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compositionComposition:LITHIUM-450MG
prescription
Prescription Medicine
info
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Intalith CR-450 Tablet is used to prevent and treat mood disorders like mania and bipolar disorder. It contains Lithium, which helps to treat mental disorders by increasing the activity of chemical messengers in the brain, thereby suppressing the excessive and abnormal activity of nerve cells in the brain and helping in stabilizing a person's mood. Some people may experience loss of appetite, dizziness, dry mouth, taste change, diarrhoea, blurred vision, slurred speech, shaky movements, increased thirst, and urination. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.

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Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

LITHIUM-450MG

Manufacturer/Marketer :

Intas Pharmaceuticals Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Intalith CR-450 Tablet

Intalith CR-450 Tablet is prescribed to treat and prevent manic episodes in people with bipolar disorder. Its primary medical purpose is to stabilize extreme shifts in mood, helping to restore a more balanced emotional state. It is also used to prevent recurrent depressive episodes and manage long-term mental stability.

To achieve the best results, you must take this medication consistently at the exact times prescribed by your doctor. It is typically taken with or after meals to help reduce stomach upset. Additionally, keeping a steady daily intake of salt and water is a crucial lifestyle habit that helps maintain stable medicine levels in your body.

While using Intalith CR-450 Tablet , you may experience common side effects like mild hand tremors, increased thirst, or a mild upset stomach. However, you should consult your doctor immediately if you face serious side effects such as persistent vomiting, slurred speech, or extreme drowsiness. Regular blood tests are required to ensure the medication remains at a safe level.

Talk to your doctor before starting this medicine if you have kidney disease, heart problems, or thyroid issues. You should not take this medicine if you have severe kidney disease, severe heart disease, or if you are suffering from severe dehydration. Your doctor will assess whether this treatment is safe for your health history.

Certain medicines like pain relievers, water pills, and blood pressure drugs can interact with Intalith CR-450 Tablet , raising its levels in your body to unsafe amounts. Drinking alcohol should be avoided as it can increase drowsiness and risk of dehydration. Pregnant, breastfeeding, or elderly individuals must consult their doctor before using this medicine to ensure safety.

Managing bipolar disorder can be challenging, but many people achieve long-term mood stability and lead productive, fulfilling lives with the help of appropriate treatment, regular monitoring, and ongoing support. 

Uses of Intalith CR-450 Tablet

Intalith CR-450 Tablet is a mood stabiliser commonly prescribed to manage certain mental health conditions and help maintain long-term emotional stability. It is used for:

  • Bipolar Disorder: Intalith CR-450 Tablet helps control and prevent manic episodes, reducing symptoms such as extreme excitement, overactivity, rapid speech, impulsive behaviour, and poor judgment.
  • Recurrent Depression: It may be used to help prevent recurring depressive episodes, particularly in individuals who do not achieve adequate symptom control with antidepressants alone.
  • Aggressive Behaviour: In selected cases, doctors may prescribe Intalith CR-450 Tablet to help manage aggression, impulsivity, anger outbursts, or self-harming behaviours associated with certain psychiatric conditions. This use is typically reserved for specialist care and may be considered an off-label application depending on the clinical situation. 

Key Benefits

By helping to stabilise mood and reduce emotional extremes, Intalith CR-450 Tablet can significantly improve overall mental well-being and quality of life.

