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  3. Intalith CR-450 Tablet 10's

Intalith CR-450 Tablet 10's, Pack of 10 TabletS
Intalith CR-450 Tablet 10's, Pack of 10 TabletS
Intalith CR-450 Tablet 10's, Pack of 10 TabletS
Intalith CR-450 Tablet 10's, Pack of 10 TabletS
Intalith CR-450 Tablet 10's, Pack of 10 TabletS
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Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Intalith CR-450 Tablet is used to prevent and treat mood disorders like mania and bipolar disorder. It contains Lithium, which helps to treat mental disorders by increasing the activity of chemical messengers in the brain, thereby suppressing the excessive and abnormal activity of nerve cells in the brain and helping in stabilizing a person's mood. Some people may experience loss of appetite, dizziness, dry mouth, taste change, diarrhoea, blurred vision, slurred speech, shaky movements, increased thirst, and urination. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.
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Composition :

LITHIUM-450MG

Manufacturer/Marketer :

Intas Pharmaceuticals Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Intalith CR-450 Tablet

Intalith CR-450 Tablet is used to prevent and treat mood disorders like mania and bipolar disorder. Mania is a mental condition that causes intense excitement, high energy, and delusions (misbeliefs). Bipolar disorder is a mental condition associated with extreme mood swings ranging from the hyper stage of mania to low-mood depression.

Intalith CR-450 Tablet contains Lithium that helps to treat mental disorders by increasing the activity of chemical messengers in the brain, thereby suppressing the excessive and abnormal activity of nerve cells in the brain and helping in stabilizing a person’s mood.

Take Intalith CR-450 Tablet as prescribed. Your doctor will advise how often you take Intalith CR-450 Tablet based on your medical condition. Some people may experience loss of appetite, dizziness, dry mouth, taste change, diarrhoea, blurred vision, slurred speech, shaky movements, increased thirst, and urination. Most of these side effects of Intalith CR-450 Tablet do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

If you are known to be allergic to Intalith CR-450 Tablet or any other medicines, please tell your doctor. If you are pregnant or breastfeeding, it is advised to consult a doctor before using Intalith CR-450 Tablet . Regular blood tests are recommended while taking Intalith CR-450 Tablet to monitor the levels of lithium in blood. If you have fits, kidney or heart problems, thyroid, persistent headache, vision problems, and if you are planning or have had weight loss surgery, please inform your doctor before taking Intalith CR-450 Tablet .

Uses of Intalith CR-450 Tablet

Treatment of Bipolar disorder, Mania.

Directions for Use

Take Intalith CR-450 Tablet as prescribed by your doctor.

Medicinal Benefits

Intalith CR-450 Tablet is a mood stabilizer that is used to prevent and treat mood disorders such as mania and bipolar disorder. Intalith CR-450 Tablet contains Lithium that helps to treat mental disorders by increasing the activity of chemical messengers in the brain, thereby suppressing the excessive and abnormal activity of nerve cells in the brain and helping in stabilizing a person’s mood. Thus, Intalith CR-450 Tablet relaxes nerves and calms the mood, which helps in having a better social life and enables one to do daily activities comfortably.

How Intalith CR-450 Tablet Works

Intalith CR-450 Tablet contains Lithium that helps to treat mental disorders by increasing the activity of chemical messengers in the brain, thereby suppressing the excessive and abnormal activity of nerve cells in the brain and helping in stabilizing a person’s mood.

