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compositionComposition:HYDROXYPROGESTERONE-250MG
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Prescription Medicine
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Gynonys Injection 1 ml is used to prevent premature labour. It contains Hydroxyprogesterone, which modulates the immune response of pregnant women to prevent rejection of the embryo and allow its attachment to the uterus. It prevents miscarriage and helps lower the risk of premature birth in pregnant women who have had past premature labour. In some cases, you may experience certain common side effects such as nausea, vomiting, itching, hives (skin rashes), swelling in the face, lips, tongue, or throat, and diarrhea.

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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

HYDROXYPROGESTERONE-250MG

Manufacturer/Marketer :

Uni Sankyo Ltd

Consume Type :

Parenteral

Expires on or after :

Jan-29

Return Policy :

Not Returnable

About Gynonys Injection 1 ml

Gynonys Injection 1 ml is a prescription hormonal treatment used to help reduce the risk of preterm birth in pregnant women who have previously delivered a baby too early. This injection provides essential hormonal support to help carry a pregnancy closer to its full term. It is medically indicated only for individuals with a history of a single, spontaneous premature delivery.

This therapy is typically injected once a week by a healthcare professional, and maintaining a highly consistent schedule is vital for its effectiveness. Because it is given as an injection, its absorption is not affected by food, meaning it can be taken regardless of meal times. Adopting supportive lifestyle habits, such as staying well-hydrated and avoiding prolonged standing, can further help optimise your pregnancy outcomes while on this treatment.

Common side effects of this medication include redness, swelling, or pain at the injection site, as well as mild nausea or diarrhoea. While these are usually manageable, you must consult your doctor immediately if you experience serious side effects like sudden leg pain, warmth, or swelling, which could indicate a blood clot. Seeking prompt medical advice ensures any severe issues are addressed quickly and safely.

Before starting this medication, it is essential to talk to your doctor if you have a history of diabetes, high blood pressure, kidney disease, or depression. Do not take this if you have a history of blood clots, severe liver damage, breast cancer, or unusual vaginal bleeding that has not been evaluated by a physician. Your healthcare provider will determine if this therapy is safe for your specific health profile.

This injection can interact with certain liver-enzyme medications, which may reduce how well the hormone works. It is specifically designed for pregnant individuals, but you should consult your doctor if you are breastfeeding or have specific age-related concerns. Avoid smoking and alcohol, as smoking significantly increases your risk of dangerous blood clots during hormone therapy.

Uses of Gynonys Injection 1 ml

Gynonys Injection 1 ml is used to help reduce the risk of preterm birth. The detailed uses of Gynonys Injection 1 ml are as follows:

  • Preterm birth prevention: Gynonys Injection 1 ml helps lower the risk of early delivery in pregnant individuals who have already had a single baby born prematurely in the past.
  • Other hormonal uses: Hydroxyprogesterone formulations have been used in various hormone-related conditions; however, management of menstrual irregularities is not a standard indication for hydroxyprogesterone caproate. Use outside its approved pregnancy-related indication should only occur when specifically recommended by a healthcare professional.

Key Benefits

Gynonys Injection 1 ml helps support reproductive health by providing pregnancy-focused hormonal support when prescribed by a healthcare professional. By supporting normal hormonal function during pregnancy, it may contribute to better maternal health and pregnancy management in appropriately selected patients. 

  • Supports Pregnancy-Focused Hormonal Management: When prescribed by a qualified obstetrician, Gynonys Injection 1 ml may be used as part of an individualised strategy for patients considered at risk of recurrent preterm birth. It provides progesterone-like hormonal support intended to help maintain a pregnancy-favourable uterine environment. The potential benefits, limitations, and appropriateness of treatment should be assessed on an individual basis in the context of current clinical evidence and guidance.

Directions for Use

This medication is administered as an injection, typically given by a healthcare provider. Always follow your doctor's exact instructions regarding your injection schedule.

  • The injection is usually given slowly into the muscle of the buttocks (intramuscularly).
  • Ensure the injection site is cleaned thoroughly with an alcohol swab before the shot is administered.
  • Rotate the injection site each week (alternating buttocks) to minimise pain, redness, or skin irritation.
  • Keep all scheduled appointments with your healthcare provider to ensure you receive the injection at the same time each week.
  • For patients receiving hydroxyprogesterone caproate for prevention of recurrent preterm birth, treatment is commonly initiated between 16 and 20 weeks of pregnancy and continued until approximately 37 weeks of gestation or delivery, according to the treating physician's recommendations.

