a natural substance called serotonin (5HT3, 5-hydroxytryptamine). This serotonin binds to serotonin receptors on nerves that induce nausea and vomiting. Granicip Syrup works by blocking the brain's serotonin activity and preventing post-operative nausea and vomiting.

How Granicip Syrup Works

Granicip Syrup contains an anti-emetic (eases vomiting symptoms) medicine, 'Granisetron' that belongs to the class of serotonin receptor antagonists or serotonin blockers. It works by blocking the activity of serotonin (chemical messenger) in the brain that triggers nausea and vomiting during cancer treatment (chemotherapy or radiation therapy) or after surgery.

Storage

Store in a cool and dry place away from sunlight

What if I have taken an overdose of Granicip Syrup

Take Granicip Syrup only as prescribed by the physician. Avoid exceeding the recommended dose as it could lead to an overdose. Symptoms of overdose may include a headache. If you experience these symptoms or suspect you have taken an overdose, seek immediate medical attention.

Drug Warnings

Granicip Syrup may cause serotonin syndrome/toxicity when used with other drugs like ecstasy (MDMA) and antidepressants. Hence it is suggested to seek medical advice if you are using any prescription or non-prescription medicines. Inform your doctor if you have a history of stomach/intestinal problems like stomach ache, wind, feeling or being sick, and difficulty passing stools, heart problems, electrolyte imbalance (potassium, sodium or calcium), and liver or kidney diseases before starting Granicip Syrup. Please consult your doctor if you are pregnant or breastfeeding if the doctor has advised you Granicip Syrup. Granicip Syrup may make you feel dizzy, so drive only if you are alert. Avoid consuming alcohol as it could lead to increased dizziness. Granicip Syrup is not recommended in children below two years of age.

Drug-Drug Interactions

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GranisetronMesoridazine
Critical

Drug-Drug Interactions

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How does the drug interact with Granicip Syrup 10 ml:
Taking Granicip Syrup 10 ml with Sparfloxacin can increase the chance of a serious abnormal heart rhythm.

How to manage the interaction:
Taking Granicip Syrup 10 ml with Sparfloxacin is not recommended as it can result in an interaction, it can be taken if a doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, breathing difficulty, or rapid heartbeat, consult the doctor immediately. Do not stop using any medications without talking to a doctor.
GranisetronMesoridazine
Critical
How does the drug interact with Granicip Syrup 10 ml:
Taking Granicip Syrup 10 ml with mesoridazine can increase the risk of an irregular heart rhythm. I

How to manage the interaction:
Taking Mesoridazine with Granicip Syrup 10 ml is not recommended as it can result in an interaction, it can be taken if a doctor has advised it. However, if you experience abrupt dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations while taking any of these drugs, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.
How does the drug interact with Granicip Syrup 10 ml:
Taking Granicip Syrup 10 ml with Dronedarone can increase the risk of irregular heart rhythm.

How to manage the interaction:
Taking Granicip Syrup 10 ml with Dronedarone is not recommended as it can result in an interaction, it can be taken if a doctor has advised it. However, if you experience abrupt dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations while taking any of these drugs, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.
How does the drug interact with Granicip Syrup 10 ml:
Taking Granicip Syrup 10 ml with Pimozide can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Taking Granicip Syrup 10 ml with Pimozide is not recommended as it can result in an interaction, it can be taken if a doctor has advised it. However, if you experience abrupt dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations while taking any of these drugs, consult a doctor immediately. Do not stop using any medications without talking to a doctor.
How does the drug interact with Granicip Syrup 10 ml:
Taking Granicip Syrup 10 ml with Cisapride can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Taking Granicip Syrup 10 ml with Cisapride is not recommended as it can result in an interaction, it can be taken if a doctor has advised it. However, if you experience abrupt dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations while taking any of these drugs, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.
How does the drug interact with Granicip Syrup 10 ml:
Taking Granicip Syrup 10 ml with Ziprasidone can increase the risk of abnormal heart rhythm.

