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compositionComposition:AMOXYCILLIN-400MG+CLAVULANIC ACID-57MG
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Instaclav-DS 457 mg Mango Flavour Oral Suspension is used to treat bacterial infections, including ear, sinus, respiratory tract, urinary tract, skin, soft tissue, dental, joint and bone infections. It works by killing the infection-causing bacteria. In some cases, this medicine may cause side effects such as vomiting, nausea, and diarrhoea. Before taking this medicine, inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.

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Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

AMOXYCILLIN-400MG+CLAVULANIC ACID-57MG

Manufacturer/Marketer :

Instaray Pharmaceuticals

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Instaclav-DS 457 mg Mango Flavour Oral Suspension

Instaclav-DS 457 mg Mango Flavour Oral Suspension is used to treat bacterial infections in the body that affect the skin, soft tissues, lungs, ears, urinary tract, and nasal sinuses. It should be mentioned that viral infections like the flu and the common cold are not treated by this medication.

Instaclav-DS 457 mg Mango Flavour Oral Suspension consists of Amoxycillin and Clavulanic acid. This medicine works by destroying the outer protein layer, thereby killing the bacteria (bactericidal action). As a result, it helps treat infection and reduce the further spread of infection. Instaclav-DS 457 mg Mango Flavour Oral Suspension does not work against infections caused by viruses, including colds and flu.

Not everyone who is taking Instaclav-DS 457 mg Mango Flavour Oral Suspension will get these side effects. The common side effects of Instaclav-DS 457 mg Mango Flavour Oral Suspension include vomiting, nausea, and diarrhoea. Everyone may not experience the above side effects. In case of any discomfort, speak with a doctor.

You can take Instaclav-DS 457 mg Mango Flavour Oral Suspension with food to avoid any stomach upset. It should be swallowed as a whole with a glass of water. Do not chew, bite, crush, or break it. Your doctor will advise you on how often you should take your medicine based on your medical condition. It is always important to complete your treatment course for better results.

Before starting Instaclav-DS 457 mg Mango Flavour Oral Suspension, please inform your doctor if you have any allergy (against any antibiotic) or any other components. Do not take Instaclav-DS 457 mg Mango Flavour Oral Suspension on your own as it may lead to antibiotic resistance, in which antibiotics fail to act against specific bacterial infections. Instaclav-DS 457 mg Mango Flavour Oral Suspension is safe for children if prescribed by a doctor; the dose and duration may vary depending on the child’s weight and the severity of the infection. Inform your doctor if you are pregnant or breadfeeding before taking Instaclav-DS 457 mg Mango Flavour Oral Suspension.

Uses of Instaclav-DS 457 mg Mango Flavour Oral Suspension

Instaclav-DS 457 mg Mango Flavour Oral Suspension is used to treat Bacterial Infections. The detailed uses of Instaclav-DS 457 mg Mango Flavour Oral Suspension are as follows:

  • Bacterial Infections: Instaclav-DS 457 mg Mango Flavour Oral Suspension helps treat bacterial illnesses, including pneumonia and bronchitis. The composition of Instaclav-DS 457 mg Mango Flavour Oral Suspension improves efficacy against resistant microorganisms.
  • Sinusitis: Instaclav-DS 457 mg Mango Flavour Oral Suspension treats bacterial sinus infections by lowering inflammation and cleaning them.
  • Urinary Tract Infections (UTIs): Instaclav-DS 457 mg Mango Flavour Oral Suspension treats urinary tract infections caused by susceptible bacteria and provides broad-spectrum protection.
  • Skin and Soft Tissue Infection: Instaclav-DS 457 mg Mango Flavour Oral Suspension is also prescribed for treating skin and soft tissue infections, such as cellulitis and bite wounds, by its antibacterial effects to speed up the healing process.
  • Otitis Media: Instaclav-DS 457 mg Mango Flavour Oral Suspension helps to treat middle ear infections.
  • Pneumonia: Instaclav-DS 457 mg Mango Flavour Oral Suspension is also involved in treating pneumonia by efficiently fighting against the microorganisms that cause the condition.

