Buy Hysotan-15 mg Tablet 10's online | Uses, Side Effects, Price and substitutes

Select Delivery Location

Prescription Medicine

Hysotan-15 mg Tablet 10's is used to treat low sodium levels and autosomal dominant polycystic kidney disease. It contains Tolvaptan which works by increasing the amount of water released from the body via urine. In some cases, this medicine may cause side effects such as dizziness, headache, dry mouth, fatigue, diarrhoea, thirst and increased urge to urinate. Inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.

Written By Santoshini Reddy G , M Pharmacy

Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Offers & Discounts

Get Free delivery (₹99) with

Join Circle

Get Extra 18% Off with Coupons

Extra 10% Off with Bank Offers

More about the Product

Composition :

TOLVAPTAN-15MG

Manufacturer/Marketer :

Lia Life Sciences Pvt Ltd

Consume Type :

Oral

Expires on or after :

Jan-28

Return Policy :

Not Returnable

About Hysotan-15 mg Tablet 10's

Hysotan-15 mg Tablet 10's is used to treat hyponatremia (low levels of sodium) in patients with heart failure, liver disease and hormonal imbalances such as Syndrome of Inappropriate Antidiuretic Hormone (SIADH). Additionally, Hysotan-15 mg Tablet 10's is also used to treat autosomal dominant polycystic kidney disease (ADPKD).

Hysotan-15 mg Tablet 10's contains ‘tolvaptan’ that works by blocking the effect of vasopressin, resulting in decreased water reabsorption, a net increase in free water excretion (aquaresis) and an increase in serum sodium concentrations.

In some cases, you may experience certain common side effects such as dizziness, headache, dry mouth, fatigue, diarrhoea, thirst and increased urge to urinate. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.

You can take Hysotan-15 mg Tablet 10's with food or as advised by your doctor. It should be swallowed whole with a glass of water. Do not chew, bite, or break it. You are advised to take Hysotan-15 mg Tablet 10's as long as your doctor has prescribed it for you, depending on your medical condition.

Do not take Hysotan-15 mg Tablet 10's if you are allergic to it or any of its components. Avoid taking Hysotan-15 mg Tablet 10's if you are pregnant as it may cause foetal harm. Consult your doctor before taking Hysotan-15 mg Tablet 10's if you are breastfeeding. Hysotan-15 mg Tablet 10's is not recommended for children below 18 years as the efficacy and safety have not been established.

Uses of Hysotan-15 mg Tablet 10's

Hysotan-15 mg Tablet 10's used in the treatment of hyponatremia (low sodium levels) and autosomal dominant polycystic kidney disease (ADPKD). The detailed uses of Hysotan-15 mg Tablet 10's are as follows:

Hyponatremia Treatment: Hysotan-15 mg Tablet 10's helps the body eliminate excess water and increase sodium levels in patients with heart failure or SIADH.
ADPKD Treatment: Hysotan-15 mg Tablet 10's slows the rate of kidney function decline in adults with rapidly progressing ADPKD, potentially delaying disease progression.

Key Benefits

Hysotan-15 mg Tablet 10's belongs to a group of medicines called vasopressin V2 receptor antagonist.
Hysotan-15 mg Tablet 10's is also used to treat autosomal dominant polycystic kidney disease (ADPKD).
By blocking the effect of vasopressin, Hysotan-15 mg Tablet 10's slows down the development of cysts in kidneys and reduces the symptoms of the disease.
Hysotan-15 mg Tablet 10's antagonises the effect of vasopressin; this results in an increase in free water clearance and decreases urine osmolality due to increased urinary excretion, thereby increasing serum sodium concentrations.

Side effects of Hysotan-15 mg Tablet

Dry Mouth

Here are the steps to Dry Mouth (xerostomia) caused by medication:

Inform your doctor about dry mouth symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
Drink plenty of water throughout the day to help keep your mouth moist and alleviate dry mouth symptoms.
Chew sugar-free gum or candies to increase saliva production and keep your mouth moisturized.
Use saliva substitutes, such as mouthwashes or sprays, only if your doctor advises them to help moisturize your mouth and alleviate dry mouth symptoms.
Avoid consuming smoking, alcohol, spicy or acidic foods, and other irritants that may aggravate dry mouth symptoms.
Schedule regular dental check-ups to keep track of your oral health and handle any dry mouth issues as they arise.

