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compositionComposition:MIDAZOLAM-1MG
prescription
Prescription Medicine
info
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Isedaz Injection is used to induce sedation and relieve anxiety and muscle tension. It is used to induce sleepiness during therapeutic procedures (like endoscopy or colonoscopy) or complicated medical tests known as procedural sedation. It contains Midazolam, which relaxes muscles, reduces anxiety and induces drowsiness. It may cause side effects such as redness, pain or swelling at the injection site, headache, drowsiness, dizziness, confusion, dry mouth, tiredness or muscle spasms.

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Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

MIDAZOLAM-1MG

Manufacturer/Marketer :

6Ipain Healthcare Pvt Ltd

Consume Type :

Parenteral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Isedaz Injection

Isedaz Injection is a prescription injection used to produce drowsiness, relieve anxiety, and prevent memory of medical procedures or surgery. It is also used to induce anaesthesia or provide continuous sedation for critically ill patients in intensive care. This medicine is given on an as-needed basis in a hospital or clinic setting, meaning there is no daily dosing schedule or food requirements. To support safe sedation and recovery, patients are typically advised to follow strict fasting guidelines before their scheduled procedure.

Common side effects include mild sleepiness, hiccups, and slight pain at the injection site, which usually fade quickly. However, you should alert your healthcare provider immediately if you experience breathing difficulties or signs of a severe allergic reaction. Before receiving this medicine, tell your doctor if you have lung disease, kidney issues, or a history of severe allergies. You should not receive this medicine if you have acute narrow-angle glaucoma or a known allergy to similar sedatives.

Combining this injection with alcohol, opioids, or sleep medications can cause dangerously slow breathing and extreme drowsiness. Additionally, pregnant women, breastfeeding mothers, and elderly individuals should consult their doctor to fully evaluate the risks and benefits before receiving this medicine.

Uses of Isedaz Injection

Isedaz Injection is used to produce drowsiness, relieve anxiety, and prevent memory of medical procedures or surgery. The detailed uses of Isedaz Injection are as follows:

  • Conscious sedation: Helps patients relax, feel sleepy, and lose memory of minor procedures or examinations while remaining awake.
  • Induction of anaesthesia: Initiates a deep sleep before other general anaesthetics are given for major surgery.
  • Continuous sedation in intensive care: Keeps critically ill, mechanically ventilated patients calm and comfortable in the hospital.

Key Benefits

Isedaz Injection helps provide calmness and relaxation before or during medical procedures. By reducing anxiety and producing temporary sedation, it supports a more comfortable and controlled clinical experience.

  • Helps Reduce Anxiety Before Procedures: By calming the central nervous system, Isedaz Injection helps relieve fear, anxiety, and tension before surgeries or diagnostic procedures, allowing you to remain relaxed.
  • Provides Sedation and Temporary Memory Loss: Isedaz Injection produces short-term sedation and temporary amnesia, making you less likely to remember unpleasant aspects of the procedure and improving overall comfort.
  • Acts Rapidly for Medical Procedures: When administered by a healthcare professional, Isedaz Injection works quickly to provide reliable sedation, allowing procedures to be carried out safely and efficiently while supporting a smoother recovery experience.
Side effects of Isedaz Injection 10 ml
  • Get plenty of fresh air.
  • Take regular sips of a cold drink.
  • Take ginger containing foods like ginger tea and ginger biscuits.
  • Do not take heavy meals at a time, take small and frequent meals.
  • Hiccups can be controlled if you can hold your breath for a short time.
  • Drink plenty of warm fluids and gargle with salt water.
  • Swallow some sugar as it can give relief to some extent.
  • You can try to pull your knees up to your chest and lean forward, which helps relieve hiccups.
  • Try to breathe in a paper bag for a while, but don't keep the paper over your head.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
  • Get enough sleep. Maintain a regular sleep cycle.
  • Eat a healthy diet and exercise regularly.
  • Manage stress with yoga or meditation.
  • Limit alcohol and caffeine.
  • Avoid driving or operating machinery unless you are alert.
Managing Low Blood Pressure Triggered by Medication: Expert Advice:
  • If you experience low blood pressure symptoms like dizziness, lightheadedness, or fainting while taking medication, seek immediate medical attention.
  • Make lifestyle modifications and adjust your medication regimen under medical guidance to manage low blood pressure.
  • As your doctor advises, regularly check your blood pressure at home. Record your readings to detect any changes and share them with your doctor.
  • Fluid intake plays a vital role in managing blood pressure by maintaining blood volume, regulating blood pressure, and supporting blood vessel function. Drinking enough fluids helps prevent dehydration, maintain electrolyte balance, and regulate fluid balance.
  • Take regular breaks to sit or lie down if you need to stand for long periods.
  • When lying down, elevate your head with extra pillows to help improve blood flow.
  • Avoid heavy exercise or strenuous activities that can worsen low blood pressure.
  • Wear compression socks as your doctor advises to enhance blood flow, reduce oedema, and control blood pressure.
  • If symptoms persist or worsen, or if you have concerns about your condition, seek medical attention for personalized guidance and care.

