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compositionComposition:IFOSFAMIDE-2GM
prescription
Prescription Medicine
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Ipamide 2gm Injection is used to treat blood cancer, breast cancer, non-small cell lung cancer, ovarian cancer, testicular cancer, and pancreatic cancer. It contains Ifosfamide which works by preventing the growth and multiplication of cancer cells. In some cases, this medicine may cause side effects such as nausea, vomiting, low number of red/white blood cells, hair loss, and infection. Inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.

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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

IFOSFAMIDE-2GM

Manufacturer/Marketer :

Fresenius Kabi India Pvt Ltd

Consume Type :

Parenteral

Expires on or after :

Dec-28

Return Policy :

Not Returnable

About Ipamide 2gm Injection

Ipamide 2gm Injection is a specialised prescription medication injected into the body to treat specific types of cancer, particularly testicular cancer that has not responded well to other treatments. It belongs to a group of cancer-fighting medicines that target and slow down the growth of abnormal cells. Because of its strength and the way it must be given, this medicine is only administered under the direct supervision of an experienced medical team in a hospital or specialised clinic.

This medication is not a daily home drug; it is given in treatment cycles. Your medical team will schedule your treatment sessions with specific rest periods in between to allow your body to recover. Since it is delivered directly into a vein, it does not depend on food intake, but eating light meals before your scheduled treatment can help manage potential nausea. Staying highly hydrated by drinking plenty of water before, during, and after your session is one of the most important steps you must take to protect your bladder from irritation.

While Ipamide 2gm Injection is highly effective, it can cause side effects. Common temporary issues include hair loss, nausea, vomiting, and feeling very tired. However, you must contact your doctor immediately if you notice serious symptoms such as blood in your urine, painful urination, severe confusion, or signs of an infection like a sudden fever or chills.

Before you begin treatment, it is vital to tell your healthcare provider about your complete medical history. Do not take this if you have a severe bladder infection, active bladder inflammation or if your bone marrow is severely suppressed, meaning your body is not producing enough blood cells. Your doctor will carefully evaluate your kidneys, liver, and blood counts before starting each cycle.

Ipamide 2gm Injection can interact with other medicines, such as certain antibiotics, anti-seizure drugs, or other chemotherapy medicines, which may increase the risk of kidney or liver damage. You should avoid alcohol during your treatment because it can worsen nausea and place extra strain on your liver. If you are pregnant, planning to become pregnant, or breastfeeding, you must consult your doctor immediately, as this medicine can harm an unborn baby. Elderly individuals may also require closer monitoring, as they are often more sensitive to the side effects on the kidneys and brain.

Uses of Ipamide 2gm Injection

Your doctor may prescribe Ipamide 2gm Injection for several serious conditions, often as part of a combination chemotherapy plan:

  • Testicular cancer: Ipamide 2gm Injection helps by stopping the growth and spread of cancer cells in the testicles, particularly when initial treatments have not been successful.
  • Soft tissue sarcomas: This medicine is used to treat cancers that develop in supporting tissues of the body, such as muscles, fat, blood vessels, and nerves, by slowing down the division of abnormal cells.
  • Other solid tumours: In certain specialised cases, doctors use Ipamide 2gm Injection to treat bone cancers or lung cancers by interfering with the replication of cancer cells.
     

Key Benefits

Ipamide 2gm Injection helps treat certain advanced and difficult-to-treat cancers by slowing or stopping the growth of rapidly dividing cancer cells. By controlling tumour growth, it supports cancer treatment and helps improve quality of life.

  • Helps Control Cancer Growth: By targeting rapidly dividing cancer cells, Ipamide 2gm Injection helps shrink tumours, slows disease progression, and may improve the effectiveness of other cancer treatments, including surgery.
  • Helps Prevent the Spread of Cancer: By limiting the multiplication of cancer cells, Ipamide 2gm Injection helps reduce the risk of the cancer spreading to other parts of the body.
  • Relieves Cancer-Related Symptoms: By reducing tumour size and controlling disease progression, Ipamide 2gm Injection may help relieve symptoms such as pain, pressure, or discomfort caused by the tumour, improving daily comfort and overall well-being during treatment.
     
