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compositionComposition:ISOSORBIDE DINITRATE-5MG
prescription
Prescription Medicine
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Isordril-5 Tablet 10's is used in the prevention of angina (heart-related chest pain) or heart failure. It contains Isosorbide dinitrate, which works by dilating, relaxing, and widening the constricted blood vessels, thereby increasing the blood and oxygen supply to the heart. Thus, it effectively helps prevent the risk of future heart attack and stroke in the future, especially in high blood pressure patients. It may cause common side effects such as headache (during initial days of therapy) and flushing (reddening of the skin, especially the face). Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.

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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

ISOSORBIDE DINITRATE-5MG

Manufacturer/Marketer :

Ipca Laboratories Ltd

Consume Type :

Oral

Expires on or after :

Jan-28

Return Policy :

Not Returnable

About Isordril-5 Tablet 10's

Isordril-5 Tablet 10's is a prescription oral medication used to prevent chest pain, also known as angina, in people with coronary artery disease. It works by relaxing blood vessels, which helps improve blood flow to the heart muscle. Please note that this oral form is designed to prevent chest pain episodes and should not be used to treat a sudden attack of chest pain.

To get the most benefit, you must take Isordril-5 Tablet 10's regularly and exactly as prescribed by your doctor, even if you feel well. You can take this tablet with or without food, but keeping your routine consistent daily is highly recommended. Combining this treatment with lifestyle changes like eating a heart-healthy diet low in salt and fat, maintaining a healthy weight, and quitting smoking can significantly support your heart health.

While taking Isordril-5 Tablet 10's, you may experience mild side effects, with headaches being the most common, especially when you first start. It is important to contact your doctor immediately if you experience severe dizziness, an unusually fast or slow heartbeat, or fainting.

Talk to your doctor before taking Isordril-5 Tablet 10's if you have low blood pressure, have recently had a heart attack, or have severe anaemia. Do not take this medicine if you are using medications for erectile dysfunction or pulmonary arterial hypertension (such as sildenafil, tadalafil, or vardenafil), as this can cause a life-threatening drop in blood pressure.

Consuming alcohol while taking Isordril-5 Tablet 10's can dangerously lower your blood pressure and increase dizziness, so it should be avoided. If you are pregnant, planning to become pregnant, breastfeeding, or are an older adult, consult your doctor to ensure this medication is safe for your specific situation.

Uses of Isordril-5 Tablet 10's

Isordril-5 Tablet 10's is used for the treatment of angina (heart-related chest pain). The detailed uses of this medicine are as follows:

  • Prevention of chest pain (angina pectoris): Isordril-5 Tablet 10's helps prevent episodes of chest pain caused by coronary artery disease by relaxing and widening the blood vessels, allowing blood to flow more easily to the heart.
  • Heart failure management: In some clinical cases, when combined with other specific heart medications, Isordril-5 Tablet 10's may be prescribed to help manage long-term heart failure by reducing the workload on the heart.

