What is the use of Isorus Tablet ?

Isorus Tablet is used to treat heart failure, a condition that occurs when the heart does not pump enough blood for the body's needs.

How does Isorus Tablet work?

Isorus Tablet relaxes the heart's muscles and widens the heart's veins and arteries for easy flow of blood to every part of our body. It helps lower raised blood pressure by relaxing and widening the heart's muscles.

Can I stop taking Isorus Tablet if I feel well?

No, keep using the Isorus Tablet as advised by your doctor, even if you feel well. Stopping the Isorus Tablet suddenly may lead to serious complications of heart failure.

Can the use of Isorus Tablet causes dizziness?

Yes, the use of Isorus Tablet can make you feel dizzy. This may often occur when you suddenly rise from a sitting or lying position. To lower the chance of feeling dizzy (faint) or passing out, rise slowly if you have been lying down or sitting.

Are there any special instructions regarding the storage and disposal of this medicine?

Keep this medicine tightly closed in the container or the original packaging. Store it according to the instructions mentioned on the pack or label. Dispose of unused medicine. Make sure pets, children, and other people do not consume it.

Can the use of Isorus Tablet cause headache?

Isorus Tablet may cause headache in some individuals, as it is reported as a common side effect. However, this effect does not require medical attention and gradually resolves over time. If this side effect persists longer, please consult your doctor.

How should I take Isorus Tablet ?

Take Isorus Tablet with or without food, accompanied by a glass of water. Swallow the medicine whole, without chewing, breaking, or crushing it. Follow your doctor's instructions for dose and duration, and complete the entire prescribed course.

What are the common side effects of Isorus Tablet ?

The common side effects of the Isorus Tablet that may occur in some individuals are headache, nausea, dizziness, and lightheadedness (a fainting sensation). Most of these side effects of Isorus Tablet do not require medical attention and gradually resolve over time. However, if these side effects persist longer, please consult your doctor.

Can I consume alcohol while taking Isorus Tablet ?

No, it is advisable not to drink alcohol while taking Isorus Tablet . Drinking alcohol during treatment may cause increased dizziness and drowsiness, or it may cause unpleasant side effects.

Are there any precautions or warnings associated with Isorus Tablet ?

Yes, there are some precautions or warnings associated with Isorus Tablet . Exercise caution while using this medication and it is not advisable for individuals with low blood pressure. Pregnant or breastfeeding women should consult their doctor before use. Additionally, it may cause dizziness, so driving after taking this medication is not recommended.

What should I do if I miss a dose of Isorus Tablet ?

If you miss a dose of Isorus Tablet , take it as soon as you remember. However, if it's close to your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Never take a double dose to make up for a missed one.

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Written By Santoshini Reddy G , M Pharmacy

Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Isorus Tablet is used to treat heart failure. It contains Isosorbide dinitrate and Hydralazine, which relaxes the heart's muscles and widens the heart's veins and arteries for easy flow of blood to every part of the body. Thus, it helps lower raised blood pressure and treat heart failure. It may cause side effects like headache, nausea, dizziness, and lightheadedness (feeling faint). Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.

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About Isorus Tablet

Isorus Tablet belongs to a group of medicines called vasodilators used to treat heart failure. Heart failure occurs when the heart muscle does not pump blood normally, including shortness of breath, swollen legs, fatigue and increased heartbeat.

Isorus Tablet contains Isosorbide dinitrate and Hydralazine. Isosorbide dinitrate relaxes the heart's muscles and widens the heart's veins and arteries for easy flow of blood to every part of the body. Hydralazine helps lower raised blood pressure by relaxing and widening the heart's muscles.

In some cases, Isorus Tablet can cause side effects like headache, nausea, dizziness, and lightheadedness. Most of these side effects of Isorus Tablet do not require medical attention and gradually resolve over time. However, if these side effects persist longer, please consult your doctor.

If you are known to be allergic to Isorus Tablet or any other medicines, please inform your doctor. Before taking Isorus Tablet , let your doctor know if you have had a heart attack within the last 30 days, low blood pressure, stroke (inadequate blood supply in the brain that causes damage to the brain), or high pressure within the brain.