Storage

Store in a cool and dry place away from sunlight
Side effects of Intalith CR-450 Tablet
Here are the steps to manage medication-triggered tremors or involuntary shaking:
  • Notify your doctor immediately if you experience tremors or involuntary shaking after taking medication or adjusting your medication regimen.
  • Your doctor may adjust your medication regimen or recommend alternative techniques like relaxation, meditation, or journaling to alleviate tremor symptoms.
  • Your doctor may direct you to practice stress-reducing techniques, such as deep breathing exercises, yoga, or journaling.
  • Regular physical activity, such as walking or jogging, can help reduce anxiety and alleviate tremor symptoms.
  • Your doctor may recommend lifestyle changes, such as avoiding caffeine, getting enough sleep, and staying hydrated, to help manage tremors.
  • Maintain regular follow-up appointments with your doctor to monitor tremor symptoms and adjust treatment plans as needed.
  • Reduce fluid intake 2-3 hours prior to bedtime.
  • Limit alcohol and caffeine as they can increase urination and affect bladder health.
  • Maintain sleep hygiene.
  • Eat a low-salt and healthy diet.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
  • Confusion is a major psychotic disorder that needs immediate medical attention.
  • Acknowledge your experience and put effort to control confusion.
  • Avoid smoking and alcohol intake as it can worsen the condition and increase your confusion.
  • Practice meditation and yoga to avoid anxiety, which can be one of the leading causes.
  • Talk to your dietician and consume food that can improve your mental health.
Here are the steps to Dry Mouth (xerostomia) caused by medication:
  • Inform your doctor about dry mouth symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Drink plenty of water throughout the day to help keep your mouth moist and alleviate dry mouth symptoms.
  • Chew sugar-free gum or candies to increase saliva production and keep your mouth moisturized.
  • Use saliva substitutes, such as mouthwashes or sprays, only if your doctor advises them to help moisturize your mouth and alleviate dry mouth symptoms.
  • Avoid consuming smoking, alcohol, spicy or acidic foods, and other irritants that may aggravate dry mouth symptoms.
  • Schedule regular dental check-ups to keep track of your oral health and handle any dry mouth issues as they arise.
  • Limit or eliminate caffeine and alcohol from your diet, as these substances can worsen hand trembling.
  • Practice relaxation techniques like deep breathing, yoga, or mindfulness meditation to reduce stress-induced tremors.
  • Engage in regular exercise to improve muscle control and coordination.
  • Ensure adequate sleep (7-8 hours) to prevent fatigue, which can worsen tremors.
  • Identify and minimize triggers that cause tremors, such as stress or certain activities.
  • Consider occupational therapy for tailored exercises and adaptive tools to manage daily tasks with trembling hands.
  • Consult a doctor if hand trembling interferes with your daily activities or is accompanied by other concerning neurological symptoms such as weakness, numbness, or speech difficulties.

What if I have taken an overdose of Intalith CR-450 Tablet

Do not take more than the prescribed dose of Intalith CR-450 Tablet as too much Lithium may be dangerous. The symptoms include blurred vision, feeling or being sick, vomiting, fainting, sleepiness, lightheadedness, increased urge to urinate, lack of control over pee or poo, shaking or muscle weakness, muscle twitches, spasms or jerks affecting the face, eyes, neck or tongue, confusion and blackouts. If you suspect you have taken overdose or notice signs of overdose, please consult a doctor immediately.

Drug Warnings

Regular blood tests are recommended while taking Intalith CR-450 Tablet to check lithium levels in blood. If you are pregnant or breastfeeding, please inform your doctor before taking Intalith CR-450 Tablet . If you have hypothyroidism (underactive thyroid gland), please inform your doctor before taking Intalith CR-450 Tablet as it may cause low thyroid levels. If you notice decreased amount of urine, dark, reddish urine, muscle pain or weakness, inform your doctor immediately as it may be due to a serious condition called rhabdomyolysis (muscle tissue breakdown) which may lead to kidney problems.

Drug-Drug Interactions

verifiedApollotooltip
LithiumCidofovir
Critical
LithiumCisapride
Critical

Drug-Drug Interactions

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LithiumCidofovir
Critical
How does the drug interact with Intalith CR-450 Tablet:
Cidofovir can cause higher levels of Intalith CR-450 Tablet carbonate in the blood which increases risk of kidney problems.