  • Stabilises Mood Effectively: Helps reduce the severity of manic and depressive episodes, promoting greater emotional balance.
  • Prevents Mood Relapses: Long-term treatment can lower the risk of future mood episodes and reduce the frequency of relapses.
  • Improves Daily Functioning: Enhanced mood stability can help improve concentration, productivity, decision-making, and social interactions.
  • Supports Healthier Relationships: By reducing mood fluctuations, Intalith CR-450 Tablet can help maintain more consistent communication and interpersonal relationships.
  • Reduces Hospitalisation Risk: Ongoing treatment may decrease the likelihood of severe mood episodes that require emergency care or hospital admission.
  • Promotes Long-Term Stability: Continuous protection against mood swings allows individuals to plan for the future with greater confidence and maintain a more stable, fulfilling life.
Side effects of Intalith CR-450 Tablet
Here are the steps to manage medication-triggered tremors or involuntary shaking:
  • Notify your doctor immediately if you experience tremors or involuntary shaking after taking medication or adjusting your medication regimen.
  • Your doctor may adjust your medication regimen or recommend alternative techniques like relaxation, meditation, or journaling to alleviate tremor symptoms.
  • Your doctor may direct you to practice stress-reducing techniques, such as deep breathing exercises, yoga, or journaling.
  • Regular physical activity, such as walking or jogging, can help reduce anxiety and alleviate tremor symptoms.
  • Your doctor may recommend lifestyle changes, such as avoiding caffeine, getting enough sleep, and staying hydrated, to help manage tremors.
  • Maintain regular follow-up appointments with your doctor to monitor tremor symptoms and adjust treatment plans as needed.
  • Reduce fluid intake 2-3 hours prior to bedtime.
  • Limit alcohol and caffeine as they can increase urination and affect bladder health.
  • Maintain sleep hygiene.
  • Eat a low-salt and healthy diet.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
  • Confusion is a major psychotic disorder that needs immediate medical attention.
  • Acknowledge your experience and put effort to control confusion.
  • Avoid smoking and alcohol intake as it can worsen the condition and increase your confusion.
  • Practice meditation and yoga to avoid anxiety, which can be one of the leading causes.
  • Talk to your dietician and consume food that can improve your mental health.
Here are the steps to Dry Mouth (xerostomia) caused by medication:
  • Inform your doctor about dry mouth symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Drink plenty of water throughout the day to help keep your mouth moist and alleviate dry mouth symptoms.
  • Chew sugar-free gum or candies to increase saliva production and keep your mouth moisturized.
  • Use saliva substitutes, such as mouthwashes or sprays, only if your doctor advises them to help moisturize your mouth and alleviate dry mouth symptoms.
  • Avoid consuming smoking, alcohol, spicy or acidic foods, and other irritants that may aggravate dry mouth symptoms.
  • Schedule regular dental check-ups to keep track of your oral health and handle any dry mouth issues as they arise.

Directions for Use

To get the safest and most effective results from Intalith CR-450 Tablet , follow these step-by-step instructions carefully:

  • Take this medicine by mouth exactly as directed by your doctor. It is usually taken daily as directed by your doctor.
  • Swallow the tablet or capsule whole with a full glass of water. Do not crush, chew, or break the medication unless your doctor or pharmacist specifically tells you to do so.
  • Take your doses at the same times every day to keep a steady amount of the medicine in your body.
  • You can take this medication with or immediately after food to help prevent stomach irritation or nausea.
  • Drink plenty of water throughout the day to stay well-hydrated, unless your doctor advises otherwise.

Always follow your doctor's exact instructions regarding your dose and schedule. Never change your dose or stop taking this medication suddenly without consulting your healthcare provider first, as doing so can cause your symptoms to return quickly.

How Intalith CR-450 Tablet Works

Intalith CR-450 Tablet works directly on the central nervous system to restore the natural balance of chemical messengers in your brain. While the exact way it functions is complex, it is known to influence the release and activity of neurotransmitters—the chemicals that brain cells use to communicate with one another. By regulating these chemicals, the medicine helps calm overactive nerve signals that lead to extreme mood elevations. Additionally, this medication helps protect brain cells and improves the way your nerves send signals over time. It stabilizes cell membranes and influences the transport of sodium and other minerals within brain and muscle cells. This dual action helps prevent the sudden, intense neurological storms that trigger both manic highs and depressive lows, keeping your brain activity within a stable, healthy range.
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Alcohol

Unsafe

You are recommended to avoid consumption of alcohol with Intalith CR-450 Tablet as it may increase the risk of side effects such as drowsiness, dizziness or difficulty in concentrating.

