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compositionComposition:TRASTUZUMAB-440MG
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Hertrust 440 Powder For Solution Combipack Injection 1's is used to treat Breast Cancer and Stomach Cancer. Hertrust 440 Powder For Solution Combipack Injection 1's contains Trastuzumab, which works by attaching itself to the HER2 proteins so that the cancer cells are no longer stimulated to grow. It also helps the body's immune system to destroy breast cancer cells. It should not be taken during pregnancy as it might cause fetal harm. Inform your doctor immediately if you are conceiving while on therapy. Advise women not to breastfeed while taking Hertrust 440 Powder For Solution Combipack Injection 1's.

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Written By Dr. Lakshmithulasi Yarragunta , PharmD (PB)
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

TRASTUZUMAB-440MG

Manufacturer/Marketer :

Axiommax Oncology Pvt Ltd

Consume Type :

Parenteral

Expires on or after :

Jan-28

Return Policy :

Not Returnable

About Hertrust 440 Powder For Solution Combipack Injection 1's

Hertrust 440 Powder For Solution Combipack Injection 1's is a specialised injection used to treat certain types of breast and stomach cancers that produce too much of a protein called HER2. By targeting these specific cancer cells, it helps slow down or stop their growth. This medicine is a key part of targeted cancer therapy prescribed by oncology specialists.

Hertrust 440 Powder For Solution Combipack Injection 1's is given as an injection or infusion, typically once every week or every three weeks, depending on your treatment plan. Consistency is vital, so keeping all your scheduled appointments is highly recommended. To support your body during treatment, maintaining a balanced diet, staying well-hydrated, and getting plenty of rest can help manage physical demands.

Some people experience mild side effects like chills, fever, or nausea, particularly during or after the first few sessions. However, you must seek immediate medical help if you experience serious symptoms such as shortness of breath, swelling in your legs, or a rapid heartbeat, as these can point to heart or lung complications.

Before starting Hertrust 440 Powder For Solution Combipack Injection 1's, inform your doctor if you have a history of heart disease, high blood pressure, or lung disorders. Do not take this medicine if you have had a severe allergic reaction to it or its ingredients in the past. Pregnant women should also avoid this medicine as it can cause harm to an unborn baby.

It is important to tell your healthcare provider about all other medicines you take, as some can increase the risk of heart damage when combined with Hertrust 440 Powder For Solution Combipack Injection 1's. Limit or avoid alcohol and smoking to prevent extra strain on your organs. If you are breastfeeding or elderly, talk to your doctor to understand the risks and benefits before starting treatment.

Uses of Hertrust 440 Powder For Solution Combipack Injection 1's

Hertrust 440 Powder For Solution Combipack Injection 1's is used to treat certain types of breast and stomach cancers that produce too much HER2. The detailed uses of Hertrust 440 Powder For Solution Combipack Injection 1's are as follows:

  • HER2-positive breast cancer: Hertrust 440 Powder For Solution Combipack Injection 1's helps by targeting and blocking the HER2 receptors on cancer cells, which slows down tumor growth and reduces the risk of the cancer returning after surgery or chemotherapy.
  • HER2-positive metastatic stomach (gastric) cancer: Hertrust 440 Powder For Solution Combipack Injection 1's works in combination with chemotherapy to slow the progression of advanced stomach or gastroesophageal junction cancers that overexpress the HER2 protein.

Key Benefits

Hertrust 440 Powder For Solution Combipack Injection 1's offers significant clinical benefits for individuals facing specific types of aggressive cancers. By focusing directly on cancer cells rather than all rapidly dividing cells, it helps limit damage to healthy tissues, resulting in a more targeted approach to cancer care. Key benefits include:

  • Reduced risk of cancer recurrence: When used after surgery for early-stage breast cancer, it significantly lowers the chances of the cancer coming back.
  • Extended survival times: In advanced or metastatic cases of breast and stomach cancer, it helps control tumour growth, which can help extend life and improve comfort.
  • Synergy with chemotherapy: It enhances the effectiveness of standard chemotherapy drugs, making the overall treatment regimen more successful at shrinking tumours.
Side effects of Hertrust 440 Powder For Solution Combipack Injection
Here's a comprehensive approach to managing medication-triggered fever:
  • Inform your doctor immediately if you experience a fever after starting a new medication.
  • Your doctor may adjust your medication regimen or dosage as needed to minimize fever symptoms.
  • Monitor your body temperature to monitor fever progression.
  • Drink plenty of fluids, such as water or electrolyte-rich beverages, to help your body regulate temperature.
  • Get plenty of rest and engage in relaxation techniques, such as deep breathing or meditation, to help manage fever symptoms.
  • Under the guidance of your doctor, consider taking medication, such as acetaminophen or ibuprofen, to help reduce fever.
  • If your fever is extremely high (over 103°F), or if you experience severe symptoms such as confusion, seizures, or difficulty breathing, seek immediate medical attention.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
  • Talk to your doctor about medicines to manage neutropenia based on the underlying cause.
  • Avoid contact with people who are sick.
  • Wash your hands regularly with soap and water.
  • Avoid unpasteurized dairy products.
  • Include iron-rich foods like dark leafy vegetables, lean red meat, legumes and fish in your diet.
  • Consume vitamin C-rich foods as they aid iron absorption.
  • Limit tea, cocoa, and coffee as these can slow iron absorption.
  • Exercise regularly; however, do not overdo it.

Directions for Use

  • Follow your doctor’s instructions on the dosage and timing of this medication.
  • Hertrust 440 Powder For Solution Combipack Injection 1's will be administered in a hospital setting under the supervision of a physician qualified by training and experience to administer cancer chemotherapeutic agents.
  • Do not self-administer.

How Hertrust 440 Powder For Solution Combipack Injection 1's Works

Hertrust 440 Powder For Solution Combipack Injection 1's contains trastuzumab, which is a monoclonal antibody, which is a type of protein designed to recognise and attach to specific targets in the body. In certain cancers, tumour cells have an abnormally high number of human epidermal growth factor receptor 2 (HER2) proteins on their surface. These receptors send signals that tell the cancer cells to grow and divide rapidly. When injected, Hertrust 440 Powder For Solution Combipack Injection 1's travels through the bloodstream and binds specifically to these HER2 receptors. By locking onto them, it blocks the growth signals, effectively starving the cancer cells of the instructions they need to multiply. Additionally, this binding action acts as a marker, alerting your body's own immune system to target and destroy the marked cancer cells.
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Alcohol

Unsafe

Avoid consumption of alcohol as it may cause serious side effects.

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Pregnancy

Unsafe

Hertrust 440 Powder For Solution Combipack Injection 1's is not recommended for use in pregnancy as it may harm your foetus. Hence, if you are pregnant or planning pregnancy, inform your doctor before receiving Hertrust 440 Powder For Solution Combipack Injection 1's. Use reliable methods of birth control while on treatment with Hertrust 440 Powder For Solution Combipack Injection 1's.

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Breast Feeding

Unsafe

Avoid nursing your child while on treatment with Hertrust 440 Powder For Solution Combipack Injection 1's as it can cause serious side effects to the baby.

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Driving

Not applicable

-

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Liver

Caution

If you have a pre-existing or a history of liver disease, inform your doctor before receiving Hertrust 440 Powder For Solution Combipack Injection 1's. Your doctor may adjust the dose of this medicine or prescribe a suitable alternative based on your condition.

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Kidney

Caution

Limited data are available on the effect of Hertrust 440 Powder For Solution Combipack Injection 1's in kidney-impaired patients. Hence, if you have a pre-existing or a history of kidney disease, inform your doctor.

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Children

Unsafe

Hertrust 440 Powder For Solution Combipack Injection 1's is not recommended for use in children as the safety and efficacy are not established.