Uses of Isorus Tablet

Isorus Tablet is used for the treatment of heart failure. The detailed uses of Isorus Tablet are as follows:

Angina pectoris treatment: Isorus Tablet helps to relieve angina pectoris symptoms by widening blood vessels and improving blood flow to the heart, reducing chest pain.
Prevention of angina attacks: Isorus Tablet can be administered to prevent the occurrence of angina attacks, especially during physical activity or stressful situations.
Management of heart failure: Isorus Tablet helps to manage heart failure symptoms by reducing the heart workload and improving blood flow, often used alongside other medications for better heart function.

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Directions for Use

Isorus Tablet can be taken with or without food, as advised by your doctor.
It is usually taken 3 times daily or as prescribed by your doctor.
Swallow Isorus Tablet as a whole with a glass of water.
Do not crush, chew, or break it.

Medicinal Benefits

Isorus Tablet belongs to a group of vasodilators used to treat heart failure.
Isorus Tablet contains Isosorbide dinitrate and Hydralazine. Isosorbide dinitrate belongs to a group of drugs known as nitrates.
Isosorbide dinitrate relaxes the heart's muscles and stretches or enlarges the heart's veins and arteries.
Hydralazine belongs to a group of drugs known as vasodilators, which help lower raised blood pressure by relaxing and widening the heart's blood vessels.

How Isorus Tablet Works

Isorus Tablet contains Isosorbide dinitrate and Hydralazine. Isosorbide dinitrate relaxes the heart's muscles and widens the heart's veins and arteries for easy flow of blood to every part of the body. Hydralazine helps lower raised blood pressure by relaxing and widening the heart's muscles. Together, Isorus Tablet helps treat heart failure.

Storage

• Store in a cool and dry place away from sunlight. • Keep out of sight and reach of children. • Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.

Side effects of Isorus Tablet

Nausea

Overcome Medication-Induced Nausea: A 9-Step Plan

Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
Divide your daily food intake into smaller, more frequent meals to reduce nausea.
Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
Use ginger (tea, ale, or candies) to help relieve nausea.
Get adequate rest and also avoid strenuous activities that can worsen nausea.
Talk to your doctor about taking anti-nausea medication if your nausea is severe.
Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.

Headache

Dealing with Medication-Induced Headache:

Hydrate your body: Drink enough water to prevent dehydration and headaches.
Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
Take rest: lie down in a quiet, dark environment.
Cold or warm compresses can help reduce tension.
Stay Upright: Maintain good posture to keep symptoms from getting worse.
To treat headaches naturally, try acupuncture or massage therapy.
Over-the-counter pain relievers include acetaminophen and ibuprofen.
Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
Frequent Headaches: If you get reoccurring headaches, consult your doctor.
Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.

Dizziness

Here are the 7 steps to manage Dizziness caused by medication:

Inform your doctor about dizziness symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
Follow your doctor's instructions for taking medication, and take it at the same time every day to minimize dizziness.
When standing up, do so slowly and carefully to avoid sudden dizziness.
Avoid making sudden movements, such as turning or bending quickly, which can exacerbate dizziness.
Drink plenty of water throughout the day to stay hydrated and help alleviate dizziness symptoms.
If you're feeling dizzy, sit or lie down and rest until the dizziness passes.
Track when dizziness occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.

Weakness

Rest well; get enough sleep.
Eat a balanced diet and drink enough water.
Manage stress with yoga and meditation.
Limit alcohol and caffeine.
Physical activities like walking or jogging might help boost energy and make you feel less tired.

Burning Or Tingling Sensation

Change positions or take a break from activity to relieve symptoms.
Avoid postures that put a lot of pressure on just one area of the body.
If you have vitamin deficiency, take supplements or change your diet.
Exercise regularly like cycling, walking or swimming.
Avoid sitting with your legs crossed.
Clench and unclench your fists and wiggle your toes.
Massage the affected area.

