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compositionComposition:HUMAN INSULIN-40IU
prescription
Prescription Medicine
info
Human Actrapid 40IU/ml Solution for Injection 10 ml
Human Actrapid 40IU/ml Solution for Injection 10 ml
Human Actrapid 40IU/ml Solution for Injection 10 ml

Human Actrapid 40IU/ml Solution for Injection is used in the treatment of type 1 and 2 diabetes mellitus. It contains Human Insulin, which works by suppressing the production of sugar in the liver and facilitating the reuptake of sugar in the fat and muscle cells, thereby maintaining consistent sugar control. Common side effects include low blood sugar, swelling in your hands or feet, weight gain, or thickening of the skin at the injection site. Before starting this medicine, inform your doctor if you are pregnant, breastfeeding, taking any other medicines or have pre-existing medical conditions.

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Written By Lakshmithulasi Yarragunta , PharmD (PB)
Reviewed By Santoshini Reddy G , M Pharmacy
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More about the Product

Composition :

HUMAN INSULIN-40IU

Manufacturer/Marketer :

Novo Nordisk India Pvt Ltd

Consume Type :

Parenteral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Human Actrapid 40IU/ml Solution for Injection

Human Actrapid 40IU/ml Solution for Injection is used to treat type 1 and type 2 diabetes mellitus. Diabetes mellitus is a condition in which glucose levels are elevated in the body.

Human Actrapid 40IU/ml Solution for Injection contains Human Insulin, which suppresses the production of sugar in the liver and facilitates the reuptake of sugar in the fat and muscle cells; thereby, Human Actrapid 40IU/ml Solution for Injection ensures rapid and consistent sugar control.

It can cause some side effects, such as low blood sugar, swelling in your hands or feet, weight gain, or thickening of the skin at the injection site. Consult your doctor if any of these side effects persist or get worse.

Do not take Human Actrapid 40IU/ml Solution for Injection if you are allergic to insulin or have an episode of hypoglycemia (low blood sugar). Talk to your doctor if you have a history of liver or kidney diseases and if you are pregnant or breastfeeding.

Uses of Human Actrapid 40IU/ml Solution for Injection

Human Actrapid 40IU/ml Solution for Injection is used in the treatment of Type 1 and type 2 diabetes mellitus. The detailed uses of Human Actrapid 40IU/ml Solution for Injection are as follows:

  • Type 1 Diabetes Mellitus: Human Actrapid 40IU/ml Solution for Injection replaces the insulin that the body no longer produces, helping maintain normal glucose levels in type 1 diabetes mellitus.
  • Type 2 Diabetes Mellitus: Human Actrapid 40IU/ml Solution for Injection is used to treat type 2 diabetes mellitus when oral antidiabetic drugs are insufficient or contraindicated.

Key Benefits

  • Human Actrapid 40IU/ml Solution for Injection helps lower and control high blood sugar levels in both adults and children with diabetes.
  • It improves the uptake of sugar (glucose) into muscles and fat cells for energy and suppresses excess sugar production in the liver.
  • Human Actrapid 40IU/ml Solution for Injection provides effective glycemic control, which helps reduce the risk of diabetes-related complications such as eye damage (diabetic retinopathy), kidney damage (diabetic nephropathy), nerve damage (diabetic neuropathy), delayed wound healing, and diabetic foot ulcers.
  • It has a rapid onset of action (starts working within 30 minutes after injection) and provides blood sugar control for up to 8 hours.
Side effects of Human Actrapid 40IU/ml Solution for Injection 10 ml
  • If you experience low blood sugar levels, inform your doctor. They will assess the severity and make recommendations for the next actions.
  • Your doctor will assess your symptoms, blood sugar levels, and overall health before recommending the best course of action, which may include treatment, lifestyle modifications, or prescription adjustments.
  • Follow your doctor's instructions carefully to manage the episode and adjust your treatment plan.
  • Make medication adjustments as recommended by your doctor to prevent future episodes.
  • Implement diet and lifestyle modifications as your doctor advises to manage low blood sugar levels.
  • Monitor your blood sugar levels closely for patterns and changes.
  • Track your progress by recording your blood sugar levels, food intake, and physical activity.
  • Seek further guidance from your doctor if symptoms persist or worsen so that your treatment plan can be revised.

Directions for Use

  • Follow your doctor's instructions regarding the dosage and duration of treatment.
  • Human Actrapid 40IU/ml Solution for Injection should be administered subcutaneously (under the skin) in the abdomen, thigh or upper arm.
  • Rotate the injection site each time to prevent skin damage.
  • Never reuse needles or syringes and never share needles, syringes, cartridges, or pens.