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Heart

Caution

Hertrust 440 Powder For Solution Combipack Injection 1's may increase the risk of heart problems. Therefore, please inform your doctor if you have any heart-related problems before using Hertrust 440 Powder For Solution Combipack Injection 1's.

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Geriatrics

Consult your doctor

Please consult a doctor before administering Hertrust 440 Powder For Solution Combipack Injection 1's to geriatric patients. Your doctor will prescribe Hertrust 440 Powder For Solution Combipack Injection 1's if the benefits outweigh the risks.

What if I have taken an overdose of Hertrust 440 Powder For Solution Combipack Injection 1's

Since this medication is prepared and administered by trained medical professionals in a clinical environment, an accidental overdose is highly unlikely. However, if you suspect an error has occurred or experience sudden, severe symptoms after an injection, notify your healthcare provider or seek emergency medical attention immediately.

Diet & Lifestyle Advise

Supporting your body during cancer treatment can help you manage side effects and maintain your strength. Here are some evidence-based practical tips:

  • Prioritise heart-healthy foods: Because this medicine can affect your heart, eat foods low in saturated fats and sodium. Focus on whole grains, lean proteins, and plenty of vegetables.
  • Stay hydrated: Drink plenty of water throughout the day, especially around your treatment days, to help your kidneys clear medications and reduce fatigue.
  • Eat small, frequent meals: If you experience nausea or a loss of appetite, eating five to six small meals a day instead of three large ones can make eating easier.
  • Protect your immune system: Wash your hands frequently, avoid close contact with people who are sick, and ensure all meats and vegetables are thoroughly cooked and cleaned.
  • Engage in gentle exercise: With your doctor's approval, light activities like walking can help combat treatment-related fatigue and support overall well-being.
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How Soon It Starts Working

The time required for Hertrust 440 Powder For Solution Combipack Injection 1's to start to work: The time required for Hertrust 440 Powder For Solution Combipack Injection 1's to show its action is not clinically established. The time for which the effects of Hertrust 440 Powder For Solution Combipack Injection 1's last: The duration of action for Hertrust 440 Powder For Solution Combipack Injection 1's is not clinically established.

What if you forget to take Hertrust 440 Powder For Solution Combipack Injection 1's

If you miss an appointment for your injection, call your doctor or clinic immediately to reschedule. It is crucial to keep your treatment timeline as consistent as possible to ensure the medicine works effectively. Talk to your doctor or pharmacist to establish a clear plan for missed appointments.

Storage

• Store the medicine in a refrigerator at a temperature between 2°C and 8°C (36°F to 46°F).

Drug Warnings

  • Monitor your heart: Your doctor will perform echocardiograms or MUGA scans to check your heart function before starting and every few months during treatment.
  • Watch for infusion reactions: Tell your nurse immediately if you experience shaking, chills, fever, or dizziness during your injection.
  • Inspect the solution: If you see the vial beforehand, ensure the liquid is clear to slightly pale yellow and free of visible particles. Do not use if cloudy or discoloured.
  • Report breathing changes: Inform your healthcare team immediately if you develop a new or worsening cough or find it hard to breathe.
  • Avoid getting pregnant: Use highly effective birth control during treatment and for at least seven months after your final dose to prevent severe birth defects.

Drug-Drug Interactions

verifiedApollotooltip
  • Anthracycline-based chemotherapies (such as doxorubicin or epirubicin): Taking these medicines close to or alongside Hertrust 440 Powder For Solution Combipack Injection 1's can significantly increase the risk of heart damage or heart failure.
  • Other cardiotoxic drugs: Any medications that can affect heart function may cause cumulative heart strain when used with Hertrust 440 Powder For Solution Combipack Injection 1's.
TrastuzumabClozapine
Severe
TrastuzumabIdarubicin
Severe

Drug-Drug Interactions

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TrastuzumabClozapine
Severe
How does the drug interact with Hertrust 440 Powder For Solution Combipack Injection:
Co-administration of Hertrust 440 Powder For Solution Combipack Injection and clozapine can increase the risk of toxicity.

