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compositionComposition:LINEZOLID-200MG
prescription
Prescription Medicine
info
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Gufilinoz Injection 300 ml is an antibiotic medication used to treat bacterial infections of the skin and soft tissues, lungs (pneumonia) and bloodstream infections. It is also used to treat infections that are resistant to other antibiotics, such as vancomycin-resistant enterococcal infections.

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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

LINEZOLID-200MG

Manufacturer/Marketer :

Gufic Bioscience Ltd

Consume Type :

Parenteral

Expires on or after :

Jan-28

Return Policy :

Not Returnable

About Gufilinoz Injection 300 ml

Gufilinoz Injection 300 ml is a sterile injection used to treat serious bacterial infections, including certain types of pneumonia and severe skin infections. It belongs to a class of antibiotics that stop the growth of bacteria, helping your body fight off the infection. Doctors reserve this medicine for complicated infections, especially those resistant to other antibiotics.

Because this medicine is given directly into a vein, healthcare professionals usually give it at regular intervals to maintain a steady level in your blood. You do not need to worry about taking it with food, as the injection bypasses the stomach. Eating a balanced diet and staying well-hydrated can support your immune system during treatment.

While using Gufilinoz Injection 300 ml, you may experience mild side effects like diarrhoea, headaches, or nausea. However, you must contact your healthcare provider immediately if you experience severe symptoms such as blurred vision, persistent diarrhoea, or unusual bruising.

Talk to your doctor before starting this medicine if you have high blood pressure, thyroid problems, or a history of seizures. Do not take this if you are currently taking, or have taken in the last two weeks, a monoamine oxidase inhibitor (MAOI) for depression.

Gufilinoz Injection 300 ml can interact with certain foods containing tyramine (like aged cheeses) and medicines that increase serotonin levels, which can cause a dangerous rise in blood pressure. It is also important to avoid alcohol during treatment, and you should consult your doctor if you are pregnant, breastfeeding, or an older adult.
 

Uses of Gufilinoz Injection 300 ml

Gufilinoz Injection 300 ml is used to treat serious bacterial infections. The detailed uses of Gufilinoz Injection 300 ml are as follows:

  • Pneumonia: Gufilinoz Injection 300 ml helps clear severe lung infections, including hospital-acquired and community-acquired pneumonia caused by susceptible bacteria.
  • Complicated skin and soft tissue infections: Gufilinoz Injection 300 ml targets and eliminates bacteria causing deep skin infections, helping the tissue heal properly.
  • Vancomycin-resistant Enterococcus (VRE) infections: Gufilinoz Injection 300 ml is highly effective against specific drug-resistant bacterial strains that other antibiotics cannot treat.
     

Key Benefits

Gufilinoz Injection 300 ml provides critical therapeutic benefits for patients facing hard-to-treat bacterial infections:

  • Targeted treatment of resistant bacteria: It overcomes bacterial resistance, giving patients a reliable treatment option when standard antibiotics fail.
  • Faster recovery from severe illness: By rapidly stopping bacterial growth, it helps reduce fever, chest discomfort, and skin inflammation, allowing you to regain your strength sooner.
  • Direct delivery into the bloodstream: The parenteral route ensures 100% of the medication is immediately available to fight infection throughout the body.

Directions for Use

  • Follow your doctor’s instructions on the dosage and timing of this medication to ensure safe and effective use.
  • Gufilinoz Injection 300 ml will be administered by the doctor or healthcare professional.
  • Do not self-administer.

How Gufilinoz Injection 300 ml Works

Gufilinoz Injection 300 ml contains linezolid, which works by stopping bacteria from growing and multiplying. It does this by binding to a specific part of the bacterial cell (the ribosome) and preventing it from making essential proteins that the bacteria need to survive and replicate. Without these vital proteins, the bacteria cannot spread or maintain their structure. This stops the infection in its tracks, allowing your body's natural immune system to easily target and clear the remaining bacteria.
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Alcohol

Unsafe

Avoid consuming alcohol while taking Gufilinoz Injection 300 ml as it may cause increased dizziness.

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Pregnancy

Consult your doctor

The safety of Gufilinoz Injection 300 ml in pregnant women is not known. If you are pregnant, consult your doctor.

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Breast Feeding

Caution

If you are a breastfeeding mother, inform your doctor before receiving this medicine. Gufilinoz Injection 300 ml passes into breastmilk and can cause diarrhoea and vomiting in infants; therefore, discontinue breastfeeding prior to and throughout the treatment.

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Driving

Caution

Gufilinoz Injection 300 ml may cause dizziness and vision problems. So, drive only if you are alert.

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Liver

Caution

Long-term treatment with Gufilinoz Injection 300 ml may worsen your liver condition if you have liver problems. Dose adjustment may be needed. Please inform your doctor before taking Gufilinoz Injection 300 ml if you have liver impairment/liver disease or a history of liver conditions.

