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compositionComposition:GRISEOFULVIN-500MG
prescription
Prescription Medicine
info
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Grisofline 500mg Tablet is used to treat fungal infections of the skin like ringworm, jock itch, athlete's foot, and fungal infections of nails and hair. It contains Griseofulvin, which works by binding to the keratin (a protein that is formed in the cells of the skin, hair follicles, and nail bed) and inhibits the growth and multiplication of fungal cells. Thereby, it prevents newly grown keratin from being infected by fungal cells. The infected keratin dies and sheds from the body, leaving new healthy keratin. Some people may experience side effects such as nausea, diarrhoea, headache, and discomfort in the stomach. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.

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Written By Veda Maddala , M Pharmacy
Reviewed By Santoshini Reddy G , M Pharmacy
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More about the Product

Composition :

GRISEOFULVIN-500MG

Consume Type :

Oral

Expires on or after :

Dec-28

Return Policy :

Not Returnable

About Grisofline 500mg Tablet

Grisofline 500mg Tablet is an antifungal medication prescribed to treat fungal infections of the skin, hair, and nails. It is used for stubborn infections that do not clear up with topical creams or ointments alone. This medicine works from the inside out to clear the infection at its source.

For this medicine to work effectively, you must take it consistently every day at the same time as directed by your doctor. Taking your dose with a meal containing healthy fats, such as whole milk, cheese, or butter, significantly improves how your body absorbs the medication. Keeping your skin clean and dry and avoiding sharing personal items like towels or hairbrushes can also speed up your recovery.

While taking Grisofline 500mg Tablet, you might experience mild side effects like headaches, dizziness, or a mild upset stomach. However, you should contact your doctor immediately if you experience signs of liver damage, such as yellowing of the eyes or skin, dark urine, pale stools, or severe stomach pain.

Talk to your doctor before taking Grisofline 500mg Tablet if you have a history of liver disease, lupus, or porphyria. Do not take this medicine if you are pregnant, planning to become pregnant, or have severe liver failure, as it can cause serious complications.

This medicine can interact with alcohol, causing flushing and a rapid heartbeat, and can make hormonal birth control less effective. If you are pregnant, breastfeeding, or an older adult, consult your doctor to ensure this treatment is safe for your specific situation.

Uses of Grisofline 500mg Tablet

Your doctor may prescribe Grisofline 500mg Tablet to treat several conditions, including:

  • Fungal scalp infections (Tinea capitis): Grisofline 500mg Tablet goes deep into the hair shafts to kill the fungi causing scaling, itching, and temporary hair loss.
  • Fungal skin infections: It treats severe or widespread ringworm, jock itch, and athlete's foot when topical creams fail to provide relief.
  • Fungal nail infections (Onychomycosis): It builds up in the newly growing nail tissue to slowly replace the infected nail with healthy, fungus-free growth.
     

Key Benefits

Grisofline 500mg Tablet provides effective systemic antifungal treatment to help eliminate fungal infections from deeper areas of the body. By reaching infection sites that are difficult to treat with topical medicines, this medicine offers several key health benefits:

  • Deep Treatment of Fungal Infections: Grisofline 500mg Tablet works through the bloodstream to reach hard-to-access areas such as hair roots and nails, helping target and eliminate fungal infections at their source.
  • Relief from Fungal Symptoms: By stopping fungal growth and spread, Grisofline 500mg Tablet helps reduce symptoms such as intense itching, scaling, redness, and irritation, allowing affected skin and scalp areas to heal.
  • Restoration of Healthy Hair and Nails: With successful treatment, Grisofline 500mg Tablet supports the gradual growth of healthier hair and nails, helping restore their normal appearance and strength over time.
     

Directions for Use

To ensure you get the full benefit of Grisofline 500mg Tablet and minimise the risk of side effects, please follow these instructions carefully:

  • Take Grisofline 500mg Tablet by mouth exactly as directed by your doctor.
  • Swallow the tablet whole with a glass of water. If you are taking the liquid form, shake the bottle well before measuring your dose with a proper medical measuring spoon.
  • Always take this medicine with a fat-rich meal (such as whole milk, cheese, or yoghurt) to help your body absorb the drug properly.
  • Complete the entire course prescribed by your doctor, even if your symptoms clear up before you finish the medicine. Stopping too early can cause the infection to return.
     

How Grisofline 500mg Tablet Works

Grisofline 500mg Tablet contains griseofulvin. It works by binding to a protein called keratin in your body. Keratin is the main ingredient that makes up your skin, hair, and nails. Once the medicine binds to keratin, it acts like a shield that prevents the fungus from invading these tissues. Additionally, it disrupts the process of cell division within the fungal cells themselves. By stopping the fungus from multiplying, Grisofline 500mg Tablet prevents the infection from spreading to new hair, skin, or nail tissue as it grows. Over time, the old, infected tissue naturally sheds off and is replaced by healthy, fungus-free tissue.
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Alcohol

Unsafe

Avoid consumption of alcohol with Grisofline 500mg Tablet as it may increase the risk of adverse effects such as fast heartbeat, increased sweating, flushing or redness of the face.

