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compositionComposition:TRASTUZUMAB-150MG
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Hervycta Plus 150 Injection is used to treat Breast Cancer and Stomach Cancer. Hervycta Plus 150 Injection contains Trastuzumab, which works by attaching itself to the HER2 proteins so that the cancer cells are no longer stimulated to grow. It also helps the body's immune system to destroy breast cancer cells. It should not be taken during pregnancy as it might cause fetal harm. Inform your doctor immediately if you are conceiving while on therapy. Advise women not to breastfeed while taking Hervycta Plus 150 Injection.

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Written By Dr. Lakshmithulasi Yarragunta , PharmD (PB)
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

TRASTUZUMAB-150MG

Manufacturer/Marketer :

Dr Reddy's Laboratories Ltd

Consume Type :

Parenteral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Hervycta Plus 150 Injection

Hervycta Plus 150 Injection is a specialised injection used to treat certain types of breast and stomach cancers that produce too much of a protein called HER2. By targeting these specific cancer cells, it helps slow down or stop their growth. This medicine is a key part of targeted cancer therapy prescribed by oncology specialists.

Hervycta Plus 150 Injection is given as an injection or infusion, typically once every week or every three weeks, depending on your treatment plan. Consistency is vital, so keeping all your scheduled appointments is highly recommended. To support your body during treatment, maintaining a balanced diet, staying well-hydrated, and getting plenty of rest can help manage physical demands.

Some people experience mild side effects like chills, fever, or nausea, particularly during or after the first few sessions. However, you must seek immediate medical help if you experience serious symptoms such as shortness of breath, swelling in your legs, or a rapid heartbeat, as these can point to heart or lung complications.

Before starting Hervycta Plus 150 Injection, inform your doctor if you have a history of heart disease, high blood pressure, or lung disorders. Do not take this medicine if you have had a severe allergic reaction to it or its ingredients in the past. Pregnant women should also avoid this medicine as it can cause harm to an unborn baby.

It is important to tell your healthcare provider about all other medicines you take, as some can increase the risk of heart damage when combined with Hervycta Plus 150 Injection. Limit or avoid alcohol and smoking to prevent extra strain on your organs. If you are breastfeeding or elderly, talk to your doctor to understand the risks and benefits before starting treatment.

Uses of Hervycta Plus 150 Injection

Hervycta Plus 150 Injection is used to treat certain types of breast and stomach cancers that produce too much HER2. The detailed uses of Hervycta Plus 150 Injection are as follows:

  • HER2-positive breast cancer: Hervycta Plus 150 Injection helps by targeting and blocking the HER2 receptors on cancer cells, which slows down tumor growth and reduces the risk of the cancer returning after surgery or chemotherapy.
  • HER2-positive metastatic stomach (gastric) cancer: Hervycta Plus 150 Injection works in combination with chemotherapy to slow the progression of advanced stomach or gastroesophageal junction cancers that overexpress the HER2 protein.

Key Benefits

Hervycta Plus 150 Injection offers significant clinical benefits for individuals facing specific types of aggressive cancers. By focusing directly on cancer cells rather than all rapidly dividing cells, it helps limit damage to healthy tissues, resulting in a more targeted approach to cancer care. Key benefits include:

  • Reduced risk of cancer recurrence: When used after surgery for early-stage breast cancer, it significantly lowers the chances of the cancer coming back.
  • Extended survival times: In advanced or metastatic cases of breast and stomach cancer, it helps control tumour growth, which can help extend life and improve comfort.
  • Synergy with chemotherapy: It enhances the effectiveness of standard chemotherapy drugs, making the overall treatment regimen more successful at shrinking tumours.
Side effects of Hervycta Plus 150 Injection

Directions for Use

  • Follow your doctor’s instructions on the dosage and timing of this medication.
  • Hervycta Plus 150 Injection will be administered in a hospital setting under the supervision of a physician qualified by training and experience to administer cancer chemotherapeutic agents.
  • Do not self-administer.

How Hervycta Plus 150 Injection Works

Hervycta Plus 150 Injection contains trastuzumab, which is a monoclonal antibody, which is a type of protein designed to recognise and attach to specific targets in the body. In certain cancers, tumour cells have an abnormally high number of human epidermal growth factor receptor 2 (HER2) proteins on their surface. These receptors send signals that tell the cancer cells to grow and divide rapidly. When injected, Hervycta Plus 150 Injection travels through the bloodstream and binds specifically to these HER2 receptors. By locking onto them, it blocks the growth signals, effectively starving the cancer cells of the instructions they need to multiply. Additionally, this binding action acts as a marker, alerting your body's own immune system to target and destroy the marked cancer cells.
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Alcohol

Unsafe

Avoid consumption of alcohol as it may cause serious side effects.

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Pregnancy

Unsafe

Hervycta Plus 150 Injection is not recommended for use in pregnancy as it may harm your foetus. Hence, if you are pregnant or planning pregnancy, inform your doctor before receiving Hervycta Plus 150 Injection. Use reliable methods of birth control while on treatment with Hervycta Plus 150 Injection.

