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compositionComposition:ISAVUCONAZOLE-100MG
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Isacrest 100 mg Capsule 7's is used to treat fungal infections such as invasive aspergillosis and mucormycosis. It contains Isavuconazole which works by killing or inhibiting the growth of the fungus. In some cases, this medicine may cause side effects such as headache, decreased appetite, drowsiness, nausea, vomiting, stomach pain, diarrhoea or chest pain. Before taking this medicine, inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.

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Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

ISAVUCONAZOLE-100MG

Manufacturer/Marketer :

Concord Biotech Ltd

Consume Type :

Oral

Expires on or after :

Jan-28

Return Policy :

Not Returnable

About Isacrest 100 mg Capsule 7's

Isacrest 100 mg Capsule 7's is an oral prescription medication used to treat serious, invasive fungal infections in adults. It is primarily prescribed to combat deep tissue infections, such as those affecting the lungs or other internal organs, caused by specific types of molds. This medication helps clear these complex infections by stopping the growth of the fungi responsible for them.

For the treatment to be successful, you must take Isacrest 100 mg Capsule 7's regularly and exactly as prescribed by your doctor. You can take this medicine with or without food, making it easy to incorporate into your daily routine. While undergoing treatment, getting plenty of rest, staying well-hydrated, and avoiding environments with high mold exposure can support your body's recovery process.

While taking Isacrest 100 mg Capsule 7's, some people may experience mild side effects like nausea, vomiting, or headache. However, you should contact your healthcare provider immediately if you notice signs of liver damage, such as yellowing of your skin or eyes, dark urine, or severe upper stomach pain. Your doctor may perform regular blood tests to monitor your liver health during your treatment.

Before starting Isacrest 100 mg Capsule 7's, inform your doctor if you have a history of liver disease, heart rhythm issues, or severe allergies. Do not take this if you have a genetic heart condition known as familial short QT syndrome, as this medicine can affect your heart's electrical activity. It is crucial to share your complete medical history to ensure this treatment is safe for you.

This medication can interact with several other drugs, including certain heart medicines, antibiotics, or herbal supplements, which may alter how they or Isacrest 100 mg Capsule 7's work in your body. Avoid drinking alcohol while on this medication, as it can place extra strain on your liver. If you are pregnant, planning to become pregnant, breastfeeding, or are an older adult, talk to your doctor or pharmacist before starting treatment.

You may notice the name isavuconazonium sulfate on your medicine pack or hospital records. This is the inactive form (prodrug) of the medicine that is converted into active Isacrest 100 mg Capsule 7's inside your body. Both names refer to the same treatment. 
 

Uses of Isacrest 100 mg Capsule 7's

Your doctor may prescribe this medicine to treat several conditions, including:

  • Invasive aspergillosis: This is a severe fungal infection that typically affects the lungs of individuals with weakened immune systems. Isacrest 100 mg Capsule 7's helps target and eliminate the Aspergillus fungus to stop the infection from spreading to other parts of the body.
  • Invasive mucormycosis: This is a rare but highly serious fungal infection caused by mucormycete molds, often affecting the sinuses, brain, or lungs. Isacrest 100 mg Capsule 7's works to clear this aggressive infection and support the healing of affected tissues.

This medicine is most commonly prescribed for people with weakened immune systems, such as those who have received an organ or stem cell transplant, are being treated for certain blood cancers, or have other conditions that reduce the body's ability to fight infections. If this applies to you, follow your doctor's advice carefully, attend all follow-up appointments, and avoid exposure to environments where mold is common whenever possible. 
 

Key Benefits

Isacrest 100 mg Capsule 7's provides the following benefits when used as prescribed:

  • Treat Severe Fungal Infection: Isacrest 100 mg Capsule 7's provides crucial support for patients fighting severe fungal infections, helping them on the path to recovery. By stopping the spread of dangerous fungi, this medication allows your body's immune system to heal and reduces the risk of life-threatening complications.
  • High Oral Absorption: Isacrest 100 mg Capsule 7's is well absorbed when taken by mouth, allowing many patients who start treatment with intravenous (IV) medicine in the hospital to switch to oral capsules once their condition is stable. This makes long-term treatment more convenient. Any switch between IV and oral treatment should always be decided by your doctor. 
     