Directions for Use

  • Follow your doctor’s recommendations on the dosage and timing of this medication to achieve optimal results.
  • Isedaz Injection will be administered by a healthcare professional.
  • Do not self-administer.

How Isedaz Injection Works

Isedaz Injection contains midazolam. This medicine belongs to a class of drugs known as benzodiazepines. It works by targeting specific receptors in the brain called GABA receptors. By enhancing the activity of a natural calming chemical in your brain (GABA), it slows down the central nervous system. This action results in rapid muscle relaxation, anxiety relief, and deep sleepiness, making medical procedures easier to tolerate.
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Alcohol

Unsafe

Avoid consumption of alcohol with Isedaz Injection as it may increase the sedative effect of Isedaz Injection and may also cause breathing problems.

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Pregnancy

Caution

If you are pregnant or planning for pregnancy, inform your doctor before taking Isedaz Injection. However, if Isedaz Injection is used for prolonged treatment during the last trimester, it may cause physical dependence and risk of withdrawal symptoms after birth in the baby.

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Breast Feeding

Caution

Isedaz Injection may be excreted in breast milk. Therefore, avoid breastfeeding for 24 hours after taking Isedaz Injection.

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Driving

Unsafe

Isedaz Injection may cause drowsiness or affect concentration and coordination. It is an offence to drive after taking Isedaz Injection and if it affects your ability to drive. Therefore, avoid driving if you feel drowsy after taking Isedaz Injection.

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Liver

Caution

If you have liver conditions, inform your doctor before taking Isedaz Injection.

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Kidney

Caution

If you have kidney problems, inform your doctor before taking Isedaz Injection.

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Children

Caution

If your child has a heart condition, notify your doctor before giving Isedaz Injection. The dose will be adjusted specifically, and your child will be closely watched. Isedaz Injection is only advised for sedation in intensive care units for newborns and babies under six months of age, and their breathing and oxygen levels must be closely monitored.

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Heart

Caution

Isedaz Injection should be taken with caution in patients with heart problems. Please inform your doctor about any existing heart problems before using Isedaz Injection.

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Geriatrics

Caution

Isedaz Injection can be given in elderly patients with extreme caution due to the risk of increased side effects

What if I have taken an overdose of Isedaz Injection

Because this medicine is injected under close medical supervision, an overdose is rare. If an overdose is suspected, healthcare professionals will immediately treat it with supportive care and reversal medications.

Diet & Lifestyle Advise

  • Follow strict fasting guidelines (no food or drink) provided by your doctor before receiving this injection to prevent complications.
  • Avoid drinking alcohol for at least 24 hours after receiving this injection, as it can dangerously increase drowsiness and slow your breathing.
  • Do not drive, operate heavy machinery, or perform tasks that require mental alertness for at least 24 hours after your procedure.
  • Arrange for a responsible adult to drive you home and stay with you for several hours after your discharge.
health query

Have a query?