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Pregnancy

Unsafe

Intalith CR-450 Tablet is a Category D pregnancy drug and is not recommended for use during pregnancy as it may cause harm to the unborn baby.

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Breast Feeding

Unsafe

Avoid breastfeeding while taking Intalith CR-450 Tablet as it may be excreted in breast milk and cause adverse effects in the baby.

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Driving

Unsafe

Intalith CR-450 Tablet may cause dizziness, drowsiness or other severe adverse effects. Therefore, avoid driving if you feel drowsy or dizzy after taking Intalith CR-450 Tablet .

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Liver

Safe if prescribed

Intalith CR-450 Tablet is safe to use in patients with Liver diseases/conditions if prescribed by a doctor.

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Kidney

Caution

Take Intalith CR-450 Tablet with caution, especially if you have a history of Kidney diseases/conditions. The dose may be adjusted by your doctor as required. Intalith CR-450 Tablet is not recommended for patients with severe kidney problems.

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Children

Caution

Intalith CR-450 Tablet is generally not recommended for children below 12 years. However, Intalith CR-450 Tablet may be used in children above 7 years for treating bipolar I disorder only if prescribed by a doctor.

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Heart

Consult your doctor

It is unknown whether Intalith CR-450 Tablet is safe for use in heart patients or not. Please consult your physician.

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Geriatrics

Consult your doctor

Limited information is available for use in erderly patients. Please consult your doctor.

What if I have taken an overdose of Intalith CR-450 Tablet

Do not take more than the prescribed dose of Intalith CR-450 Tablet as too much Lithium may be dangerous. The symptoms include blurred vision, feeling or being sick, vomiting, fainting, sleepiness, lightheadedness, increased urge to urinate, lack of control over pee or poo, shaking or muscle weakness, muscle twitches, spasms or jerks affecting the face, eyes, neck or tongue, confusion and blackouts. If you suspect you have taken overdose or notice signs of overdose, please consult a doctor immediately.

Diet & Lifestyle Advise

  • Keep your salt intake consistent: Do not suddenly start a low-salt diet or dramatically increase your salt intake. Lower salt intake can cause Intalith CR-450 Tablet levels to rise and increase the risk of toxicity, while a significantly higher salt intake can reduce Intalith CR-450 Tablet levels and make the treatment less effective. Consistency is essential.
  • Stay consistently hydrated: Drink a steady, healthy amount of water every day (usually 8 to 12 glasses, unless your doctor advises otherwise). Avoid becoming severely dehydrated from heavy exercise, hot weather, or saunas.
  • Limit caffeine intake: Keep your daily intake of coffee, tea, and soda consistent. Sudden changes in caffeine consumption can alter how your body processes this medication.
  • Avoid alcohol completely: Alcohol can increase drowsiness, impair judgment, and cause dehydration, which significantly raises the risk of medication side effects.
  • Monitor your weight: Since weight gain can sometimes occur with long-term use of this medication, try to eat a balanced diet rich in vegetables, lean proteins, and whole grains, and engage in regular, moderate physical activity.

Health Queries

Is it safe to take Intalith CR 450 long-term, or should I consider switching to Intalith CR 300?

Dr. S Aneela

Dr. S Aneela

M. Pharm (Pharmacology)., PhD

Long-term use of Intalith CR 450 is generally safe if prescribed and monitored, but dose adjustments may be needed based on your condition and blood levels. Please consult your doctor before switching to Intalith CR 300, as they can decide the correct dose and schedule for your safety.
health query

Have a query?

How Soon It Starts Working

The time required for Intalith CR-450 Tablet to start to work: The time required for Intalith CR-450 Tablet to show its action is unknown. The time for which the effects of Intalith CR-450 Tablet last: The duration of action for Intalith CR-450 Tablet is unknown.

