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compositionComposition:ISOTRETINOIN-20MG
prescription
Prescription Medicine
info
Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

ISOTRETINOIN-20MG

Manufacturer/Marketer :

Oziel Pharmaceuticals Pvt Ltd

Consume Type :

Oral

Expires on or after :

Dec-28

Return Policy :

Not Returnable

About Isonise-20 Softgel Capsule 10's

Isonise-20 Softgel Capsule 10's is a prescription medication primarily used to treat severe, painful, and deep nodular acne. When other treatments like topical creams or oral antibiotics fail to clear your skin, doctors prescribe this medication to help control severe breakouts and prevent long-term damage. It works by targeting the root causes of severe acne to give you clearer skin.

During the first few weeks of treatment, some people may notice a temporary increase in acne breakouts, redness, or skin irritation. This initial flare happens as the medicine begins changing oil production and skin cell activity. It usually improves with continued treatment, but inform your doctor if the worsening is severe, painful, or difficult to manage.

To achieve the best results, you must take this medication consistently every day, typically once or twice daily as directed by your doctor. It is highly recommended to take this capsule with a meal containing healthy fats, as food significantly increases how well your body absorbs the medicine. Alongside your treatment, adopting a gentle skincare routine, staying hydrated, and avoiding harsh facial scrubs can help support your skin's healing process.

While this medication is highly effective, it is common to experience side effects such as dry skin, chapped lips, and dry eyes. However, you must contact your doctor immediately if you experience more serious issues, such as severe stomach pain, changes in your vision, or sudden changes in your mood or mental health.

Talk to your doctor before starting this treatment if you have a history of liver problems, high blood lipids, depression, or diabetes. Do not take this medicine if you are pregnant, planning to become pregnant, or breastfeeding, as it carries an extremely high risk of causing severe, life-threatening birth defects.

This medication can interact with other substances; for instance, you should avoid taking vitamin A supplements, certain tetracycline antibiotics, or consuming alcohol while on this treatment. If you are part of a specific group, such as the elderly or those with underlying metabolic conditions, consult your healthcare provider to discuss safe usage.

Uses of Isonise-20 Softgel Capsule 10's

Your doctor may prescribe this medicine to treat several conditions, including:

  • Severe nodular acne:  Isonise-20 Softgel Capsule 10's helps clear deep, painful lumps and cysts under the skin when other standard treatments, including oral antibiotics, do not work.
  • Acne scarring prevention: By rapidly clearing severe acne lesions, this medicine helps prevent permanent physical scarring and long-term skin texture damage.
  • Other uses: In some cases, doctors may prescribe Isonise-20 Softgel Capsule 10's for conditions other than severe acne, such as certain difficult-to-treat skin disorders including rosacea or hidradenitis suppurativa. These uses may be based on specialist judgment and are not the primary approved use of the medicine.
     

Key Benefits

Isonise-20 Softgel Capsule 10's provides powerful acne treatment by targeting severe breakouts and addressing the underlying causes of acne formation. By reducing oil production and preventing new lesions, this medicine offers several key health benefits:

  • Long-Lasting Control of Severe Acne: Isonise-20 Softgel Capsule 10's helps clear persistent, severe acne and may provide lasting improvement after completing a prescribed treatment course, reducing the need for continuous acne medications.
  • Relief from Painful Acne Lesions: By reducing deep, inflamed cysts and nodules, Isonise-20 Softgel Capsule 10's helps decrease skin tenderness, soreness, and discomfort caused by severe breakouts.
  • Prevention of New Acne Formation: Isonise-20 Softgel Capsule 10's helps interrupt the cycle of recurring breakouts, allowing the skin barrier to heal and reducing the likelihood of new severe acne lesions developing over time.
     

Directions for Use

Take  Isonise-20 Softgel Capsule 10's exactly as prescribed by your healthcare provider. Follow these simple steps for safe administration:

  • Swallow the capsule whole with a full glass of water. Do not chew, crush, or suck on the capsule.
  • Take this medicine with a high-fat meal or snack, as food significantly increases how well your body absorbs it.
  • Take your doses at the same time(s) each day to maintain a steady level of the medicine in your body.