How Soon It Starts Working

The time required for Isedaz Injection to start to work: The time required for Isedaz Injection to show its action is unknown. The time for which the effects of Isedaz Injection last: The duration of action for Isedaz Injection is unknown.

What if you forget to take Isedaz Injection

Since this medicine is injected by a healthcare professional for specific procedures, missing a scheduled dose is highly unlikely. Talk to your doctor if you have concerns about your procedure schedule.

Storage

• Store this medicine at controlled room temperature between 20°C and 25°C (68°F to 77°F). • Keep the injection vials in their original carton to protect them from light. Do not freeze the solution.

Drug Warnings

  • Before the injection, verify that the liquid is clear, colourless, and free of any visible particles.
  • Inform your healthcare provider if you have a history of snoring or sleep apnoea, as this medicine can further slow your breathing.
  • Do not receive this medicine if you have acute narrow-angle glaucoma.
  • If you are elderly or have chronic health conditions, your body may clear this medicine more slowly, requiring a lower dose and longer monitoring.

Drug-Drug Interactions

verifiedApollotooltip
  • Opioids or sleep aids: Taking this medicine with strong pain relievers, sleeping pills, or muscle relaxants can cause extreme sleepiness, severe breathing problems, or coma.
  • Liver enzyme inhibitors: Medicines that slow down liver enzymes (such as certain antifungals or antibiotics) can increase the levels of Isedaz Injection in your body, prolonging its sedating effects.
MidazolamAtazanavir
Critical
MidazolamTelaprevir
Critical

Drug-Drug Interactions

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MidazolamAtazanavir
Critical
How does the drug interact with Isedaz Injection 10 ml:
Atazanavir and Isedaz Injection 10 ml co-administration may considerably enhance Isedaz Injection 10 ml blood levels and effects.

How to manage the interaction:
Although taking Atazanavir and Isedaz Injection 10 ml together may result in an interaction, they can be taken if prescribed by a doctor. Consult a doctor if you have excessive or prolonged sleepiness and breathing issues. Do not discontinue any medication without consulting a doctor.
MidazolamTelaprevir
Critical
How does the drug interact with Isedaz Injection 10 ml:
Telaprevir and Isedaz Injection 10 ml co-administration may considerably enhance Isedaz Injection 10 ml blood levels and effects.

How to manage the interaction:
Although taking Telaprevir and Isedaz Injection 10 ml together may result in an interaction, they can be taken if prescribed by a doctor. Consult a doctor if you have excessive or prolonged sleepiness and breathing issues. Do not discontinue any medication without consulting a doctor.
MidazolamMifepristone
Critical
How does the drug interact with Isedaz Injection 10 ml:
Co-administration of Mifepristone and Isedaz Injection 10 ml may significantly increase Isedaz Injection 10 ml blood levels and effects, which increases the risk of side effects.

How to manage the interaction:
Although taking Mifepristone and Isedaz Injection 10 ml together may result in an interaction, they can be taken if prescribed by a doctor. Consult a doctor if you have excessive or prolonged sleepiness and breathing issues. Do not discontinue any medication without consulting a doctor.
MidazolamCeritinib
Critical
How does the drug interact with Isedaz Injection 10 ml:
Taking ceritinib and Isedaz Injection 10 ml may significantly increase the blood levels and effects of Isedaz Injection 10 ml.

How to manage the interaction:
Although taking ceritinib and Isedaz Injection 10 ml together may result in an interaction, they can be taken if prescribed by a doctor. However, if you experience any unusual symptoms contact your doctor immediately. Do not stop using any medications without first talking to your doctor.
MidazolamSodium oxybate
Critical
How does the drug interact with Isedaz Injection 10 ml:
Sodium oxybate and Isedaz Injection 10 ml co-administration may considerably enhance Isedaz Injection 10 ml blood levels and effects.