Side effects of Ipamide 2gm Injection
  • Eat protein-rich foods like fish, poultry, eggs, and legumes.
  • Include foods with minerals and vitamins essential for hair health.
  • Join a support group to connect with others experiencing hair loss.
  • Openly discuss your feelings about hair loss.
  • Consider covering up with wigs, hats, or scarves.
  • Be patient and avoid seeking miracle cures.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
  • Boost your immunity by including immune rich foods in your diet and always remember to stay hydrated.
  • Get sufficient sleep and manage stress which helps in improving white blood cell count.
  • Consult your doctor for an effective treatment to improve the blood cell count and get regular body check up to monitor changes in the count.
  • Try to prevent the factors that cause a decrease in the white blood cells that may lead to impaired immunity.
  • Include iron-rich foods like dark leafy vegetables, lean red meat, legumes and fish in your diet.
  • Consume vitamin C-rich foods as they aid iron absorption.
  • Limit tea, cocoa, and coffee as these can slow iron absorption.
  • Exercise regularly; however, do not overdo it.
  • Staying hydrated helps prevent hematuria by increasing urine production. You should drink about eight glasses of fluid per day, and more in hot weather.
  • Avoiding smoking as it is linked to urinary tract cancers.
  • Eat berries like Cranberries, blueberries, and raspberries can help promote urinary tract health and protect against infection.
  • Taking Vitamin C can help treat urinary tract infections.
  • Avoid irritants that can contribute to hematuria.
  • Empty the bladder regularly, as it can helps in preventing hematuria.
  • Wash your hands regularly with soap and water or use a hand sanitizer to prevent the spread of infections.
  • Wear masks, gloves and other protective clothing.
  • Cover sneezes and coughs with a medical mask or tissue or your elbow.
  • Take vaccinations to enhance your immunity to specific diseases.
  • Clean your utensils, linen and surfaces regularly.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.

Directions for Use

  • Follow your doctor’s instructions on the dosage and timing of this medication.
  • Ipamide 2gm Injection will be administered by a nurse or doctor.
  • Do not self-administer

How Ipamide 2gm Injection Works

To understand how Ipamide 2gm Injection works, it helps to think of cancer cells as rapidly copying machines. This medicine works by attaching itself to the DNA inside these fast-growing cancer cells. Once attached, it damages the DNA strands so they cannot separate or replicate correctly. Because the cancer cells cannot repair this damage, they are prevented from dividing and growing, which eventually causes them to break down and die. Since cancer cells divide much faster than most healthy cells in your body, they are far more sensitive to this DNA damage.
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Alcohol

Caution

Consumption of alcohol is not recommended while receiving this Ipamide 2gm Injection as it may increase the risk of adverse effects such as dizziness, drowsiness, abnormal muscle movements, seizures.

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Pregnancy

Unsafe

Ipamide 2gm Injection is not recommended for use in pregnant women unless necessary. All the risks and benefits should be discussed with the doctor before receiving this Ipamide 2gm Injection.

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Breast Feeding

Caution

Ipamide 2gm Injection is not recommended for use in breastfeeding women unless necessary. All the risks and benefits should be discussed with the doctor before receiving this medicine. Your doctor may advise you to discontinue breastfeeding for a specific period of time or prescribe an alternative medicine based on your clinical condition.

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Driving

Caution

Use of this Ipamide 2gm Injection may cause blurred vision or dizziness in some patients. It is advised that you do not perform any activities such as driving a vehicle or operating machinery if you experience any of these symptoms during treatment with this Ipamide 2gm Injection.

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Liver

Caution

Ipamide 2gm Injection should be used with caution in patients with liver disease. A dose adjustment of Ipamide 2gm Injection may be needed. Please consult your doctor.

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Kidney

Caution

Ipamide 2gm Injection should be used with caution in patients with kidney disease. A dose adjustment of Ipamide 2gm Injection may be needed. Please consult your doctor.