Key Benefits

  • Provides long-term support for your heart: Helps relax and widen your blood vessels, improving blood flow and reducing the workload on your heart when taken regularly as prescribed.
  • Helps prevent angina (chest pain): Reduces the frequency and severity of chest pain episodes, allowing you to carry out daily activities with greater comfort and confidence.
  • Supports better heart function: By reducing strain on the heart over time, it helps protect the heart during everyday activities and contributes to better long-term cardiovascular health. Continue taking the medicine as prescribed, even if you feel well.
Side effects of Isordril-5 Tablet
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
  • If you experience low blood pressure symptoms like dizziness, lightheadedness, or fainting while taking medication, seek immediate medical attention.
  • Make lifestyle modifications and adjust your medication regimen under medical guidance to manage low blood pressure.
  • As your doctor advises, regularly check your blood pressure at home. Record your readings to detect any changes and share them with your doctor.
  • Fluid intake plays a vital role in managing blood pressure by maintaining blood volume, regulating blood pressure, and supporting blood vessel function. Drinking enough fluids helps prevent dehydration, maintain electrolyte balance, and regulate fluid balance.
  • Take regular breaks to sit or lie down if you need to stand for long periods.
  • When lying down, elevate your head with extra pillows to help improve blood flow.
  • Avoid heavy exercise or strenuous activities that can worsen low blood pressure.
  • Wear compression socks as your doctor advises to enhance blood flow, reduce oedema, and control blood pressure.
  • If symptoms persist or worsen, or if you have concerns about your condition, seek medical attention for personalized guidance and care.
  • Wear compression garments like stockings, sleeves, or gloves to apply pressure and help stop fluid from building up, especially after the swelling goes down.
  • Move around and do exercises to help the fluid circulate, especially in swollen limbs. Ask your doctor for specific exercises.
  • Raise the swollen area above your heart level several times a day, even while sleeping, to help reduce swelling.
  • Gently massage the swollen area with firm but not painful pressure.
  • Keep the swollen area clean and moisturized to prevent injury and infection.
  • Reduce salt intake to help prevent fluid from building up and worsening the swelling, as advised by a doctor.
  • If the swelling does not get better after a few days of home treatment or worsens, consult your doctor right away.
Here are the 7 steps to manage Dizziness caused by medication:
  • Inform your doctor about dizziness symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Follow your doctor's instructions for taking medication, and take it at the same time every day to minimize dizziness.
  • When standing up, do so slowly and carefully to avoid sudden dizziness.
  • Avoid making sudden movements, such as turning or bending quickly, which can exacerbate dizziness.
  • Drink plenty of water throughout the day to stay hydrated and help alleviate dizziness symptoms.
  • If you're feeling dizzy, sit or lie down and rest until the dizziness passes.
  • Track when dizziness occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.

Directions for Use

To ensure you get the maximum benefit from Isordril-5 Tablet 10's, please follow these step-by-step instructions:

  • Swallow the tablet whole with a full glass of water. Do not crush, chew, or break the tablet, as this can affect how the medicine is released into your body.
  • Take this medication exactly at the times prescribed by your doctor. Your doctor may schedule your doses at specific intervals to include a 'nitrate-free' period, which helps prevent your body from becoming used to the drug (tolerance).
  • Do not suddenly stop taking this medicine without consulting your doctor, as this can cause your chest pain to return or worsen.
  • Always follow your doctor's exact instructions regarding your specific dose and schedule.

How Isordril-5 Tablet 10's Works

Isordril-5 Tablet 10's belongs to a group of medicines called nitrates. This medicine contains 'isosorbide dinitrate'. It works by releasing nitric oxide inside your blood vessels. Nitric oxide is a natural compound that signals the smooth muscles in your vessel walls to relax and widen. When these blood vessels dilate, it becomes much easier for blood and oxygen to reach your heart muscle. This dilation also reduces the amount of pressure the heart has to pump against, lowering its oxygen demand and directly preventing the chest pain that occurs when the heart muscle is overworked.
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Alcohol

Caution

Alcohol may worsen the condition by increasing the risk of side-effects. So, do not consume alcohol.

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Pregnancy

Caution

Isordril-5 Tablet 10's is a category C medicine and may cause harm to the fetus. It should be used in pregnant women if clinically needed and when benefits outweigh the risks.

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Breast Feeding

Caution

Isordril-5 Tablet 10's should be used with caution in breastfeeding mothers.

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Driving

Caution

Isordril-5 Tablet 10's may cause dizziness and affect your ability to drive. So, avoid driving or operating heavy machinery while using Isordril-5 Tablet 10's.

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Liver

Caution

Isordril-5 Tablet 10's should be used with caution in patients with liver diseases. Dose adjustments may be required in severe liver disease patient.

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Kidney

Caution

Isordril-5 Tablet 10's should be used with caution in patients with kidney diseases. Dose adjustments may be required.

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Children

Caution

$should not be used in children unless clinically needed. Dose adjustments may be necessary.

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Heart

Caution

Isordril-5 Tablet 10's is used with caution in cardiac patients and regular monitoring is required.

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Geriatrics

Safe if prescribed

Isordril-5 Tablet 10's is safe for use in elderly patients if prescribed by the physician.

What if I have taken an overdose of Isordril-5 Tablet 10's

If you suspect an overdose, call emergency services (112) immediately or go to the nearest emergency department. You can also contact your local poison control center for further guidance. Symptoms of an overdose may include a severe throbbing headache, confusion, fever, rapid heartbeat, vision changes, or excessive sweating. Do not wait for symptoms to worsen before seeking medical help.