Side effects of Isacrest 100 mg Capsule
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
  • Drink water or other clear fluids.
  • To prevent worsening of pain, limit intake of tea, coffee, or alcohol.
  • Include bland foods like rice, toast, crackers, and rice in your diet.
  • Avoid lying down immediately after eating as it may cause indigestion or heartburn.
  • Avoid acidic and spicy food as it may cause indigestion.
Here are the steps to cope with constipation as a side effect of medication:
  • Inform your doctor about your constipation symptoms. They may adjust your medication or advise alternative treatments.
  • Stay hydrated by drinking sufficient of water (at least 8-10 glasses a day) to help soften stool and promote bowel movements.
  • Increase fibre intake by eating foods high in fibre, such as fruits, whole grains, vegetables and legumes, to help bulk up the stool.
  • Establish a bowel routine by trying to go to the bathroom at the same time each day to train your bowels.
  • Engaging in regular exercise, like walking or yoga, can support in bowel movement stimulation.
  • Consult your doctor if constipation persists, and discuss alternative treatments or adjustments to your medication.

Directions for Use

  • Isacrest 100 mg Capsule 7's can be taken with or without food.
  • It is recommended to take Isacrest 100 mg Capsule 7's 3 times a day on the first two days, then once daily afterward, or as advised by your doctor.
  • Swallow Isacrest 100 mg Capsule 7's as a whole with a glass of water.
  • Do not crush, chew, or open it.

How Isacrest 100 mg Capsule 7's Works

This medication belongs to a class of drugs known as triazole antifungals. It works by targeting the outer protective layer, or cell membrane, of the fungus. Specifically, it blocks a vital enzyme that the fungus needs to produce a compound called ergosterol. Without ergosterol, the fungal cell membrane becomes weak, develops holes, and eventually breaks down. This prevents the fungi from growing, multiplying, and spreading throughout your body, allowing your immune system to successfully clear the remaining infection.
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Alcohol

Unsafe

Avoid consumption of alcohol while taking Isacrest 100 mg Capsule 7's as it may increase the risk of liver damage.

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Pregnancy

Caution

Isacrest 100 mg Capsule 7's is given to a pregnant woman if the doctor thinks benefits outweigh risks. Please consult a doctor if you are pregnant or planning for pregnancy.

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Breast Feeding

Unsafe

Avoid breastfeeding while taking Isacrest 100 mg Capsule 7's. Please consult a doctor if you are breastfeeding.

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Driving

Caution

Drive only if you are alert after taking Isacrest 100 mg Capsule 7's as it may cause drowsiness, confusion or tiredness.

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Liver

Caution

Isacrest 100 mg Capsule 7's should be given with caution, especially if you have a history of Liver diseases/conditions.

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Kidney

Caution

Isacrest 100 mg Capsule 7's should be given with caution, especially if you have a history of Kidney diseases/conditions.

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Children

Unsafe

Isacrest 100 mg Capsule 7's is not recommended for children below 18 years as the safety and effectiveness were not established.

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Heart

Caution

Please inform your doctor if you have a history of heart disease before using Isacrest 100 mg Capsule 7's. Your doctor will prescribe it only if the benefits outweigh the risks.

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Geriatrics

Consult your doctor

Isacrest 100 mg Capsule 7's should be given to elderly patients only if prescribed by a doctor. Please consult your doctor before using Isacrest 100 mg Capsule 7's.

What if I have taken an overdose of Isacrest 100 mg Capsule 7's

If you suspect an overdose or have taken more than your prescribed amount, seek emergency medical attention.

Diet & Lifestyle Advise

  • Eat Balanced Diet: Keep your immune system supported by eating a balanced diet rich in vitamins and minerals, as recommended by your healthcare provider.
  • Avoid Mold Exposure: Avoid environments with a high risk of mold spores, such as damp basements, construction sites, or heavily wooded areas, especially if you have a weakened immune system.
  • Stay Hydrated: Stay well-hydrated by drinking plenty of water throughout the day to help your kidneys and liver process the medication efficiently.
  • Avoid Alcohol: Avoid drinking alcohol during your treatment, as both alcohol and this medication are processed by the liver, and combining them can increase the risk of liver strain.