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Children

Caution

Ipamide 2gm Injection is not recommended for use in patients below 18 years of age unless prescribed by your physician. Your doctor may prescribe this medicine if the benefits significantly outweigh the risks. In such a case, the patient should be monitored closely for any adverse effects.

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Heart

Consult your doctor

Please inform your doctor if you have a history of heart disease before using Ipamide 2gm Injection. Your doctor will prescribe it only if the benefits outweigh the risks.

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Geriatrics

Consult your doctor

Limited information available for use of Ipamide 2gm Injection in elderly patients. Please consult your doctor.

What if I have taken an overdose of Ipamide 2gm Injection

Your medical team will carefully measure and administer every dose under strict protocols, making an overdose highly unlikely. In the rare event of an accidental overdose, clinical staff are trained to recognise the signs immediately and will provide supportive care to manage symptoms. If you experience severe sudden side effects shortly after a treatment session, notify your healthcare team immediately.

Diet & Lifestyle Advise

  • Drink plenty of fluids: Try to drink 2 to 3 liters of water daily, especially on treatment days, to flush your bladder and help prevent severe irritation.
  • Eat small, frequent meals: To manage nausea and keep your energy up, eat light, bland meals (such as crackers, toast, or rice) throughout the day instead of three large meals.
  • Avoid raw foods: Wash all fruits and vegetables thoroughly, and avoid raw fish, runny eggs, or undercooked meats to protect yourself from infections while your immune system is weak.
  • Practise gentle oral care: Use a soft-bristled toothbrush to clean your teeth and avoid alcohol-based mouthwashes to prevent bleeding gums and mouth sores.
     
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How Soon It Starts Working

The time required for Ipamide 2gm Injection to start to work: Ipamide 2gm Injection starts to show its action within 2 hours of administration. The time for which the effects of Ipamide 2gm Injection last: Ipamide 2gm Injection effect lasts for 24 hours.

What if you forget to take Ipamide 2gm Injection

Since this medication is given by professionals in a clinical setting, a missed dose is very rare. However, if you miss a scheduled treatment appointment, contact your cancer clinic immediately to reschedule your session and keep your therapy on track.

Storage

• The dry powder is kept at room temperature, between 20°C to 25°C (68°F to 77°F), away from direct light and excessive heat. • Once the healthcare team mixes the powder into a liquid, it must be used within a specific time or stored under strict ref

Drug Warnings

  • Check your urine colour frequently during your treatment cycle; if it looks pink, red, or smoky, contact your doctor immediately.
  • Watch your injection site closely during the infusion and tell your nurse immediately if you feel any burning, stinging, or swelling where the needle is placed.
  • Avoid receiving live vaccines (such as the shingles or yellow fever vaccine) while using Ipamide 2gm Injection, as your weakened immune system cannot handle them safely.
  • Use highly effective birth control during treatment and for several months afterward, as Ipamide 2gm Injection can cause severe birth defects.
  • Keep a safe distance from anyone who is actively sick with a cold, flu, or other contagious infections.
     

Drug-Drug Interactions

verifiedApollotooltip
  • Other chemotherapy drugs: Combining these may increase the risk of bone marrow suppression, lowering your blood counts further.
  • Medicines that cause kidney damage: Taking certain antibiotics or antivirals alongside Ipamide 2gm Injection can significantly increase the strain on your kidneys.
  • Anti-seizure medications: Some of these drugs can speed up how your liver processes Ipamide 2gm Injection, which can either make the treatment less effective or increase its toxic side effects.
     
IfosfamideCidofovir
Critical
IfosfamideClozapine
Severe

Drug-Drug Interactions

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IfosfamideCidofovir
Critical
How does the drug interact with Ipamide 2gm Injection:
Taking cidofovir with Ipamide 2gm Injection can increase the risk of kidney problems.

How to manage the interaction:
Taking Ipamide 2gm Injection with Cidofovir together can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you experience nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or loss, fluid retention, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, or an irregular heart rhythm, consult a doctor. Do not discontinue any medications without consulting a doctor.
IfosfamideClozapine
Severe
How does the drug interact with Ipamide 2gm Injection:
Co-administration of Ipamide 2gm Injection with Clozapine can increase the risk of neutropenia (low levels of neutrophils in blood).