Storage

• Store Intalith CR-450 Tablet tablets or capsules at room temperature, ideally between 20°C and 25°C (68°F to 77°F). • Keep the medication in its original, tightly closed container to protect it from moisture and direct light.

Drug Warnings

  • Attend all scheduled blood tests: Regular blood draws are essential to monitor the levels of Intalith CR-450 Tablet in your system and protect your kidneys and thyroid.
  • Watch for signs of dehydration: If you develop a fever, severe diarrhea, or vomiting, contact your doctor immediately, as dehydration can rapidly cause the medicine to build up to toxic levels.
  • Check your skin and neck: Keep an eye out for any unusual swelling in your neck (a sign of thyroid changes) or severe skin breakouts, and report them to your doctor.
  • Inform all healthcare providers: Ensure all doctors, dentists, and pharmacists you visit know that you are taking Intalith CR-450 Tablet , especially before you start any new prescription or over-the-counter medicine.
  • Be careful when driving: This medicine can cause drowsiness or dizziness, especially when you first start taking it. Do not drive or operate machinery until you know how it affects you.
  • Monitor changes in mood: Inform your doctor promptly if you notice worsening depression, unusual mood changes, increasing irritability, or any thoughts of self-harm or suicide. Early recognition allows your treatment plan to be adjusted safely. 

Drug-Drug Interactions

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Drug-Drug Interactions

Certain medicines can affect the blood levels of Intalith CR-450 Tablet or increase the risk of serious side effects. Inform your doctor about all medications, supplements, and herbal products you are taking.

  • NSAID Pain Relievers (such as ibuprofen or naproxen): These medicines may increase Intalith CR-450 Tablet levels in the blood, raising the risk of toxicity.
  • Diuretics (Water Pills): Diuretics can increase Intalith CR-450 Tablet concentrations by causing the body to lose salt and water, which may lead to toxic effects.
  • ACE Inhibitors and ARBs: These blood pressure medicines can reduce the kidney's ability to remove Intalith CR-450 Tablet from the body, increasing the risk of harmful accumulation.
  • Selective Serotonin Reuptake Inhibitors (SSRIs): Taking Intalith CR-450 Tablet with certain antidepressants may increase the risk of serotonin syndrome, a rare but potentially serious condition.
  • Other Mood-Stabilising or Antipsychotic Medicines: Concurrent use may increase the risk of neurological side effects and requires careful monitoring.


Drug-Food Interactions

Dietary habits can significantly influence Intalith CR-450 Tablet levels in the body. Maintaining consistency in your diet is important during treatment.

  • High-Sodium or Low-Sodium Foods: Sudden changes in salt intake can alter Intalith CR-450 Tablet levels in the bloodstream. Maintaining a consistent dietary sodium intake is recommended.
  • Caffeine: Significant increases or decreases in caffeine consumption from coffee, tea, soft drinks, or energy drinks may affect how quickly Intalith CR-450 Tablet is eliminated from the body.
  • Fluid Intake: Inadequate fluid intake or excessive sweating may increase the risk of dehydration and Intalith CR-450 Tablet toxicity. Drink adequate amounts of water unless otherwise directed by your doctor.


Drug-Disease Interactions

Certain medical conditions may affect the safety and effectiveness of Intalith CR-450 Tablet therapy and may require close monitoring.

  • Kidney Disease: Since Intalith CR-450 Tablet is primarily removed through the kidneys, impaired kidney function can lead to dangerous drug accumulation and toxicity.
  • Heart Disease: Intalith CR-450 Tablet may affect heart rhythm and electrical conduction, requiring caution in patients with existing cardiovascular conditions.
  • Thyroid Disorders: Long-term use may reduce thyroid hormone production and increase the risk of hypothyroidism, necessitating regular thyroid function monitoring.
  • Dehydration or Low Sodium Levels (Hyponatraemia): Conditions that cause dehydration or sodium depletion can significantly increase the risk of Intalith CR-450 Tablet toxicity.
  • Severe Gastrointestinal Illness: Persistent vomiting or diarrhoea can alter fluid and electrolyte balance, increasing the likelihood of toxic Intalith CR-450 Tablet levels.
LithiumCisapride
Critical
LithiumCidofovir
Critical

Drug-Drug Interactions

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LithiumCisapride
Critical
How does the drug interact with Intalith CR-450 Tablet:
Taking Cisapride with Intalith CR-450 Tablet can increase the risk of irregular heart rhythm.

