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compositionComposition:IBRUTINIB-140MG
prescription
Prescription Medicine
info
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Ibrunat Capsule is used to treat Mantle cell lymphoma, chronic lymphocytic leukaemia, and Waldenstr's macroglobulinaemia. It contains Ibrutinib, which works by blocking Bruton's tyrosine kinase, a protein in the body that helps cancer cells grow and survive. Thereby, it kills and reduces the number of cancer cells. It also slows down the worsening of cancer. Sometimes, Ibrunat Capsule may cause side effects such as nausea, vomiting, diarrhoea, constipation, indigestion, and fatigue.

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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

IBRUTINIB-140MG

Manufacturer/Marketer :

Natco Pharma Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Ibrunat Capsule

Ibrunat Capsule is a prescription medicine used to treat certain blood cancers, including chronic lymphocytic leukaemia, small lymphocytic lymphoma, and Waldenström's macroglobulinaemia. It may also be used for certain other conditions, depending on the approved use and your treatment history.

Take this medicine regularly at the same time each day. Swallow it with water and follow the instructions for your prescribed formulation. It can generally be taken with or without food. Avoid grapefruit and Seville oranges, including their juices, because they can increase the amount of medicine in your blood and raise the risk of side effects.

Common side effects may include diarrhoea, tiredness, nausea, rash, and muscle or joint pain. This medicine can also cause serious problems, including bleeding, infections, high blood pressure, and abnormal heart rhythms. Consult your doctor right away if you develop unusual bleeding, signs of infection, chest discomfort, severe dizziness, or a fast or irregular heartbeat.

Before starting treatment, tell your doctor if you have bleeding problems, heart disease or an abnormal heart rhythm, high blood pressure, liver problems, or an infection. Do not take this medicine if you have had an allergic reaction to ibrutinib or any ingredient in your prescribed product.

Tell your doctor about all medicines, vitamins, supplements, and herbal products you take because some can affect how ibrutinib works or increase the risk of side effects. Tell your doctor if you are pregnant, planning a pregnancy, breastfeeding, or are an older adult. Your doctor will advise you about appropriate contraception during and after treatment.

Uses of Ibrunat Capsule

Your doctor may prescribe Ibrunat Capsule to help manage certain blood cancers and related conditions:

  • Chronic lymphocytic leukaemia (CLL): Ibrunat Capsule helps control abnormal B cells (a type of white blood cell) and slow the progression of the disease.
  • Small lymphocytic lymphoma (SLL): This medicine helps control abnormal B cells that build up mainly in the lymph nodes and other tissues.
  • Waldenström's macroglobulinaemia: It helps control abnormal B cells that produce excessive amounts of an abnormal protein in the blood.
  • Other conditions: Ibrutinib may be used for other approved conditions depending on the country, treatment history, age, and individual clinical situation.

Key Benefits

Ibrunat Capsule provides targeted treatment for certain blood cancers by blocking signals that abnormal B cells need to survive and grow.