Nausea

Overcome Medication-Induced Nausea: A 9-Step Plan

Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
Divide your daily food intake into smaller, more frequent meals to reduce nausea.
Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
Use ginger (tea, ale, or candies) to help relieve nausea.
Get adequate rest and also avoid strenuous activities that can worsen nausea.
Talk to your doctor about taking anti-nausea medication if your nausea is severe.
Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.

Frequent Urination

Drink six to eight glasses of water per day to be healthy.
Healthy urinary habits can help minimize pollakiuria (frequent urinating).
Avoid liquids containing caffeine, artificial sweeteners, and soda, as they might cause bladder discomfort.
Add bladder-friendly foods such as omega-3 fatty acids, blueberries, and cranberries.

Excessive Urination

Reduce fluid intake 2-3 hours prior to bedtime.
Limit alcohol and caffeine as they can increase urination and affect bladder health.
Maintain sleep hygiene.
Eat a low-salt and healthy diet.

Thirsty

Weakness

Rest well; get enough sleep.
Eat a balanced diet and drink enough water.
Manage stress with yoga and meditation.
Limit alcohol and caffeine.
Physical activities like walking or jogging might help boost energy and make you feel less tired.

High Body Temperature

Here's a comprehensive approach to managing medication-triggered fever:

Inform your doctor immediately if you experience a fever after starting a new medication.
Your doctor may adjust your medication regimen or dosage as needed to minimize fever symptoms.
Monitor your body temperature to monitor fever progression.
Drink plenty of fluids, such as water or electrolyte-rich beverages, to help your body regulate temperature.
Get plenty of rest and engage in relaxation techniques, such as deep breathing or meditation, to help manage fever symptoms.
Under the guidance of your doctor, consider taking medication, such as acetaminophen or ibuprofen, to help reduce fever.
If your fever is extremely high (over 103°F), or if you experience severe symptoms such as confusion, seizures, or difficulty breathing, seek immediate medical attention.

Directions for Use

Hysotan-15 mg Tablet 10's can be taken with or without food. However, avoid taking it with grapefruit or its juice, as this may increase the effects of the medication.
It is usually taken once daily; however, your doctor may adjust the dosage based on your serum sodium and fluid levels.
Swallow Hysotan-15 mg Tablet 10's as a whole with a glass of water.
Do not crush, break, or chew it.

How Hysotan-15 mg Tablet 10's Works

Hysotan-15 mg Tablet 10's contains tolvaptan that works by blocking the effect of vasopressin, resulting in decreased water reabsorption, a net increase in free water excretion (aquaresis) and an increase in serum sodium concentrations. This decrease in free water is not associated with an increased excretion of sodium or potassium ions; the increase in serum sodium concentration is solely a result of increased urine production.

Alcohol

Unsafe

Avoid consuming alcohol while taking Hysotan-15 mg Tablet 10's as it may cause increased dizziness.

Pregnancy

Unsafe

Hysotan-15 mg Tablet 10's belongs to pregnancy category C. Hysotan-15 mg Tablet 10's is not recommended for use in pregnant women as it may cause foetal harm. Women of childbearing age must use effective contraception while taking Hysotan-15 mg Tablet 10's.

Breast Feeding

Unsafe

Hysotan-15 mg Tablet 10's is not recommended for use in breastfeeding women. Consult your doctor if you are breastfeeding; your doctor will decide whether Hysotan-15 mg Tablet 10's can be taken by breastfeeding mothers or not.

Driving

Caution

Hysotan-15 mg Tablet 10's may cause dizziness, weakness and tiredness. Do not drive or operate heavy machinery if you feel dizzy.

Liver

Caution

Hysotan-15 mg Tablet 10's should be used with caution in patients with liver impairment/liver disease. Please consult your doctor if you have liver problems or any concerns regarding this.

Kidney

Caution

Hysotan-15 mg Tablet 10's should be used with caution in patients with kidney disease. Please consult your doctor if you have kidney problems or any concerns regarding this.

Children

Unsafe

Hysotan-15 mg Tablet 10's is not recommended for children below 18 years as efficacy and safety have not been established.

Heart

Consult your doctor

Please inform your doctor if you have a history of heart disease before using Hysotan-15 mg Tablet 10's. Your doctor will prescribe it only if the benefits outweigh the risks.

Geriatrics

Caution

Hysotan-15 mg Tablet 10's can be given in elderly patients with extreme caution, if prescribed by the physician.