How to manage the interaction:
Taking Intalith CR-450 Tablet with Cidofovir is not recommended, but can be taken together if prescribed by a doctor. However, if you experience nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or loss, fluid retention, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, or an irregular heart rhythm, consult a doctor. Do not discontinue any medications without consulting a doctor.
LithiumCisapride
Critical
How does the drug interact with Intalith CR-450 Tablet:
Taking Cisapride with Intalith CR-450 Tablet can increase the risk of irregular heart rhythm.

How to manage the interaction:
Taking Intalith CR-450 Tablet with Cisapride is not recommended as it can possibly result in an interaction, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience sudden dizziness, lightheadedness, fainting, shortness of breath. Do not discontinue any medications without consulting a doctor.
LithiumIbuprofen
Severe
How does the drug interact with Intalith CR-450 Tablet:
Coadministration of Intalith CR-450 Tablet and Ibuprofen can increases the blood levels of Intalith CR-450 Tablet.

How to manage the interaction:
Co-administration of Intalith CR-450 Tablet and Ibuprofen can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like drowsiness, dizziness, confusion, diarrhea, vomiting, muscle weakness, muscle inco-ordination, tremor, blurred vision, ringing in the ear, excessive thirst, and increased urination, consult the doctor immediately. Do not stop using any medications without a doctor's advice.
LithiumDolasetron
Severe
How does the drug interact with Intalith CR-450 Tablet:
Taking Intalith CR-450 Tablet with Dolasetron can increase the risk of serotonin syndrome(a condition in which a chemical called serotonin increase in your body).

How to manage the interaction:
Although there is a interaction between Dolasetron and Intalith CR-450 Tablet, but can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, hallucination(seeing and hearing things that do not exist), fits, blood pressure alteration, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, incoordination, stomach cramps, nausea, vomiting, and loose stools. Do not discontinue any medications without consulting a doctor.
LithiumEsketamine
Severe
How does the drug interact with Intalith CR-450 Tablet:
Taking Intalith CR-450 Tablet carbonate with Esketamine can increase the risk of side effects.

How to manage the interaction:
Although taking Intalith CR-450 Tablet and Esketamine together can evidently cause an interaction, but it can be taken if your doctor has suggested it. However, if you experience drowsiness, confusion, difficulty concentrating, and impairment in thinking, judgment, reaction speed, and motor coordination contact a doctor. Do not stop using any medications without talking to a doctor.
LithiumPhenelzine
Severe
How does the drug interact with Intalith CR-450 Tablet:
Taking Intalith CR-450 Tablet with Phenelzine can increase the risk of serotonin syndrome(a condition in which a chemical called serotonin increase in your body).

How to manage the interaction:
Although there is a interaction between Phenelzine and Intalith CR-450 Tablet, but can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, hallucination(seeing and hearing things that do not exist), fits, blood pressure alteration, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, incoordination, stomach cramps, nausea, vomiting, and loose stools. Do not discontinue any medications without consulting a doctor.
LithiumTenofovir disoproxil
Severe
How does the drug interact with Intalith CR-450 Tablet:
Co-administration of Intalith CR-450 Tablet carbonate with Tenofovir Disoproxil can increase the risk of developing kidney problems.

How to manage the interaction:
Although there is a possible interaction between Tenofovir disoproxil and Intalith CR-450 Tablet, you can take these medicines when prescribed by your doctor. Consult the doctor immediately if you experience symptoms such as vomiting, loss of hunger, increased or decreased urination, sudden weight gain or weight loss, shortness of breath, muscle cramps, or weakness. Do not discontinue any medications without consulting a doctor.
LithiumHydroxychloroquine
Severe
How does the drug interact with Intalith CR-450 Tablet:
Taking Intalith CR-450 Tablet with Hydroxychloroquine can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Co-administration of Intalith CR-450 Tablet and Hydroxychloroquine can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations, consult the doctor immediately. Do not stop using any medications without a doctor's advice.
LithiumSodium Valproate
Severe
How does the drug interact with Intalith CR-450 Tablet:
Co-administration of Intalith CR-450 Tablet with sodium valproate can increase the risk irregular heart rhythm.