How to manage the interaction:
Although taking Sodium oxybate and Isedaz Injection 10 ml together may result in an interaction, they can be taken if prescribed by a doctor. Consult a doctor if you have excessive or prolonged sleepiness and breathing issues. Do not discontinue any medication without consulting a doctor.
MidazolamDelavirdine
Critical
How does the drug interact with Isedaz Injection 10 ml:
The negative effects of Isedaz Injection 10 ml and Delavirdine might be increased when used together.

How to manage the interaction:
Taking Isedaz Injection 10 ml together Delavirdine may cause an interaction. They can, however, be taken if a doctor has prescribed them. Consult a doctor if you have any of the following symptoms: excessive sleepiness, dizziness, confusion, or weak or rapid breathing. Do not discontinue any medication without consulting a doctor.
MidazolamBoceprevir
Critical
How does the drug interact with Isedaz Injection 10 ml:
Boceprevir and Isedaz Injection 10 ml co-administration may considerably enhance Isedaz Injection 10 ml blood levels and effects.

How to manage the interaction:
Although taking Boceprevir and Isedaz Injection 10 ml together may result in an interaction, they can be taken if prescribed by a doctor. Consult a doctor if you have excessive or prolonged sleepiness and breathing issues. Do not discontinue any medication without consulting a doctor.
MidazolamKetoconazole
Critical
How does the drug interact with Isedaz Injection 10 ml:
Co-administration of Ketoconazole and Isedaz Injection 10 ml may increase the risk of side effects.

How to manage the interaction:
Although taking Ketoconazole and Isedaz Injection 10 ml together is not recommended as it may result in an interaction, they can be taken if prescribed by a doctor. Consult a doctor if you have excessive or prolonged sleepiness and breathing issues. Do not discontinue any medication without consulting a doctor.
MidazolamIdelalisib
Critical
How does the drug interact with Isedaz Injection 10 ml:
Idelalisib and Isedaz Injection 10 ml co-administration may considerably enhance Isedaz Injection 10 ml blood levels and effects.

How to manage the interaction:
Although taking Idelalisib and Isedaz Injection 10 ml together may result in an interaction, they can be taken if prescribed by a doctor. Consult a doctor if you have excessive or prolonged sleepiness and breathing issues. Do not discontinue any medication without consulting a doctor.
MidazolamIndinavir
Critical
How does the drug interact with Isedaz Injection 10 ml:
Indinavir and Isedaz Injection 10 ml co-administration may considerably enhance Isedaz Injection 10 ml blood levels and effects.

How to manage the interaction:
Although taking Indinavir and Isedaz Injection 10 ml together may result in an interaction, they can be taken if prescribed by a doctor. Consult a doctor if you have excessive or prolonged sleepiness and breathing issues. Do not discontinue any medication without consulting a doctor.

Drug-Food Interactions

verifiedApollotooltip
  • Grapefruit: Grapefruit and grapefruit juice can interfere with how your body processes this medicine, potentially making its sedative effects last longer.
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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All Substitutes & Brand Comparisons

Habit Forming

Yes

Therapeutic Class

[SEDATIVE-HYPNOTIC DRUGS]