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Kidney

Consult your doctor

If you have kidney problems, inform your doctor before receiving this injection.

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Children

Consult your doctor

Your doctor will weigh the benefits and potential risks before prescribing Gufilinoz Injection 300 ml for your children based on age and the condition of the child.

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Heart

Caution

Gufilinoz Injection 300 ml can be used in heart patients but requires caution due to potential blood pressure changes. Always inform your doctor about your heart condition and medications to avoid serious interactions.

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Geriatrics

Caution

Geriatric patients can receive Gufilinoz Injection 300 ml, but it may be more prone to side effects like low blood cell counts or neuropathy. Regular monitoring and dose adjustments help ensure safe and effective treatment.

What if I have taken an overdose of Gufilinoz Injection 300 ml

If you receive too much of this medicine, or experience severe dizziness, vomiting, or muscle tremors, seek emergency medical care immediately.

Diet & Lifestyle Advise

  • Avoid foods high in tyramine: While using Gufilinoz Injection 300 ml, avoid aged cheeses, air-dried or cured meats, red wine, tap beers, sauerkraut, and soy sauce. These foods can react with the medicine and cause a dangerous spike in your blood pressure.
  • Stay hydrated: Drink plenty of water throughout your treatment to help your kidneys process the medication and to prevent dehydration, especially if you experience mild diarrhoea.
  • Limit caffeine intake: High amounts of caffeine from coffee, tea, energy drinks, or chocolate can increase the risk of elevated blood pressure when combined with this medicine.
  • Get plenty of rest: Your body needs energy to fight off a serious infection, so prioritise sleep and avoid strenuous physical activities during your recovery.
     
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How Soon It Starts Working

  • The time required for Gufilinoz Injection 300 ml to start to work: Gufilinoz Injection 300 ml ideally shows its action within 1 to 2 hours after administration.
  • The time for which the effects of Gufilinoz Injection 300 ml last: The effect of Gufilinoz Injection 300 ml lasts for 12 hours.

What if you forget to take Gufilinoz Injection 300 ml

Since Gufilinoz Injection 300 ml is usually given by a healthcare provider, a missed dose is unlikely. If you are injecting it at home and miss a scheduled infusion, contact your doctor or nurse immediately for guidance. Do not double the dose to make up for a missed one.

Storage

• Store Gufilinoz Injection 300 ml infusion bags at room temperature, ideally between 20°C and 25°C (68°F to 77°F).

Drug Warnings

  • Inspect the solution before use: Always check the infusion bag for leaks, cloudiness, or floating particles. If you notice any of these, do not inject it and contact your pharmacist.
  • Monitor your blood counts: If you use this medicine for more than two weeks, your doctor will likely order weekly blood tests to check your platelet and red blood cell levels.
  • Check your vision: Tell your doctor immediately if you experience any changes in your eyesight, especially if your treatment lasts longer than 28 days.
  • Watch for nerve symptoms: Report any numbness, tingling, or weakness in your hands or feet, as these can be signs of nerve damage.
  • Rotate injection sites: If you are injecting this at home, rotate the injection site as directed by your nurse to prevent irritation or vein inflammation.
     

Drug-Drug Interactions

verifiedApollotooltip
  • Antidepressants (such as SSRIs, SNRIs, and MAOIs): Combining these with Gufilinoz Injection 300 ml can lead to a life-threatening condition called serotonin syndrome, causing confusion, high fever, and muscle stiffness.
  • Decongestants and cold medicines: Medications containing pseudoephedrine or phenylephrine can cause a severe, sudden increase in blood pressure when taken with Gufilinoz Injection 300 ml.
  • Migraine medications (triptans): These can also increase the risk of serotonin syndrome.
     
LinezolidCarbamazepine
Critical
LinezolidVortioxetine
Critical

Drug-Drug Interactions

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LinezolidCarbamazepine
Critical
How does the drug interact with Gufilinoz Injection 300 ml:
Using Carbamazepine with Gufilinoz Injection 300 ml can cause serotonin syndrome(a condition in which a chemical called serotonin builds up in your body).

How to manage the interaction:
Taking Carbamazepine and Gufilinoz Injection 300 ml together is not recommended, but it can be taken if prescribed by a doctor. However, if you experience symptoms such as confusion, hallucination, seizure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, stomach pain, nausea, vomiting, and diarrhea, consult the doctor. Do not discontinue any medications without consulting a doctor.
LinezolidVortioxetine
Critical
How does the drug interact with Gufilinoz Injection 300 ml:
Co-administration of Gufilinoz Injection 300 ml with Vortioxetine can increase the risk of serotonin syndrome (A condition in which a chemical called serotonin increases in your body).