 

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How Soon It Starts Working

The time required for Isacrest 100 mg Capsule 7's to start to work: Isacrest 100 mg Capsule 7's starts to show its action within 1 to 2 hours of administration. The time for which the effects of Isacrest 100 mg Capsule 7's last: Isacrest 100 mg Capsule 7's effect lasts for 24 hours.

What if you forget to take Isacrest 100 mg Capsule 7's

If you miss a dose of Isacrest 100 mg Capsule 7's, take it as soon as you remember. However, if your next scheduled dose is less than a few hours away, skip the missed dose and return to your regular schedule. Do not take two doses at the same time to make up for a missed one.

Storage

• Store the capsules at room temperature, specifically between 20°C to 25°C (68°F to 77°F).

Drug Warnings

  • Complete the Full Course: Always complete the entire course of treatment prescribed by your doctor, even if you start feeling better after a few days.
  • Inspect Packaging Before Use: Regularly inspect your medication packaging to ensure the blister seals are completely intact before taking a capsule.
  • Monitor Liver Function: Have regular blood tests as recommended by your doctor to monitor your liver function while taking this medication.
  • Inform all Healthcare Providers: Inform every healthcare provider you visit that you are currently taking Isacrest 100 mg Capsule 7's, as it can interact with many other drugs.
  • Use Effective Contraception: Use effective birth control during treatment and for a specified time after your final dose, as this medication may harm an unborn baby.
  • Attend Follow-up Appointments: Your doctor may recommend additional blood tests or other monitoring during treatment to check how well the medicine is working and ensure it remains safe for you. In some complex cases, special blood tests may be performed to measure medicine levels in your body. 
     

Drug-Drug Interactions

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Some medicines may affect how Isacrest 100 mg Capsule 7's works or increase the risk of side effects:

  • CYP Enzyme Interaction: Taking Isacrest 100 mg Capsule 7's with strong liver enzyme inhibitors or inducers (such as rifampin, ketoconazole, or carbamazepine) can significantly alter the levels of the medicine in your body.
  • Increase Other Drug Levels: It may also increase the levels of other drugs, such as certain blood thinners, immunosuppressants, or cholesterol-lowering medicines, raising the risk of their side effects.

 

IsavuconazolePhenobarbital
Critical
IsavuconazoleKetoconazole
Critical

Drug-Drug Interactions

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IsavuconazolePhenobarbital
Critical
How does the drug interact with Isacrest 100 mg Capsule:
When Isacrest 100 mg Capsule is taken with Phenobarbital, may decrease the blood levels of Isacrest 100 mg Capsule, which may make Isacrest 100 mg Capsule less effective.

How to manage the interaction:
Taking Isacrest 100 mg Capsule with Phenobarbital is not recommended it can be taken if prescribed by the doctor. Do not stop using any medications without talking to a doctor.
IsavuconazoleKetoconazole
Critical
How does the drug interact with Isacrest 100 mg Capsule:
Co-administration of Ketoconazole and Isacrest 100 mg Capsule can significantly increase the blood levels of Isacrest 100 mg Capsule, which may increase the risk of side effects.

How to manage the interaction:
Taking Isacrest 100 mg Capsule with Ketoconazole is not recommended as it can cause an interaction, it can be taken if prescribed by the doctor. However, if you experience symptoms like nausea, stomach pain, headache while on therapy with these drugs, consult the doctor. Do not discontinue any medication without consulting a doctor.
IsavuconazoleClarithromycin
Critical
How does the drug interact with Isacrest 100 mg Capsule:
When Isacrest 100 mg Capsule is taken with Clarithromycin, it can increase the risk of side effects.

How to manage the interaction:
Co-administration of Clarithromycin and Isacrest 100 mg Capsule can lead to an interaction, it can be taken if advised by a doctor. However, if you experience any symptoms like nausea, vomiting, or diarrhoea, consult a doctor immediately. Do not stop using any medications without a doctor's advice.
IsavuconazolePrimidone
Critical
How does the drug interact with Isacrest 100 mg Capsule:
Taking Isacrest 100 mg Capsule with primidone may decrease the blood levels of Isacrest 100 mg Capsule and reduce its effectiveness.

