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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Integron Injection is used to treat nausea and vomiting caused by medical treatments after surgery, chemotherapy, or radiation treatment for cancer. It contains Granisetron, which works by blocking the brain's serotonin (chemical messenger) activity that triggers nausea and vomiting during cancer treatment (chemotherapy or radiation therapy) or after surgery. Common side effects of Integron Injection include diarrhoea, constipation, stomach pain, weakness, headache, fever, drowsiness, trouble sleeping, pain, redness, and swelling at the injection site.
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Whats That

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Composition :

GRANISETRON-1MG

Consume Type :

PARENTERAL

Return Policy :

Not Returnable

About Integron Injection

Integron Injection belongs to the class of 'anti-emetic' drugs, primarily used to treat nausea and vomiting caused by medical treatments after surgery or chemotherapy or radiation treatment for cancer. Nausea is defined as stomach discomfort and the sensation of an urge to vomit. Vomiting is the forcible voluntary or involuntary emptying of contents of the stomach through the mouth.

Integron Injection contains an anti-emetic (eases vomiting symptoms) medicine, 'Granisetron', that belongs to the class of 5-HT3 receptor antagonists (also called serotonin receptor antagonists or serotonin blockers). It works by blocking the brain's serotonin (chemical messenger) activity that triggers nausea and vomiting during cancer treatment (chemotherapy or radiation therapy) or after surgery.

Integron Injection will be administered by a healthcare professional; do not self-administer. Your doctor will decide the dose and duration based on the severity of your medical condition. Common side effects of Integron Injection include diarrhoea, constipation, stomach pain, weakness, headache, fever, drowsiness, trouble sleeping, pain, redness, and swelling at the injection site. These side effects are not familiar to everyone and vary individually. If you notice any side effects that are not manageable, please consult your doctor.

If you use other prescription or non-prescription medicines, inform your doctor before using Integron Injection. Let your doctor know if you have any liver, kidney or heart diseases, stomach/intestinal problems, allergic reactions, and low levels of potassium and magnesium in the blood before starting Integron Injection. This medicine may make you dizzy or drowsy; hence avoid driving or operating machinery if you are not mentally alert. Consult your doctor before using Integron Injection if you are pregnant, planning for pregnancy or breastfeeding. Avoid consuming alcohol while being treated with Integron Injection as it could lead to unwanted side effects. 

Uses of Integron Injection

Treatment of Nausea and vomiting

Directions for Use

It will be administered by a healthcare professional; do not self-administer.

Medicinal Benefits

Integron Injection contains an anti-emetic medicine, 'Granisetron', that treats nausea and vomiting caused due to cancer treatment (chemotherapy or radiation therapy) or after surgery. Granisetron belongs to the class of 5-HT3 receptor antagonists (also called serotonin receptor antagonists or serotonin blockers). When the cells lining the gastrointestinal tract are damaged by chemotherapy or radiation therapy, they release a natural substance called serotonin (5HT3, 5-hydroxytryptamine). This serotonin binds to serotonin receptors on nerves that induces nausea and vomiting. Integron Injection works by blocking the brain's serotonin activity and preventing postoperative nausea and vomiting. 

How Integron Injection Works

Integron Injection contains an anti-emetic (eases vomiting symptoms) medicine, 'Granisetron', that belongs to the class of 5-HT3 receptor antagonists (also called serotonin receptor antagonists or serotonin blockers). It works by blocking the brain's serotonin (chemical messenger) activity that triggers nausea and vomiting during cancer treatment (chemotherapy or radiation therapy) or after surgery.

Storage

Store in a cool and dry place away from sunlight

What if I have taken an overdose of Integron Injection

Since Integron Injection is given in a controlled medical setting by a healthcare professional, an overdose is not likely to occur. If you think there has been an overdose or experiencing any adverse events, get medical care right away. In a medical setting, an overdose would be treated quickly. Overdose of Integron Injection may cause headache.

Drug Warnings

Seeking medical advice if you use prescription or non-prescription medicines while being treated with Integron Injection is suggested. Inform your doctor about a history of stomach/intestinal problems, heart diseases, electrolyte imbalance (potassium, sodium or calcium), and liver or kidney diseases before starting Integron Injection. Please consult your doctor if you are pregnant or breastfeeding if the doctor advised you Integron Injection. This medicine may make you feel dizzy, so drive or operate machinery only if you are alert. Avoid consuming alcohol during the course, as it could lead to increased dizziness. Integron Injection is not recommended in children below two years of age.

Drug-Drug Interactions

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GranisetronMesoridazine
Critical

Drug-Drug Interactions

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How does the drug interact with Integron Injection:
Taking Integron Injection with Pimozide can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Taking Integron Injection with Pimozide is not recommended as it can result in an interaction, it can be taken if a doctor has advised it. However, if you experience abrupt dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations while taking any of these drugs, consult a doctor immediately. Do not stop using any medications without talking to a doctor.
GranisetronMesoridazine
Critical
How does the drug interact with Integron Injection:
Taking Integron Injection with mesoridazine can increase the risk of an irregular heart rhythm. I

How to manage the interaction:
Taking Mesoridazine with Integron Injection is not recommended as it can result in an interaction, it can be taken if a doctor has advised it. However, if you experience abrupt dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations while taking any of these drugs, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.
How does the drug interact with Integron Injection:
Taking Integron Injection with Thioridazine can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Taking Integron Injection with Thioridazine is not recommended as it can result in an interaction, it can be taken if a doctor has advised it. However, if you experience abrupt dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations while taking any of these drugs, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.
How does the drug interact with Integron Injection:
Taking Integron Injection with Dronedarone can increase the risk of irregular heart rhythm.