  • Helps control the disease: By reducing the growth and survival of abnormal cells, this medicine can slow disease progression.
  • May reduce disease-related symptoms: As the condition responds to treatment, symptoms such as swollen lymph nodes, tiredness, or night sweats may improve.
  • Provides an oral treatment option: Because the medicine is taken by mouth, treatment can usually be taken at home rather than requiring an intravenous infusion for each dose.
  • Supports long-term disease management: Treatment may continue for as long as it remains effective and side effects can be safely managed.
Side effects of Ibrunat Capsule
Managing Medication-Triggered UTIs: A Comprehensive Approach:
  • Inform your doctor about the medication you're taking and the UTI symptoms you're experiencing.
  • Your doctor may adjust your medication regimen or consider alternative medications or dosages that may reduce the risk of UTIs.
  • Drink plenty of water (at least 8-10 glasses a day) to help flush out bacteria. Avoid sugary drinks and caffeine, which can exacerbate UTI symptoms.
  • Urinate when you feel the need rather than holding it in. This can help prevent bacterial growth and reduce the risk of UTIs.
  • Consider cranberry supplements: Cranberry supplements may help prevent UTIs by preventing bacterial adhesion.
  • Monitor UTI symptoms and report any changes to your doctor.
  • If antibiotics are prescribed, take them as directed and complete the full course.
  • Managing a low platelet count (thrombocytopenia) caused by medication usage requires a multi-step approach. Here are some steps to help manage the condition:
  • Inform your doctor about your low platelet count and medication usage. They will assess the situation and guide the best course of action.
  • Your doctor may recommend adjusting or stopping the medication that is causing a low platelet count. This could involve switching to alternative medication or reducing the dosage.
  • Monitor your platelet count regularly through blood tests to track any changes. This will help the doctor determine the effectiveness of the treatment plan.
  • If an underlying condition, such as infection or inflammation, contributes to the low platelet count, your doctor will treat it.
  • In some cases, alternative treatments like platelet transfusions or medications that stimulate platelet production may be necessary.
  • Avoid risky activities and certain medications; eat a balanced diet with plenty of water to reduce bleeding risk and boost overall health.
  • If you experience severe bleeding or bruising, seek emergency medical attention immediately.
  • Avoid taking raw fruits, nuts and vegetables.
  • Do not share your personal things with others like toothbrushes.
  • Clean the wounds and cuts using soap and water.
  • Wash your hands thoroughly and frequently and maintain hygiene.
  • Get a good quality of sleep.
  • Include lean proteins like skinless poultry and fish.
  • Choose whole grains and low-fat dairy products.
  • Limit intake of fat and oil.
  • Stay hydrated by drinking plenty of water.
  • Restrict heavy sugar intake.
  • Avoid red meat, processed foods, and refined sugar.
  • Eat more fruits and vegetables.
  • Stay hydrated by drinking plenty of water.
  • Avoid rubbing your eyes, which can exacerbate the issue.
  • Lubricate your eyes using artificial tears or eye drops.
  • Wear sunglasses while you are out in the sun to protect your eyes from sun and wind.
  • Avoid irritants like smoke, dust, and strong chemicals.
  • Get enough rest and sleep to help your eyes recover.

Directions for Use

  • Ibrunat Capsule can be taken with or without food.
  • It is usually recommended once daily; however, follow your doctor’s advice regarding the dosage and duration.
  • Swallow the capsule as a whole with a glass of water.
  • Do not break, chew or crush Ibrunat Capsule .

How Ibrunat Capsule Works

Ibrunat Capsule contains ibrutinib, a targeted medicine that blocks Bruton’s tyrosine kinase (BTK), a protein that helps certain B cells grow and survive. In some blood cancers, abnormal B cells depend on BTK signals to keep growing. By blocking BTK, this medicine reduces these growth and survival signals, helping control the abnormal cells and slow the progression of the disease.
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Alcohol

Consult your doctor

It is not known if alcohol affects Ibrunat Capsule . However, avoid consumption of alcohol while on treatment with Ibrunat Capsule as it may worsen your condition.

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Pregnancy

Unsafe

Ibrutinib belongs to pregnancy category D. Ibrunat Capsule should not be used during pregnancy. Use effective contraception and avoid pregnancy during treatment with Ibrunat Capsule .

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Breast Feeding

Unsafe

Avoid breastfeeding while taking Ibrunat Capsule .

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Driving

Caution

Ibrunat Capsule may cause dizziness and tiredness. Do not drive or operate machinery if you experience any side effects that might lessen your ability to do so.

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Liver

Caution

Avoid taking Ibrunat Capsule if you have moderate or severe baseline liver impairment. Dose adjustment may be needed in patients with mild liver impairment. If you have a history of liver disease, inform the doctor.

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Kidney

Consult your doctor

If you have a history of kidney disease, inform your doctor before taking Ibrunat Capsule .