Rapid Heart Rythm In Lower Chambers

Low Blood Pressure

Managing Low Blood Pressure Triggered by Medication: Expert Advice:

If you experience low blood pressure symptoms like dizziness, lightheadedness, or fainting while taking medication, seek immediate medical attention.
Make lifestyle modifications and adjust your medication regimen under medical guidance to manage low blood pressure.
As your doctor advises, regularly check your blood pressure at home. Record your readings to detect any changes and share them with your doctor.
Fluid intake plays a vital role in managing blood pressure by maintaining blood volume, regulating blood pressure, and supporting blood vessel function. Drinking enough fluids helps prevent dehydration, maintain electrolyte balance, and regulate fluid balance.
Take regular breaks to sit or lie down if you need to stand for long periods.
When lying down, elevate your head with extra pillows to help improve blood flow.
Avoid heavy exercise or strenuous activities that can worsen low blood pressure.
Wear compression socks as your doctor advises to enhance blood flow, reduce oedema, and control blood pressure.
If symptoms persist or worsen, or if you have concerns about your condition, seek medical attention for personalized guidance and care.

What if I have taken an overdose of Isorus Tablet

Do not take more than the prescribed dose of Isorus Tablet as it may cause serious adverse effects. If you suspect you have taken overdose, please consult a doctor immediately.

Drug Warnings

Do not take Isorus Tablet if you are allergic to any of its components.
Do not take Isorus Tablet if you have low blood pressure because even a low dose of Isorus Tablet may cause your blood pressure to drop.
If you are pregnant or planning any pregnancy, let your doctor know about this before taking Isorus Tablet as it crosses the placenta and can affect the unborn baby (fetus).
Do not drive while using this Isorus Tablet because it can cause dizziness that may lead to an accident.
You may experience tingling or numbness, so your doctor may prescribe a vitamin B6 supplement (pyridoxine).
Hydralazine passes into breast milk, so its use in lactating mothers should be avoided.

Drug-Drug Interactions

Isosorbide dinitrateSildenafil

Critical

Isosorbide dinitrateTadalafil

Critical

Drug-Drug Interactions

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Isosorbide dinitrateSildenafil

Critical

How does the drug interact with Isorus Tablet:
Coadministration of Isorus Tablet and Sildenafil can increase the risk of low blood pressure.

How to manage the interaction:
Taking Isorus Tablet and Sildenafil together is generally avoided as it can lead to an interaction, it can be taken only if advised by your doctor. However, if you experience dizziness, lightheadedness, fainting, headache, flushing, heart palpitations, and priapism (prolonged and painful erection unrelated to sexual activity) contact your doctor immediately. Do not discontinue any medications without first consulting your doctor.

Isosorbide dinitrateTadalafil

Critical

How does the drug interact with Isorus Tablet:
Taking Tadalafil with Isorus Tablet can increase the risk or severity of low blood pressure.

How to manage the interaction:
Taking Isorus Tablet with Tadalafil is not recommended, but it can be taken together if prescribed by a doctor. However, consult a doctor if you experience dizziness, or heart palpitations. Do not discontinue any medications without consulting a doctor.

Isosorbide dinitrateAvanafil

Critical

How does the drug interact with Isorus Tablet:
Taking Avanafil with Isorus Tablet can cause low blood pressure.

How to manage the interaction:
Taking Isorus Tablet with Avanafil is not recommended, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience dizziness, lightheadedness, fainting, headache, flushing, heart palpitations, priapism in males (persistent and painful erection unrelated to sexual activity). Do not discontinue any medications without consulting a doctor.

Isosorbide dinitrateRiociguat

Critical

How does the drug interact with Isorus Tablet:
Taking Riociguat with Isorus Tablet may lead to excessively low blood pressure.

How to manage the interaction:
Taking Isorus Tablet with Riociguat is not recommended, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience dizziness, lightheadedness, fainting, headache, flushing, heart palpitations, priapism in males (persistent and painful erection unrelated to sexual activity). Do not discontinue any medications without consulting a doctor.

Isosorbide dinitrateLevobupivacaine

Severe

How does the drug interact with Isorus Tablet:
Taking Isorus Tablet with levobupivacaine may cause methemoglobinemia (blood disorder in which too little oxygen is delivered to your cells).