How to manage the interaction:
Taking Isacrest 100 mg Capsule with primidone is not recommended, it can be taken if prescribed by a doctor. However, if you experience any unusual symptoms, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
IsavuconazolePhenytoin
Critical
How does the drug interact with Isacrest 100 mg Capsule:
Co-administration of phenytoin and Isacrest 100 mg Capsule may significantly reduce the blood levels of Isacrest 100 mg Capsule, which may make Isacrest 100 mg Capsule less effective in treating your condition.

How to manage the interaction:
Taking Isacrest 100 mg Capsule with Phenytoin is not recommended as it can cause an interaction, consult a doctor before taking it. Do not discontinue any medication without consulting a doctor.
IsavuconazoleCeritinib
Critical
How does the drug interact with Isacrest 100 mg Capsule:
Taking ceritinib with Isacrest 100 mg Capsule may significantly increase the blood levels of Isacrest 100 mg Capsule.

How to manage the interaction:
Taking Isacrest 100 mg Capsule with Ceritinib is not recommended as it can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like nausea, vomiting, loose stools, yellow discoloration of skin and eyes, consult a doctor immediately. Do not stop using any medications without a doctor's advice.
IsavuconazoleCisapride
Critical
How does the drug interact with Isacrest 100 mg Capsule:
When Isacrest 100 mg Capsule is taken with Cisapride, it can increase the chance of a serious abnormal heart rhythm.

How to manage the interaction:
Taking Isacrest 100 mg Capsule with Cisapride is not recommended, it can be taken if prescribed by the doctor. However, if you experience sudden dizziness, lightheadedness, fainting, breathing difficulty, or rapid heartbeat, consult the doctor immediately. Do not stop any medications without a doctor's advice.
IsavuconazoleRitonavir
Critical
How does the drug interact with Isacrest 100 mg Capsule:
Taking Isacrest 100 mg Capsule with Ritonavir may significantly increase the blood levels of Isacrest 100 mg Capsule, which may increase the risk of side effects.

How to manage the interaction:
Taking Isacrest 100 mg Capsule with Ritonavir is not recommended as it can possibly result in an interaction, it can be taken if a doctor has advised it. If you notice any of these symptoms like nausea, vomiting, loose stools, light color stools or dark urine, consult a doctor. Do not discontinue any medications without consulting a doctor.
IsavuconazolePosaconazole
Critical
How does the drug interact with Isacrest 100 mg Capsule:
When Isacrest 100 mg Capsule is taken with Posaconazole, it can increase the levels of Isacrest 100 mg Capsule in the blood.

How to manage the interaction:
Although there is an interaction between Isacrest 100 mg Capsule and posaconazole, it can be taken if prescribed by the doctor. However, if you experience nausea, vomiting, diarrhea, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
IsavuconazoleFosamprenavir
Critical
How does the drug interact with Isacrest 100 mg Capsule:
When Fosamprenavir is taken with Isacrest 100 mg Capsule, it can increase the risk of side effects like liver damage.

How to manage the interaction:
Taking Isacrest 100 mg Capsule with Fosamprenavir is not recommended, it can be taken if prescribed by the doctor. However, if you experience nausea, vomiting, diarrhea while on therapy with these drugs, consult the doctor.

Drug-Food Interactions

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No clinically significant food interactions are known with Isacrest 100 mg Capsule 7's when used as directed.

ISAVUCONAZOLE-100MGGrapefruit and Grapefruit Juice

Drug-Food Interactions

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ISAVUCONAZOLE-100MGGrapefruit and Grapefruit Juice
Common Foods to Avoid:
Grapefruit Juice, Grapefruit

How to manage the interaction:
Taking grapefruit and grapefruit juice during Isacrest 100 mg Capsule treatment may cause an interaction. Avoid grapefruit products during treatment with Isacrest 100 mg Capsule

All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[ANTIFUNGALS]