How to manage the interaction:
Taking Intalith CR-450 Tablet with Cisapride is not recommended as it can possibly result in an interaction, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience sudden dizziness, lightheadedness, fainting, shortness of breath. Do not discontinue any medications without consulting a doctor.
LithiumCidofovir
Critical
How does the drug interact with Intalith CR-450 Tablet:
Cidofovir can cause higher levels of Intalith CR-450 Tablet carbonate in the blood which increases risk of kidney problems.

How to manage the interaction:
Taking Intalith CR-450 Tablet with Cidofovir is not recommended, but can be taken together if prescribed by a doctor. However, if you experience nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or loss, fluid retention, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, or an irregular heart rhythm, consult a doctor. Do not discontinue any medications without consulting a doctor.
LithiumArsenic trioxide
Severe
How does the drug interact with Intalith CR-450 Tablet:
Taking arsenic trioxide together with Intalith CR-450 Tablet can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Although there is a interaction between Arsenic trioxide and Intalith CR-450 Tablet, but it can be taken if prescribed by a doctor. However, consult the doctor immediately if you experience symptoms such as dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations. Do not stop using any medications without consulting doctor.
LithiumChloroquine
Severe
How does the drug interact with Intalith CR-450 Tablet:
Taking chloroquine with Intalith CR-450 Tablet together can increase the risk ofabnormal heart rhythm.

How to manage the interaction:
Taking chloroquine and Intalith CR-450 Tablet together can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, or rapid heartbeat, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
LithiumHydrochlorothiazide
Severe
How does the drug interact with Intalith CR-450 Tablet:
Coadministration of Intalith CR-450 Tablet and Hydrochlorothiazide can increase the effects of Intalith CR-450 Tablet.

How to manage the interaction:
Taking Intalith CR-450 Tablet and Hydrochlorothiazide together can possibly result in an interaction, but it can be taken if advised by your doctor. However, if you experience any symptoms like loose stools, vomiting, drowsiness, shaking of hands and legs, thirst, increased urination, lack of coordination, or muscle weakness, consult the doctor immediately. Do not stop using any medications without a doctor's advice.
LithiumPolythiazide
Severe
How does the drug interact with Intalith CR-450 Tablet:
Taking Polythiazide with Intalith CR-450 Tablet may increase the blood levels of Intalith CR-450 Tablet.

How to manage the interaction:
Although taking Polythiazide and Intalith CR-450 Tablet together can evidently cause an interaction, it can be taken if your doctor has suggested it. However, consult your doctor if you experience diarrhea, vomiting, drowsiness, shaking of hands and legs, thirst, increased urination, lack of coordination, or muscle weakness. Do not discontinue any medications without consulting a doctor.
LithiumMefenamic acid
Severe
How does the drug interact with Intalith CR-450 Tablet:
Co-administration of Mefenamic acid with Intalith CR-450 Tablet can increase Intalith CR-450 Tablet levels in the body.