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Pregnancy

Unsafe

Grisofline 500mg Tablet is a Category X pregnancy drug and is unsafe for pregnant women as it may cause harm to the fetus.

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Breast Feeding

Unsafe

Grisofline 500mg Tablet is excreted in human milk. Therefore, it is not advised for breastfeeding mothers as it may cause adverse effects in the baby.

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Driving

Caution

Grisofline 500mg Tablet may cause dizziness, drowsiness, lack of coordination or confusion. Therefore, drive only if you alert after taking Grisofline 500mg Tablet.

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Liver

Caution

Take Grisofline 500mg Tablet with caution if you have liver disease. However, Grisofline 500mg Tablet is not recommended for patients suffering from liver failure.

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Kidney

Caution

Take Grisofline 500mg Tablet with caution, especially if you have a history of kidney diseases/conditions. The dose may be adjusted by your doctor as required.

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Children

Caution

Grisofline 500mg Tablet is not recommended for children below 2 years. However, for children above 2 years, Grisofline 500mg Tablet should be used only if advised by a doctor.

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Heart

Caution

Grisofline 500mg Tablet should be used with caution in patients with heart problems.

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Geriatrics

Consult your doctor

Please consult a doctor before administering Grisofline 500mg Tablet to geriatric patients. Your doctor will prescribe Grisofline 500mg Tablet if the benefits outweigh the risks.

What if I have taken an overdose of Grisofline 500mg Tablet

Do not take more than the prescribed dose of Grisofline 500mg Tablet as it may cause overdose. If you suspect you have taken overdose, please consult a doctor immediately.

Diet & Lifestyle Advise

  • Eat a meal containing healthy fats (such as avocado, nuts, cheese, or whole milk) whenever you take your dose of Grisofline 500mg Tablet to maximise its effectiveness.
  • Keep the affected skin or nail areas clean and thoroughly dry, as fungi thrive in warm, moist environments.
  • Avoid sharing personal items like towels, clothing, combs, hairbrushes, or nail clippers to prevent spreading the infection or reinfecting yourself.
  • Wear loose-fitting, breathable cotton clothing and change your socks daily if you are treating a skin or foot infection.
     
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How Soon It Starts Working

The time required for Grisofline 500mg Tablet to start to work: Grisofline 500mg Tablet ideally shows its action within 4 to 5 hours after administration. The time for which the effects of Grisofline 500mg Tablet last: The effect of Grisofline 500mg Tablet lasts for 20 to 40 hours.

What if you forget to take Grisofline 500mg Tablet

If you miss a dose of Grisofline 500mg Tablet, take it as soon as you remember. However, if it is almost time for the next dose, skip the missed one and continue with your regular schedule. Do not take a double dose to make up for the missed one.

Storage

Store Grisofline 500mg Tablet at room temperature, between 20°C and 25°C (68°F to 77°F). •Keep the medication in its original container, tightly closed, and away from direct light,

Drug Warnings

  • Always shake the liquid oral suspension well before each use to ensure the medication is evenly mixed.
  • This medicine makes your skin more sensitive to the sun; wear protective clothing, a wide-brimmed hat, and use a high-SPF sunscreen when outdoors.
  • Men should avoid fathering a child during treatment and for at least six months after stopping Grisofline 500mg Tablet, as it can affect sperm development.
  • Women of childbearing potential must use effective, non-hormonal backup birth control (like condoms) because this medicine can make hormonal contraceptives fail.
  • Complete the full duration of your prescribed therapy, which may take several weeks for skin infections and several months for nail infections, to ensure the fungus is fully cleared.
     

Drug-Drug Interactions

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Drug-Drug Interactions:

Inform your doctor if you are taking any of the following medicines, as they may interact.

  • May lower the effectiveness of hormonal birth control pills, patches, and rings, increasing the risk of unplanned pregnancy.
  • May reduce the effectiveness of blood thinners like warfarin, requiring closer monitoring of your blood clotting times.
  • Taking it alongside barbiturates (medicines used for sleep or seizures) may reduce the effectiveness of Grisofline 500mg Tablet.

Drug-Food Interactions:

  • May cause a severe physical reaction when combined with alcohol, resulting in a rapid heartbeat, skin flushing, and heavy sweating.
  • Absorption is significantly increased when taken with high-fat foods.

Drug-Disease Interactions:

Inform your doctor if you have a history of the following conditions before taking Grisofline 500mg Tablet, as it may worsen your condition or cause complications.