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Children

Unsafe

Ibrunat Capsule is not recommended for children as safety and effectiveness have not been established.

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Heart

Caution

Take Ibrunat Capsule with caution, especially if you have a history of heart diseases/conditions. The dose may be adjusted by your doctor as required.

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Geriatrics

Caution

Ibrunat Capsule should be used with caution in elderly patients. Please consult your doctor before use.

What if I have taken an overdose of Ibrunat Capsule

If you take more medicine than prescribed, contact your doctor or seek medical care promptly. Take the medicine packaging with you if possible so healthcare professionals know what you have taken.

Diet & Lifestyle Advise

  • Stay hydrated: Drink enough fluids, particularly if you develop diarrhoea, unless your doctor has advised you to limit fluids.
  • Avoid grapefruit and Seville oranges: These fruits and their juices can increase the amount of ibrutinib in your blood and raise the risk of side effects.
  • Reduce infection risk: Wash your hands regularly and avoid close contact with people who have contagious infections when possible.
  • Protect yourself from bleeding: Use a soft toothbrush and take care when using sharp objects, particularly if you bruise or bleed easily.
  • Eat a balanced diet: Choose a varied diet that supports your nutritional needs during treatment, and discuss significant appetite or weight changes with your healthcare team.
health query

Have a query?

How Soon It Starts Working

The time required for Ibrunat Capsule to start to work: Ibrunat Capsule ideally shows its action within 1 to 2 hours after administration. The time for which the effects of Ibrunat Capsule last: The effect of Ibrunat Capsule lasts for 4 to 6 hours.

What if you forget to take Ibrunat Capsule

If you miss a dose, take it as soon as you remember on the same day. If the day has already passed, skip the missed dose and take your next dose at the usual time. Do not take an extra dose to make up for the one you missed.

Storage

•Store Ibrunat Capsule at room temperature, preferably between 20°C and 25°C, or according to the storage instructions on the product label.

Drug Warnings

  • Watch for bleeding: Tell your doctor about unusual bruising, prolonged bleeding, black stools, blood in your urine, or other signs of bleeding.
  • Tell your doctor before procedures: Your doctor may advise stopping this medicine for a short period before and after surgery or dental procedures because of the risk of bleeding.
  • Watch for infections: Consult your doctor if you develop fever, chills, persistent cough, or other signs of infection.
  • Monitor your heart health: Tell your doctor promptly about a racing or irregular heartbeat, chest discomfort, fainting, or new shortness of breath.
  • Check your blood pressure: This medicine can cause or worsen high blood pressure, so your doctor may monitor it during treatment.
  • Discuss vaccinations: Ask your doctor before receiving any vaccine. Live vaccines are generally avoided during treatment.
  • Use contraception as advised: Ibrutinib may harm an unborn baby. Follow your doctor's instructions about effective contraception during treatment and for the recommended period after your last dose.
  • Keep your monitoring appointments: Your doctor may arrange blood tests and other checks to monitor blood cell counts, liver function, infections, bleeding risk, and other side effects.

Drug-Drug Interactions

verifiedApollotooltip
  • Blood Thinners (like warfarin, aspirin, or ibuprofen): Taking these with Ibrunat Capsule can significantly increase your risk of serious bleeding.
  • Strong CYP3A Inhibitors (like ketoconazole, clarithromycin, or ritonavir): These can slow down how your body clears this medicine, raising its levels in your blood and increasing the risk of severe side effects.
  • Strong CYP3A Inducers (like rifampin, phenytoin, or carbamazepine): These can speed up how your body processes the medicine, making it less effective.
IbrutinibOxaprozin
Severe
IbrutinibEtodolac
Severe

Drug-Drug Interactions

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IbrutinibOxaprozin
Severe
How does the drug interact with Ibrunat Capsule:
Co-administration of Ibrunat Capsule with Oxaprozin can increase the risk of bleeding.