How to manage the interaction:
Taking Gufilinoz Injection 300 ml with Vortioxetine can result in an interaction, it can be taken if a doctor has advised it. If you notice any of these symptoms like confusion, hallucination, seizure, extreme changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremor, incoordination, stomach cramp, nausea, vomiting, and diarrhea consult a doctor. Do not discontinue any medications without consulting a doctor.
LinezolidAtomoxetine
Critical
How does the drug interact with Gufilinoz Injection 300 ml:
Using Gufilinoz Injection 300 ml together with atomoxetine can cause high blood pressure.

How to manage the interaction:
Taking Gufilinoz Injection 300 ml with Atomoxetine is not recommended, consult a doctor before taking it. You should seek immediate medical attention if you experience sudden and severe headache, blurred vision, confusion, seizures, chest pain, nausea or vomiting, sudden numbness or weakness (especially on one side of the body), speech difficulties, fever, sweating, lightheadedness, and/or fainting. Do not stop using any medications without talking to a doctor.
LinezolidMephentermine
Critical
How does the drug interact with Gufilinoz Injection 300 ml:
Taking Gufilinoz Injection 300 ml and Mephentermine together may cause high blood pressure.

How to manage the interaction:
Taking Mephentermine with Gufilinoz Injection 300 ml is not recommended, as it can result in an interaction, it can be taken if a doctor has advised it. However, consult a doctor immediately if you experience any unusual symptoms. Do not discontinue any medications without consulting a doctor.
LinezolidAmitriptyline
Critical
How does the drug interact with Gufilinoz Injection 300 ml:
Taking Gufilinoz Injection 300 ml with Amitriptyline can increase the risk of serotonin syndrome (increased serotonin hormone).

How to manage the interaction:
Although using Gufilinoz Injection 300 ml and Amitriptyline together may cause an interaction, they can be taken if prescribed by a doctor. Consult a doctor if you have symptoms such as confusion, hallucination, fits, blood pressure alteration, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, incoordination, stomach cramps, nausea, vomiting, and diarrhea. Inform a doctor if you have recently taken amitriptyline. Do not discontinue any medications without consulting a doctor.
LinezolidCaffeine
Critical
How does the drug interact with Gufilinoz Injection 300 ml:
Taking these two together can cause your blood pressure to rise, a condition known as a hypertensive crisis.

How to manage the interaction:
Taking Caffeine with Gufilinoz Injection 300 ml is not recommended, please consult your doctor before taking it. It can be taken if your doctor prescribes it. Do not stop taking any medication without consulting your doctor.
LinezolidCyproheptadine
Critical
How does the drug interact with Gufilinoz Injection 300 ml:
Using Gufilinoz Injection 300 ml together with cyproheptadine may increase side effects of Cyproheptadine.

How to manage the interaction:
Taking Cyproheptadine with Gufilinoz Injection 300 ml is not recommended, consult a doctor before taking it. Contact a doctor if you experience dizziness, drowsiness, blurred vision, dry mouth, constipation, heat intolerance, flushing, decreased sweating, difficulty urinating, palpitation, rapid heartbeat, confusion, disorientation, and memory problems. Do not stop using any medications without talking to a doctor.
LinezolidTetrabenazine
Critical
How does the drug interact with Gufilinoz Injection 300 ml:
Coadministration of Gufilinoz Injection 300 ml and Tetrabenazine can increase the risk of high blood pressure.

How to manage the interaction:
Taking Gufilinoz Injection 300 ml and Tetrabenazine together is not recommended as it can lead to an interaction, but it can be taken if a doctor advises. However, if you experience any symptoms like severe headache, blurred vision, confusion, seizures, chest pain, nausea or vomiting, sudden numbness or weakness (especially on one side of the body), speech difficulties, fever, sweating, lightheadedness, and fainting, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
LinezolidTramadol
Critical
How does the drug interact with Gufilinoz Injection 300 ml:
Co-administration of Gufilinoz Injection 300 ml with Tramadol can increase the risk of serotonin syndrome and seizures.

How to manage the interaction:
Taking Gufilinoz Injection 300 ml with Tramadol is not recommended, consult a doctor before taking it. Consult a doctor if you experience confusion, hallucination, seizure, extreme changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremor, incoordination, stomach cramp, nausea, vomiting, and diarrhea. Do not stop using any medications without talking to a doctor.
LinezolidClomipramine
Critical
How does the drug interact with Gufilinoz Injection 300 ml:
When Clomipramine is taken with Gufilinoz Injection 300 ml, may increase the risk of serotonin syndrome (a condition in which a chemical called serotonin increases in your body).