How Human Actrapid 40IU/ml Solution for Injection Works

Human Actrapid 40IU/ml Solution for Injection contains 'Human Insulin'. It replaces the deficient hormone 'insulin' in patients with diabetes. Human Actrapid 40IU/ml Solution for Injection suppresses the production of sugar in the liver and facilitates the reuptake of sugar in the fat and muscle cells; thereby, Human Actrapid 40IU/ml Solution for Injection ensures rapid and consistent sugar control. It starts to work within 30 minutes after injection, and its action lasts up to 8 hours.
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Alcohol

Unsafe

It is advised to avoid alcohol intake since it may worsen the side effects and increase the risk of developing low blood sugar levels.

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Pregnancy

Caution

It is advised to use Human Actrapid 40IU/ml Solution for Injection in pregnancy only if the benefit outweighs the risk. Please consult your doctor before starting Human Actrapid 40IU/ml Solution for Injection if you are pregnant or planning to conceive.

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Breast Feeding

Caution

Human Actrapid 40IU/ml Solution for Injection should be used in breastfeeding mothers only if clinically needed.

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Driving

Caution

Your driving may be affected if your blood sugar levels are too high or too low. Do not drive or operate machinery if you also experience blurred vision, dizziness or drowsiness due to extremely low or high blood sugar.

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Liver

Caution

Human Actrapid 40IU/ml Solution for Injection should be used with caution in patients with liver diseases. Your doctor may adjust the dose of this medicine before prescribing it.

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Kidney

Caution

Human Actrapid 40IU/ml Solution for Injection should be used with caution in patients with kidney diseases. Your doctor may adjust the dose of this medicine before prescribing it.

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Children

Caution

Human Actrapid 40IU/ml Solution for Injection is not recommended for use in children below 2 years of age.

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Heart

Caution

Human Actrapid 40IU/ml Solution for Injection should be administered with caution in patients with heart problems. Please inform your doctor about any existing heart problems before using Human Actrapid 40IU/ml Solution for Injection.

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Geriatrics

Caution

Human Actrapid 40IU/ml Solution for Injection should be administered with caution in elderly patients. If you have any concerns, please consult your doctor.

What if I have taken an overdose of Human Actrapid 40IU/ml Solution for Injection

An overdose of Human Actrapid 40IU/ml Solution for Injection can cause life-threatening hypoglycemia, sleepiness, disorientation, blurred vision, tingling or numbness in the mouth, difficulty speaking, muscle weakness, jerky or clumsy movements, seizures (convulsions), or loss of consciousness. If you have taken an overdose of Human Actrapid 40IU/ml Solution for Injection, seek immediate medical help.

Diet & Lifestyle Advise

  • Include foods rich in healthy carbohydrates, fibre, fruits, whole grains, and vegetables in your diet.
  • Try eating food at regular intervals. Do not skip meals. Also, try not to overeat.
  • Follow a healthy diet and walk for at least a few minutes to complement treatment with Human Actrapid 40IU/ml Solution for Injection.
  • Maintain a healthy weight by exercising regularly.
  • Rest properly, avoid stress by doing meditation or yoga.

Health Queries

I take 15 units of Human Actrapid insulin in the morning and 15 units at night, but my fasting blood sugar is still above 200. How should I adjust my insulin or medication to control my blood sugar levels?

Vikas Singh

Vikas Singh

M Pharmacy

Human Actrapid is a short-acting insulin meant to control blood sugar around mealtimes, not fasting levels. High fasting sugar (above 200 mg/dL) usually indicates a need for a long-acting (basal) insulin overnight, or it could be a rebound from undetected nighttime low blood sugar. You should not adjust your insulin doses without medical supervision. Please consult your doctor immediately. They may suggest monitoring your blood sugar at 3 AM to identify the exact cause and will likely adjust your regimen, possibly by adding a basal insulin or modifying your evening dose. Keep a detailed log of your blood sugar and meals to share with them.

My blood sugar levels are continuously increasing despite taking Insulin HM Mixtard 30 and Insulin HM Actrapid. What changes in my medication are required to control it?

Vikas Singh

Vikas Singh

M Pharmacy

It can be concerning when blood sugars rise despite taking insulin. Please do not adjust your doses of Insulin Mixtard 30 and Actrapid on your own, as this can lead to dangerous drops in blood sugar (hypoglycemia). Your doctor may need to increase your doses, adjust the timing, or evaluate your injection technique. Infection, stress, or dietary changes can also cause insulin resistance. Next Steps: Keep a 3-day log of your blood sugar levels (fasting, pre-meals, and 2 hours post-meals). Check for expired insulin or lumps at injection sites. Consult your doctor immediately with this log to safely adjust your insulin prescription.