How to manage the interaction:
Taking Ipamide 2gm Injection with Clozapine together can possibly result in an interaction, but it can be taken if a doctor has advised it. If you notice any signs of infection like fever, chills, or a sore throat, or experience discomfort while urinating, it's best to contact a doctor right away. Do not stop using any medications without a doctor's advice.
IfosfamideLidocaine
Severe
How does the drug interact with Ipamide 2gm Injection:
Coadministration of Ipamide 2gm Injection with Lidocaine can increase the risk of methemoglobinemia (blood disorder in which too little oxygen is delivered to your cells).

How to manage the interaction:
There may be a possibility of interaction between Ipamide 2gm Injection and Lidocaine, but it can be taken if prescribed by a doctor. However, consult the doctor immediately if you develop gray discoloration of the skin, abnormal blood coloration, nausea, headache, dizziness, lightheadedness, fatigue, shortness of breath, rapid or shallow breathing, a rapid heartbeat, palpitation, anxiety, or confusion. Do not stop using any medications without consulting doctor.
IfosfamideBupivacaine
Severe
How does the drug interact with Ipamide 2gm Injection:
Taking Bupivacaine and Ipamide 2gm Injection may cause methemoglobinemia, (a condition in which the iron in the hemoglobin molecule -the red blood pigment is defective, making it unable to carry oxygen effectively to the tissues).

How to manage the interaction:
Although taking bupivacaine and Ipamide 2gm Injection together can result in an interaction, it can be taken if a doctor has advised it. However, if you experience symptoms such as gray discoloration of the skin, abnormal blood coloration, nausea, headache, dizziness, lightheadedness, fatigue, shortness of breath, rapid or shallow breathing, a rapid heartbeat, palpitation, anxiety, or confusion, consult the doctor immediately. Do not discontinue any medications without consulting a doctor.
IfosfamideTofacitinib
Severe
How does the drug interact with Ipamide 2gm Injection:
Taking Ipamide 2gm Injection with Tofacitinib may increase the risk of serious infection.

How to manage the interaction:
Taking Tofacitinib with Ipamide 2gm Injection together can possibly result in an interaction, but it can be taken if your doctor has advised it. It is important to keep a close eye on your condition. However, consult the doctor immediately if you experience symptoms such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination. Do not stop using any medications without a doctor's advice.
IfosfamideTenofovir alafenamide
Severe
How does the drug interact with Ipamide 2gm Injection:
The combined use of Ipamide 2gm Injection and Tenofovir alafenamide can increase the risk of kidney problems.

How to manage the interaction:
Taking Ipamide 2gm Injection and Tenofovir alafenamide together can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or weight loss, fluid retention, swelling, shortness of breath, bone pain, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm, contact your doctor immediately. Do not discontinue any medications without consulting your doctor.
IfosfamideThalidomide
Severe
How does the drug interact with Ipamide 2gm Injection:
Taking thalidomide together with Ipamide 2gm Injection may increase the risk of blood clots and other complications.

How to manage the interaction:
Although taking thalidomide and Ipamide 2gm Injection together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as chest pain, shortness of breath, difficulty breathing, coughing up blood, sudden loss of vision, pain, redness or swelling in an arm or leg, and numbness or weakness on one side of the body. Do not discontinue any medications without consulting a doctor.
IfosfamideBaricitinib
Severe
How does the drug interact with Ipamide 2gm Injection:
Coadministration of baricitinib and Ipamide 2gm Injection can raise the risk of developing serious infections.

How to manage the interaction:
Although there is an interaction, baricitinib can be taken with Ipamide 2gm Injection if prescribed by the doctor. However, if you experience fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning when you urinate, consult a doctor. Do not discontinue any medication without consulting a doctor.
IfosfamideCladribine
Severe
How does the drug interact with Ipamide 2gm Injection:
Combining Cladribine with Ipamide 2gm Injection can increase the risk of developing serious infections.