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Breast Feeding

Unsafe

Avoid nursing your child while on treatment with Hervycta Plus 150 Injection as it can cause serious side effects to the baby.

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Driving

Not applicable

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Liver

Caution

If you have a pre-existing or a history of liver disease, inform your doctor before receiving Hervycta Plus 150 Injection. Your doctor may adjust the dose of this medicine or prescribe a suitable alternative based on your condition.

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Kidney

Caution

Limited data are available on the effect of Hervycta Plus 150 Injection in kidney-impaired patients. Hence, if you have a pre-existing or a history of kidney disease, inform your doctor.

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Children

Unsafe

Hervycta Plus 150 Injection is not recommended for use in children as the safety and efficacy are not established.

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Heart

Caution

Hervycta Plus 150 Injection may increase the risk of heart problems. Therefore, please inform your doctor if you have any heart-related problems before using Hervycta Plus 150 Injection.

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Geriatrics

Consult your doctor

Please consult a doctor before administering Hervycta Plus 150 Injection to geriatric patients. Your doctor will prescribe Hervycta Plus 150 Injection if the benefits outweigh the risks.

What if I have taken an overdose of Hervycta Plus 150 Injection

Since this medication is prepared and administered by trained medical professionals in a clinical environment, an accidental overdose is highly unlikely. However, if you suspect an error has occurred or experience sudden, severe symptoms after an injection, notify your healthcare provider or seek emergency medical attention immediately.

Diet & Lifestyle Advise

Supporting your body during cancer treatment can help you manage side effects and maintain your strength. Here are some evidence-based practical tips:

  • Prioritise heart-healthy foods: Because this medicine can affect your heart, eat foods low in saturated fats and sodium. Focus on whole grains, lean proteins, and plenty of vegetables.
  • Stay hydrated: Drink plenty of water throughout the day, especially around your treatment days, to help your kidneys clear medications and reduce fatigue.
  • Eat small, frequent meals: If you experience nausea or a loss of appetite, eating five to six small meals a day instead of three large ones can make eating easier.
  • Protect your immune system: Wash your hands frequently, avoid close contact with people who are sick, and ensure all meats and vegetables are thoroughly cooked and cleaned.
  • Engage in gentle exercise: With your doctor's approval, light activities like walking can help combat treatment-related fatigue and support overall well-being.
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How Soon It Starts Working

The time required for Hervycta Plus 150 Injection to start to work: The time required for Hervycta Plus 150 Injection to show its action is not clinically established. The time for which the effects of Hervycta Plus 150 Injection last: The duration of action for Hervycta Plus 150 Injection is not clinically established.

What if you forget to take Hervycta Plus 150 Injection

If you miss an appointment for your injection, call your doctor or clinic immediately to reschedule. It is crucial to keep your treatment timeline as consistent as possible to ensure the medicine works effectively. Talk to your doctor or pharmacist to establish a clear plan for missed appointments.

Storage

• Store the medicine in a refrigerator at a temperature between 2°C and 8°C (36°F to 46°F).
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Keep Refrigerated. Do not freeze.Prepaid payment required.

Drug Warnings

  • Monitor your heart: Your doctor will perform echocardiograms or MUGA scans to check your heart function before starting and every few months during treatment.
  • Watch for infusion reactions: Tell your nurse immediately if you experience shaking, chills, fever, or dizziness during your injection.
  • Inspect the solution: If you see the vial beforehand, ensure the liquid is clear to slightly pale yellow and free of visible particles. Do not use if cloudy or discoloured.
  • Report breathing changes: Inform your healthcare team immediately if you develop a new or worsening cough or find it hard to breathe.
  • Avoid getting pregnant: Use highly effective birth control during treatment and for at least seven months after your final dose to prevent severe birth defects.

Drug-Drug Interactions

verifiedApollotooltip
  • Anthracycline-based chemotherapies (such as doxorubicin or epirubicin): Taking these medicines close to or alongside Hervycta Plus 150 Injection can significantly increase the risk of heart damage or heart failure.
  • Other cardiotoxic drugs: Any medications that can affect heart function may cause cumulative heart strain when used with Hervycta Plus 150 Injection.

Drug-Drug Interactions

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How does the drug interact with Hervycta Plus 150 Injection:
Co-administration of Hervycta Plus 150 Injection and clozapine can increase the risk of toxicity.

How to manage the interaction:
Although taking Hervycta Plus 150 Injection and Clozapine together can evidently cause an interaction, it can be taken if your doctor has suggested it. If you're having any of these symptoms like fever, chills, sore throat, or muscle aches, it's important to contact your doctor right away. They may be able to recommend other options for you that won't cause any problems. Don't worry, there are solutions available to help you feel better. Do not stop using any medications without first talking to your doctor.
How does the drug interact with Hervycta Plus 150 Injection:
Taking Hervycta Plus 150 Injection with Idarubicin can increase the risk of heart problems.