I am a diabetic patient, and I am currently taking 20 units of Human Actrapid injection three times daily. Can I switch to oral hypoglycaemic medicines instead of insulin? I am also experiencing erectile dysfunction.

Chandrakanta Jena

Chandrakanta Jena

Pharm D

Whether you can switch from Human Actrapid injection to oral hypoglycaemic medicines depends on your blood sugar control, duration of diabetes, pancreatic function, body weight, kidney function, and other health conditions. Many people who need multiple daily insulin doses cannot safely stop insulin, but in some cases, doctors may reduce insulin or combine it with oral medications after careful evaluation and monitoring of blood sugar levels. You should never change insulin on your own. Erectile dysfunction is common in long-standing diabetes. It can happen due to damage to blood vessels and nerves, stress, or poor sugar control. Improving blood sugar control, regular exercise, stopping smoking if applicable, and managing blood pressure and cholesterol may help. Medicines for erectile dysfunction may also be prescribed after a medical assessment. It is important to discuss both issues with your doctor for a personalised treatment plan.

I have been experiencing fluctuating blood sugar levels. Instead of using Human Actrapid, can I switch to Human Insulatard for better control of my diabetes?

Chandrakanta Jena

Chandrakanta Jena

Pharm D

Human Actrapid is a short-acting insulin that works mainly around meal times, while Human Insulatard is an intermediate-acting insulin that provides background or basal control over a longer period. These two insulins work in different ways, and one cannot simply replace the other. Changing insulin without medical guidance may lead to poor sugar control or episodes of low blood sugar. The right treatment depends on your daily sugar pattern, diet, physical activity, and overall health. Your doctor may adjust your doses or suggest a combination of insulins to achieve stable control. It is advisable to monitor your blood sugar regularly and share the readings with your doctor before making any changes.

I have insulin-dependent diabetes (IDDM) and am currently taking Human Actrapid (13 units in the morning, 10 units in the afternoon, and 13 units at night) and Human Insulatard (12 units at night). Can you suggest a suitable diet chart to manage my blood sugar?

Dr. S Aneela

Dr. S Aneela

M. Pharm (Pharmacology)., PhD

You should follow a balanced diet with consistent carbohydrate intake to match your insulin doses. Consume whole grains, brown rice, oats, vegetables, fruits, and lean proteins, while limiting refined flour, sugar, and unhealthy fats. Eat your meals and snacks evenly throughout the day to align with your insulin action and prevent large blood sugar spikes. Consult a dietitian for a personalised meal plan tailored to your insulin regimen and daily activity for optimal blood sugar control.

Have a query?

How Soon It Starts Working

The time required for Human Actrapid 40IU/ml Solution for Injection to start to work: Human Actrapid 40IU/ml Solution for Injection shows its action within 30 to 60 minutes of administration.

The time for which the effects of Human Actrapid 40IU/ml Solution for Injection last: Human Actrapid 40IU/ml Solution for Injection effects last for 6 to 8 hours.

What if you forget to take Human Actrapid 40IU/ml Solution for Injection

Consult your doctor for guidance on what to do if you miss a dose or forget to take your scheduled injection.

Storage

• Store in a cool and dry place away from sunlight. • Keep out of sight and reach of children. • Cold chain - To be stored in cold places at 2ºC to 8ºC.
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Keep Refrigerated. Do not freeze.Prepaid payment required.

Drug Warnings

  • Do not take Human Actrapid 40IU/ml Solution for Injection if you are allergic to any of the contents.
  • Inform your doctor if you have hypoglycemia (low blood glucose levels), hypokalemia (low levels of potassium in the blood), heart, kidney or liver problems.
  • Consult a doctor before taking Human Actrapid 40IU/ml Solution for Injection if you are pregnant or breastfeeding.
  • Human Actrapid 40IU/ml Solution for Injection may cause dizziness, so drive only if you are alert.
  • You are recommended not to consume alcohol as it may cause unpleasant side effects.
  • Care should be taken when you are travelling across more than 2 time zones; your doctor may adjust your insulin schedule.

