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compositionComposition:IBRUTINIB-140MG
prescriptionPrescription Medicine
Ibrunat Capsule 30's
Ibrunat Capsule 30's
Ibrunat Capsule 30's

Ibrunat Capsule is used to treat Mantle cell lymphoma, chronic lymphocytic leukaemia, and Waldenstr's macroglobulinaemia. It contains Ibrutinib, which works by blocking Bruton's tyrosine kinase, a protein in the body that helps cancer cells grow and survive. Thereby, it kills and reduces the number of cancer cells. It also slows down the worsening of cancer. Sometimes, Ibrunat Capsule may cause side effects such as nausea, vomiting, diarrhoea, constipation, indigestion, and fatigue.

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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

IBRUTINIB-140MG

Manufacturer/Marketer :

Natco Pharma Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Ibrunat Capsule

Ibrunat Capsule belongs to the group of anti-cancer medicines called protein kinase inhibitors used to treat the following blood cancers in adults- mantle cell lymphoma (cancer affecting the lymph nodes), chronic lymphocytic leukaemia (cancer affecting white blood cells and lymph nodes), and waldenström's macroglobulinaemia (cancer affecting white blood cells).

Ibrunat Capsule contains Ibrutinib, which works by blocking Bruton's tyrosine kinase, a protein in the body that helps cancer cells grow and survive. Thereby, it kills and reduces the number of cancer cells. It also slows down the worsening of cancer.

In some cases, Ibrunat Capsule may cause side effects such as nausea, vomiting, diarrhoea, constipation, indigestion, and fatigue. Most of these side effects may not require medical attention and resolve gradually over time. Do not be reluctant to talk with your doctor if any of the side effects persist or worsen.

Do not take Ibrunat Capsule if you are pregnant or breastfeeding. Consult the doctor immediately if you become pregnant during treatment with Ibrunat Capsule . This medicine is not recommended for children as safety and effectiveness have not been established. Inform the doctor about your health condition and medications to rule out any side effects/interactions.

Uses of Ibrunat Capsule

Ibrunat Capsule is used in the treatment of Mantle cell lymphoma, chronic lymphocytic leukaemia, and Waldenstramps macro globulinaemia. The detailed uses of Ibrunat Capsule are as follows:

  • Mantle cell lymphoma (MCL): Ibrunat Capsule is used in adults who have received at least one prior therapy. It helps slow the progression of this aggressive form of non-Hodgkin lymphoma.
  • Chronic lymphocytic leukemia (CLL):Ibrunat Capsule is used for patients with CLL, including those with the 17p deletion, a genetic mutation associated with poor prognosis.
  • Waldenstramps macro globulinemia (WM): Ibrunat Capsule is also used to treat this rare type of non-Hodgkin lymphoma that affects B cells and leads to abnormal protein build up in the blood.

Key Benefits

Ibrunat Capsule belongs to the group of anti-cancer medicines called protein kinase inhibitors used to treat the following blood cancers in adults- mantle cell lymphoma, chronic lymphocytic leukaemia, and waldenström's macroglobulinaemia. This medicine may also be used to treat marginal zone lymphoma (cancer that begins in a type of white blood cells that normally fights infection) and chronic graft vs host disease (a complication of hematopoietic stem-cell transplant). Ibrunat Capsule contains Ibrutinib, which works by blocking Bruton's tyrosine kinase (a protein in the body that helps cancer cells grow and survive). Thereby, it kills and reduces the number of cancer cells. It also slows down the worsening of cancer.