Key Benefits

  • Instaclav-DS 457 mg Mango Flavour Oral Suspension is a broad-spectrum antibiotic that covers a very wide range of bacterial infections.
  • Instaclav-DS 457 mg Mango Flavour Oral Suspension has Clavulanic acid, which protects amoxycillin from getting destroyed by the bacterial enzyme, thus increasing its efficacy.
  • Instaclav-DS 457 mg Mango Flavour Oral Suspension helps overcome antibiotic resistance in bacteria that is caused by the enzyme beta-lactamase.
  • Instaclav-DS 457 mg Mango Flavour Oral Suspension is an effective medicine used in multiple infections like ear infections (acute otitis media), bronchitis, pneumonia, urinary tract infections, skin infections, etc.

Directions for Use

  • Instaclav-DS 457 mg Mango Flavour Oral Suspension can be taken with food to avoid stomach upset.
  • It is usually taken every 8-12 hours or as prescribed by your doctor.
  • Swallow Instaclav-DS 457 mg Mango Flavour Oral Suspension as a whole with a glass of water.
  • Do not crush, chew, or break it.

How Instaclav-DS 457 mg Mango Flavour Oral Suspension Works

Instaclav-DS 457 mg Mango Flavour Oral Suspension consists of two medicines: Amoxycillin and Clavulanic acid. Amoxycillin acts by destroying the outer protein layer, thereby killing the bacteria (bactericidal action). Clavulanic acid inhibits the enzyme beta-lactamase, which prevents bacteria from destroying the efficacy of amoxycillin. As a result, the action of Clavulanic acid allows Amoxycillin to work better and kill the bacteria. Instaclav-DS 457 mg Mango Flavour Oral Suspension does not work against infections caused by viruses, including colds and flu.
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Alcohol

Caution

Avoid consumption of alcohol during the treatment with Instaclav-DS 457 mg Mango Flavour Oral Suspension as it may worsen the side effects like dizziness.

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Pregnancy

Consult your doctor

If you are pregnant, consult your doctor before taking Instaclav-DS 457 mg Mango Flavour Oral Suspension. Your doctor will prescribe this medicine if the benefits outweigh the risks.

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Breast Feeding

Caution

This medication passes into breast milk. If you are a nursing mother, consult your doctor before taking Instaclav-DS 457 mg Mango Flavour Oral Suspension. Your doctor will prescribe this medicine if the benefits outweigh the risks.

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Driving

Caution

Instaclav-DS 457 mg Mango Flavour Oral Suspension may cause dizziness in some people, so it may affect your ability to drive. Avoid driving or operating machines until you are alert after taking Instaclav-DS 457 mg Mango Flavour Oral Suspension.

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Liver

Caution

Instaclav-DS 457 mg Mango Flavour Oral Suspension to be taken with caution if you have a history of liver conditions. Your doctor may adjust the dose if necessary based on your condition.

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Kidney

Caution

Instaclav-DS 457 mg Mango Flavour Oral Suspension to be taken with caution, especially if you have a history of kidney conditions. Your doctor may adjust the dose if necessary based on your condition.

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Children

Consult your doctor

Please consult the doctor. Your child's doctor will decide the dosage of this medicine depending on the weight and the severity of the infection.

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Heart

Consult your doctor

Limited information is available. Please consult your doctor.

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Geriatrics

Caution

The use of Instaclav-DS 457 mg Mango Flavour Oral Suspension in elderly patients may increase the risk of serious side effects.

What if I have taken an overdose of Instaclav-DS 457 mg Mango Flavour Oral Suspension

Take Instaclav-DS 457 mg Mango Flavour Oral Suspension only as prescribed by the physician. Avoid exceeding the recommended dose as it could lead to an overdose. Symptoms may include nausea, vomiting, diarrhoea, stomach pain, drowsiness, skin rash, hyperactivity, and decreased urination. If you experience these symptoms or suspect you have taken an overdose, seek immediate medical attention.

