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About Grin-O Tablet SR
Grin-O Tablet SR is a combination medicine indicated to manage neuropathic pain associated with diabetic peripheral neuropathy and postherpetic neuralgia. Neuropathic pain is a chronic progressive nerve disease that causes nerve pain due to nerve damage or a malfunctioning nervous system. Symptoms include spontaneous, untriggered pain, unpleasant feeling, shooting, burning or stabbing pain, and evoked pain (pain caused by events usually not painful).
Grin-O Tablet SR is a combination of three drugs: Methylcobalamin (vitamin), Nortriptyline (antidepressant), and Pregabalin (anti-convulsant). Methylcobalamin is a vitamin that aids in producing myelin, a substance that protects nerve fibres and regenerates damaged nerve cells. Nortriptyline works by increasing nerve transmitters (serotonin and noradrenaline) in the brain, thereby reducing the pain messages arriving in the brain. Pregabalin reduces pain by interfering with pain messages travelling through the brain and down the spine. Together, Grin-O Tablet SR helps to treat neuropathic pain.
Take Grin-O Tablet SR as prescribed. Based on your medical condition, your doctor will decide the dose and duration. In some cases, Grin-O Tablet SR may cause dizziness, sleepiness, nausea, blurred vision, peripheral oedema (swelling of the lower legs and hands), weight gain, and dry mouth. The majority of these side effects do not necessitate medical attention and will subside gradually over time. However, if you are experiencing these side effects regularly, you should consult your doctor.
Please do not take Grin-O Tablet SR if you are allergic to any of its ingredients. Consult your doctor before taking Grin-O Tablet SR if you are pregnant or breastfeeding. Grin-O Tablet SR may cause drowsiness and dizziness, so drive only if you are alert. Grin-O Tablet SR should not be given to children as safety and effectiveness have not been established. Avoid consuming alcohol along with Grin-O Tablet SR as it could lead to increased dizziness and sleepiness. Keep your doctor informed about your health condition and medicines to rule out any side effects.
Uses of Grin-O Tablet SR
Directions for Use
Medicinal Benefits
Grin-O Tablet SR is a combination of three drugs: Methylcobalamin (a form of vitamin B), Nortriptyline (antidepressant), and Pregabalin (anti-convulsant). Grin-O Tablet SR is indicated for the management of neuropathic pain associated with diabetic peripheral neuropathy, postherpetic neuralgia, spinal cord injury, etc. Methylcobalamin aids in producing myelin, a substance that protects nerve fibres and regenerates damaged nerve cells. Nortriptyline works by increasing nerve transmitters (serotonin and noradrenaline) in the brain, thereby reducing the pain messages arriving in the brain. Pregabalin reduces pain by interfering with pain messages travelling through the brain and down the spine. Together, Grin-O Tablet SR helps to treat neuropathic pain.
How Grin-O Tablet SR Works
Storage
What if I have taken an overdose of Grin-O Tablet SR
Drug Warnings
If you are allergic to any of the ingredients in Grin-O Tablet SR, do not consume it. Please do not stop taking Grin-O Tablet SR without first consulting your doctor, as this may result in withdrawal symptoms. If you are pregnant or breastfeeding, do not take Grin-O Tablet SR unless your doctor has prescribed it. Grin-O Tablet SR may cause drowsiness and dizziness, therefore drive only if you are alert. Grin-O Tablet SR is not recommended for children as safety and effectiveness have not been established. Avoid drinking alcohol while taking Grin-O Tablet SR as it may cause drowsiness and sleepiness. If you have suicidal thoughts, consult your doctor right away.
Drug-Drug Interactions
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Drug-Food Interactions
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Diet & Lifestyle Advise
Include vitamin B and D-rich foods in your diet.
Cayenne pepper should be included in your diet because it can help with neuropathic pain.
Exercising regularly helps to improve overall health and combat pain.
Rest well and get plenty of rest.
Taking a warm bath can be very relaxing.
Avoid smoking and drinking alcohol.
Meditation and yoga can reduce stress, pain sensitivity and improve coping skills.
Acupuncture, by stimulating pressure points, can be beneficial.
Massages with essential oils can help increase circulation.
Habit Forming
Therapeutic Class
Product Substitutes
Alcohol
Unsafe
Avoid consumption of alcohol while taking Grin-O Tablet SR as it may increase drowsiness and sleepiness.
Pregnancy
Caution
If you're pregnant, don't take Grin-O Tablet SR unless your doctor tells you to. Please consult your doctor if you have any concerns about this; your doctor will only prescribe if the benefits outweigh the risks.
Breast Feeding
Caution
Consult your doctor as there is no substantial research yet on the use of Grin-O Tablet SR in breastfeeding/nursing mothers.
Driving
Unsafe
Grin-O Tablet SR causes drowsiness, sleepiness and blurred vision. Do not drive or operate machinery unless you are alert.
Liver
Caution
Dose adjustment may be needed in patients with liver impairment. Please consult your doctor if you have a liver impairment or any concerns regarding this. Your doctor will prescribe only if the benefits outweigh the risks.