Diet & Lifestyle Advise

  • Manage your standing pace: To prevent dizziness caused by low blood pressure, rise slowly from a sitting or lying position. Pause for a moment before standing up fully.
  • Follow a low-sodium diet: Reducing your salt intake helps lower blood pressure and decreases the strain on your heart.
  • Stay moderately active: Engage in gentle, doctor-approved exercise, such as walking, which helps strengthen your heart muscle. Avoid sudden, highly strenuous physical exertion.
  • Limit alcohol consumption: Alcohol can intensify the blood-pressure-lowering effect of Isordril-5 Tablet 10's, increasing your risk of dizziness and fainting.
  • Avoid smoking: Nicotine constricts blood vessels and worsens coronary artery disease, directly fighting against the benefits of this medication.
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Have a query?

How Soon It Starts Working

  • The time required for Isordril-5 Tablet 10's to start to work: Isordril-5 Tablet 10's ideally shows its action within 30 minutes after administration.
  • The time for which the effects of Isordril-5 Tablet 10's last: The effect of Isordril-5 Tablet 10's lasts for 4 to 6 hours.

What if you forget to take Isordril-5 Tablet 10's

If you miss a dose of Isordril-5 Tablet 10's, take it as soon as you remember. However, if your next scheduled dose is only a few hours away, skip the missed dose and resume your regular schedule. Do not take a double dose to make up for a missed one.

Storage

• Store in a cool and dry place away from sunlight. • Keep out of sight and reach of children. • Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.

Drug Warnings

  • Check for the nitrate-free interval: Ensure you understand your doctor's instructions about your daily 'nitrate-free' window, which is vital to keep the medicine working effectively.
  • Sit down if you feel dizzy: If you experience lightheadedness, sit or lie down immediately to prevent falls and fainting.
  • Do not use for sudden attacks: Remember that oral Isordril-5 Tablet 10's tablets are slow-acting and will not stop an active chest pain episode. Always keep your fast-acting rescue medication (such as sublingual nitroglycerin) with you if prescribed.
  • Check with your doctor before taking new drugs: Always consult your doctor before starting any over-the-counter cold, cough, or diet medications, as some can raise your blood pressure or interfere with your heart treatment.
  • Monitor your blood pressure: Keep a regular log of your blood pressure and heart rate readings, and share them with your healthcare provider during check-ups.

Drug-Drug Interactions

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Drug-Drug Interactions:

  • Erectile dysfunction medications (sildenafil, tadalafil, vardenafil): Taking these with Isordril-5 Tablet 10's can cause a severe, life-threatening drop in blood pressure. Do not take them together.
  • Blood pressure medications (beta-blockers, calcium channel blockers, diuretics): Combining these with Isordril-5 Tablet 10's may cause excessively low blood pressure, resulting in severe dizziness or fainting.
  • Certain depression medications (tricyclic antidepressants): These may increase the risk of low blood pressure when taken alongside Isordril-5 Tablet 10's.

Drug-Food Interactions:

  • Alcohol: Consuming alcohol can severely lower your blood pressure, leading to extreme dizziness, lightheadedness, and an increased risk of fainting.

Drug-Disease Interactions:

  • Low blood pressure (hypotension): Isordril-5 Tablet 10's can worsen severe hypotension, leading to poor oxygen delivery to vital organs.
  • Severe anemia: This medication should be used with extreme caution in patients with severe anemia, as it can worsen oxygen delivery to tissues.
  • Increased intracranial pressure: If you have a head injury or bleeding in the brain, Isordril-5 Tablet 10's may further increase pressure inside your skull.
Isosorbide dinitrateTadalafil
Critical
Isosorbide dinitrateSildenafil
Critical

Drug-Drug Interactions

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Isosorbide dinitrateTadalafil
Critical
How does the drug interact with Isordril-5 Tablet:
Taking Tadalafil with Isordril-5 Tablet can increase the risk or severity of low blood pressure.

How to manage the interaction:
Taking Isordril-5 Tablet with Tadalafil is not recommended, but it can be taken together if prescribed by a doctor. However, consult a doctor if you experience dizziness, or heart palpitations. Do not discontinue any medications without consulting a doctor.
Isosorbide dinitrateSildenafil
Critical
How does the drug interact with Isordril-5 Tablet:
Coadministration of Isordril-5 Tablet and Sildenafil can increase the risk of low blood pressure.