Diet & Lifestyle Advise

  • Include more fibre-enriched food in your diet, as it can be easily digested by gut bacteria, which helps stimulate their growth. Thus, fibre-rich foods may help restore healthy gut bacteria after a course of antibiotics.
  • Whole grains like whole-grain bread and brown rice should be included in your diet.
  • Probiotics should be taken after taking a full course of Instaclav-DS 457 mg Mango Flavour Oral Suspension in order to restore some healthy bacteria in the intestines that may have been killed. Taking probiotics after antibiotic treatment can reduce the risk of antibiotic-associated diarrhoea.
  • Certain fermented foods like yoghurt, cheese, sauerkraut, kombucha, and kimchi can help restore the intestine's good bacteria.
  • Avoid alcoholic beverages with Instaclav-DS 457 mg Mango Flavour Oral Suspension as they can make you dehydrated and may affect your sleep. This can make it harder for your body to aid the Instaclav-DS 457 mg Mango Flavour Oral Suspension in fighting off infections.
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How Soon It Starts Working

The time required for Instaclav-DS 457 mg Mango Flavour Oral Suspension to start to work: Instaclav-DS 457 mg Mango Flavour Oral Suspension starts to show its action within 1 to 2 hours of administration. The time for which the effects of Instaclav-DS 457 mg Mango Flavour Oral Suspension last: Instaclav-DS 457 mg Mango Flavour Oral Suspension effect lasts for 8 to 12 hours.

What if you forget to take Instaclav-DS 457 mg Mango Flavour Oral Suspension

If you miss a dose of Instaclav-DS 457 mg Mango Flavour Oral Suspension, take it as soon as you remember. However, if it is almost time for the next dose, skip the missed one and continue with your regular schedule. Do not take a double dose to make up for the missed one.

Storage

• Store in a cool and dry place away from sunlight.• Keep Instaclav-DS 457 mg Mango Flavour Oral Suspension out of the sight and reach of children.• Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.

Drug Warnings

  • Do not take Instaclav-DS 457 mg Mango Flavour Oral Suspension if you have an allergy to Instaclav-DS 457 mg Mango Flavour Oral Suspension, penicillin or cephalosporin class of antibiotics. Also, if you experience any allergic symptoms, including rash, swelling of the face/lips/throat, difficulty breathing, or chest tightness after taking $ name, immediately contact your doctor. 
  • People with liver diseases or jaundice (yellowing of skin/eyes) should not take Instaclav-DS 457 mg Mango Flavour Oral Suspension, as it can severely affect the liver. Inform your doctor if you have any kidney or heart disease before taking Instaclav-DS 457 mg Mango Flavour Oral Suspension.
  • The dose of Instaclav-DS 457 mg Mango Flavour Oral Suspension can vary depending on your condition and the severity of the infection. 
  • Additionally, it is recommended to complete the course of medicine even if you feel better, as it is an antibiotic, and leaving it incomplete may lead to a severe infection that will, in fact, stop responding to the antibiotic as well (antibiotic resistance).

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Drug-Drug Interaction: Caution should be exercised when Instaclav-DS 457 mg Mango Flavour Oral Suspension is administered in combination with gout medicine (allopurinol, probenecid), blood thinners (warfarin), anticancer, or anti-arthritis drug (methotrexate), and drug to prevent organ transplant (mycophenolate mofetil).

Drug-Food Interaction: Avoid taking eating high-fat meals as this may make it harder for your body to absorb Instaclav-DS 457 mg Mango Flavour Oral Suspension.

Drug-Disease Interaction: People affected with liver disease (like jaundice), glandular fever (viral infection with fever and sore throat), or colitis (bowel disease that affects the large intestine, causing irritation, inflammation, and ulcers in the colon) should not take Instaclav-DS 457 mg Mango Flavour Oral Suspension.