FAQs

Isacrest 100 mg Capsule 7's is used to treat fungal infections such as invasive aspergillosis and mucormycosis.
Isacrest 100 mg Capsule 7's contains Isavuconazole that works by inhibiting the synthesis of fungal cell membranes which are essential for their survival. Thereby, Isacrest 100 mg Capsule 7's kills or inhibits the growth of the fungus.
Mucormycosis is not contagious. Mucormycosis is a severe fungal infection of the skin or respiratory system that occurs in people with weakened immune system.
Isacrest 100 mg Capsule 7's may cause headache as a common side effect. However, if the condition persists or worsen, please consult a doctor.
You are not recommended to take Isacrest 100 mg Capsule 7's with ketoconazole as it may increase the levels of Isacrest 100 mg Capsule 7's in blood and increase the risk of side effects such as diarrhoea, vomiting, nausea or liver problems. However, please consult your doctor before taking Isacrest 100 mg Capsule 7's with other medicines.
Isacrest 100 mg Capsule 7's belongs to the class of medicines called antifungals used to treat fungal infections such as invasive aspergillosis and mucormycosis.
Inform your doctor about your medical history, current medications, allergies, and if you're pregnant or breastfeeding before starting treatment with Isacrest 100 mg Capsule 7's.
Isacrest 100 mg Capsule 7's should not be used in people who are allergic to any of its components and children below 18 years as the safety and effectiveness were not established.
Isacrest 100 mg Capsule 7's is safe when used as prescribed by your doctor. However, it may cause side effects like headache, decreased appetite, drowsiness, nausea, vomiting, stomach pain, and chest pain while using it.
The common side effects of Isacrest 100 mg Capsule 7's may include headache, decreased appetite, drowsiness, nausea, vomiting, stomach pain, diarrhoea or chest pain. Most of these side effects of Isacrest 100 mg Capsule 7's do not require medical attention and gradually resolve over time. However, if the side effects worsen or persist, please consult your doctor.
Yes, you can take Isacrest 100 mg Capsule 7's either with or without food. However, it is important to take it consistently and exactly as directed by your healthcare provider. Talk to your doctor or pharmacist if you experience stomach upset.
If you miss a dose, take it as soon as you remember. If it is almost time for your next scheduled dose, skip the missed dose and resume your regular routine. Do not double the dose. Talk to your doctor or pharmacist if you are unsure.
In some cases, Isacrest 100 mg Capsule 7's can cause liver strain or damage. Your doctor will likely monitor your liver enzymes with blood tests before and during treatment. Seek immediate medical attention if you notice yellow skin or eyes, dark urine, or severe stomach pain. Talk to your doctor for more information.
You should avoid drinking alcohol while taking this medication. Both alcohol and Isacrest 100 mg Capsule 7's are processed by your liver, and combining them can increase the risk of liver damage. Talk to your doctor or pharmacist for personalized advice.
This medication is generally not recommended during pregnancy as it may cause harm to an unborn baby. It is also unknown if it passes into breast milk. If you are pregnant, planning to become pregnant, or breastfeeding, talk to your doctor or pharmacist before starting this treatment.
Store the capsules at room temperature between 20°C and 25°C (68°F to 77°F) in their original blister packaging to protect them from moisture. Keep them away from heat, freezing conditions, and out of reach of children. Talk to your pharmacist about proper disposal of unused capsules.
No, you must complete the entire course of treatment prescribed by your doctor, even if you start feeling better. Stopping early can allow the fungal infection to return or worsen. Talk to your doctor before making any changes to your medication schedule.

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Reference

  1. Electronic Medicines Compendium (EMC). Pil.5071 Patient Information Leaflet (PIL). Cheshire, UK: Datapharm; 2025. [Accessed on 02 Jun. 2026]Check here
  2. Isavuconazonium sulfate [EMC Label]. 2021. [Accessed on 03 Jul. 2021]Check here
  3. Clinical research advances of isavuconazole in the treatment of invasive fungal diseases. National Center for Biotechnology Information. National Library of Medicine. PMC. PubMed Central. December 2022. [Accessed on 22nd August 2024]Check here
  4. NHS Manchester University. Isavuconazole. National Aspergillosis Centre. [Accessed on 22nd August 2024]Check here
  5. Isavuconazonium sulfate [Prescription Information]. 2021. [Accessed on 03 Jul. 2021]Check here
  6. CRESEMBA® (isavuconazonium sulfate). [Accessed on 03 Jul. 2021]Check here
  7. Isavuconazonium sulfate [Dosing and Administration Guide]. 2022. [Accessed on 05 Jul. 2023]Check here

Country of origin

India

Manufacturer/Marketer address

16Th Floor, B-Wing, Mondeal Heights, Iscon Cross Road, S.G. Highway, Ahmedabad 380015, Gujarat, India.
Other Info - ISA0048
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