How to manage the interaction:
Taking Mefenamic acid with Intalith CR-450 Tablet together can result in an interaction, it can be taken if your doctor has advised it. However, if you notice any drowsiness, dizziness, confusion, loose stools, vomiting, muscle weakness, muscle incoordination, shaking of hands and legs, blurred vision, ringing in the ear, excessive thirst, and/or increased urination, contact a doctor. Do not stop using any medications without talking to a doctor.
LithiumDisopyramide
Severe
How does the drug interact with Intalith CR-450 Tablet:
Taking Intalith CR-450 Tablet together with Disopyramide can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Although taking Intalith CR-450 Tablet and Disopyramide together can evidently cause an interaction, it can be taken if your doctor has suggested it. However, consult the doctor immediately if you experience symptoms such as dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations. Do not stop using any medications without consulting doctor.
LithiumCeritinib
Severe
How does the drug interact with Intalith CR-450 Tablet:
Taking Intalith CR-450 Tablet together with Ceritinib can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Co-administration of Ceritinib with Intalith CR-450 Tablet can possibly result in an interaction, but it can be taken if your doctor has advised it. However, consult the doctor immediately if you experience symptoms such as dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations. Do not stop using any medications without consulting doctor.
LithiumSertraline
Severe
How does the drug interact with Intalith CR-450 Tablet:
Taking Intalith CR-450 Tablet with Sertraline can increase the risk of serotonin syndrome(a condition in which a chemical called serotonin increase in your body).

How to manage the interaction:
Although there is an interaction between Sertraline and Intalith CR-450 Tablet, but can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, hallucination(seeing and hearing things that do not exist), increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, incoordination, stomach cramps, nausea, vomiting, and loose stools. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

No

Therapeutic Class

[ANTIPSYCHOTICS]

FAQs

Intalith CR-450 Tablet is used to prevent and treat mood disorders like mania and bipolar disorder. It works by increasing the activity of chemical messengers in the brain, thereby suppressing the excessive and abnormal activity of nerve cells in the brain and helping to stabilize a person’s mood.
No, you are not recommended to take Intalith CR-450 Tablet with fluoxetine or other antidepressants such as paroxetine and sertraline as co-administration of these medicines may increase the risk of a rare and serious condition known as serotonin syndrome. If you experience blurred vision, increased heart rate, hallucination, fits, confusion, muscle stiffness or spasm, vomiting, nausea, diarrhoea, excessive sweating, stomach cramps, fever, shaking or shivering, please consult a doctor immediately. However, before using Intalith CR-450 Tablet with any other medicines, you are advised to contact your doctor.
Intalith CR-450 Tablet is not recommended for hypothyroid (underactive thyroid gland) patients as it may increase the risk of low levels of thyroid hormone. Therefore, if you have hypothyroidism, please inform your doctor before taking Intalith CR-450 Tablet . Also, thyroid levels are checked generally before starting treatment with Intalith CR-450 Tablet so that if the levels are too low, Intalith CR-450 Tablet is not advised.
Yes, Intalith CR-450 Tablet may cause weight gain but it is not necessary for everyone taking Intalith CR-450 Tablet to experience this side effect. However, in order to avoid gaining weight while taking Intalith CR-450 Tablet , you are advised to do regular exercise and avoid high-calorie drinks. Instead take non-alcoholic drinks, herbal tea and lemon water.
It is advised to inform your doctor if you are planning or had weight loss surgery as the dose may be adjusted accordingly based on lithium levels in blood.
Yes, Intalith CR-450 Tablet may cause dehydration especially if you have low sodium levels in the body or consume too much alcohol. However, if you notice dark, strong smelling urine or decrease in urination, it indicates that you are dehydrated and may affect lithium levels in blood. Therefore, you are recommended to drink plenty of fluids while taking Intalith CR-450 Tablet to avoid dehydration.
Intalith CR-450 Tablet may cause side effects such as slurred speech, confusion, mood changes, bloating, or lightheadedness. If these side effects persist or worsen, please consult your doctor.
Intalith CR-450 Tablet takes some time to show improvement in your symptoms but it varies from person to person. This is because each patient reacts differently to particular medication. It may take 1 to 3 weeks or longer for you to see the full effects of Intalith CR-450 Tablet . Continue taking Intalith CR-450 Tablet even if you are not improving and consult your doctor.
Yes, Intalith CR-450 Tablet can cause drowsiness or sleepiness. If you feel dizzy or sleepy, avoid driving or using machines or performing any tasks that require your attention.
Take Intalith CR-450 Tablet with or without food or as advised by the doctor. Swallow it as whole with a glass of water. Do not break, crush or chew it.
Some medicines decrease Intalith CR-450 Tablet levels in blood which means that it will not work well. These include caffeine, theophylline (for asthma), medicines containing sodium bicarbonate, or a special group of diuretics (water tablets) called carbonic anhydrase inhibitors and urea (used to treat skin conditions). Therefore, please inform your doctor about the medicines you are taking before starting Intalith CR-450 Tablet to avoid drug interactions.
Yes, you can drink coffee, but it is highly important to keep your daily caffeine intake consistent. Sudden changes in how much coffee, tea, or soda you drink can alter the levels of the medicine in your blood. If you plan to make major changes to your caffeine habits, talk to your doctor or pharmacist.
No, you should avoid taking NSAID pain relievers like ibuprofen or naproxen while using this medication, as they can rapidly increase the drug's levels in your blood to unsafe amounts. For pain relief, consult your pharmacist or doctor for safer alternatives like acetaminophen.
Regular blood tests are necessary to measure the exact amount of the medicine in your bloodstream. This helps your doctor ensure the dose is high enough to work effectively but low enough to avoid toxicity. These tests also help monitor your kidney and thyroid function over time. Talk to your doctor if you have questions about your blood test schedule.
No, you should never stop taking this medication suddenly, even if you feel completely well. Stopping abruptly can cause your mood swings or manic symptoms to return quickly. If you want to discontinue treatment, talk to your doctor, who will guide you on how to reduce your dose gradually.
This medication can potentially cause harm to an unborn baby, especially when taken during the first trimester. If you are pregnant, planning to become pregnant, or suspect you might be, notify your healthcare provider immediately. Talk to your doctor to weigh the benefits of treatment against the potential risks to the pregnancy.
If you experience severe vomiting, heavy diarrhoea, or any condition that causes significant sweating and dehydration, contact your doctor immediately. Dehydration can quickly cause Intalith CR-450 Tablet levels in your blood to rise to dangerous levels. Do not stop or adjust your dose on your own unless your healthcare provider specifically instructs you to do so.
In some cases, long-term use of this medication can affect how well your kidneys function. This is why your doctor will order regular blood and urine tests to monitor your kidney health throughout your treatment. If any changes are detected, your doctor can adjust your treatment plan. Talk to your doctor to understand how to protect your kidneys.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Reference