How to manage the interaction:
Taking Isordril-5 Tablet and Sildenafil together is generally avoided as it can lead to an interaction, it can be taken only if advised by your doctor. However, if you experience dizziness, lightheadedness, fainting, headache, flushing, heart palpitations, and priapism (prolonged and painful erection unrelated to sexual activity) contact your doctor immediately. Do not discontinue any medications without first consulting your doctor.
Isosorbide dinitrateRiociguat
Critical
How does the drug interact with Isordril-5 Tablet:
Taking Riociguat with Isordril-5 Tablet may lead to excessively low blood pressure.

How to manage the interaction:
Taking Isordril-5 Tablet with Riociguat is not recommended, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience dizziness, lightheadedness, fainting, headache, flushing, heart palpitations, priapism in males (persistent and painful erection unrelated to sexual activity). Do not discontinue any medications without consulting a doctor.
Isosorbide dinitrateAvanafil
Critical
How does the drug interact with Isordril-5 Tablet:
Taking Avanafil with Isordril-5 Tablet can cause low blood pressure.

How to manage the interaction:
Taking Isordril-5 Tablet with Avanafil is not recommended, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience dizziness, lightheadedness, fainting, headache, flushing, heart palpitations, priapism in males (persistent and painful erection unrelated to sexual activity). Do not discontinue any medications without consulting a doctor.
Isosorbide dinitrateSodium nitrite
Severe
How does the drug interact with Isordril-5 Tablet:
Taking Isordril-5 Tablet with sodium nitrite may cause methemoglobinemia (blood disorder in which too little oxygen is delivered to your cells).

How to manage the interaction:
Although taking Isordril-5 Tablet and sodium nitrite together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you develop gray discoloration of the skin, abnormal blood coloration, nausea, headache, dizziness, lightheadedness, fatigue, shortness of breath, rapid or shallow breathing, a rapid heartbeat, palpitation, anxiety, or confusion. Do not stop using any medications without consulting doctor.
Isosorbide dinitrateCabergoline
Severe
How does the drug interact with Isordril-5 Tablet:
Taking Isordril-5 Tablet with cabergoline can increase the effects of Cabergoline.

How to manage the interaction:
Although taking Isordril-5 Tablet and cabergoline together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as headache, dizziness, lightheadedness, fainting, and/or changes in pulse or heart rate. Do not stop using any medications without consulting doctor.
Isosorbide dinitrateRopivacaine
Severe
How does the drug interact with Isordril-5 Tablet:
Taking Isordril-5 Tablet with ropivacaine may cause methemoglobinemia (blood disorder in which too little oxygen is delivered to your cells).

How to manage the interaction:
Although taking Isordril-5 Tablet and ropivacaine together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you develop gray discoloration of the skin, abnormal blood coloration, nausea, headache, dizziness, lightheadedness, fatigue, shortness of breath, rapid or shallow breathing, a rapid heartbeat, palpitation, anxiety, or confusion. Do not stop using any medications without consulting doctor.
Isosorbide dinitrateBupivacaine
Severe
How does the drug interact with Isordril-5 Tablet:
Combining Bupivacaine with Isordril-5 Tablet can increase the risk of methemoglobinemia(a rare condition that can lead to oxygen deprivation in tissues and vital organs due to reduced oxygen-carrying capacity of the blood).

How to manage the interaction:
Co-administration of Bupivacaine with Isordril-5 Tablet can result in an interaction, but it can be taken if your doctor has advised it. However, if you experience any symptoms like grey discolouration of the skin, abnormal blood colouration, nausea, headache, dizziness, lightheadedness, fatigue, shortness of breath, rapid or shallow breathing, a rapid heartbeat, palpitation, anxiety, confusion, consult a doctor right away. Do not stop using any medications without a doctor's advice.
Isosorbide dinitrateErgotamine
Severe
How does the drug interact with Isordril-5 Tablet:
Taking Isordril-5 Tablet together with ergotamine can increase the effects of ergotamine.