Side effects of Ibrunat Capsule
Managing Medication-Triggered UTIs: A Comprehensive Approach:
  • Inform your doctor about the medication you're taking and the UTI symptoms you're experiencing.
  • Your doctor may adjust your medication regimen or consider alternative medications or dosages that may reduce the risk of UTIs.
  • Drink plenty of water (at least 8-10 glasses a day) to help flush out bacteria. Avoid sugary drinks and caffeine, which can exacerbate UTI symptoms.
  • Urinate when you feel the need rather than holding it in. This can help prevent bacterial growth and reduce the risk of UTIs.
  • Consider cranberry supplements: Cranberry supplements may help prevent UTIs by preventing bacterial adhesion.
  • Monitor UTI symptoms and report any changes to your doctor.
  • If antibiotics are prescribed, take them as directed and complete the full course.
  • Managing a low platelet count (thrombocytopenia) caused by medication usage requires a multi-step approach. Here are some steps to help manage the condition:
  • Inform your doctor about your low platelet count and medication usage. They will assess the situation and guide the best course of action.
  • Your doctor may recommend adjusting or stopping the medication that is causing a low platelet count. This could involve switching to alternative medication or reducing the dosage.
  • Monitor your platelet count regularly through blood tests to track any changes. This will help the doctor determine the effectiveness of the treatment plan.
  • If an underlying condition, such as infection or inflammation, contributes to the low platelet count, your doctor will treat it.
  • In some cases, alternative treatments like platelet transfusions or medications that stimulate platelet production may be necessary.
  • Avoid risky activities and certain medications; eat a balanced diet with plenty of water to reduce bleeding risk and boost overall health.
  • If you experience severe bleeding or bruising, seek emergency medical attention immediately.
  • Avoid taking raw fruits, nuts and vegetables.
  • Do not share your personal things with others like toothbrushes.
  • Clean the wounds and cuts using soap and water.
  • Wash your hands thoroughly and frequently and maintain hygiene.
  • Get a good quality of sleep.
  • Include lean proteins like skinless poultry and fish.
  • Choose whole grains and low-fat dairy products.
  • Limit intake of fat and oil.
  • Stay hydrated by drinking plenty of water.
  • Restrict heavy sugar intake.
  • Avoid red meat, processed foods, and refined sugar.
  • Eat more fruits and vegetables.
  • Stay hydrated by drinking plenty of water.
  • Avoid rubbing your eyes, which can exacerbate the issue.
  • Lubricate your eyes using artificial tears or eye drops.
  • Wear sunglasses while you are out in the sun to protect your eyes from sun and wind.
  • Avoid irritants like smoke, dust, and strong chemicals.
  • Get enough rest and sleep to help your eyes recover.

Directions for Use

  • Ibrunat Capsule can be taken with or without food.
  • It is usually recommended once daily; however, follow your doctor’s advice regarding the dosage and duration.
  • Swallow the capsule as a whole with a glass of water.
  • Do not break, chew or crush Ibrunat Capsule .

How Ibrunat Capsule Works

Ibrunat Capsule contains Ibrutinib, which works by blocking Bruton's tyrosine kinase, a protein in the body that helps cancer cells grow and survive. Thereby, it kills and reduces the number of cancer cells. It also slows down the worsening of cancer.
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Alcohol

Consult your doctor

It is not known if alcohol affects Ibrunat Capsule . However, avoid consumption of alcohol while on treatment with Ibrunat Capsule as it may worsen your condition.

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Pregnancy

Unsafe

Ibrutinib belongs to pregnancy category D. Ibrunat Capsule should not be used during pregnancy. Use effective contraception and avoid pregnancy during treatment with Ibrunat Capsule .

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Breast Feeding

Unsafe

Avoid breastfeeding while taking Ibrunat Capsule .

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Driving

Caution

Ibrunat Capsule may cause dizziness and tiredness. Do not drive or operate machinery if you experience any side effects that might lessen your ability to do so.

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Liver

Caution

Avoid taking Ibrunat Capsule if you have moderate or severe baseline liver impairment. Dose adjustment may be needed in patients with mild liver impairment. If you have a history of liver disease, inform the doctor.

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Kidney

Consult your doctor

If you have a history of kidney disease, inform your doctor before taking Ibrunat Capsule .

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Children

Unsafe

Ibrunat Capsule is not recommended for children as safety and effectiveness have not been established.

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Heart

Caution

Take Ibrunat Capsule with caution, especially if you have a history of heart diseases/conditions. The dose may be adjusted by your doctor as required.

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Geriatrics

Caution

Ibrunat Capsule should be used with caution in elderly patients. Please consult your doctor before use.

What if I have taken an overdose of Ibrunat Capsule

Do not take more than the prescribed dose. Using more medication will not improve your symptoms; instead, they may cause poisoning or serious side effects. If you suspect that you may have overdosed of Ibrunat Capsule or observe any side effects, please go to the emergency department of the closest hospital or nursing home.

Diet & Lifestyle Advise

  • Eat a healthy diet and exercise regularly to maintain proper weight.
  • Avoid smoking and alcohol consumption.
  • Include vegetables and fruits in your diet.
  • Avoid fast food, fried food, processed meats, refined carbs and added sugar.
  • Get optimal sleep; rest well.
  • Drink enough water.

Have a query?