  1. Electronic Medicines Compendium (EMC). Pil.10828 Patient Information Leaflet (PIL). Cheshire, UK: Datapharm; 2025. [Accessed on 02 Jun. 2026]Check here
  2. U.S. Food and Drug Administration (FDA). 017812S033,018421S032,018558S027Lbl [FDA Prescribing Information]. Silver Spring, MD: FDA; 2024. [Accessed on 02 Jun. 2026]Check here
  3. Drugs.com Clinical Review Team. Lithium Clinical Drug Monograph. Auckland, NZ: Drugs.com; 2026. [Accessed on 02 Jun. 2026]Check here
  4. National Health Service (NHS). Lithium - NHS Medicines Reference Guide. London, UK: NHS; 2025. [Accessed on 02 Jun. 2026]Check here
  5. Krutika Chokhawala, Sarah Lee, Abdolreza Saadabadi. Lithium. National Library of Medicine. National Center for Biotechnology Information. PubMed Central. May 2022. [Accessed on 13th February 2024]Check here
  6. Wasdell Packaging Limited. Norgine Ltd. Hengoed. Delpharm L’Aigle. Delpharm Dijon. Electronic Medicines Compendium (EMC). [Revised in July 2022] [Accessed on 13th February 2024]Check here

Country of origin

India

Manufacturer/Marketer address

Chinubhai Centre, Off. Nehru Bridge, Ashram Road, Ahmedabad - 380009. Gujarat. India.
Other Info - INT0003

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