Drug-Drug Interactions

verifiedApollotooltip

Drug-Drug Interactions: Human Actrapid 40IU/ml Solution for Injection may interact with antidiabetic medications such as thiazolidinediones (rosiglitazone, pioglitazone) and increase the risk of heart failure. It may also interact with antibiotics (levofloxacin, norfloxacin, ofloxacin), antidepressants, medications to treat high blood pressure (enalapril, lisinopril, captopril, losartan, valsartan, propranolol, and metoprolol), diuretics and medications used to treat heart diseases.

Drug-Food Interactions: Try to avoid alcoholic beverages with Human Actrapid 40IU/ml Solution for Injection as it may alter your blood glucose levels.

Drug-Disease Interactions: Inform your doctor if you have kidney disease, liver disease, low blood sugar level (hypoglycemia), or low potassium level (hypokalaemia).

INSULIN HUMANGatifloxacin
Critical
INSULIN HUMANCiprofloxacin
Severe

Drug-Drug Interactions

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INSULIN HUMANGatifloxacin
Critical
How does the drug interact with Human Actrapid 40IU/ml Solution for Injection 10 ml:
Coadministration of Gatifloxacin with Human Actrapid 40IU/ml Solution for Injection 10 ml may sometimes affect blood glucose levels. Both low blood glucose and, less frequently, high blood glucose have been reported.

How to manage the interaction:
Although there is a possible interaction, Human Actrapid 40IU/ml Solution for Injection 10 ml can be taken with Gatifloxacin if prescribed by the doctor. Consult the prescriber if you experience symptoms such as nervousness, confusion, headache, dizziness, drowsiness, tremors, nausea, hunger, weakness, perspiration, palpitation, rapid heartbeat, increased urination, increased thirst, and increased hunger. Maintaining blood glucose levels is advised.
INSULIN HUMANCiprofloxacin
Severe
How does the drug interact with Human Actrapid 40IU/ml Solution for Injection 10 ml:
Taking Human Actrapid 40IU/ml Solution for Injection 10 ml with ciprofloxacin effects blood glucose levels, which may cause hyperglycemia (high blood sugar) or hypoglycemia (low blood sugar) less frequently.

How to manage the interaction:
Although taking ciprofloxacin and Human Actrapid 40IU/ml Solution for Injection 10 ml together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, consult a doctor if you experience headaches, dizziness, sleepiness, anxiety, disorientation, tremors, nausea, hunger, weakness, increased sweating, and a rapid heartbeat, increased hunger, increased thirst. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

verifiedApollotooltip
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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FAQs

