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compositionComposition:KETOCONAZOLE-200MG
prescriptionPrescription Medicine
Hyporal Tablet 10's

Hyporal Tablet is an antifungal medicine used in the treatment of fungal infections such as blastomycosis, coccidioidomycosis, paracoccidioidomycosis, and histoplasmosis (lung infection caused by Histoplasma fungus). This medicine works by inhibiting the growth and multiplication of fungal cells that are responsible for the growth of infection-causing fungi.

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Written By Veda Maddala , M Pharmacy
Reviewed By Santoshini Reddy G , M Pharmacy
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More about the Product

Composition :

KETOCONAZOLE-200MG

Manufacturer/Marketer :

Ipca Laboratories Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Hyporal Tablet

Hyporal Tablet is indicated to treat various systemic fungal infections such as blastomycosis (infection caused by Blastomyces fungus), chromomycosis (chronic infection of the skin and subcutaneous tissue), Coccidioidomycosis (infection caused by Coccidioides fungus), paracoccidioidomycosis (infection caused by Paracoccidioides fungus) and histoplasmosis (lung infection caused by Histoplasma fungus).

Hyporal Tablet contains ketoconazole, which works by destroying fungal cell membranes that are essential for their survival. Thus, kills fungi and treats the fungal infection.

Some people may experience headache, nausea, stomach pain, and diarrhoea as side effects. Most of these side effects do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

If you are allergic to ketoconazole or any other medicines, please tell your doctor. If you are pregnant or planning for pregnancy, inform your doctor before taking Hyporal Tablet . Avoid breastfeeding while taking Hyporal Tablet as it may be excreted in breast milk. Hyporal Tablet is not recommended for children below 2 years of age.

Uses of Hyporal Tablet

Hyporal Tablet is used in the treatment of severe fungal infections when other antifungal treatments are unsuitable or ineffective. The detailed uses of Hyporal Tablet include:

  • Treatment of systemic fungal infections: Hyporal Tablet is prescribed for serious fungal infections affecting internal organs such as the lungs, liver, or skin.
  • Management of fungal infections resistant to first-line therapy: Hyporal Tablet is used when alternative antifungal agents are not tolerated or fail to provide adequate results.
  • Destruction of fungal cell membranes: Hyporal Tablet works by disrupting the integrity of fungal cell membranes, leading to cell death and resolution of the infection.

Key Benefits

  • Hyporal Tablet is an antifungal used to treat severe fungal infections.
  • It is used only when other effective antifungal therapies are not available or tolerated and if potential benefits outweigh potential risks.
  • It destroys fungal cell membranes that are essential for their survival as they prevent the entry of unwanted substances into the cells and stop the leakage of cell contents. Thus, kills fungi and treats the fungal infection.
Side effects of Hyporal Tablet
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.

Directions for Use

  • Hyporal Tablet can be taken with or without food.
  • Your doctor will decide the dose and duration depending on your condition.
  • Swallow the medicine as a whole with a glass of water.
  • Do not crush, chew, or break Hyporal Tablet as it may affect the way the medication is absorbed.

How Hyporal Tablet Works

Hyporal Tablet contains Ketoconazole which works by destroying fungal cell membranes that are essential for their survival as they prevent the entry of unwanted substances into the cells and stop the leakage of cell contents. Thus, kills fungi and treats the fungal infection.
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Alcohol

Unsafe

Avoid consumption of alcohol while taking Hyporal Tablet as it may increase the risk of liver damage and cause adverse effects.

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Pregnancy

Consult your doctor

Hyporal Tablet is a Category C pregnancy drug and is given to pregnant women only if the doctor thinks the benefits outweigh the risks.

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Breast Feeding

Unsafe

Hyporal Tablet may be excreted in breast milk. Therefore, it is recommended to avoid breastfeeding while taking Hyporal Tablet .

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Driving

Caution

Hyporal Tablet may cause dizziness or drowsiness. Therefore, drive only if you alert after taking Hyporal Tablet .