How to manage the interaction:
Taking Ibrunat Capsule with Oxaprozin together can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult a doctor. Do not stop using any medications without a doctor's advice.
IbrutinibEtodolac
Severe
How does the drug interact with Ibrunat Capsule:
Co-administration of Ibrunat Capsule with Etodolac may increase the risk of bleeding.

How to manage the interaction:
Although taking Etodolac and Ibrunat Capsule together can cause an interaction, it can be taken if a doctor has suggested it. However, If you experience any unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, a severe headache, and/or weakness, consult a doctor immediately. Do not discontinue any medications without consulting a doctor.
IbrutinibCertolizumab
Severe
How does the drug interact with Ibrunat Capsule:
Co-administration of Ibrunat Capsule and Certolizumab can increase the risk of developing serious infections.

How to manage the interaction:
Although there is an interaction, Ibrunat Capsule can be taken with Certolizumab, if prescribed by the doctor. However, if you experience fever, chills, diarrhoea, sore throat, muscle aches, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning when you urinate, consult a doctor. Do not discontinue any medications without a doctor's advice.
IbrutinibTenecteplase
Severe
How does the drug interact with Ibrunat Capsule:
Co-administration of Ibrunat Capsule with Tenecteplase can increase the risk of bleeding leading to serious blood loss.

How to manage the interaction:
Taking Ibrunat Capsule with Tenecteplase together can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult a doctor. Do not stop using any medications without a doctor's advice.
IbrutinibEtanercept
Severe
How does the drug interact with Ibrunat Capsule:
When Etanercept is used with Ibrunat Capsule, the likelihood or severity of infection may increase.

How to manage the interaction:
Although there is a possible interaction between Ibrunat Capsule and Etanercept, you can take these medicines together if prescribed by a doctor. However, if you develop fever, chills, diarrhea, sore throat, muscular pains, shortness of breath, blood in phlegm, weight loss, red or irritated skin, body sores, or discomfort or burning during urination, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.
IbrutinibMefenamic acid
Severe
How does the drug interact with Ibrunat Capsule:
Co-administration of Mefenamic acid with Ibrunat Capsule can increase the risk or severity of bleeding, leading to serious blood loss.

How to manage the interaction:
Taking Mefenamic acid with Ibrunat Capsule together can result in an interaction, it can be taken if a doctor has advised it. However, if you notice any symptoms of unusual bleeding or bruising, dizziness, lightheadedness, red or black tarry stools, coughing up or vomiting blood, severe headache, and weakness, you should contact a doctor immediately. Do not stop using any medications without talking to a doctor.
IbrutinibAnistreplase
Severe
How does the drug interact with Ibrunat Capsule:
Co-administration of Ibrunat Capsule with Anistreplase can increase the risk of bleeding.

How to manage the interaction:
Taking Ibrunat Capsule with Anistreplase together can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult a doctor. Do not stop using any medications without a doctor's advice.
IbrutinibIdelalisib
Severe
How does the drug interact with Ibrunat Capsule:
Taking Idelalisib with Ibrunat Capsule may increase the levels of Ibrunat Capsule.

How to manage the interaction:
Although taking Ibrunat Capsule and Idelalisib together can cause an interaction, it can be taken if a doctor has suggested it. However, if you experience paleness, fatigue, dizziness, fainting, unusual bruising or bleeding, fever, chills, diarrhea, sore throat, muscle aches, breathing difficulty, blood in coughing fluid, red or inflamed skin, body sores, pain or burning during urination, nausea, vomiting, loss of hunger, increased or decreased urination, sudden weight gain or weight loss, fluid retention, swelling, irregular heart rhythm, consult a doctor. Do not discontinue any medications without a doctor's advice.
IbrutinibMitotane
Severe
How does the drug interact with Ibrunat Capsule:
Co-administration of Mitotane may decrease the blood levels of Ibrunat Capsule, which may make Ibrunat Capsule less effective in treating your condition.