What if I have taken an overdose of Hysotan-15 mg Tablet 10's

Take Hysotan-15 mg Tablet 10's only as prescribed by the physician. Avoid exceeding the recommended dose as it could lead to an overdose. Symptoms of overdose may include excessive urination, excessive thirst, dizziness, and faintness. If you experience these symptoms or suspect you have taken an overdose, seek immediate medical attention.

Diet & Lifestyle Advise

Eat a diet rich in whole grains, vegetables, and fruits.
Avoid smoking and alcohol consumption.
Maintain a healthy weight with proper diet and exercise.
Manage stress with meditation, yoga, and massage.
Drink plenty of fluids.
Rehydration beverages that contain electrolytes are also helpful.

Have a query?

How Soon It Starts Working

The time required for Hysotan-15 mg Tablet 10's to start to work: Hysotan-15 mg Tablet 10's ideally shows its action within 2 to 4 hours after administration.

The time for which the effects of Hysotan-15 mg Tablet 10's last: The effect of Hysotan-15 mg Tablet 10's lasts for 12 hours.

What if you forget to take Hysotan-15 mg Tablet 10's

If you forget to take a dose of Hysotan-15 mg Tablet 10's, take it as soon as you remember. If it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dose. Do not take a double dose to make up for the missed one.

Storage

• Store in a cool and dry place away from sunlight.• Keep Hysotan-15 mg Tablet 10's out of reach and sight of children. • Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.

Drug Warnings

Do not take Hysotan-15 mg Tablet 10's if you are allergic to any of its contents
Avoid taking this medicine if you have raised liver enzymes in the blood, very low blood volume, if there is no urine production, if you cannot tell that you are thirsty.
Inform your doctor if you have liver disease, difficulty in urination, diabetes, high levels of uric acid, advanced kidney disease or if you have to restrict fluid intake due to certain medical conditions.
Do not take Hysotan-15 mg Tablet 10's if you are pregnant as it may cause foetal harm.
Consult your doctor before taking Hysotan-15 mg Tablet 10's if you are breastfeeding.
Hysotan-15 mg Tablet 10's is not recommended for children below 18 years as efficacy and safety have not been established.
Hysotan-15 mg Tablet 10's may cause dizziness, so drive with caution. Avoid consuming alcohol as it might cause increased dizziness.

Drug-Drug Interactions

Drug-Drug Interaction: Inform the doctor if you are taking antibiotics (clarithromycin, telithromycin, sulfamethoxazole, trimethoprim), anti-fungal (ketoconazole, itraconazole), anti-HIV (ritonavir, indinavir, nelfinavir, saquinavir), antidepressant (nefazodone), aldosterone receptor antagonist (spironolactone), angiotensin receptor inhibitor (valsartan, sacubitril), blood thinner (heparin).

Drug-Food Interaction: Avoid consuming grapefruit juice and St. John’s wort (herbal supplement used to treat depression) while taking Hysotan-15 mg Tablet 10's.

Drug-Disease Interaction: Inform the doctor if you have liver disease, difficulty in urination, diabetes, high levels of uric acid or kidney disease.

TolvaptanTelithromycin

Critical

TolvaptanPosaconazole

Critical

Drug-Drug Interactions

TolvaptanTelithromycin

Critical

How does the drug interact with Hysotan-15 mg Tablet:
When Hysotan-15 mg Tablet and Telithromycin are taken together, may significantly increase the blood levels and effects of Hysotan-15 mg Tablet.

How to manage the interaction:
There may be a possibility of interaction between Hysotan-15 mg Tablet and Telithromycin, but it can be taken if prescribed by a doctor. If you notice any of these signs - like difficulty swallowing, trouble speaking, muscle weakness, trouble controlling body movements, confusion, mood changes, seizures, call a doctor right away. Do not stop using any medications without a doctor's advice.

TolvaptanPosaconazole

Critical

How does the drug interact with Hysotan-15 mg Tablet:
Taking Hysotan-15 mg Tablet and Posaconazole together results in an increase in the levels and effects of Hysotan-15 mg Tablet.

How to manage the interaction:
Although there is an interaction between Hysotan-15 mg Tablet and Posaconazole, it can be taken if prescribed by a doctor. However, consult a doctor if you experience difficulty swallowing, trouble speaking, muscle weakness, trouble controlling body movements, confusion, mood changes, or seizures (fits). Do not stop using any medications without a doctor's advice.

TolvaptanNefazodone

Critical

How does the drug interact with Hysotan-15 mg Tablet:
When Hysotan-15 mg Tablet and Nefazodone are taken together, may significantly increase the blood levels and effects of Hysotan-15 mg Tablet.