Always follow your doctor's exact instructions regarding your daily dose and how long to continue the treatment. Do not adjust your dose or stop taking this medicine without consulting your healthcare provider first.
 

How Isonise-20 Softgel Capsule 10's Works

Isonise-20 Softgel Capsule 10's contains isotretinoin. It targets all four major causes of severe acne. First, it significantly shrinks the oil-producing glands (sebaceous glands) in your skin, reducing the amount of natural oil they produce. Less oil means fewer clogged pores where acne can start. Second, it slows down the rapid growth of skin cells inside your pores, preventing blockages that lead to blackheads and pimples. Third, by reducing the skin's oil content, it naturally starves and decreases the population of acne-causing bacteria. Finally, it calms the severe redness, swelling, and deep inflammation associated with painful nodular lesions.
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Alcohol

Unsafe

Avoid consumption of alcohol with Isonise-20 Softgel Capsule 10's as it may increase the risk of liver damage and cause a rise in cholesterol levels.

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Pregnancy

Unsafe

Isonise-20 Softgel Capsule 10's is a Category X pregnancy drug and is considered unsafe for pregnant women as it may cause severe birth defects. Please consult a doctor if you are pregnant or planning to become pregnant.

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Breast Feeding

Unsafe

Isonise-20 Softgel Capsule 10's may be excreted in breast milk and cause adverse effects in the baby. Please consult a doctor before using Isonise-20 Softgel Capsule 10's while breastfeeding.

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Driving

Caution

Isonise-20 Softgel Capsule 10's may reduce night vision in some patients. Therefore, drive only if you are alert after taking Isonise-20 Softgel Capsule 10's.

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Liver

Unsafe

Isonise-20 Softgel Capsule 10's is usually not recommended for patients with impaired liver function. If you have any concerns regarding the use of Isonise-20 Softgel Capsule 10's in patients with liver problems, please consult a doctor.

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Kidney

Consult your doctor

If you have any concerns regarding the use of Isonise-20 Softgel Capsule 10's in patients with kidney problems, please consult a doctor.

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Children

Unsafe

Isonise-20 Softgel Capsule 10's is not recommended for children below 12 years of age.

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Heart

Consult your doctor

If you have any concerns regarding the use of Isonise-20 Softgel Capsule 10's in patients with heart problems, please consult a doctor.

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Geriatrics

Consult your doctor

Limited information is available. Please consult your doctor.

What if I have taken an overdose of Isonise-20 Softgel Capsule 10's

Do not take more than the prescribed dose of Isonise-20 Softgel Capsule 10's as it may cause an overdose. The symptoms of overdose include vomiting, dizziness, headache, stomach pain, loss of balance or coordination, warmth or tingling in your face and swollen or cracked lips. If you suspect you have taken an overdose or notice signs of overdose, please consult a doctor immediately.

Diet & Lifestyle Advise

  • Avoid taking any vitamin A supplements or multivitamins containing Vitamin A, as this can cause a dangerous buildup of the vitamin in your body.
  • Protect your skin from the sun. Apply a broad-spectrum sunscreen with SPF 30 or higher daily, and wear protective clothing, as your skin will burn much faster.
  • Moisturise your skin, lips, and eyes daily. Use a thick, fragrance-free moisturiser, lip balm, and lubricating eye drops to manage dryness.
  • Avoid cosmetic skin treatments like waxing, chemical peels, or dermabrasion while taking this medicine and for at least six months after stopping, as your skin is highly fragile and may scar.
  • Stay well-hydrated by drinking plenty of water throughout the day to help manage dry skin and eyes.
     

Have a query?

How Soon It Starts Working

The time required for Isonise-20 Softgel Capsule 10's to start to work: Isonise-20 Softgel Capsule 10's ideally shows its action within 1 to 4 hours after administration. The time for which the effects of Isonise-20 Softgel Capsule 10's last: The effect of Isonise-20 Softgel Capsule 10's lasts for 5 days.

What if you forget to take Isonise-20 Softgel Capsule 10's

Skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for the missed one.