How to manage the interaction:
Although taking Ibrunat Capsule and Mitotane together can result in an interaction, it can be taken if a doctor has prescribed it. Do not discontinue any medications without a doctor's advice.
IbrutinibLeflunomide
Severe
How does the drug interact with Ibrunat Capsule:
Co-administration of Ibrunat Capsule and Leflunomide can increase the risk of developing serious infections.

How to manage the interaction:
Although there is an interaction, Ibrunat Capsule can be taken with Leflunomide, if prescribed by the doctor. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning when you urinate, consult a doctor. Do not discontinue any medications without a doctor's advice.

Drug-Food Interactions

verifiedApollotooltip
  • Grapefruit and Seville oranges: Avoid these fruits and their juices because they can increase the amount of ibrutinib in your blood and increase the risk of side effects.
IBRUTINIB-140MGGrapefruit and Grapefruit Juice, Herbal products/medicines

Drug-Food Interactions

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IBRUTINIB-140MGGrapefruit and Grapefruit Juice, Herbal products/medicines
Common Foods to Avoid:
Grapefruit Juice, Grapefruit, St. John’S Wort

How to manage the interaction:
Consumption of grape fruit or its products, St. John’S Wort during Ibrunat Capsule treatment may lead to an interaction. Avoid consumption of grape fruit or its products, St. John’S Wort while on therapy with Ibrunat Capsule.

All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[CHEMOTHERAPY]

FAQs

Ibrunat Capsule is used to treat Mantle cell lymphoma, chronic lymphocytic leukaemia, and Waldenstr’s macroglobulinaemia.
Ibrunat Capsule works by blocking the action of an abnormal protein that helps cancer cells multiply. Thereby, it stops the spread of cancer cells.
Ibrunat Capsule may make you bleed more easily. Therefore, consult the doctor if you are taking blood thinner medicines (heparin, warfarin), NSAIDs (aspirin, ibuprofen, naproxen), or supplements that may increase the risk of bleeding (flaxseed, vitamin E, fish oil).
Ibrunat Capsule may affect the heart, especially if you already have heart diseases like heart failure, heart rhythm problems, diabetes, high blood pressure, or are of advanced age. Consult the doctor instantly if you experience symptoms of heart failure like breathlessness, difficulty breathing when lying down, weakness/tiredness, or swelling of the feet, ankles, or legs.
There is no well-established direct interaction between ibrutinib and alcohol. However, alcohol may worsen some side effects or increase bleeding risk in certain situations. Ask your doctor whether alcohol is appropriate for you during treatment.
Tell your doctor, dentist, or surgeon that you take this medicine. Because it can increase bleeding risk, your doctor may advise stopping treatment for a short period before and after the procedure. Do not stop it yourself.
Hair loss is not one of the most common side effects of ibrutinib. Tell your doctor if you notice significant or unexpected hair loss during treatment.
Ask your doctor before receiving any vaccine. Live vaccines are generally avoided during treatment because your immune response may be affected. Your doctor can advise which vaccines are appropriate for you.
Ibrutinib is a targeted cancer treatment rather than traditional chemotherapy. It blocks a specific protein called BTK that certain abnormal B cells need for growth and survival.
Treatment is often continued for as long as it is controlling the condition and side effects remain manageable. Your doctor will regularly review your response and decide how long treatment should continue.
Blood tests help your doctor monitor blood cell counts, liver function, and other changes that may occur during treatment. They also help your doctor decide whether your dose or treatment needs to be adjusted.
Consult your doctor right away if you notice a racing, fluttering, or irregular heartbeat, particularly if it occurs with chest pain, shortness of breath, dizziness, or fainting.
Ibrutinib may harm an unborn baby. Tell your doctor if you are pregnant, planning a pregnancy, or breastfeeding. Follow your doctor's advice about contraception during and after treatment and about whether breastfeeding is appropriate.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Country of origin

INDIA

Manufacturer/Marketer address

Natco House, Road No.2, Banjara Hills, Hyderabad-500 034, India
Other Info - IBR0005
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