  • Do not take this medicine if you have severe liver disease, as it can cause further liver damage.
  • May worsen symptoms of lupus (an autoimmune condition) or porphyria (a rare genetic blood disorder).
GriseofulvinRanolazine
Critical
GriseofulvinEtonogestrel
Severe

Drug-Drug Interactions

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GriseofulvinRanolazine
Critical
How does the drug interact with Grisofline 500mg Tablet:
When Ranolazine is taken with Grisofline 500mg Tablet, may significantly reduce the blood levels of Ranolazine, which may make the medication ineffective or less effective.

How to manage the interaction:
Taking Grisofline 500mg Tablet with Ranolazine is not recommended, they can be taken together if advised by a doctor. Do not stop taking any medications without consulting a doctor.
GriseofulvinEtonogestrel
Severe
How does the drug interact with Grisofline 500mg Tablet:
Taking Grisofline 500mg Tablet with etonogestrel may reduce blood levels and the effects of etonogestrel.

How to manage the interaction:
Although there is a possible interaction between Grisofline 500mg Tablet and Etonogestrel, you can take these medicines together if prescribed by a doctor. However, if you experience any of these symptoms like unexpected bleeding or abnormal bleeding, or if you think you might be pregnant while using birth control, it's important to contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
GriseofulvinDrospirenone
Severe
How does the drug interact with Grisofline 500mg Tablet:
Using drospirenone together with Grisofline 500mg Tablet may decrease the blood levels and effects of drospirenone.

How to manage the interaction:
Although taking Grisofline 500mg Tablet and Drospirenone together can cause an interaction, it can be taken if a doctor has suggested it. However, if you experience any of these symptoms like unexpected bleeding or abnormal bleeding, or if you think you might be pregnant while using birth control, it's important to contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
GriseofulvinLevonorgestrel
Severe
How does the drug interact with Grisofline 500mg Tablet:
Using levonorgestrel with Grisofline 500mg Tablet may reduce levonorgestrel blood levels and effects.

How to manage the interaction:
Although taking levonorgestrel and Grisofline 500mg Tablet together can result in an interaction, it can be taken if a doctor has prescribed it. If you use hormone replacement treatment(levonorgestrel) for menopause, consult the doctor if your symptoms do not improve or if you begin to bleed abnormally. Do not discontinue any medications without consulting a doctor.
GriseofulvinDesogestrel
Severe
How does the drug interact with Grisofline 500mg Tablet:
When Desogestrel is used with Grisofline 500mg Tablet may decrease the effectiveness of Desogestrel.

How to manage the interaction:
Co-administration of Desogestrel with Grisofline 500mg Tablet can result in an interaction, but it can be taken if a doctor has advised it. If you experience abnormal menstruation, dryness of the vagina, or increased hot flushes or if you're looking for other birth control options, consult a doctor. Do not discontinue any medications without consulting a doctor.
GriseofulvinMedroxyprogesterone
Severe
How does the drug interact with Grisofline 500mg Tablet:
Taking Grisofline 500mg Tablet with medroxyprogesterone may reduce blood levels and the effects of medroxyprogesterone.

How to manage the interaction:
There may be a possibility of interaction between Grisofline 500mg Tablet and Medroxyprogesterone, but it can be taken if prescribed by a doctor. However, if you experience any of these symptoms like unexpected bleeding or abnormal bleeding, or if you think you might be pregnant while using birth control, it's important to contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
GriseofulvinEverolimus
Severe
How does the drug interact with Grisofline 500mg Tablet:
When Everolimus is taken with Grisofline 500mg Tablet, it may decrease the blood levels of everolimus, which may make everolimus less effective in treating the condition.

How to manage the interaction:
There may be a possibility of interaction between Everolimus and Grisofline 500mg Tablet, but it can be taken if prescribed by a doctor. Do not stop using any medications without talking to a doctor.
GriseofulvinAminolevulinic acid
Severe
How does the drug interact with Grisofline 500mg Tablet:
Aminolaevulinic acid sensitizes skin to bright sunlight and taking it with another medication that can have the same effect (i.e., photosensitivity) such as Grisofline 500mg Tablet may increase chance of getting a serious sunburn.

How to manage the interaction:
Although taking Grisofline 500mg Tablet and Aminolaevulinic acid together can cause an interaction, it can be taken if a doctor has suggested it. After treatment, avoid exposing your eyes and skin to sunlight or intense interior lights for 48 hours. Do not discontinue any medications without consulting a doctor.
GriseofulvinEthinylestradiol
Severe
How does the drug interact with Grisofline 500mg Tablet:
Taking ethinyl estradiol with Grisofline 500mg Tablet may reduce blood levels and the effects of ethinyl estradiol.