How to manage the interaction:
There may be a possibility of interaction between Clomipramine and Gufilinoz Injection 300 ml, but it can be taken if prescribed by a doctor. If you notice any of these signs - like confusion, hallucination, seizure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremor, incoordination, stomach cramp, nausea, vomiting, and diarrhea-contact a doctor immediately. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

verifiedApollotooltip
  • Tyramine-rich foods: Foods like aged cheese, smoked meats, yeast extracts, and draft beer can cause a dangerous rise in blood pressure.

 

No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[ANTIBIOTICS]

FAQs

Gufilinoz Injection 300 ml belongs to the class of medicines called oxazolidinones, used to treat bacterial infections of the lungs (pneumonia) and skin. It is also used to treat infections which are resistant to other antibiotics.
Gufilinoz Injection 300 ml works by stopping the growth of infection-causing bacteria. Thus, it treats the infection.
Diarrhoea might be a side-effect of Gufilinoz Injection 300 ml. Drink lots of fluids and eat non-spicy food if you experience diarrhoea. If you find blood in stools (tarry stools) or if you have prolonged diarrhoea with abdominal pain while on treatment with Gufilinoz Injection 300 ml, inform your doctor. Do not take anti-diarrheal medicine on your own.
Gufilinoz Injection 300 ml may cause oral or vaginal thrush or candidiasis, which is a fungal infection occurring due to the overgrowth of yeast-like fungus in the mouth/throat or vagina. Consult your doctor if the condition persists or worsens.
Gufilinoz Injection 300 ml may affect certain laboratory test results such as blood tests, blood sugar tests, and liver and kidney function tests. Inform the lab technician that you are on treatment with Gufilinoz Injection 300 ml.
Gufilinoz Injection 300 ml may cause anaemia due to a decrease in the number of red blood cells. This could also cause unexplained bleeding or bruising. Consult your doctor if you experience unexplained bleeding or bruising.
Gufilinoz Injection 300 ml may cause side effects, such as headache, a metallic taste, diarrhoea, nausea, vomiting, dizziness, constipation, pain at the injection site, and indigestion. Most of these side effects do not require medical attention. However, talk to your doctor if you experience these side effects persistently.
Your doctor may order weekly blood tests, especially if you are on this medicine for more than 10 to 14 days, to monitor your blood cell counts, as this medicine can temporarily lower them. Talk to your doctor if you have concerns about these tests.
No, you should avoid alcohol, especially draft beers and red wine, because they contain high levels of tyramine, which can cause a severe increase in your blood pressure when combined with this medicine. Talk to your doctor for more safety advice.
If you notice redness, swelling, pain, or warmth around the injection site, contact your healthcare provider right away, as these could be signs of skin irritation or infection. Talk to your doctor or nurse for proper care steps.
Yes, long-term use of Gufilinoz Injection 300 ml (usually more than 28 days) has been linked to nerve problems, such as numbness or tingling in the hands and feet. Talk to your doctor immediately if you experience these symptoms.
Yes, you must avoid foods rich in tyramine, such as aged cheeses, cured meats, and soy sauce, to prevent a dangerous rise in blood pressure. Talk to your doctor or pharmacist for a complete list of foods to avoid.
No, Gufilinoz Injection 300 ml is an antibiotic and only works against bacterial infections. It will not treat viral infections like the common cold or flu. Talk to your doctor to get an accurate diagnosis for your symptoms.

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Reference

  1. Electronic Medicines Compendium (EMC). Pil.2931 Patient Information Leaflet (PIL). Cheshire, UK: Datapharm; 2025. [Accessed on 02 Jun. 2026]Check here
  2. U.S. Food and Drug Administration (FDA). 021130S028Lbl [FDA Prescribing Information]. Silver Spring, MD: FDA; 2024. [Accessed on 02 Jun. 2026]Check here
  3. Drugs.com Clinical Review Team. Linezolid Injection Clinical Drug Monograph. Auckland, NZ: Drugs.com; 2026. [Accessed on 02 Jun. 2026]Check here
  4. ScienceDirect ScienceDirect. [Accessed on 30 Mar. 2019]Check here
  5. Linezolid Linezolid. 2000. [Accessed on 30 Mar. 2019]Check here
  6. Linezolid 600 mg Tablet- Summary of Product Characteristics (SmPC) - (emc) [Internet]. Medicines.org.uk. 2025 [Accessed on 29 Dec 2025]Check here
  7. Linezolid 600 mg Tablet- Patient Information Leaflet (PIL) - (emc) [Internet]. Medicines.org.uk. 2025 [Accessed on 29 Dec 2025]Check here

Country of origin

India

Manufacturer/Marketer address

37,1St Floor, Kamala Bhavan Ii, Swami Nityanand Road, Andheri (East), Mumbai - 400 069. (India).
Other Info - GUF0043
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