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Liver

Unsafe

Hyporal Tablet is contraindicated in patients with chronic or acute liver disease. Therefore, inform your doctor if you have any Liver diseases/conditions.

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Kidney

Consult your doctor

If you have any concerns regarding the use of Hyporal Tablet in patients with kiver diseases/conditions, consult a doctor.

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Children

Consult your doctor

Hyporal Tablet is not recommended for children below 2 years of age. For children above 2 years, it is recommended to use only if the doctor has determined that benefits outweigh risks.

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Heart

Caution

If you have any concerns regarding the use of Hyporal Tablet in patients with heart diseases/conditions, consult a doctor.

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Geriatrics

Caution

Hyporal Tablet should be used with caution in elderly patients. Please consult your doctor before use.

What if I have taken an overdose of Hyporal Tablet

Never take more than the prescribed dose. When Hyporal Tablet is used at high doses, it may, though unlikely, result in decreased testosterone levels, sperm production, and an issue with the adrenal glands (adrenal insufficiency). Seek emergency medical help if an overdose is suspected.

Diet & Lifestyle Advise

  • Avoid high-risk areas such as renovated buildings, construction sites, pigeon or chick coops, and caves.
  • Wear a respiratory mask when there is a risk of exposure to spores.
  • People with a weak immune system are advised to avoid activities that involve close contact with dust or dirt including digging, yard work, and gardening.
  • Close windows and stay inside during dust storms.
  • Clean skin injuries well with soap and water to reduce the risk of developing a skin infection.

Have a query?

How Soon It Starts Working

  • The time required for Hyporal Tablet to start to work: Hyporal Tablet ideally shows its action within 1 hour after administration. 
  • The time for which the effects of Hyporal Tablet last: The effect of Hyporal Tablet lasts for 8 hours.

What if you forget to take Hyporal Tablet

If you miss a dose, take it as soon as you remember. If it's time for the next dose, skip the missed dose and continue with your regular schedule.

Storage

• Store in a cool and dry place away from sunlight.• Keep Hyporal Tablet out of the sight and reach of children.• Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.

Drug Warnings

  • If you are allergic to Ketoconazole or any other medicines, please tell your doctor.
  • If you are pregnant or planning for pregnancy, inform your doctor before taking Hyporal Tablet .
  • Avoid breastfeeding while taking Hyporal Tablet as it may be excreted in breast milk.
  • You are recommended to avoid alcohol consumption with Hyporal Tablet .
  • If you have a loss of appetite, tiredness, stomach pain, vomiting, yellowing of skin or eyes, dark urine, or light-coloured stools, inform your doctor immediately as they might be symptoms of hepatotoxicity (liver damage). 

Drug-Drug Interactions

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Drug-Drug Interaction: Hyporal Tablet may interact with antiarrhythmic agents (quinidine, dofetilide), antipsychotic drugs (pimozide), drugs used to treat heartburn and acidity (omeprazole, cisapride), cholesterol-lowering medicines (simvastatin, lovastatin), medicines used to treat migraine (dihydroergotamine, ergotamine), high blood pressure lowering drugs (nisoldipine, eplerenone) and benzodiazepines (alprazolam, triazolam, midazolam).

Drug-Food Interaction: Hyporal Tablet may interact with caffeine. Therefore, avoid foods containing chocolate and caffeine such as cocoa beans, tea, coffee, cola, and energy drinks as it may increase the adverse effects of caffeine. Do not take marijuana with Hyporal Tablet as it may worsen the adverse effects of marijuana. Also, avoid consumption of alcohol with Hyporal Tablet as it may increase the risk of liver damage and cause adverse effects.

Drug-Disease Interaction: If you have adrenal insufficiency, heart or liver problems, inform your doctor before taking Hyporal Tablet .