How to manage the interaction:
Co-administration of Hervycta Plus 150 Injection with Idarubicin can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you experience difficulty breathing, fluid retention, or chest pain, consult a doctor. Do not discontinue any medications without a doctor's advice.
How does the drug interact with Hervycta Plus 150 Injection:
When Etanercept is used with Hervycta Plus 150 Injection, the likelihood or severity of infection may increase.

How to manage the interaction:
There may be a possibility of interaction between Hervycta Plus 150 Injection and Etanercept, but it can be taken if prescribed by a doctor. However, if you develop fever, chills, diarrhea, sore throat, muscular pains, shortness of breath, blood in phlegm, weight loss, red or irritated skin, body sores, or discomfort or burning during urination, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.
How does the drug interact with Hervycta Plus 150 Injection:
Combining Hervycta Plus 150 Injection with Tofacitinib can increase the risk of neutropenia.

How to manage the interaction:
Although there is a possible interaction between Hervycta Plus 150 Injection and Tofacitinib, you can take these medicines together if prescribed by your doctor. However, consult the doctor immediately if you experience symptoms such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination. Do not stop using any medications without a doctor's advice.
How does the drug interact with Hervycta Plus 150 Injection:
Coadministration of Hervycta Plus 150 Injection with Baricitinib can increase the risk of developing serious infections.

How to manage the interaction:
Although there is a possible interaction between Hervycta Plus 150 Injection and Baricitinib, you can take these medicines together if prescribed by your doctor. However, consult a doctor if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning when you urinate. Do not stop using any medications without a doctor's advice.
How does the drug interact with Hervycta Plus 150 Injection:
Combining Hervycta Plus 150 Injection with Cladribine can increase the risk of developing serious infections.

How to manage the interaction:
Taking Cladribine with Hervycta Plus 150 Injection together can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning sensation when you urinate, consult a doctor. Do not stop using any medications without a doctor's advice.
How does the drug interact with Hervycta Plus 150 Injection:
Combining Hervycta Plus 150 Injection with Infliximab can lead to or increase the risk or severity of developing serious infections.

How to manage the interaction:
Taking Hervycta Plus 150 Injection with Infliximab together can result in an interaction, but it can be taken if your doctor has advised it. However, if you experience symptoms of fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in sputum, weight loss, red or inflamed skin, body sores, and pain or burning during urination, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Hervycta Plus 150 Injection:
Taking thalidomide together with Hervycta Plus 150 Injection may increase the risk of blood clots and other complications.

How to manage the interaction:
Although taking thalidomide and Hervycta Plus 150 Injection together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as chest pain, shortness of breath, difficulty breathing, coughing up blood, sudden loss of vision, pain, redness or swelling in an arm or leg, and numbness or weakness on one side of the body. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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No clinically significant food interactions are known with Hervycta Plus 150 Injection when used as directed.

No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

No

Therapeutic Class

[ANTINEOPLASTIC]

FAQs

Hervycta Plus 150 Injection should not be used during pregnancy because it can seriously harm the unborn baby. Use effective contraception during treatment and for at least 7 months after your last dose. If you are pregnant, planning to become pregnant, or become pregnant during treatment, contact your doctor immediately for advice.
The duration of treatment depends on your cancer type, stage, and response to therapy. For early HER2-positive breast cancer, treatment is commonly given for about one year. For advanced or metastatic HER2-positive cancers, treatment may continue as long as it remains effective and is well tolerated. Your doctor will decide the appropriate treatment duration.
Hervycta Plus 150 Injection may affect heart function and, in some people, can reduce the heart's pumping ability or lead to heart failure. Your doctor will perform heart tests before starting treatment and repeat them regularly during therapy to monitor your heart and detect any changes early. The frequency of testing depends on your medical condition, treatment plan, and previous test results.
No, Hervycta Plus 150 Injection is not a traditional chemotherapy drug. It is a targeted immunotherapy called a monoclonal antibody. While chemotherapy kills rapidly dividing cells throughout the body, Hervycta Plus 150 Injection specifically targets cells that have too much of the HER2 protein. Talk to your doctor to understand how these treatments differ.
It is given as an injection, either slowly into a vein (intravenously) or as a quick injection under the skin (subcutaneously). This is always done by a healthcare professional in a medical setting. Talk to your doctor about which option is right for you.
On its own, Hervycta Plus 150 Injection does not typically cause hair loss. However, because it is very often given in combination with chemotherapy, you may experience hair loss from the chemotherapy drugs. Talk to your doctor or pharmacist to learn more about the side effects of your combined treatment plan.
Avoid getting live vaccines, as your immune system may be compromised during treatment. Additionally, limit alcohol intake and avoid smoking to minimise extra stress on your heart and liver. Talk to your doctor before taking any new medications, vitamins, or supplements.
If you miss an appointment, contact your clinic immediately to reschedule. Keeping your doses on schedule is highly important for the treatment to be effective. Talk to your doctor or pharmacist to help you set up a reminder system.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Country of origin

India

Manufacturer/Marketer address

Dr. Reddy'S Laboratories Ltd., 8-2-337, Road No. 3, Banjara Hills, Hyderabad, Telangana 500034, India
Other Info - HER0218
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