How Gynonys Injection 1 ml Works

Gynonys Injection 1 ml contains 'Hydroxyprogesterone', a progestin (female hormones) that modulates the immune response of pregnant women to prevent rejection of the embryo and allow its attachment to the uterus. Gynonys Injection 1 ml prevents miscarriage and helps lower the risk of premature birth in pregnant women who have had past premature labour.
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Alcohol

Consult your doctor

There is not enough scientific data available for Gynonys Injection 1 ml interaction with alcohol, hence it is best to consult a doctor.

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Pregnancy

Safe if prescribed

Gynonys Injection 1 ml can be used during pregnancy if prescribed by the doctor.

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Breast Feeding

Consult your doctor

Please consult your doctor before using Gynonys Injection 1 ml during breastfeeding.

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Driving

Caution

It is advised to drive with caution after taking Gynonys Injection 1 ml as it may interfere with driving capabilities. It can make you feel drowsy.

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Liver

Caution

Gynonys Injection 1 ml should be taken with caution, especially if you have a history of liver diseases. Your doctor may have to adjust the dose.

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Kidney

Caution

Gynonys Injection 1 ml should be taken with caution, especially if you have a history of kidney diseases. Your doctor may have to adjust the dose.

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Children

Unsafe

Gynonys Injection 1 ml not indicated for use in children. Safety and effectiveness in pediatric patients less than 16 years of age have not been established.

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Heart

Unsafe

Gynonys Injection 1 ml is not recommended for use in heart patients as it can lead to cardiovascular effects.

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Geriatrics

Unsafe

Gynonys Injection 1 ml is not recommended for use in elderly patients as it can lead to side effects.

What if I have taken an overdose of Gynonys Injection 1 ml

Since a trained professional typically injects this medication, an overdose is highly unlikely. However, if you suspect an accidental overdose or experience severe symptoms like extreme dizziness, breathing difficulties, or severe nausea, seek immediate medical attention or contact emergency services.

Diet & Lifestyle Advise

  • Eat a nutrient-dense diet rich in folic acid, iron, and calcium to support your baby's development and protect your own bone health during pregnancy.
  • Drink plenty of water throughout the day, as staying hydrated helps prevent uterine irritability and early contractions.
  • Avoid prolonged sitting or standing to help reduce the risk of blood clots, which is a known risk during pregnancy and hormonal therapies.
  • Perform safe, low-impact exercises like walking only if approved by your doctor to promote healthy blood circulation.
  • Ensure complete avoidance of smoking, alcohol, and exposure to secondhand smoke to minimise the risk of vascular complications and early labour.
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Have a query?

How Soon It Starts Working

  • The time required for Gynonys Injection 1 ml to start to work: The time required for Gynonys Injection 1 ml to show its action is unknown.
  • The time for which the effects of Gynonys Injection 1 ml last: The duration of action for Gynonys Injection 1 ml is unknown.

What if you forget to take Gynonys Injection 1 ml

Because this medication is usually injected by a healthcare professional, missing a dose means missing an appointment. If you miss a scheduled injection, contact your doctor or clinic immediately to reschedule. Do not double the next dose or receive injections closer together than prescribed.

Storage

•Store the vials or syringes at room temperature, ideally between 20°C to 25°C (68°F to 77°F). •Do not freeze this medication. If the injection solution freezes, it must be discarded.

Drug Warnings

  • Check the solution: Inspect the vial before injecting. The liquid should be clear and pale yellow. Do not use if it is cloudy, contains particles, or is dark yellow.
  • Rotate injection sites: Alternate sides of your buttocks with each weekly injection to prevent skin thickening, deep bruising, or scar tissue.
  • Track your schedule: Use a calendar or phone alarm to ensure you get your injection exactly every 7 days. Consistency is key for preventing early labour.
  • Monitor blood sugar: If you have gestational diabetes, check your blood glucose levels regularly, as this hormonal injection can alter sugar tolerance.
  • Pre-surgery warning: Inform your surgeon or dentist that you are receiving a progestin injection, as you may need to pause treatment temporarily before surgeries to avoid blood clots.
  • The role of Gynonys Injection 1 ml in preventing preterm birth: It has been the subject of ongoing regulatory and scientific review in some countries. Decisions regarding its use should be made by the treating obstetrician based on an individual assessment of potential benefits, risks, and current clinical guidance. 