How to manage the interaction:
Although taking Hertrust 440 Powder For Solution Combipack Injection and Clozapine together can evidently cause an interaction, it can be taken if your doctor has suggested it. If you're having any of these symptoms like fever, chills, sore throat, or muscle aches, it's important to contact your doctor right away. They may be able to recommend other options for you that won't cause any problems. Don't worry, there are solutions available to help you feel better. Do not stop using any medications without first talking to your doctor.
TrastuzumabIdarubicin
Severe
How does the drug interact with Hertrust 440 Powder For Solution Combipack Injection:
Taking Hertrust 440 Powder For Solution Combipack Injection with Idarubicin can increase the risk of heart problems.

How to manage the interaction:
Co-administration of Hertrust 440 Powder For Solution Combipack Injection with Idarubicin can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you experience difficulty breathing, fluid retention, or chest pain, consult a doctor. Do not discontinue any medications without a doctor's advice.
TrastuzumabEtanercept
Severe
How does the drug interact with Hertrust 440 Powder For Solution Combipack Injection:
When Etanercept is used with Hertrust 440 Powder For Solution Combipack Injection, the likelihood or severity of infection may increase.

How to manage the interaction:
There may be a possibility of interaction between Hertrust 440 Powder For Solution Combipack Injection and Etanercept, but it can be taken if prescribed by a doctor. However, if you develop fever, chills, diarrhea, sore throat, muscular pains, shortness of breath, blood in phlegm, weight loss, red or irritated skin, body sores, or discomfort or burning during urination, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.
TrastuzumabTofacitinib
Severe
How does the drug interact with Hertrust 440 Powder For Solution Combipack Injection:
Combining Hertrust 440 Powder For Solution Combipack Injection with Tofacitinib can increase the risk of neutropenia.

How to manage the interaction:
Although there is a possible interaction between Hertrust 440 Powder For Solution Combipack Injection and Tofacitinib, you can take these medicines together if prescribed by your doctor. However, consult the doctor immediately if you experience symptoms such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination. Do not stop using any medications without a doctor's advice.
TrastuzumabBaricitinib
Severe
How does the drug interact with Hertrust 440 Powder For Solution Combipack Injection:
Coadministration of Hertrust 440 Powder For Solution Combipack Injection with Baricitinib can increase the risk of developing serious infections.

How to manage the interaction:
Although there is a possible interaction between Hertrust 440 Powder For Solution Combipack Injection and Baricitinib, you can take these medicines together if prescribed by your doctor. However, consult a doctor if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning when you urinate. Do not stop using any medications without a doctor's advice.
TrastuzumabCladribine
Severe
How does the drug interact with Hertrust 440 Powder For Solution Combipack Injection:
Combining Hertrust 440 Powder For Solution Combipack Injection with Cladribine can increase the risk of developing serious infections.

How to manage the interaction:
Taking Cladribine with Hertrust 440 Powder For Solution Combipack Injection together can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning sensation when you urinate, consult a doctor. Do not stop using any medications without a doctor's advice.
TrastuzumabInfliximab
Severe
How does the drug interact with Hertrust 440 Powder For Solution Combipack Injection:
Combining Hertrust 440 Powder For Solution Combipack Injection with Infliximab can lead to or increase the risk or severity of developing serious infections.

How to manage the interaction:
Taking Hertrust 440 Powder For Solution Combipack Injection with Infliximab together can result in an interaction, but it can be taken if your doctor has advised it. However, if you experience symptoms of fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in sputum, weight loss, red or inflamed skin, body sores, and pain or burning during urination, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
TrastuzumabThalidomide
Severe
How does the drug interact with Hertrust 440 Powder For Solution Combipack Injection:
Taking thalidomide together with Hertrust 440 Powder For Solution Combipack Injection may increase the risk of blood clots and other complications.