How to manage the interaction:
Taking Integron Injection with Dronedarone is not recommended as it can result in an interaction, it can be taken if a doctor has advised it. However, if you experience abrupt dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations while taking any of these drugs, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.
How does the drug interact with Integron Injection:
Taking Integron Injection with Sparfloxacin can increase the chance of a serious abnormal heart rhythm.

How to manage the interaction:
Taking Integron Injection with Sparfloxacin is not recommended as it can result in an interaction, it can be taken if a doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, breathing difficulty, or rapid heartbeat, consult the doctor immediately. Do not stop using any medications without talking to a doctor.
How does the drug interact with Integron Injection:
Taking Integron Injection with Cisapride can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Taking Integron Injection with Cisapride is not recommended as it can result in an interaction, it can be taken if a doctor has advised it. However, if you experience abrupt dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations while taking any of these drugs, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.
GranisetronSaquinavir
Critical
How does the drug interact with Integron Injection:
When Integron Injection is taken with Saquinavir, can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Taking Integron Injection with Saquinavir is not recommended as it can result in an interaction, it can be taken if a doctor has advised it. However, if you experience abrupt dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations while taking any of these drugs, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.
How does the drug interact with Integron Injection:
Taking Integron Injection with Ziprasidone can increase the risk of abnormal heart rhythm.

How to manage the interaction:
Taking Integron Injection with Ziprasidone is not recommended, as it can result in an interaction, it can be taken if a doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, breathing difficulty, or rapid heartbeat, consult the doctor immediately. Do not stop using any medications without talking to a doctor.
How does the drug interact with Integron Injection:
When bupropion, is taken with Integron Injection it can cause serotonin syndrome (a condition in which a chemical called serotonin builds up in body)

How to manage the interaction:
Co- administration of bupropion along with Integron Injection can lead to an interaction, it can be taken if recommended by a doctor. While taking these medications if you experience, confusion, hallucination, seizure, extreme changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, a shaking sensation, incoordination, stomach cramp, nausea, vomiting, and diarrhea, consult the doctor. Do not discontinue any medications without consulting a doctor.
GranisetronHalofantrine
Severe
How does the drug interact with Integron Injection:
Taking Integron Injection with halofantrine increases the risk of an abnormal heart rhythm.

How to manage the interaction:
Co-administration of Integron Injection with Halofantrine can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience abrupt dizziness, lightheadedness, fainting, shortness of breath, or rapid heartbeat, consult a doctor immediately. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Avoid chocolates, junk food, cheese, processed food, alcohol, and smoking. 
  • You can try increasing your mindfulness by doing yoga, meditation, mindfulness-based cognitive therapy, and stress reduction techniques.
  • Drink enough water to stay hydrated and limit or avoid alcohol and caffeine.
  • Include a diet rich in whole grains, vegetables, and fruits.
  • You can include antioxidants in your daily diet, like ashwagandha, omega-3 fatty acids, green tea, and lemon.
  • Try to spend time with your friends and family. Having a strong social network may help you lower your risk of anxiety.

Habit Forming

No

Therapeutic Class

ANTIEMETICS
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Alcohol

Caution

You are recommended to limit or avoid alcohol consumption while taking Integron Injection. Alcohol intake, along with Integron Injection, may lead to unwanted side effects and cause increased dizziness.

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Pregnancy

Caution

It is not known if Integron Injection affects pregnancy. Please inform your doctor if you are pregnant or planning pregnancy before receiving Integron Injection.

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Breast Feeding

Caution

It is not known if this medicine passes into breast milk. Please inform your doctor before taking Integron Injection if you are a nursing mother.

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Driving

Caution

Integron Injection may make you feel dizzy, affecting your mental ability. Do not drive or operate machinery if you experience dizziness.

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Liver

Caution

Integron Injection should be used with caution if you have liver disease. Please inform your doctor if you have a history of liver impairment before starting Integron Injection.

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Kidney

Caution

Integron Injection should be used with caution if you have kidney problems. Please inform your doctor if you have a history of kidney impairment/kidney disease.

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Children

Caution

Safety and efficacy of Integron Injection have not been established in children below 2 years of age.

Have a query?

FAQs

Integron Injection is used to treat Nausea and vomiting.

Integron Injection contains Granisetron, an anti-emetic drug. It is a serotonin blocker that blocks the activity of serotonin, a chemical messenger that induces nausea and vomiting after treatments like chemotherapy and radiation therapy. Thus, Integron Injection relieves post-operative nausea and vomiting symptoms.

Integron Injection may cause constipation as one of its side effects. You can avoid it by including high-fibre food in your diet that improves your digestion. Limit the intake of alcohol to manage your constipation.

Integron Injection should be used with caution if you have recent stomach/intestinal problems like stomach ache, wind, feeling or being sick, difficulty passing stools, heart rhythm disorder, a recent stomach or intestinal surgery, electrolyte imbalance (potassium, sodium or calcium), and liver or kidney diseases.

You are advised to complete the course prescribed by your doctor. Please do not stop taking this medicine unless advised by your doctor since it may lead to recurrent episodes of nausea and vomiting.

Common side effects of Integron Injection include diarrhoea, constipation, stomach pain, weakness, headache, fever, drowsiness, trouble sleeping, pain, redness, and swelling at the injection site. These side effects are not familiar to everyone and vary individually. If you notice any side effects that are not manageable, please consult your doctor.

It is not known if Integron Injection affects pregnancy. Please inform your doctor if you are pregnant or planning pregnancy before receiving Integron Injection. The doctor will prescribe Integron Injection only if clearly needed.

Few studies suggest that Integron Injection is more effective than ondansetron. However, the doctor will decide which medicine is suitable and better for you based on your condition.

Country of origin

India
Other Info - IN89461

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