How to manage the interaction:
There may be a possibility of interaction between Hysotan-15 mg Tablet and Nefazodone, but it can be taken if prescribed by a doctor. If you notice any of these signs - like difficulty swallowing, trouble speaking, muscle weakness, trouble controlling body movements, confusion, mood changes, seizures, call a doctor right away. Do not stop using any medications without a doctor's advice.

TolvaptanFosamprenavir

Critical

How does the drug interact with Hysotan-15 mg Tablet:
When Hysotan-15 mg Tablet is taken with Fosamprenavir, may significantly increase the blood levels and effects of Hysotan-15 mg Tablet.

How to manage the interaction:
There may be a possibility of interaction between Hysotan-15 mg Tablet and Fosamprenavir, but it can be taken if prescribed by a doctor. If you notice any of these signs -difficulty swallowing, trouble speaking, muscle weakness, trouble controlling body movements, confusion, mood changes, seizures, call a doctor right away. Do not stop using any medications without a doctor's advice.

TolvaptanClarithromycin

Critical

How does the drug interact with Hysotan-15 mg Tablet:
When Hysotan-15 mg Tablet and Clarithromycin are taken together, may significantly increase the blood levels and effects of Hysotan-15 mg Tablet.

How to manage the interaction:
There may be a possibility of interaction between Hysotan-15 mg Tablet and Clarithromycin, but it can be taken if prescribed by a doctor. If you notice any of these signs -difficulty swallowing, trouble speaking, muscle weakness, trouble controlling body movements, confusion, mood changes, seizures, call a doctor right away. Do not stop using any medications without a doctor's advice.

TolvaptanRitonavir

Critical

How does the drug interact with Hysotan-15 mg Tablet:
Taking Ritonavir and Hysotan-15 mg Tablet may significantly increase the blood levels of Hysotan-15 mg Tablet.

How to manage the interaction:
Taking Hysotan-15 mg Tablet with Ritonavir is not recommended as it can possibly result in an interaction, it can be taken if a doctor has advised it. If you notice any of these symptoms like difficulty swallowing, trouble speaking, muscle weakness, trouble controlling body movements, confusion, mood changes, fits, contact a doctor. Do not discontinue any medications without consulting a doctor.

TolvaptanVoriconazole

Critical

How does the drug interact with Hysotan-15 mg Tablet:
Co-administration of Hysotan-15 mg Tablet together with Voriconazole may significantly increase the blood levels and effects of Hysotan-15 mg Tablet.

How to manage the interaction:
There may be a possibility of interaction between Hysotan-15 mg Tablet and Voriconazole, but it can be taken if prescribed by a doctor. If you experience difficulty swallowing, trouble speaking, muscle weakness call a doctor right away. Do not stop using any medications without a doctor's advice.

TolvaptanTelaprevir

Critical

How does the drug interact with Hysotan-15 mg Tablet:
When Hysotan-15 mg Tablet and Telaprevir are taken together, may significantly increase the blood levels and effects of Hysotan-15 mg Tablet.

How to manage the interaction:
There may be a possibility of interaction between Hysotan-15 mg Tablet and Telaprevir, but it can be taken if prescribed by a doctor. If you notice any of these signs - like difficulty swallowing, trouble speaking, muscle weakness, trouble controlling body movements, confusion, mood changes, seizures, call a doctor right away. Do not stop using any medications without a doctor's advice.

TolvaptanIndinavir

Critical

How does the drug interact with Hysotan-15 mg Tablet:
When Hysotan-15 mg Tablet and Indinavir are taken together, may significantly increase the blood levels and effects of Hysotan-15 mg Tablet.

How to manage the interaction:
There may be a possibility of interaction between Hysotan-15 mg Tablet and Indinavir, but it can be taken if prescribed by a doctor. If you notice any of these signs -difficulty swallowing, trouble speaking, muscle weakness, trouble controlling body movements, confusion, mood changes, seizures, call a doctor right away. Do not stop using any medications without a doctor's advice.

TolvaptanSaquinavir

Critical

How does the drug interact with Hysotan-15 mg Tablet:
When Hysotan-15 mg Tablet and Saquinavir are taken together, may significantly increase the blood levels and effects of Hysotan-15 mg Tablet.