How to manage the interaction:
Although taking thalidomide and Hertrust 440 Powder For Solution Combipack Injection together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as chest pain, shortness of breath, difficulty breathing, coughing up blood, sudden loss of vision, pain, redness or swelling in an arm or leg, and numbness or weakness on one side of the body. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

verifiedApollotooltip

No clinically significant food interactions are known with Hertrust 440 Powder For Solution Combipack Injection 1's when used as directed.

No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[ANTINEOPLASTIC]

FAQs

Hertrust 440 Powder For Solution Combipack Injection 1's should not be used during pregnancy because it can seriously harm the unborn baby. Use effective contraception during treatment and for at least 7 months after your last dose. If you are pregnant, planning to become pregnant, or become pregnant during treatment, contact your doctor immediately for advice.
The duration of treatment depends on your cancer type, stage, and response to therapy. For early HER2-positive breast cancer, treatment is commonly given for about one year. For advanced or metastatic HER2-positive cancers, treatment may continue as long as it remains effective and is well tolerated. Your doctor will decide the appropriate treatment duration.
Hertrust 440 Powder For Solution Combipack Injection 1's may affect heart function and, in some people, can reduce the heart's pumping ability or lead to heart failure. Your doctor will perform heart tests before starting treatment and repeat them regularly during therapy to monitor your heart and detect any changes early. The frequency of testing depends on your medical condition, treatment plan, and previous test results.
No, Hertrust 440 Powder For Solution Combipack Injection 1's is not a traditional chemotherapy drug. It is a targeted immunotherapy called a monoclonal antibody. While chemotherapy kills rapidly dividing cells throughout the body, Hertrust 440 Powder For Solution Combipack Injection 1's specifically targets cells that have too much of the HER2 protein. Talk to your doctor to understand how these treatments differ.
It is given as an injection, either slowly into a vein (intravenously) or as a quick injection under the skin (subcutaneously). This is always done by a healthcare professional in a medical setting. Talk to your doctor about which option is right for you.
On its own, Hertrust 440 Powder For Solution Combipack Injection 1's does not typically cause hair loss. However, because it is very often given in combination with chemotherapy, you may experience hair loss from the chemotherapy drugs. Talk to your doctor or pharmacist to learn more about the side effects of your combined treatment plan.
Avoid getting live vaccines, as your immune system may be compromised during treatment. Additionally, limit alcohol intake and avoid smoking to minimise extra stress on your heart and liver. Talk to your doctor before taking any new medications, vitamins, or supplements.
If you miss an appointment, contact your clinic immediately to reschedule. Keeping your doses on schedule is highly important for the treatment to be effective. Talk to your doctor or pharmacist to help you set up a reminder system.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Reference

  1. U.S. Food and Drug Administration (FDA). 103792S5250Lbl [FDA Prescribing Information]. Silver Spring, MD: FDA; 2024. [Accessed on 02 Jun. 2026]Check here
  2. Drugs.com Clinical Review Team. Trastuzumab Clinical Drug Monograph. Auckland, NZ: Drugs.com; 2026. [Accessed on 02 Jun. 2026]Check here
  3. MedlinePlus. A699019 Patient Information Monograph. Bethesda, MD: U.S. National Library of Medicine (NLM); 2025. [Accessed on 02 Jun. 2026]Check here
  4. Trastuzumab Trastuzumab. 1998. [Accessed on 27 Mar. 2019]Check here
  5. Drugs and Lactation Database (LactMed) [Internet]. 2006. [Accessed on 19 Feb. 2020]Check here
  6. Herceptin 150mg Powder for concentrate for solution for infusion - Summary of Product Characteristics (SmPC) - (emc) [Internet]. Medicines.org.uk. 2025 [Accessed on 6 January 2025]Check here
  7. Herceptin 150mg Powder for concentrate for solution for infusion - Patient Information Leaflet (PIL) - (emc) [Internet]. Medicines.org.uk. 2025 [Accessed on 6 January 2025]Check here

Country of origin

India

Manufacturer/Marketer address

A/303, Atrium -1, Andheri - Kurla Road, Mumbai 400 059 India
Other Info - HER0354
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