Storage

Store Isonise-20 Softgel Capsule 10's capsules at room temperature, between 68°F and 77°F (20°C to 25°C). •Keep the capsules in their original packaging to protect them from light and moisture.

Drug Warnings

  • Do not share this medicine with anyone else, even if they have similar severe acne symptoms, as it can cause severe harm, especially to unborn babies.
  • Do not donate blood while taking  Isonise-20 Softgel Capsule 10's and for at least one month after your final dose to ensure none of your blood is given to a pregnant woman.
  • Avoid consuming alcohol while on this medicine, as both alcohol and the medication are processed by the liver, and combining them increases the risk of liver damage.
  • Do not get pregnant while taking this medicine. Women of childbearing age must use two effective forms of birth control simultaneously and undergo monthly pregnancy tests before, during, and for one month after treatment.
  • Be cautious when driving or operating machinery at night, as this medicine can cause sudden decreases in night vision.
  • Do not use Isonise-20 Softgel Capsule 10's longer than prescribed. Regular follow-up appointments help your doctor decide how long treatment should continue and whether dose adjustments are needed.
  • Men taking Isonise-20 Softgel Capsule 10's should discuss contraception and family planning with their doctor. Although the risk to a partner is much lower than with pregnancy in women taking the medicine, avoiding pregnancy during treatment is still recommended.
  • Complete all recommended blood tests and follow-up visits during treatment, even if your acne is improving.
     

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Drug-Drug Interactions:

Inform your doctor if you are taking any of the following medicines, as they may interact.

  • Tetracycline antibiotics: Taking these with  Isonise-20 Softgel Capsule 10's increases the risk of high pressure inside the skull, which can cause severe headaches and vision loss.
  • Vitamin A supplements: Combining these can lead to additive toxic effects, similar to a severe Vitamin A overdose.
  • Progesterone-only birth control pills: This medicine may reduce the effectiveness of these specific contraceptives. Use two robust forms of birth control as directed.
  • Systemic corticosteroids: May increase the risk of bone loss or weak bones when combined.

Drug-Food Interactions:

  • High-fat meals: Taking  Isonise-20 Softgel Capsule 10's with fatty foods significantly increases its absorption and effectiveness. Do not take it on an empty stomach unless specifically instructed.

Drug-Disease Interactions:

Inform your doctor if you have a history of the following conditions before taking  Isonise-20 Softgel Capsule 10's, as it may worsen your condition or cause complications.

  • Liver disease: Do not take this medicine if you have severe liver impairment, as it can cause further liver damage.
  • High blood lipids: This medicine can increase blood fat levels (cholesterol and triglycerides). Your doctor will monitor your blood lipids closely if you have high cholesterol.
  • Depression or mental health conditions: Let your doctor know if you have a history of depression or mood disorders, as this medicine can occasionally worsen these conditions.
     

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[RETINOIDS]

FAQs

Isonise-20 Softgel Capsule 10's is used to treat a severe form of acne known as nodular acne that cannot be cleared by any other treatments, including antibiotics.

Isonise-20 Softgel Capsule 10's may cause decreased night vision temporarily or permanently in some patients. It is not necessary for everyone taking Isonise-20 Softgel Capsule 10's to experience this side effect. Avoid driving after taking Isonise-20 Softgel Capsule 10's if you are unable to see in the dark, and consult a doctor if you notice any changes in vision or have painful or persistent dry eyes.

Isonise-20 Softgel Capsule 10's may increase the skin sensitivity to sunlight. Therefore, avoid or limit exposure to sunlight and sunlamps. You are advised to use sunscreen and wear protective clothing while going out to prevent sunburn.

No, you are not recommended to undergo any cosmetic procedures to smoothen your skin, including waxing, laser procedures or dermabrasion (an exfoliating technique to remove outer layers of skin with a rotating instrument) while taking Isonise-20 Softgel Capsule 10's and for a minimum of 6 months after stopping treatment with Isonise-20 Softgel Capsule 10's, as it may increase the risk of scarring.