Kidney
Caution
Dose adjustment may be needed in patients with kidney impairment. Please consult your doctor if you have kidney impairment or any concerns regarding this. Your doctor will prescribe only if the benefits outweigh the risks.
Children
Unsafe
Grin-O Tablet SR should not be given to children as the safety and efficacy have not been established.
Have a query?
Grin-O Tablet SR is used to treat neuropathic pain associated with diabetic peripheral neuropathy and postherpetic neuralgia.
Grin-O Tablet SR contains Methylcobalamin, Nortriptyline, and Pregabalin. Methylcobalamin aids in producing myelin, a substance that protects nerve fibres and regenerates damaged nerve cells. Nortriptyline alters the way nerves receive pain signals, thereby decreasing pain. Pregabalin reduces pain by interfering with pain messages travelling through the brain and down the spine. Together, Grin-O Tablet SR helps to treat neuropathic pain.
Dry mouth could be a side-effect of Grin-O Tablet SR. Limiting caffeine intake, avoiding smoking and mouthwashes containing alcohol, drinking water regularly and chewing sugar-free gum/candy might stimulate saliva and prevent drying of the mouth.
Do not stop taking Grin-O Tablet SR without consulting your doctor, as this could result in withdrawal symptoms. Continue taking Grin-O Tablet SR for as long as prescribed to treat your condition effectively. If you experience any difficulty while taking Grin-O Tablet SR, do not be afraid to speak with your doctor.
Grin-O Tablet SR is used to treat diabetic neuropathy. Diabetic neuropathy is a condition that causes nerve damage due to high blood glucose levels. It primarily affects the nerves in the legs and feet.
Grin-O Tablet SR may cause peripheral oedema. The swelling of the hands and lower legs are known as peripheral oedema. If you experience oedema, avoid sitting or standing for extended periods. Raise your legs by laying down and placing a pillow under them.
Grin-O Tablet SR is not a painkiller. However, it is a combination medicine used to manage neuropathic pain, particularly in conditions like diabetic peripheral neuropathy and postherpetic neuralgia.
The common side effects of Grin-O Tablet SR include sleepiness, dizziness, nausea, blurred vision, peripheral oedema (swelling of the lower legs and hands), weight gain, and dry mouth. Most of these side effects do not require medical attention and gradually resolve over time. However, please consult the doctor if these symptoms persist or worsen.
Grin-O Tablet SR is a medication combination consisting of Methylcobalamin (Vitamin B12), Nortriptyline (Tricyclic Antidepressant), and Pregabalin (Anticonvulsant), commonly prescribed for managing neuropathic pain and nerve damage.
To manage weight gain associated with Grin-O Tablet SR, maintain a balanced diet rich in fibre and protein while avoiding processed and sugary foods. Engage in regular physical activity, including cardio and strength training, to boost your metabolism. Monitor your weight and consult your doctor if you notice any significant changes.
Yes, Grin-O Tablet SR may cause sleepiness or dizziness as a common side effect. Therefore, avoid driving or operating heavy machinery unless you are fully alert.
Grin-O Tablet SR may affect sexual health in some individuals. It may cause side effects such as reduced libido, erectile dysfunction, or difficulty achieving orgasm, mainly due to Nortriptyline and Pregabalin affecting neurotransmitters and nerve function. Please consult the doctor for guidance or alternative treatment options if you experience any changes in your sexual health.
Grin-O Tablet SR is generally well tolerated, but in very rare cases, it may cause allergic reactions, such as rash, itching, or swelling, and breathing difficulties, especially in individuals with pre-existing lung conditions or when combined with CNS depressants.
Grin-O Tablet SR starts working as soon as you begin taking it. However, it may take a few weeks to show its complete effects. Therefore, continue taking it as prescribed by the doctor, and please consult your doctor if you have any concerns.
If you forget a dose of Grin-O Tablet SR, take it as soon as you remember. However, if it's almost time for your next dose, skip the missed one and continue with your regular dosing schedule. Do not double the dose.
If you accidentally overdose on Grin-O Tablet SR, seek immediate medical attention. Overdose symptoms can be severe and include drowsiness, confusion, vision problems, dizziness, irregular heartbeat, low blood pressure, convulsions, and breathing difficulties. In extreme cases, an overdose can lead to coma or even life-threatening complications. Call your doctor or emergency services right away for urgent treatment.
No, taking a higher dose of Grin-O Tablet SR than recommended will not necessarily be more effective and may increase the risk of serious side effects. Always follow the dosage instructions provided by your doctor or pharmacist.
Avoid consuming alcohol while taking Grin-O Tablet SR as it may increase drowsiness or sleepiness. Avoid driving or operating heavy machinery until you know how the medication affects you. Avoid taking other medicines, including herbal supplements and OTC medications, without a doctor’s advice.
While taking Grin-O Tablet SR, your doctor may recommend regular check-ups based on your medical condition to monitor your response, adjust dosages, and manage potential side effects. Please consult your doctor immediately if you experience any changes in your condition.
Grin-O Tablet SR should be stored in a cool and dry place, away from sunlight. Keep it out of sight and reach of children.
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