How to manage the interaction:
Taking Granicip Syrup 10 ml with Ziprasidone is not recommended, as it can result in an interaction, it can be taken if a doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, breathing difficulty, or rapid heartbeat, consult the doctor immediately. Do not stop using any medications without talking to a doctor.
How does the drug interact with Granicip Syrup 10 ml:
Taking Granicip Syrup 10 ml with Thioridazine can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Taking Granicip Syrup 10 ml with Thioridazine is not recommended as it can result in an interaction, it can be taken if a doctor has advised it. However, if you experience abrupt dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations while taking any of these drugs, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.
GranisetronSaquinavir
Critical
How does the drug interact with Granicip Syrup 10 ml:
When Granicip Syrup 10 ml is taken with Saquinavir, can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Taking Granicip Syrup 10 ml with Saquinavir is not recommended as it can result in an interaction, it can be taken if a doctor has advised it. However, if you experience abrupt dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations while taking any of these drugs, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.
How does the drug interact with Granicip Syrup 10 ml:
Taking amisulpride with Granicip Syrup 10 ml increases the risk of an abnormal heart rhythm.

How to manage the interaction:
Although taking Granicip Syrup 10 ml along with amisulpride can result in an interaction, it can be taken if a doctor has advised it. However, if you experience abrupt dizziness, lightheadedness, fainting, shortness of breath, or rapid heartbeat, consult a doctor immediately. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Granicip Syrup 10 ml:
Using Moxifloxacin together with Granicip Syrup 10 ml can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Taking Moxifloxacin with Granicip Syrup 10 ml together can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience dizziness, breathing difficulty, or rapid heartbeat, consult the doctor immediately. Do not stop using any medications without talking to a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Avoid chocolates, junk food, cheese, processed food, alcohol and smoking.
  • You can try increasing your mindfulness by doing yoga, meditation, mindfulness-based cognitive therapy and stress reduction techniques.
  • Drink enough water to stay hydrated and limit or avoid alcohol and caffeine.
  • Include a diet rich in whole grains, vegetables and fruits. This is a healthier option than eating a lot of simple carbohydrates found in processed foods.
  • You can include antioxidants in your daily diet like ashwagandha, omega-3 fatty acids, green tea and lemon balm.
  • Try to spend time with your friends and family. Having a strong social network may help you lower your risk of anxiety.

Habit Forming

No

Therapeutic Class

[ANTIEMETICS]

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Alcohol

Unsafe

You are recommended to limit or avoid alcohol consumption while taking Granicip Syrup. Alcohol intake, along with Granicip Syrup, may cause increased dizziness.

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Pregnancy

Consult your doctor

It is not known if Granicip Syrup affects pregnancy. Please consult your doctor if you are pregnant or planning to conceive before using Granicip Syrup.

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Breast Feeding

Caution

It is not known if this medicine passes into breast milk. Please consult your doctor before taking Granicip Syrup if you are a nursing mother.

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Driving

Unsafe

Granicip Syrup may make you feel dizzy that affects your mental ability. Do not drive or operate machinery if you experience dizziness.

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Liver

Caution

Granicip Syrup should be cautiously used by patients with liver diseases. Please consult your doctor if you have a history of liver impairment before starting Granicip Syrup.

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Kidney

Caution

Granicip Syrup should be cautiously used by patients with kidney problems. Please consult your doctor if you have a history of kidney impairment/kidney disease.

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Children

Consult your doctor

Safety and efficacy of Granicip Syrup are not established in children below 2 years of age.

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Heart

Caution

Granicip Syrup should be taken with caution in patients with heart problems. Please inform your doctor about any existing heart problems before using Granicip Syrup.

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Geriatrics

Safe if prescribed

Granicip Syrup is safe for use in elderly patients if prescribed by the physician.

FAQs

Granicip Syrup is used to treat nausea and vomiting caused by medical treatments.

Granicip Syrup contains Granisetron, an anti-emetic drug. It is a serotonin blocker that blocks the activity of serotonin, a chemical messenger that induces nausea and vomiting after treatments like chemotherapy and radiation therapy. Thus, Granicip Syrup relieves from post-operative nausea and vomiting symptoms.

Granicip Syrup may cause constipation as one of its side effects. You can avoid it by including high fibre food in your diet that improves your digestion. Limit the intake of alcohol to manage your constipation.

Granicip Syrup should be used with caution if you have recent stomach/intestinal problems like stomach ache, wind, feeling or being sick or difficulty passing stools, heart problems, electrolyte imbalance (potassium, sodium or calcium), and liver or kidney diseases.

You are advised to complete the course prescribed by your doctor. Please do not stop taking this medicine unless advised by your doctor since it may lead to recurrent episodes of nausea and vomiting.

Take Granicip Syrup as soon as possible. However, if it is time for the next dose, skip the missed dose and go back to your regular dosing schedule. Do not double the dose.

Country of origin

India

Manufacturer/Marketer address

Cipla House, Peninsula Business Park, Ganpatrao Kadam Marg, Lower Parel, Mumbai-400013.
Other Info - GRA0175

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