How to manage the interaction:
Co-administration of Intalith CR-450 Tablet and sodium valproate can lead to an interaction, but it can be taken if advised by your doctor. However, consult your doctor immediately if you experience any symptoms like dizziness, drowsiness, confusion, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, and difficulty concentrating. Do not discontinue any medications without consulting a doctor.
LithiumTacrolimus
Severe
How does the drug interact with Intalith CR-450 Tablet:
Taking tacrolimus with Intalith CR-450 Tablet may increase risk of kidney problems.

How to manage the interaction:
Although taking tacrolimus and Intalith CR-450 Tablet together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as nausea, vomiting, loss of hunger, increased or decreased urination, sudden weight gain or weight loss, fluid retention, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

verifiedApollotooltip
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Avoid low-sodium diet as it may increase lithium levels in blood and cause adverse effects.
  • Limit the intake of caffeine as it may reduce the effectiveness of Intalith CR-450 Tablet .
  • Do regular exercise and maintain a stable weight as Intalith CR-450 Tablet may cause weight gain.
  • Drink plenty of water to avoid dehydration and try to drink same amount of water everyday as any major changes in quantity may affect lithium levels.
  • Avoid consumption of alcohol as it may increase drowsiness.

Habit Forming

No

Therapeutic Class

ANTIPSYCHOTICS

Intalith CR-450 Tablet Substitute

Substitutes safety advice

Product Substitutes

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Alcohol

Unsafe

You are recommended to avoid consumption of alcohol with Intalith CR-450 Tablet as it may increase the risk of side effects such as drowsiness, dizziness or difficulty in concentrating.

bannner image

Pregnancy

Unsafe

Intalith CR-450 Tablet is a Category D pregnancy drug and is not recommended for use during pregnancy as it may cause harm to the unborn baby.

bannner image

Breast Feeding

Unsafe

Avoid breastfeeding while taking Intalith CR-450 Tablet as it may be excreted in breast milk and cause adverse effects in the baby.

bannner image

Driving

Unsafe

Intalith CR-450 Tablet may cause dizziness, drowsiness or other severe adverse effects. Therefore, avoid driving if you feel drowsy or dizzy after taking Intalith CR-450 Tablet .

bannner image

Liver

Safe if prescribed

Intalith CR-450 Tablet is safe to use in patients with Liver diseases/conditions if prescribed by a doctor.

bannner image

Kidney

Caution

Take Intalith CR-450 Tablet with caution, especially if you have a history of Kidney diseases/conditions. The dose may be adjusted by your doctor as required. Intalith CR-450 Tablet is not recommended for patients with severe kidney problems.

bannner image

Children

Caution

Intalith CR-450 Tablet is generally not recommended for children below 12 years. However, Intalith CR-450 Tablet may be used in children above 7 years for treating bipolar I disorder only if prescribed by a doctor.

Have a query?

FAQs

Intalith CR-450 Tablet is used to prevent and treat mood disorders like mania and bipolar disorder. It works by increasing the activity of chemical messengers in the brain, thereby suppressing the excessive and abnormal activity of nerve cells in the brain and helping to stabilize a person’s mood.

No, you are not recommended to take Intalith CR-450 Tablet with fluoxetine or other antidepressants such as paroxetine and sertraline as co-administration of these medicines may increase the risk of a rare and serious condition known as serotonin syndrome. If you experience blurred vision, increased heart rate, hallucination, fits, confusion, muscle stiffness or spasm, vomiting, nausea, diarrhoea, excessive sweating, stomach cramps, fever, shaking or shivering, please consult a doctor immediately. However, before using Intalith CR-450 Tablet with any other medicines, you are advised to contact your doctor.

Intalith CR-450 Tablet is not recommended for hypothyroid (underactive thyroid gland) patients as it may increase the risk of low levels of thyroid hormone. Therefore, if you have hypothyroidism, please inform your doctor before taking Intalith CR-450 Tablet . Also, thyroid levels are checked generally before starting treatment with Intalith CR-450 Tablet so that if the levels are too low, Intalith CR-450 Tablet is not advised.