KetoconazoleIvabradine
Critical
KetoconazoleMethylergometrine
Critical

Drug-Drug Interactions

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KetoconazoleIvabradine
Critical
How does the drug interact with Hyporal Tablet:
Coadministration of Ivabradine with Hyporal Tablet can increase the risk or severity of side effects.

How to manage the interaction:
Taking Ivabradine with Hyporal Tablet is not recommended as it can result in an interaction, it can be taken if a doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, or memory loss, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
KetoconazoleMethylergometrine
Critical
How does the drug interact with Hyporal Tablet:
Using Hyporal Tablet with Methylergometrine can increase the concentration of Methylergometrine, which may lead to side effects.

How to manage the interaction:
Taking Hyporal Tablet with Methylergometrine is not recommended as it can cause an interaction, but it can be taken if prescribed by the doctor. Do not discontinue any medication without consulting a doctor.
KetoconazoleIrinotecan
Critical
How does the drug interact with Hyporal Tablet:
Using irinotecan together with Hyporal Tablet can increase the risk of side effects.

How to manage the interaction:
Taking Hyporal Tablet with Irinotecan is not recommended as it can cause an interaction, but it can be taken if prescribed by the doctor. However, if you experience any symptoms such as paleness, fatigue, dizziness, fainting, unexpected bruising or bleeding, fever, chills, diarrhea, sore throat, muscle aches, breathing difficulty, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination, consult the doctor immediately.
KetoconazoleEplerenone
Critical
How does the drug interact with Hyporal Tablet:
Coadministration of Hyporal Tablet with Eplerenone can increase the levels of blood potassium which can lead to kidney damage and irregular heart rate.

How to manage the interaction:
Taking Hyporal Tablet with Eplerenone is not recommended as it can result in an interaction, but it can be taken if a doctor has advised it. However, if you notice any symptoms of headaches, irritation, confusion, edema (swelling caused by too much fluid accumulation), weakness, palpitations, or constipation, you should contact a doctor immediately. Do not stop using any medications without the doctor's advice.
KetoconazoleHalofantrine
Critical
How does the drug interact with Hyporal Tablet:
Using Hyporal Tablet with Halofantrine can increase the chance of a serious abnormal heart rhythm.

How to manage the interaction:
Taking Hyporal Tablet with Halofantrine is not recommended as it can cause an interaction, it can be taken if prescribed by the doctor. However, if you experience sudden dizziness, lightheadedness, fainting, breathing difficulty, or rapid heartbeat, consult the doctor immediately. Do not stop any medications without a doctor's advice.
KetoconazoleIsavuconazole
Critical
How does the drug interact with Hyporal Tablet:
Co-administration of Hyporal Tablet and Isavuconazole can significantly increase the blood levels of Isavuconazole, which may increase the risk of side effects.

How to manage the interaction:
Taking Isavuconazole with Hyporal Tablet is not recommended as it can cause an interaction, it can be taken if prescribed by the doctor. However, if you experience symptoms like nausea, stomach pain, headache while on therapy with these drugs, consult the doctor. Do not discontinue any medication without consulting a doctor.
KetoconazoleNisoldipine
Critical
How does the drug interact with Hyporal Tablet:
When Nisoldipine is taken with Hyporal Tablet, it can increase the blood levels of Nimodipine which may lead to serious side effects (irregular heart rhythm, fluid retention, swelling, and extremely low blood pressure).

How to manage the interaction:
Taking Hyporal Tablet with Nisoldipine can cause an interaction, but it can be taken if prescribed by the doctor. However, if you experience irregular heart rhythm, fluid retention, swelling, and extremely low blood pressure while using these medications, consult the doctor. Do not stop using any medications without talking to a doctor.
KetoconazoleTriazolam
Critical
How does the drug interact with Hyporal Tablet:
When Triazolam is taken with Hyporal Tablet, it can increase the risk of drowsiness and slowed breathing.