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Habit Forming

No

Therapeutic Class

[ANTI- INFECTIVES]

FAQs

Instaclav-DS 457 mg Mango Flavour Oral Suspension is used to prevent middle ear and sinus infections, throat or lung respiratory tract infections, urinary tract infections, skin infections, soft tissue infections, dental infections, and joint and bone infections.
Instaclav-DS 457 mg Mango Flavour Oral Suspension contains Amoxycillin and Clavulanic acid. Amoxycillin works by preventing the formation of bacterial cell covering, which is necessary for the survival of the bacteria. Thus it kills the bacteria. Clavulanic acid works by decreasing bacterial resistance and enhancing the activity of amoxycillin against the bacteria. Together, Instaclav-DS 457 mg Mango Flavour Oral Suspension helps in treating bacterial infections.
Instaclav-DS 457 mg Mango Flavour Oral Suspension is known to cause stomach upset, indigestion, nausea, and diarrhea. To avoid these side effects, please take Instaclav-DS 457 mg Mango Flavour Oral Suspension with a meal. Also, Instaclav-DS 457 mg Mango Flavour Oral Suspension should be taken at evenly spaced intervals to avoid any unpleasant side effects and for best results.
Generally, the penicillin group of antibiotics is not advised to be taken with methotrexate, which is used for conditions like psoriasis, rheumatoid arthritis, etc. They may cause unpleasant side effects when taken together. However, Instaclav-DS 457 mg Mango Flavour Oral Suspension is relatively safer to take with methotrexate, but only if prescribed by the doctor. It is best to discuss with your doctor about using the two medicines together, who may weigh the pros and cons and decide what is best for you.
Usually, Instaclav-DS 457 mg Mango Flavour Oral Suspension does not cause jaundice. But sometimes, it can cause jaundice in elderly people who have been taking the medication for a prolonged time. Please consult your doctor immediately if you notice any yellowing of the skin/eyes.
Instaclav-DS 457 mg Mango Flavour Oral Suspension does not treat a viral infection like the flu or a common cold. It is best to consult the doctor to know if you need Instaclav-DS 457 mg Mango Flavour Oral Suspension for your condition.
Yes, after taking Instaclav-DS 457 mg Mango Flavour Oral Suspension, you may have diarrhea. So, drink plenty of fluids and take probiotics to prevent excessive loss of fluids from the body (dehydration). Do not take anti-diarrhea medicine on your own; consult your doctor if the condition worsens.
Instaclav-DS 457 mg Mango Flavour Oral Suspension is not known to reduce the efficacy of birth control pills and emergency contraceptive pills. However, if you develop diarrhea or vomiting due to Instaclav-DS 457 mg Mango Flavour Oral Suspension, you are recommended to use other contraceptive methods such as condoms along with contraceptives to avoid unwanted pregnancies. Discuss with your doctor if you have any concerns regarding using Instaclav-DS 457 mg Mango Flavour Oral Suspension and your birth control pills.
Instaclav-DS 457 mg Mango Flavour Oral Suspension may show its effect 1.5 hours after taking the medicine. However, clinical improvement may be noticed after 48 hours.
Instaclav-DS 457 mg Mango Flavour Oral Suspension should be taken for the duration prescribed by the doctor based on your condition. Usually, it is taken every 8-12 hours.
Instaclav-DS 457 mg Mango Flavour Oral Suspension contains amoxicillin and clavulanic acid used to treat bacterial infections of the ear, sinus, respiratory tract, urinary tract, skin, soft tissue, dental, joints and bones.
Yes, Instaclav-DS 457 mg Mango Flavour Oral Suspension is safe to use if prescribed by the doctor.
Instaclav-DS 457 mg Mango Flavour Oral Suspension should not be used if you are allergic to any of its components or if you had jaundice or liver problems when taking an antibiotic.
Do not exceed the recommended dose of Instaclav-DS 457 mg Mango Flavour Oral Suspension as it might cause stomach upset or convulsions. Take Instaclav-DS 457 mg Mango Flavour Oral Suspension only as advised by the doctor.
Store Instaclav-DS 457 mg Mango Flavour Oral Suspension at room temperature (below 25°C). Keep it out of sight and reach of children. To help protect the environment, avoid throwing away any medicines via wastewater or household waste. Ask your pharmacist regarding the disposal of medicines.
To treat your infection effectively, continue taking Instaclav-DS 457 mg Mango Flavour Oral Suspension for the prescribed duration even if your symptoms are relieved.
Instaclav-DS 457 mg Mango Flavour Oral Suspension may cause an allergic reaction like skin rash, vasculitis (inflammation of blood vessels), angioedema (swelling), and difficulty breathing. Consult the doctor if you experience these symptoms.
No, Instaclav-DS 457 mg Mango Flavour Oral Suspension does not cause drowsiness. Sometimes, it might cause dizziness as an uncommon side effect. Drive or operate machinery only if you are alert.
Instaclav-DS 457 mg Mango Flavour Oral Suspension should be swallowed as a whole with water. Take the medicine with a meal.
If you are pregnant or breastfeeding, think you may be pregnant or are planning to have a baby, ask your doctor for advice before taking Instaclav-DS 457 mg Mango Flavour Oral Suspension.
The common side effects of Instaclav-DS 457 mg Mango Flavour Oral Suspension include vomiting, nausea, and diarrhoea. In case of any discomfort, speak with a doctor.
Instaclav-DS 457 mg Mango Flavour Oral Suspension should be taken only if prescribed by the doctor. It should not be taken by people who are allergic to amoxicillin, clavulanic acid, penicillin or any of the other ingredients of this medicine, ever had a severe allergic reaction (skin rash or swelling of the face or throat) to any other antibiotic or liver problems/jaundice (yellowing of the skin) when taking an antibiotic.
Let the doctor know if you are taking gout medicine (allopurinol, probenecid), blood thinners (warfarin), anticancer, or anti-arthritis drugs (methotrexate), and drugs to prevent organ transplant (mycophenolate mofetil).
Seek immediate medical attention if you have overdosed on Instaclav-DS 457 mg Mango Flavour Oral Suspension. Taking too much of Instaclav-DS 457 mg Mango Flavour Oral Suspension may cause upset stomach (nausea, vomiting or diarrhoea) or convulsions.