Yes, Intalith CR-450 Tablet may cause weight gain but it is not necessary for everyone taking Intalith CR-450 Tablet to experience this side effect. However, in order to avoid gaining weight while taking Intalith CR-450 Tablet , you are advised to do regular exercise and avoid high-calorie drinks. Instead take non-alcoholic drinks, herbal tea and lemon water.

It is advised to inform your doctor if you are planning or had weight loss surgery as the dose may be adjusted accordingly based on lithium levels in blood.

Yes, Intalith CR-450 Tablet may cause dehydration especially if you have low sodium levels in the body or consume too much alcohol. However, if you notice dark, strong smelling urine or decrease in urination, it indicates that you are dehydrated and may affect lithium levels in blood. Therefore, you are recommended to drink plenty of fluids while taking Intalith CR-450 Tablet to avoid dehydration.

No, you are not recommended to stop taking Intalith CR-450 Tablet without consulting your doctor as it may worsen the condition or cause recurring symptoms. Therefore, take Intalith CR-450 Tablet for as long as your doctor has prescribed it and if you experience any difficulty while taking Intalith CR-450 Tablet , please consult your doctor so that the dose may be gradually reduced.

Intalith CR-450 Tablet may cause side effects such as slurred speech, confusion, mood changes, bloating, or lightheadedness. If these side effects persist or worsen, please consult your doctor.

Intalith CR-450 Tablet takes some time to show improvement in your symptoms but it varies from person to person. This is because each patient reacts differently to particular medication. It may take 1 to 3 weeks or longer for you to see the full effects of Intalith CR-450 Tablet . Continue taking Intalith CR-450 Tablet even if you are not improving and consult your doctor.

Yes, Intalith CR-450 Tablet can cause drowsiness or sleepiness. If you feel dizzy or sleepy, avoid driving or using machines or performing any tasks that require your attention.

Yes, Intalith CR-450 Tablet may cause kidney problems. Intalith CR-450 Tablet is not advised in patients who already have severe kidney impairment. Before starting treatment with Intalith CR-450 Tablet , your doctor will recommend blood tests to see if your kidney function is normal. During treatment with Intalith CR-450 Tablet , any gradual or sudden changes in kidney function, may indicate that the treatment needs re-evaluation.

Intalith CR-450 Tablet should only be started if sufficient facilities are available for evaluating Intalith CR-450 Tablet levels as increased blood levels of Intalith CR-450 Tablet is related to Intalith CR-450 Tablet toxicity. Even at dose which is effective for treatment, Intalith CR-450 Tablet toxicity can occur. Therefore, your doctor may closely monitor your Intalith CR-450 Tablet levels weekly until stabilization is reached, then weekly for one month and then every month after that.

Take Intalith CR-450 Tablet with or without food or as advised by the doctor. Swallow it as whole with a glass of water. Do not break, crush or chew it.

Some medicines decrease Intalith CR-450 Tablet levels in blood which means that it will not work well. These include caffeine, theophylline (for asthma), medicines containing sodium bicarbonate, or a special group of diuretics (water tablets) called carbonic anhydrase inhibitors and urea (used to treat skin conditions). Therefore, please inform your doctor about the medicines you are taking before starting Intalith CR-450 Tablet to avoid drug interactions.

Country of origin

India

Manufacturer/Marketer address

Chinubhai Centre, Off. Nehru Bridge, Ashram Road, Ahmedabad - 380009. Gujarat. India.
Other Info - INT0003

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Author Details

Veda MaddalaDoctor badge

Written By

Veda Maddala

M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jan 1, 2025 | 2:50 PM IST

Doctor imageWe provide you with authentic, trustworthy and relevant information

Reference

  1. https://www.medicines.org.uk/emc/files/pil.10828.pdf
  2. https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/017812s033,018421s032,018558s027lbl.pdf
  3. https://www.drugs.com/lithium.html
  4. https://www.nhs.uk/medicines/lithium/
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