How to manage the interaction:
Although taking Isordril-5 Tablet and ergotamine together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience an irregular heartbeat, nausea, vomiting, weakness, or coldness, numbness, chest pain or pain in the hands, feet, arms, or legs. Do not discontinue any medications without consulting a doctor.
Isosorbide dinitrateCabergoline
Severe
How does the drug interact with Isordril-5 Tablet:
Coadministration of Isordril-5 Tablet and cabergoline may decrease your blood pressure.

How to manage the interaction:
Co-administration of Isordril-5 Tablet with Cabergoline can result in an interaction, but it can be taken if your doctor has advised it. If you notice any of these signs - headache, dizziness, feeling lightheaded, or fainting, contact your doctor immediately. Do not stop using any medications without talking to your doctor.

Drug-Food Interactions

verifiedApollotooltip
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

No

Therapeutic Class

[ANTIANGINALS]

FAQs

Isordril-5 Tablet 10's is used to prevent angina (heart-related chest pain) or heart failure.
Isordril-5 Tablet 10's is a 'vasodilator' and can prevent angina effectively. It works by relaxing the muscles of blood vessels. It helps to dilate the narrowed blood vessels resulting in increased blood and oxygen supply to the heart. This prevents heart-related chest pain known as angina.
No, oral Isordril-5 Tablet 10's tablets are designed for long-term prevention of chest pain, not for treating sudden attacks. For quick relief during an active angina episode, you must use a fast-acting rescue medication as prescribed by your doctor. Talk to your doctor if you do not have a rescue medication.
Isordril-5 Tablet 10's may decrease blood pressure (hypotension). So it should not be used in patients with severe hypotension.
Lisinopril is a medication used to treat high blood pressure. Using Isordril-5 Tablet 10's with lisinopril may cause a decrease in blood pressure (hypotension). So, consult your doctor before taking other medications while using Isordril-5 Tablet 10's.
Use of Isordril-5 Tablet 10's together with sildenafil is not recommended as it may cause a sudden decrease in blood pressure leading to loss of consciousness, even leading to coma stage.
Isordril-5 Tablet 10's is given for heart-related chest pain (angina), a life-long or chronic disease, especially in high blood pressure patients and coronary heart disease (CAD). So, do not stop taking Isordril-5 Tablet 10's even if you feel better. It would be best if you took Isordril-5 Tablet 10's until your doctor tells you to stop.
Isordril-5 Tablet 10's is sometimes used only when needed, you may not be on a dosing schedule. If you are on a schedule, take the missed dose as soon as you remember or if it's nearly time for your next dose, skip your missed dose. Do not use extra medicine to make up a missed dose.
Isordril-5 Tablet 10's is not typically used to treat a heart attack. However, it can help manage angina, which can be a symptom of an underlying heart condition. In the event of a heart attack, it's crucial to seek immediate medical attention. Call emergency services or go to the hospital right away.
Isordril-5 Tablet 10's works by relaxing and widening blood vessels, which can lead to reduced blood pressure and increased blood flow. However, this can also trigger a reflexive response, causing increased heart rate (tachycardia). As a result, while Isordril-5 Tablet 10's can help alleviate angina symptoms, it may not lower heart rate and might even increase it in some cases.
Yes, Isordril-5 Tablet 10's can lower blood pressure. It works by relaxing and widening blood vessels, which decreases the pressure on the heart and allows blood to flow more easily. This can result in a reduction in blood pressure. Please consult your doctor before taking Isordril-5 Tablet 10's.
Headaches are a very common side effect because Isordril-5 Tablet 10's dilates (widens) blood vessels throughout your body, including those in your head. These headaches usually become less severe and happen less often as your body adapts to the medicine. Talk to your doctor if the headaches are severe or do not go away.
A nitrate-free interval is a period of several hours during the day (usually at night) when you do not take Isordril-5 Tablet 10's. This break prevents your body from building up a tolerance to the drug, ensuring that it remains highly effective at preventing chest pain. Talk to your doctor to understand your specific dosing schedule.
If you feel dizzy or lightheaded, sit or lie down immediately to prevent falling. To help prevent this sensation, try rising very slowly from a sitting or lying position. If the dizziness is severe or continues to happen, talk to your doctor.

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Country of origin

India

Manufacturer/Marketer address

142 Ab, Kandivli Industrial Estate, Kandivli (West), Mumbai - 400 067, Maharashtra.
Other Info - ISO0408
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