You are not recommended to take vitamin A supplements with Isonise-20 Softgel Capsule 10's as it may cause hypervitaminosis A (excessive levels of vitamin A in the body), leading to an increased risk of adverse effects. However, please consult a doctor before taking other medicines or supplements with Isonise-20 Softgel Capsule 10's.

Isonise-20 Softgel Capsule 10's is safe to use if prescribed by the doctor. Use Isonise-20 Softgel Capsule 10's exactly as advised by the doctor as it is associated with adverse effects.

Isonise-20 Softgel Capsule 10's is not a steroid. It is a retinoid used to treat severe nodular acne.

Pregnancy tests, lipid profile tests, liver function tests, blood glucose tests, and creatine phosphokinase (CPK) tests are recommended tests during Isonise-20 Softgel Capsule 10's treatment.

In most cases, the effect of Isonise-20 Softgel Capsule 10's is permanent. Isotretinoin is a clinically effective anti-acne therapy that shows significant improvement in many patients.

Isonise-20 Softgel Capsule 10's does not cause cancer. In fact, isotretinoin slows the growth of cancer cells by activating protein receptors in cells, including cancer cells.

Long-term use of Isonise-20 Softgel Capsule 10's, even in low doses, has not been studied and is not recommended. Hence, long-term side effects of Isonise-20 Softgel Capsule 10's have not been established.

Isonise-20 Softgel Capsule 10's is not known to affect male fertility.

Isonise-20 Softgel Capsule 10's might elevate liver enzymes. Therefore, regular liver function tests are advised.

Side effects of Isonise-20 Softgel Capsule 10's include chapped lips and dry skin, eyes, nose, or lips. These side effects may not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

No, you must not get pregnant while taking Isonise-20 Softgel Capsule 10's. It causes severe, life-threatening birth defects. Women who can get pregnant must use two effective forms of birth control and have regular pregnancy tests. Talk to your doctor if you have questions about birth control.

Taking Isonise-20 Softgel Capsule 10's with a meal, especially one containing healthy fats, helps your body absorb the medicine properly. If taken on an empty stomach, the medicine may not work as effectively. Talk to your doctor or pharmacist for specific meal advice.

Most people begin to notice improvement within 1 to 2 months of starting Isonise-20 Softgel Capsule 10's. During the first few weeks, your acne may temporarily become worse before it starts improving. This early flare is usually temporary, but you should inform your doctor if it becomes severe. A typical treatment course lasts about 4 to 6 months, although the duration may vary depending on your response and your doctor's advice.

It is highly recommended to avoid alcohol while taking Isonise-20 Softgel Capsule 10's. Both alcohol and this medicine are processed by your liver, and combining them increases the risk of liver damage and elevated blood fats. Talk to your doctor for advice.

No, you should avoid waxing, laser treatments, and chemical peels while taking Isonise-20 Softgel Capsule 10's and for at least six months after stopping. The medicine makes your skin highly fragile, increasing the risk of severe skin irritation, tearing, and scarring. Talk to your dermatologist.

Yes, dryness of the skin, lips, eyes, and nose is the most common side effect of Isonise-20 Softgel Capsule 10's. You can manage this by using thick moisturizers, lip balms, and lubricating eye drops regularly. Talk to your pharmacist for product recommendations.

No, you must not donate blood while taking Isonise-20 Softgel Capsule 10's and for at least one month after you stop taking it. This precaution prevents the risk of your blood being given to a pregnant woman, which could cause severe birth defects. Talk to your doctor for more information.

If you or your family notice any unusual mood changes, severe sadness, anxiety, or thoughts of self-harm while taking Isonise-20 Softgel Capsule 10's, stop taking the medicine immediately and contact your healthcare provider. Talk to your doctor right away if you experience these symptoms.

Yes, your doctor may recommend blood tests before and during treatment to monitor your liver function and blood fat levels such as cholesterol and triglycerides. Some patients may also require other tests depending on their health history. These checks help ensure that the medicine remains safe and appropriate for you.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Country of origin

India

Manufacturer/Marketer address

Pk-75, Sector 122, Noida, Uttar Pradesh 201301
Other Info - ISO0420
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