How Soon It Starts Working

The time required for Ibrunat Capsule to start to work: Ibrunat Capsule ideally shows its action within 1 to 2 hours after administration. The time for which the effects of Ibrunat Capsule last: The effect of Ibrunat Capsule lasts for 4 to 6 hours.

What if you forget to take Ibrunat Capsule

If you miss a dose, take it as soon as you remember. If it is almost time for the next dose, skip the missed dose and continue with the regular dosing schedule. Do not take a double dose.

Storage

• Store in a cool and dry place away from sunlight. • Keep Ibrunat Capsule out of reach and sight of children. • Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.

Drug Warnings

Do not take Ibrunat Capsule if you are allergic to any of its components, if you are taking St. John's wort (herbal medicine) or if you are pregnant/breastfeeding. Inform the doctor if you have/had unusual bruising or bleeding, irregular heartbeat, heart failure, hepatitis B infection, liver problems, high blood pressure, kidney problems, or if you are due to undergo any surgery. Seek immediate medical attention if you experience symptoms of progressive multifocal leukoencephalopathy, a serious brain infection (trouble thinking, memory loss, sight loss, or difficulty walking), stroke (sudden confusion, numbness or weakness, trouble speaking, sight loss, loss of balance, or sudden severe headache), heart failure (breathlessness, difficulty breathing when lying down, weakness/tiredness, or swelling of the feet, ankles, or legs), rupture of the spleen (left abdominal pain, pain below the left rib cage or at the tip of left shoulder), infection (chills, fever, weakness, body aches, cold, flu symptoms, or confusion), or haemophagocytic lymphohistiocytosis, an inflammatory disorder (fever, bruising, swollen glands, or skin rash).

Drug-Drug Interactions

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Drug-Drug Interactions: Inform the doctor if you are taking CYP3A inhibitors or inducers.

Drug-Food Interactions: Avoid taking grapefruit or Seville oranges (bitter oranges) or their juice, as they might increase the amount of ibrutinib in your blood.

Drug-Disease Interactions: Inform the doctor if you have an irregular heartbeat, heart failure, hepatitis B infection, liver problems, high blood pressure, or kidney problems.

IbrutinibDasatinib
Severe
IbrutinibEnzalutamide
Severe

Drug-Drug Interactions

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IbrutinibDasatinib
Severe
How does the drug interact with Ibrunat Capsule:
Co-administration of Dasatinib together with Ibrunat Capsule may increase the risk of bleeding.

How to manage the interaction:
Taking Ibrunat Capsule with Dasatinib together can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience bruising, dizziness, red or black, tarry stools, severe headache, and weakness, consult the doctor. Do not stop using any medications without a doctor's advice.
IbrutinibEnzalutamide
Severe
How does the drug interact with Ibrunat Capsule:
Co-administration of Enzalutamide may decrease the blood levels of Ibrunat Capsule, which may make Ibrunat Capsule less effective in treating your condition.

How to manage the interaction:
Although taking Enzalutamide and Ibrunat Capsule together can result in an interaction, it can be taken if a doctor has prescribed it. Do not discontinue any medications without a doctor's advice.
IbrutinibAnagrelide
Severe
How does the drug interact with Ibrunat Capsule:
Co-administration of Ibrunat Capsule with Anagrelide can increase the risk of bleeding.

How to manage the interaction:
Taking Ibrunat Capsule with Anagrelide together can result in an interaction, but it can be taken if a doctor has advised it. However, consult a doctor if you notice any symptoms like unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood resembling coffee grounds, severe headache, and weakness. Do not stop using any medications without a doctor's advice.
IbrutinibDextran
Severe
How does the drug interact with Ibrunat Capsule:
Co-administration of Ibrunat Capsule with Dextran can increase the risk of bleeding leading to serious blood loss.

How to manage the interaction:
Taking Ibrunat Capsule with Dextran together can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult a doctor. Do not stop using any medications without a doctor's advice.
IbrutinibLepirudin
Severe
How does the drug interact with Ibrunat Capsule:
Co-administration of Ibrunat Capsule with Lepirudin can increase the risk of bleeding leading to serious blood loss.

How to manage the interaction:
Taking Ibrunat Capsule with Lepirudin together can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult a doctor. Do not stop using any medications without a doctor's advice.
IbrutinibFosphenytoin
Severe
How does the drug interact with Ibrunat Capsule:
When Ibrunat Capsule is taken with Fosphenytoin, it can cause the body to process Ibrunat Capsule faster. This can lead to poor treatment outcomes.