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Reference

  1. Electronic Medicines Compendium (EMC). Pil.9127 Patient Information Leaflet (PIL). Cheshire, UK: Datapharm; 2025. [Accessed on 02 Jun. 2026]Check here
  2. National Health Service (NHS). Co Amoxiclav - NHS Medicines Reference Guide. London, UK: NHS; 2025. [Accessed on 02 Jun. 2026]Check here
  3. Drugs.com Clinical Review Team. Augmentin Clinical Drug Monograph. Auckland, NZ: Drugs.com; 2026. [Accessed on 02 Jun. 2026]Check here
  4. Amoxicillin/clavulanate potassium. [Accessed on 25 Jan. 2019]Check here
  5. Amoxicillin and clavulanic acid. 2017. [Accessed on 01 Feb. 2019]Check here
  6. Amoxicillin trihydrate and potassium clavulanate [EMC SmPC]. 2025. [Accessed on 02 Jul. 2025]Check here
  7. Augmentin 625 mg Capsules - Summary of Product Characteristics (SmPC) - (emc) [Internet]. Medicines.org.uk. 2025 [Accessed on 7 July 2025]Check here

Country of origin

India

Manufacturer/Marketer address

11 Vinca -1 , Cosmos Park, Vijay Garden Road, G. B. Road, Thane West, 400615. Maharashtra
Other Info - INS0460
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