How to manage the interaction:
Although taking Ethinylestradiol and Grisofline 500mg Tablet together can cause an interaction, it can be taken if a doctor has suggested it. However, if you use hormone replacement therapy (ethinyl estradiol) for menopause, inform a doctor if your symptoms are no longer controlled or if you deal with unusual bleeding. Do not stop using any medications without a doctor's advice.
GriseofulvinNorethisterone
Severe
How does the drug interact with Grisofline 500mg Tablet:
Taking Grisofline 500mg Tablet with norethisterone may reduce blood levels and the effects of norethisterone.

How to manage the interaction:
Although there is a possible interaction between Grisofline 500mg Tablet and Norethisterone, you can take these medicines together if prescribed by a doctor. However, if you experience any of these symptoms like unexpected bleeding or abnormal bleeding, it's important to contact a doctor immediately. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

verifiedApollotooltip
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[ANTIFUNGALS]

FAQs

Grisofline 500mg Tablet is used to treat fungal infections of the skin like ringworm, jock itch, athlete’s foot, and fungal infections of nails and hair.
You are not recommended to take Grisofline 500mg Tablet with warfarin as co-administration of these two medicines may change the effects of warfarin. Please consult a doctor if you experience dizziness, unusual bleeding or bruising, blood in urine or stools, vomiting or weakness. Also, contact your doctor before using Grisofline 500mg Tablet with other medicines so that the dose may be adjusted accordingly.
Grisofline 500mg Tablet may damage sperm. Therefore, it is not recommended to father a child while taking Grisofline 500mg Tablet and for 6 months after stopping treatment with Grisofline 500mg Tablet. It is advised to use effective contraceptive measures during this period to avoid pregnancy.
Grisofline 500mg Tablet may increase the skin sensitivity to sunlight. Therefore, avoid or limit exposure to sunlight and sunlamps. You are advised to use sunscreen and wear protective clothing while going out to prevent sunburn. However, if you notice any unusual sensitivity to the sun like a rash while using Grisofline 500mg Tablet, please consult a doctor.
You are not recommended to take oral contraceptive pills with Grisofline 500mg Tablet to prevent pregnancy as it may reduce the effect of oral contraceptive pills. Therefore, you are advised to use other contraceptive methods such as condoms to prevent pregnancy while taking Grisofline 500mg Tablet, and for 4 weeks (in females) and 6 months (in males) after stopping treatment with Grisofline 500mg Tablet.
Yes, fungal infection is a contagious skin condition which spreads from one person to another through direct skin-to-skin contact or by contact with contaminated soil/surfaces and infected animals. Therefore, it is recommended to avoid close direct contact until the infection is clear and avoid sharing things with the infected person as it can also spread the infection.
You are not recommended to stop using Grisofline 500mg Tablet without consulting your doctor as it may cause recurring infections. Therefore, take Grisofline 500mg Tablet for as long as your doctor has prescribed it, and if you experience any difficulty while taking Grisofline 500mg Tablet, please consult your doctor.
It is highly recommended to take Grisofline 500mg Tablet with a fat-rich meal or snack rather than on an empty stomach. Dietary fat helps your body absorb the medicine properly, ensuring it works effectively against the infection. Talk to your doctor or pharmacist if you have questions about suitable food options.
Stop taking the medicine immediately and contact your doctor right away. Grisofline 500mg Tablet can cause serious harm to an unborn baby and should not be used during pregnancy.
Fungal nail infections can take several months to clear completely, often requiring 6 months or longer of daily treatment. The medicine works by protecting new nail growth, so the infection is only fully resolved once the old, infected nail grows out and is cut away. Talk to your doctor to monitor your progress.
You should avoid alcohol while taking Grisofline 500mg Tablet. Combining the two can trigger an uncomfortable reaction characterized by a rapid heart rate, skin flushing, and heavy sweating, and it may also increase the risk of liver irritation. Talk to your doctor if you have concerns.
Take the missed dose as soon as you remember. If your next scheduled dose is only a few hours away, skip the missed dose and return to your normal schedule. Never take two doses at once to make up for a missed one. Talk to your doctor or pharmacist if you frequently miss doses.
Yes, Grisofline 500mg Tablet can reduce the effectiveness of hormonal contraceptives, including birth control pills, patches, and implants. You should use an effective barrier method of birth control, such as condoms, while taking this medicine and for at least one month after stopping it. Talk to your doctor about your options.
Yes, Grisofline 500mg Tablet is commonly prescribed to children to treat fungal scalp infections (ringworm of the scalp). However, the dose must be carefully calculated by a pediatrician based on the child's weight. Talk to your doctor for specific pediatric guidance.

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Country of origin

India
Other Info - GR64513
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