How to manage the interaction:
Taking Ibrunat Capsule with Fosphenytoin together can result in an interaction, but it can be taken if a doctor has advised it. Do not discontinue any medications without consulting a doctor.
IbrutinibIdelalisib
Severe
How does the drug interact with Ibrunat Capsule:
Taking Idelalisib with Ibrunat Capsule may increase the levels of Ibrunat Capsule.

How to manage the interaction:
Although taking Ibrunat Capsule and Idelalisib together can cause an interaction, it can be taken if a doctor has suggested it. However, if you experience paleness, fatigue, dizziness, fainting, unusual bruising or bleeding, fever, chills, diarrhea, sore throat, muscle aches, breathing difficulty, blood in coughing fluid, red or inflamed skin, body sores, pain or burning during urination, nausea, vomiting, loss of hunger, increased or decreased urination, sudden weight gain or weight loss, fluid retention, swelling, irregular heart rhythm, consult a doctor. Do not discontinue any medications without a doctor's advice.
IbrutinibVerapamil
Severe
How does the drug interact with Ibrunat Capsule:
Taking Ibrunat Capsule with verapamil may increase the levels of Ibrunat Capsule. This may increase the risk of side effects.

How to manage the interaction:
Although taking Ibrunat Capsule together with Verapamil can result in an interaction, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience paleness, fatigue, dizziness, fainting, unusual bruising or bleeding, fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination, nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or weight loss, fluid retention, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm. Do not stop taking any medication without consulting a doctor.
IbrutinibPhenylbutazone
Severe
How does the drug interact with Ibrunat Capsule:
Co-administration of Ibrunat Capsule with Phenylbutazone can increase the risk of bleeding leading to serious blood loss.

How to manage the interaction:
Taking Ibrunat Capsule with Phenylbutazone together can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult a doctor. Do not stop using any medications without a doctor's advice.
IbrutinibAtazanavir
Severe
How does the drug interact with Ibrunat Capsule:
Co-administration of Ibrunat Capsule with Atazanavir may significantly raise the blood levels of Ibrunat Capsule.

How to manage the interaction:
Taking Ibrunat Capsule with Atazanavir together can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience symptoms like paleness, fatigue, dizziness, fainting, unusual bruising or bleeding, fever, chills, diarrhea, sore throat, muscle aches, breathing difficulty, blood in coughing fluid, red or inflamed skin, body sores, pain or burning during urination, nausea, vomiting, loss of hunger, increased or decreased urination, sudden weight gain or weight loss, fluid retention, swelling, irregular heart rhythm, consult the doctor. Do not discontinue any medications without a doctor's advice.

Drug-Food Interactions

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IBRUTINIB-140MGGrapefruit and Grapefruit Juice, Herbal products/medicines

Drug-Food Interactions

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IBRUTINIB-140MGGrapefruit and Grapefruit Juice, Herbal products/medicines
Common Foods to Avoid:
Grapefruit Juice, Grapefruit, St. John’S Wort

How to manage the interaction:
Consumption of grape fruit or its products, St. John’S Wort during Ibrunat Capsule treatment may lead to an interaction. Avoid consumption of grape fruit or its products, St. John’S Wort while on therapy with Ibrunat Capsule.

All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[CHEMOTHERAPY]

FAQs

Ibrunat Capsule is used to treat Mantle cell lymphoma, chronic lymphocytic leukaemia, and Waldenstr’s macroglobulinaemia.

Ibrunat Capsule works by blocking the action of an abnormal protein that helps cancer cells multiply. Thereby, it stops the spread of cancer cells.

Ibrunat Capsule may make you bleed more easily. Therefore, consult the doctor if you are taking blood thinner medicines (heparin, warfarin), NSAIDs (aspirin, ibuprofen, naproxen), or supplements that may increase the risk of bleeding (flaxseed, vitamin E, fish oil).

Ibrunat Capsule may affect the heart, especially if you already have heart diseases like heart failure, heart rhythm problems, diabetes, high blood pressure, or are of advanced age. Consult the doctor instantly if you experience symptoms of heart failure like breathlessness, difficulty breathing when lying down, weakness/tiredness, or swelling of the feet, ankles, or legs.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Country of origin

INDIA

Manufacturer/Marketer address

Natco House, Road No.2, Banjara Hills, Hyderabad-500 034, India
Other Info - IBR0005
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