How to manage the interaction:
Taking Triazolam with Hyporal Tablet is not recommended as it can cause an interaction, it can be taken if prescribed by the doctor. Do not stop using any medications without talking to a doctor.
KetoconazoleRegorafenib
Critical
How does the drug interact with Hyporal Tablet:
When Regorafenib is taken with Hyporal Tablet, it can increase the levels of Regorafenib, which may lead to side effects.

How to manage the interaction:
Taking Regorafenib with Hyporal Tablet is not recommended as it can cause an interaction, but it can be taken if prescribed by the doctor. Do not stop using any medications without talking to a doctor.
KetoconazoleConivaptan
Critical
How does the drug interact with Hyporal Tablet:
Using conivaptan together with Hyporal Tablet may significantly increase the blood levels of conivaptan, which may increase the risk of side effects.

How to manage the interaction:
Taking Hyporal Tablet with Conivaptan is not recommended as it can cause an interaction, but it can be taken if prescribed by the doctor. However, if you experience difficulty swallowing, trouble speaking, muscle weakness, trouble controlling body movements, confusion, mood changes, seizures(fits), consult the doctor immediately. Do not discontinue any medication without consulting a doctor.

Drug-Food Interactions

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KETOCONAZOLE-200MGGrapefruit and Grapefruit Juice
Moderate

Drug-Food Interactions

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KETOCONAZOLE-200MGGrapefruit and Grapefruit Juice
Moderate
Common Foods to Avoid:
Grapefruit Juice, Grapefruit

How to manage the interaction:
Consumption of grapefruit or its juice with Hyporal Tablet may result in side effects such as joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of hunger, dark urine, light colored stools, and yellowing of the skin or eyes. Avoid consuming grapefruit, grapefruit juice, or any supplements that include grapefruit extract while taking Hyporal Tablet.

All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[ANTIFUNGALS - ORAL]

FAQs

Hyporal Tablet belongs to a class of drugs called antifungals indicated to treat various systemic fungal infections such as blastomycosis (infection caused by Blastomyces fungus), chromomycosis (chronic infection of the skin and subcutaneous tissue), Coccidioidomycosis (infection caused by Coccidioides fungus), paracoccidioidomycosis (infection caused by Paracoccidioides fungus) and histoplasmosis (lung infection caused by Histoplasma fungus).

Hyporal Tablet works by destroying fungal cell membranes that are essential for their survival as they prevent the entry of unwanted substances into the cells and stop the leakage of cell contents. Thus, kills fungi and treats the fungal infection.

Hyporal Tablet is not recommended to treat fungal meningitis (fungal infection spreads to the brain and spinal cord) as it poorly penetrates into the cerebrospinal fluid. Therefore, inform your doctor if you have fungal meningitis so that appropriate medication may be prescribed.

You are recommended to avoid foods containing chocolate and caffeine such as cocoa beans, tea, coffee, cola and energy drinks while taking Hyporal Tablet as it may increase the adverse effects of caffeine such as drowsiness, nervousness or nausea.

You are not recommended to take Hyporal Tablet with simvastatin (lipid-lowering drug) as co-administration of these medicines may cause muscle problems. Therefore, please consult a doctor before taking Hyporal Tablet with other medicines.

No, you are not recommended to stop taking Hyporal Tablet without consulting your doctor as it may cause recurring infection. Therefore, take Hyporal Tablet for as long as your doctor has prescribed it and if you experience any difficulty while taking Hyporal Tablet , please consult your doctor.

Disclaimer

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Author Details

Veda MaddalaDoctor badge

Written By

  • Veda Maddala

    M Pharmacy

Santoshini Reddy GDoctor badge

Reviewed By

  • Santoshini Reddy G

    M Pharmacy

Last Updated

Doctor imageWe provide you with authentic, trustworthy and relevant information

Country of origin

India

Manufacturer/Marketer address

142 Ab, Kandivli Industrial Estate, Kandivli (West), Mumbai - 400 067, Maharashtra
Other Info - HYP0013
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