FAQs

Isedaz Injection is used to induce sedation and relieve anxiety and muscle tension. It is used to induce sleepiness during therapeutic procedures (like endoscopy or colonoscopy) or complicated medical tests known as procedural sedation.
Isedaz Injection contains Midazolam which works by increasing the activity of GABA (a chemical messenger in the brain that acts as a natural nerve-calming agent) that is involved in inducing drowsiness. Thus, it relaxes muscles, reduces anxiety and causes drowsiness.
You are not recommended to take Isedaz Injection with opioids as co-administration of these medicines as it may increase the risk of adverse effects such as difficulties in breathing, drowsiness or coma. Therefore, before using Isedaz Injection with any other medicines, please consult your doctor so that the dosage may be adjusted accordingly to use safely.
Yes, Isedaz Injection may cause dizziness, drowsiness or affect concentration and coordination. Therefore, it is recommended to avoid driving or any other activities that require mental alertness after taking Isedaz Injection. Also, it is an offence to drive if Isedaz Injection affects your ability to drive.
Yes, Isedaz Injection may cause physical dependence and withdrawal symptoms if used for prolonged periods. Therefore, do not stop treatment with Isedaz Injection suddenly. Your doctor will reduce the dose gradually to avoid withdrawal symptoms.
Isedaz Injection is not recommended for patients suffering from myasthenia gravis (severe muscle weakness) as it may worsen the condition. Therefore, inform your doctor if you have myasthenia gravis before taking Isedaz Injection.
Isedaz Injection is safe if used under the supervision of a doctor. Follow your doctor’s instructions carefully and inform your doctor if you experience any side effects.
Yes, Isedaz Injection is classified as a controlled substance due to its potential for abuse and dependence. Therefore, it should be used only under the supervision of a doctor and according to the prescribed dosage.
Yes, Isedaz Injection is a sedative. It is used to induce drowsiness, and relieve anxiety before minor surgical, dental, or other medical procedures.
Yes, Isedaz Injection contains midazolam, which is a type of benzodiazepine. Benzodiazepines are a class of sedative medications.
Yes, Isedaz Injection have analgesic properties. It inhibits pain (anaesthetic) during a medical test or procedure.
The common side effects of Isedaz Injection are redness, pain or swelling at the injection site, headache, drowsiness, dizziness, confusion, dry mouth, tiredness or muscle spasms. If any of these side effects persist or worsen, please consult your doctor.
Most patients experience temporary forgetfulness and will not remember the medical procedure. This is a normal and intended effect of the medicine. Talk to your doctor for more details.
No, you should not drive, operate machinery, or make important decisions for at least 24 hours after receiving this injection. Always arrange for someone to take you home safely. Talk to your doctor about post-procedure safety.
Elderly individuals are often more sensitive to the effects of this medicine. Doctors usually adjust the amount given and monitor them more closely. Talk to your doctor or pharmacist about these risks.
This medicine is generally not recommended during pregnancy unless absolutely necessary, as it can potentially harm the unborn baby. Talk to your doctor to discuss safer alternatives.
No, you must avoid alcohol for at least 24 hours after receiving this injection. Combining them can lead to dangerous sedation and severe breathing problems. Talk to your doctor for specific advice.
This medicine is often used for conscious sedation, meaning you remain relaxed and sleepy but can still respond to verbal cues, unlike the deep, unconscious state of general anaesthesia. Talk to your doctor about what to expect.
For most people, the main sedative effects wear off within a few hours, but traces of the medicine can remain in the body for up to 24 hours. Talk to your doctor if you experience prolonged drowsiness.

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Reference

  1. Electronic Medicines Compendium (EMC). Pil.5668 Patient Information Leaflet (PIL). Cheshire, UK: Datapharm; 2025. [Accessed on 02 Jun. 2026]Check here
  2. Electronic Medicines Compendium (EMC). Pil.3693 Patient Information Leaflet (PIL). Cheshire, UK: Datapharm; 2025. [Accessed on 02 Jun. 2026]Check here
  3. Midazolam Midazolam. 2023. [Accessed on 23 Apr 2026]Check here
  4. Proximagen, LLC. U.S. Food and Drug Administration. [Revised in May 2019] [Accessed on August 2022] docs/label/2019/211321s000lbl.pdfCheck here
  5. Chaves RG, Lamounier JA Breastfeeding and maternal medications. J Pediatr (Rio J). 2004;80(5 Suppl):S189-S198Check here
  6. Dundee, J.W., Halliday, N.J., Harper, K.W. et al. Midazolam. Drugs. [Revised in Oct 2012] [Accessed on August 2022]Check here
  7. NAYZILAM. Patient Leaflet. [Accessed on August 2022]Check here

Country of origin

INDIA

Manufacturer/Marketer address

49 Khasra No 53/2/1 Hasanpur Village I.P.Extn Delhi East Delhi Dl 110092 In
Other Info - ISE0006

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