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Drug-Drug Interactions

  • Liver-enzyme inducers: Medicines like rifampin or certain anti-seizure medications (such as carbamazepine) can speed up how your body processes this hormone, which may reduce the effectiveness of Gynonys Injection 1 ml in preventing preterm birth.

Drug-Disease Interactions

  • Liver disease: Do not use this medication if you have active or severe liver disease unless specifically advised by your healthcare provider. Impaired liver function can alter the metabolism and clearance of Gynonys Injection 1 ml, potentially leading to unpredictable hormone levels and changes in treatment response.
  • Blood clotting disorders: Avoid use if you have a history of blood clots, strokes, or deep vein thrombosis, as hormone therapy can increase clotting risks.
  • Hormone-sensitive cancers: Do not use if you have or are suspected of having breast cancer or other hormone-dependent tumours.
  • Unexplained vaginal bleeding: Use is restricted if you have undiagnosed vaginal bleeding, as the underlying cause must be evaluated first.

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[HORMONES]

FAQs

Gynonys Injection 1 ml is used to prevent premature labour. It prevents miscarriage and helps lower the risk of premature birth in pregnant women.
Gynonys Injection 1 ml may cause weight gain. It can be due to water retention. If you feel that you are gaining a lot of weight while taking Gynonys Injection 1 ml, please consult your doctor.
Gynonys Injection 1 ml works by modulating the immune response of pregnant women to prevent the rejection of the embryo and allow its attachment to the uterus.
Gynonys Injection 1 ml should be taken in the dose and duration as prescribed by the doctor.
Progesterone is an endogenous steroid and progestogen sex hormone secreted by the female reproductive part in the second half of the menstrual cycle to prepare for the release of the egg in the uterus. It is also necessary for the implantation of the fertilized egg in the uterus, for maintaining pregnancy and in hormonal replacement therapy in women deficient in progesterone.
Some of the common side effects of Gynonys Injection 1 ml include nausea, vomiting, itching, hives (skin rashes), swelling of the face, lips, tongue, or throat, and diarrhea.
You should stop using Gynonys Injection 1 ml and tell a doctor before using Gynonys Injection 1 ml if you have uncontrolled high blood pressure (hypertension), unusual vaginal bleeding, liver disease, liver cancer, jaundice during pregnancy, circulation problems or bleeding problems, stroke, blood clot problems, breast cancer, uterus/cervix/vaginal cancer.
Since Gynonys Injection 1 ml is administered by a doctor, it's unlikely you will stop taking Gynonys Injection 1 ml on your own. Complete the duration of treatment as prescribed by the doctor.
Gynonys Injection 1 ml will be administered by a doctor. The doctor will determine the dose based on your condition.
Since Gynonys Injection 1 ml is administered by a doctor, it's unlikely for you to miss a dose. Consult the doctor if you think you have missed a dose.
You should not receive Gynonys Injection 1 ml if you are allergic to any of its components, if you have blood clotting problems, uncontrolled high blood pressure, or breast cancer.
No, this medication is only established for use in women carrying a single baby who have a history of preterm birth. It is not shown to be effective or safe for multiple pregnancies. Talk to your doctor.
It is given as an intramuscular injection, usually in the buttocks, by a trained healthcare professional on a weekly schedule. Talk to your doctor.
Mild injection site reactions like pain, redness, or swelling are common. Applying a warm compress can help soothe the area, but if you notice pus, severe warmth, or worsening swelling, talk to your doctor.
It is highly recommended to avoid alcohol during your treatment, both to protect your pregnancy and to prevent additional stress on your liver. Talk to your doctor.
Yes, hormonal injections can increase the risk of blood clots. You should seek immediate medical help if you experience sudden leg swelling, chest pain, or breathing problems. Talk to your doctor.
This hormone injection can affect how your body processes glucose, potentially raising your blood sugar levels. You will need to monitor your blood sugar more closely. Talk to your doctor.
For prevention of recurrent preterm birth, treatment is commonly started between 16 and 20 weeks of pregnancy and continued until around 37 weeks of gestation or until delivery, depending on your doctor's assessment and treatment plan. Talk to your doctor.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Country of origin

India

Manufacturer/Marketer address

No 13, Road No. 2, Sagar Society, Sri Nagar Colony, Aurora Colony, Banjara Hills, Hyderabad, Telangana 500034
Other Info - GYN0012

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