Human Actrapid 40IU/ml Solution for Injection is used to treat type 1 and type 2 diabetes mellitus.
Human Actrapid 40IU/ml Solution for Injection works by increasing the glucose uptake by fats and muscles, suppressing the production of glucose in the liver, and also the formation of glycogen from glucose. Thereby, Human Actrapid 40IU/ml Solution for Injection helps in reducing the glucose levels in the blood.
In hypoglycemia, blood sugar levels decrease significantly. It causes symptoms such as dizziness, headache, sweating, hunger, loss of consciousness, rapid breathing, or seizure (fits). In such cases, seek medical attention immediately.
If you experience low blood sugar, eat glucose tablets, chocolate, or another high-sugar snack, such as a sweet or biscuit. Use a blood glucose monitor to test your blood sugar levels after 15 minutes if possible.
Do not stop taking Human Actrapid 40IU/ml Solution for Injection without consulting your doctor on your own, as it may cause an increase in blood glucose levels. Continue taking Human Actrapid 40IU/ml Solution for Injection for as long as your doctor has prescribed it to you. Do not be reluctant to speak with your doctor if you experience any difficulty while taking Human Actrapid 40IU/ml Solution for Injection.
You are recommended to avoid white bread, maida, poori, naan, noodles, biryani, fried rice, corn flakes, cheese, ice creams, milkshakes, beef, pork, sugarcane juice, soft drinks, sweetened health drinks and beverages. Also, avoid mango, seetaphal, jack fruit, fruit salads with ice cream, and fruit-based desserts.
No, do not stop taking Human Actrapid 40IU/ml Solution for Injection without consulting your doctor as it may lead to high blood sugar levels and may worsen your condition resulting in complications. If you experience any side effects or discomfort, contact your doctor. You may need dose adjustment.
Taking an injection at the same site may cause local irritation, itching and lump formation. Therefore, it is best to avoid taking injections at the same site or maintain a gap of at least one day.
Maintain a diet that includes chapatis, puffed rice with vegetables, multigrain bread, plain cooked dal, roasted grams soups, sprouts, cooked vegetables with less oil, steamed vegetables, orange, jamun, guava, watermelon, apple, papaya, curd, cow’s milk, thin buttermilk, fish (baked, grilled, or steamed), cashew nuts, peanuts, and walnuts (handful). Avoid alcohol consumption and quit smoking. Exercise regularly and walk briskly daily for 30 minutes. Also, limit intake of sugar.
The risk factors for developing low blood sugar levels include not taking adequate meals or skipping meals, excessive insulin use, too much alcohol intake, fever and too much exercise. Some medications, like other diabetes medicines, glimepiride, medicines used for fever and pain (salicylates), ramipril, etc., can result in such episodes when used with insulin. Inform your doctor about these episodes, as you may need a dose adjustment.
It depends on whether you have type 1 diabetes mellitus or type 2. If you have type 1 diabetes, Human Actrapid 40IU/ml Solution for Injection should be used for the rest of your life as your body does not produce adequate insulin and the only treatment available is external source of insulin which cannot be stopped. However, if you have type 2 diabetes mellitus, the doctor may stop Human Actrapid 40IU/ml Solution for Injection if your blood sugar levels are well controlled with healthy diet, exercise and other diabetic medications. However, do not stop taking it on your own without consulting your doctor as it may worsen your condition.
Human Actrapid 40IU/ml Solution for Injection can be used with other diabetes medicines only if prescribed by a doctor. Thus, please consult a doctor before using Human Actrapid 40IU/ml Solution for Injection with other medicines.
Human Actrapid 40IU/ml Solution for Injection is injected under the skin in the areas such as thighs, buttocks, abdomen or upper arms. Never inject Human Actrapid 40IU/ml Solution for Injection into a muscle or vein. However, it is recommended to rotate your injection sites with each dose to reduce the risk of developing pitted or thick skin and lumps at the injection site. Inject Human Actrapid 40IU/ml Solution for Injection as shown by the doctor.
It is advised to take doctor’s advice before using Human Actrapid 40IU/ml Solution for Injection if you are pregnant or planning pregnancy. Your doctor will prescribe Human Actrapid 40IU/ml Solution for Injection if benefits are greater than the risks.
Yes, Human Actrapid 40IU/ml Solution for Injection is safe to use in type 2 diabetes if used as advised by the doctor. Monitor your blood sugar levels regularly. Your dosage may need to be changed as per your needs. Follow the lifestyle changes as advised by your doctor. Discuss with your doctor about the managing and preventing side effects.
The side effects of Human Actrapid 40IU/ml Solution for Injection include injection site reactions such as swelling, itching or redness, weight gain, and swelling due to fluid retention. Also, it may cause lipodystrophy (skin thickening or pits at the injection site). To avoid this side effect, rotate injection site for each dose.
Yes, Human Actrapid 40IU/ml Solution for Injection cause hypoglycaemia (low blood sugar) as the most common side effect. It occurs more frequently if you skip meals or delay food, drink alcohol, over-excessive or use other antidiabetic medications along with Human Actrapid 40IU/ml Solution for Injection. So, do not skip meals and be consistent in amount and timing of your meals. If you over exercise, take some snacks as per your requirement. It is important to monitor your blood sugar levels regularly. Always carry some fruit juice, sugary candies, glucose, or glucon-D with you. If you notice any fluctuations in your blood sugar levels, consult your doctor.
If you experience weight loss or gain, increased stress, illness, dietary changes such as missed meals or alcohol consumption, then you should consult your doctor for dose adjustment. If you have recently changed your workout routine or are taking any medicines, your dose may need to be changed. Also, lookout for certain side effects caused by Human Actrapid 40IU/ml Solution for Injection. Your doctor will advise you on how to prevent them. These side effects are usually temporary but if they are very severe, you may need dose adjustments.
Human Actrapid 40IU/ml Solution for Injection needs to be refrigerated before its first use. Unopened vials, disposable dosing devices and human insulin pens must be stored in a refrigerator where the temperature is between 2°C to 8°C. Do not freeze and do not use Human Actrapid 40IU/ml Solution for Injection that has been frozen. When the cartridge has been inserted into the injection pen, it should not be refrigerated and should be kept at room temperature, (below 30°C) and must be used within 28 days or be discarded, even if they still contain Human Actrapid 40IU/ml Solution for Injection.
Human Actrapid 40IU/ml Solution for Injection is a man-made version of human insulin, produced by a biotechnology method called recombinant DNA technology.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Country of origin

India

Manufacturer/Marketer address

16th Floor, Godrej BKC, Plot – C, “G” Block, Bandra-Kurla Complex, Bandra (East), Mumbai – 400 051, India
Other Info - HUM0013

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