How to manage the interaction:
There may be a possibility of interaction between Hysotan-15 mg Tablet and Saquinavir, but it can be taken if prescribed by a doctor. If you notice any of these signs - like difficulty swallowing, trouble speaking, muscle weakness, trouble controlling body movements, confusion, mood changes, seizures, call a doctor right away. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

TOLVAPTAN-15MGGrapefruit and Grapefruit Juice

Moderate

Drug-Food Interactions

TOLVAPTAN-15MGGrapefruit and Grapefruit Juice

Moderate

Common Foods to Avoid:
Grapefruit

How to manage the interaction:
Consuming grapefruit juice while taking Hysotan-15 mg Tablet can increase the effects of Hysotan-15 mg Tablet. Avoid taking Hysotan-15 mg Tablet with grapefruit juice.

All Substitutes & Brand Comparisons

RX
Natremia-15 Tablet 10's
Renauxe Pharma India Pvt Ltd
₹421.5
(₹42.15 per unit)
10% CHEAPER
RX
Neph-Tolvaptan Tablet 4's
EVERVITAL LIFESCIENCES
₹300
(₹75.0 per unit)
60% COSTLIER
RX
Hyponat-O 15 Tablet 10's
Zydus Healthcare Ltd
₹771
(₹77.1 per unit)
64% COSTLIER

Habit Forming

Therapeutic Class

[CARDIOVASCULAR AGENTS]

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Author Details

Written By

Santoshini Reddy G
M Pharmacy

Reviewed By

Dr Aneela Siddabathuni
MPharma., PhD

Last Updated

Jun 26, 2026 | 8:18 AM IST

We provide you with authentic, trustworthy and relevant information.

See our editorial policy

Reference

Country of origin

India

Manufacturer/Marketer address

Lia Life Sciences Pvt. Ltd., Lia House,Old No.340, New No.7, 8Th Avenue, Ashok Nagar, Chennai-600 083. Tamil Nadu, India.

Other Info - HYS0031

Buy Now

Add to Cart

Welcome User

Hysotan-15 mg Tablet 10's

Delivery Information

More about the Product

Composition :

Manufacturer/Marketer :

Consume Type :

Expires on or after :

Return Policy :

About Hysotan-15 mg Tablet 10's

Uses of Hysotan-15 mg Tablet 10's

Key Benefits

Dry Mouth

Nausea

Frequent Urination

Excessive Urination

Thirsty

Weakness

High Body Temperature

Directions for Use

How Hysotan-15 mg Tablet 10's Works

Alcohol

Pregnancy

Breast Feeding

Driving

Liver

Kidney

Children

Heart

Geriatrics

What if I have taken an overdose of Hysotan-15 mg Tablet 10's

Diet & Lifestyle Advise

How Soon It Starts Working

What if you forget to take Hysotan-15 mg Tablet 10's

Storage

Drug Warnings

Drug-Drug Interactions

Drug-Drug Interactions

Drug-Food Interactions

Drug-Food Interactions

All Substitutes & Brand Comparisons

Natremia-15 Tablet 10's

Neph-Tolvaptan Tablet 4's

Hyponat-O 15 Tablet 10's

Habit Forming

Therapeutic Class

FAQs

What is the use of Hysotan-15 mg Tablet 10's?

How does Hysotan-15 mg Tablet 10's work?

How to cope with dry mouth?

Does Hysotan-15 mg Tablet 10's cause diarrhoea?

Does Hysotan-15 mg Tablet 10's cause liver problems?

How to cope with side-effects such as thirst?

I am diabetic, can I take Hysotan-15 mg Tablet 10's?

For how long do I need to take Hysotan-15 mg Tablet 10's?

Does Hysotan-15 mg Tablet 10's affect the sugar levels in the blood?

Who should not take Hysotan-15 mg Tablet 10's?

Can I have grapefruit juice while taking Hysotan-15 mg Tablet 10's?

What will happen if I take an excess of Hysotan-15 mg Tablet 10's?

Can Hysotan-15 mg Tablet 10's be used by patients with kidney disease?

What should I do if I miss a dose of Hysotan-15 mg Tablet 10's?

Can I take Hysotan-15 mg Tablet 10's while pregnant or breastfeeding?

What are the common side effects of Hysotan-15 mg Tablet 10's?

How should I store Hysotan-15 mg Tablet 10's?

What is the most important information I need to be aware of while taking Hysotan-15 mg Tablet 10's?

Author Details

Reference

Country of origin

Manufacturer/Marketer address

Buy best Cardiology products by

Category

Sub-Category

Brand

Manufacturer

Product-Type