How to manage the interaction:
There may be a possibility of interaction between Ipamide 2gm Injection and Cladribine, but it can be taken if prescribed by a doctor. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning sensation when you urinate, consult a doctor. Do not stop using any medications without a doctor's advice.
IfosfamideInfliximab
Severe
How does the drug interact with Ipamide 2gm Injection:
Combining Infliximab with Ipamide 2gm Injection can speed up the breakdown of Ipamide 2gm Injection in the body. This can increase the risk or severity of developing serious infections.

How to manage the interaction:
Co-administration of Ipamide 2gm Injection with Infliximab can possibly result in an interaction, but it can be taken if your doctor has advised it. If you have any of these symptoms like fever, chills, diarrhea, sore throat, muscle aches, difficulty breathing, weight loss, and pain or burning when you urinate, contact a doctor right away. Don't hesitate to reach out to your doctor if you experience any of these. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

verifiedApollotooltip
  • Grapefruit and grapefruit juice: Can interfere with the liver enzymes that break down Ipamide 2gm Injection, potentially raising the levels of the medicine in your blood and increasing side effects.
     
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[ANTINEOPLASTIC]

FAQs

Ipamide 2gm Injection is used to treat blood cancer, breast cancer, non-small cell lung cancer, ovarian cancer, testicular cancer and pancreatic cancer.
Ipamide 2gm Injection contains ‘ifosfamide’, which is an anti-cancer drug. Ipamide 2gm Injection works by damaging the genetic material (DNA and RNA) of the cancer cells. This stops their growth and multiplication.Â
Ipamide 2gm Injection causes common side effects like nausea, vomiting, anemia (low number of red blood cells), hair loss, decreased white blood cell count, infection, blood in urine, CNS toxicity. Most of these side effects of Ipamide 2gm Injection do not require medical attention and gradually resolve over time. However, if these side effects persist longer, please consult your doctor.
Yes, Ipamide 2gm Injection used in combination with other chemotherapy medicines, radiotherapy, and surgery to treat cancer of blood, breast, lung, ovaries, pancreas, testes, and lymph nodes.
Ipamide 2gm Injection may increase the risk of toxic effects on the heart and could lead to congestive heart failure. So Ipamide 2gm Injection should be taken as advised by your doctor.
Ipamide 2gm Injection is given as a slow injection or infusion directly into a vein (intravenously) by a trained medical professional in a hospital or clinic setting. Talk to your doctor for more details about your specific infusion schedule.
Drinking plenty of water helps flush the medicine out of your bladder quickly. This prevents the drug's breakdown products from sitting in your bladder and causing severe bleeding or irritation. Talk to your doctor about how much fluid you should drink.
Doctors usually inject a protective medicine called mesna alongside Ipamide 2gm Injection. Mesna safely binds to harmful substances in your bladder to shield the bladder lining from damage. Talk to your doctor or pharmacist if you want to know more about this protective treatment.
Yes, temporary hair loss is a very common side effect of Ipamide 2gm Injection. Hair typically begins to grow back a few months after your final chemotherapy session is completed. Talk to your doctor if you have concerns about managing hair loss.
You should avoid live vaccines during your treatment because your immune system is weakened by Ipamide 2gm Injection, making these vaccines unsafe. Always consult your healthcare team before getting any vaccine, including flu shots. Talk to your doctor or pharmacist to plan safe vaccinations.
Ipamide 2gm Injection can temporarily lower your white blood cells, red blood cells, and platelets. This increases your risk of catching infections, feeling extremely tired, and bruising or bleeding easily. Talk to your doctor about having your blood counts monitored regularly.
It is best to avoid alcohol during your treatment. Alcohol can stress your liver and kidneys, make nausea worse, and increase the risk of dehydration. Talk to your doctor or pharmacist for personalized guidance.
No, Ipamide 2gm Injection can cause severe harm to an unborn baby. Both men and women must use highly reliable birth control during treatment and for a specified time after the last dose. Talk to your doctor to discuss safe family planning and fertility options before starting treatment.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Manufacturer/Marketer address

Cipla House, Peninsula Business Park, Ganpatrao Kadam Marg, Lower Parel, Mumbai-400013.
Other Info - IP65492
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