How to manage the interaction:
Although taking Isorus Tablet and levobupivacaine together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you develop gray discoloration of the skin, abnormal blood coloration, nausea, headache, dizziness, lightheadedness, fatigue, shortness of breath, rapid or shallow breathing, a rapid heartbeat, palpitation, anxiety, or confusion. Do not stop using any medications without consulting doctor.

Isosorbide dinitrateBupivacaine

Severe

How does the drug interact with Isorus Tablet:
Combining Bupivacaine with Isorus Tablet can increase the risk of methemoglobinemia(a rare condition that can lead to oxygen deprivation in tissues and vital organs due to reduced oxygen-carrying capacity of the blood).

How to manage the interaction:
Co-administration of Bupivacaine with Isorus Tablet can result in an interaction, but it can be taken if your doctor has advised it. However, if you experience any symptoms like grey discolouration of the skin, abnormal blood colouration, nausea, headache, dizziness, lightheadedness, fatigue, shortness of breath, rapid or shallow breathing, a rapid heartbeat, palpitation, anxiety, confusion, consult a doctor right away. Do not stop using any medications without a doctor's advice.

Isosorbide dinitrateRopivacaine

Severe

How does the drug interact with Isorus Tablet:
Taking Isorus Tablet with ropivacaine may cause methemoglobinemia (blood disorder in which too little oxygen is delivered to your cells).

How to manage the interaction:
Although taking Isorus Tablet and ropivacaine together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you develop gray discoloration of the skin, abnormal blood coloration, nausea, headache, dizziness, lightheadedness, fatigue, shortness of breath, rapid or shallow breathing, a rapid heartbeat, palpitation, anxiety, or confusion. Do not stop using any medications without consulting doctor.

Isosorbide dinitrateLidocaine

Severe

How does the drug interact with Isorus Tablet:
Taking Isorus Tablet with lidocaine may cause methemoglobinemia (blood disorder in which too little oxygen is delivered to your cells).

How to manage the interaction:
Although taking Isorus Tablet and lidocaine together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you develop gray discoloration of the skin, abnormal blood coloration, nausea, headache, dizziness, lightheadedness, weakness, shortness of breath, rapid or shallow breathing, a rapid heartbeat, palpitation, anxiety, or confusion. Do not stop using any medications without consulting doctor.

Isosorbide dinitrateCabergoline

Severe

How does the drug interact with Isorus Tablet:
Taking Isorus Tablet with cabergoline can increase the effects of Cabergoline.

How to manage the interaction:
Although taking Isorus Tablet and cabergoline together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as headache, dizziness, lightheadedness, fainting, and/or changes in pulse or heart rate. Do not stop using any medications without consulting doctor.

Isosorbide dinitrateChloroprocaine

Severe

How does the drug interact with Isorus Tablet:
Taking Isorus Tablet with chloroprocaine may cause methemoglobinemia (blood disorder in which too little oxygen is delivered to your cells).

How to manage the interaction:
Although taking Isorus Tablet and chloroprocaine together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you develop gray discoloration of the skin, abnormal blood coloration, nausea, headache, dizziness, lightheadedness, fatigue, shortness of breath, rapid or shallow breathing, a rapid heartbeat, palpitations, anxiety, or confusion. Do not stop using any medications without consulting doctor.

Drug-Food Interactions

No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

Follow a cholesterol-lowering diet.
Consume low salt and a low-fat diet.
Exercise regularly. It helps in maintaining proper weight and lowers cholesterol.
Limit salt and sugar intake.
Avoid smoking and alcohol consumption.
Choose healthy fats and cut down on trans fat.
Include omega-3 fatty acids, fibre-rich food, fruits, and vegetables.
Get active by doing physical activities such as swimming, brisk walking, or jogging. Take the stairs instead of elevators/lifts.

Habit Forming

No

Therapeutic Class

VASODILATORS

Alcohol

Unsafe

Consuming alcohol with the Isorus Tablet is not advisable as it may cause unpleasant side effects, or you may become more sensitive to the effects of alcohol.