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Isryl-Trio 2 mg Tablet 10's is used to treat type-2 diabetes mellitus as an add-on to diet and exercise. It helps control high blood sugar levels when lifestyle measures alone are not sufficient, thereby improving overall glycaemic control. Regular use supports better blood sugar management and helps reduce the risk of long-term complications associated with diabetes.

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Written By Dr. Lakshmithulasi Yarragunta , PharmD (PB)
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

DAPAGLIFLOZIN-10MG+GLIMEPIRIDE-2MG+METFORMIN-1000MG

Manufacturer/Marketer :

Systopic Laboratories Pvt Ltd

Consume Type :

Oral

Expires on or after :

Jan-28

Return Policy :

Not Returnable

About Isryl-Trio 2 mg Tablet 10's

Isryl-Trio 2 mg Tablet 10's is a prescription tablet used to manage high blood sugar in adults with Type 2 diabetes mellitus. It is typically prescribed when single or double medicine therapies are not enough to keep blood sugar levels within a healthy range. By controlling blood sugar, this medication helps prevent serious long-term health complications.

For this medicine to work effectively, you must take it consistently every day, exactly as prescribed by your doctor. It is usually taken once daily with your first main meal of the day to lower the risk of stomach upset. Along with taking Isryl-Trio 2 mg Tablet 10's, maintaining a balanced, low-sugar diet and engaging in regular exercise are essential steps to achieve the best results.

While taking Isryl-Trio 2 mg Tablet 10's, you may experience some common side effects like mild nausea or an increased need to urinate. However, you should contact your doctor immediately if you notice serious symptoms such as severe dizziness, extreme fatigue, breathing difficulties, or signs of low blood sugar. Regular monitoring of your blood sugar levels can help you spot these issues early.

Do not take this if you have severe kidney disease, advanced liver damage, or if you are experiencing diabetic ketoacidosis. It is also not suitable for individuals with Type 1 diabetes. Always discuss your complete medical history with your healthcare provider before starting this treatment.

Certain medicines, as well as drinking alcohol, can interact with Isryl-Trio 2 mg Tablet 10's and increase your risk of developing dangerously low blood sugar or a serious condition called lactic acidosis. If you are pregnant, planning to become pregnant, breastfeeding, or are over 65 years old, consult your doctor or pharmacist to ensure this medicine is safe for you.

Uses of Isryl-Trio 2 mg Tablet 10's

  • Type 2 Diabetes Mellitus: Isryl-Trio 2 mg Tablet 10's is used to improve blood sugar control in adults whose high blood glucose levels are not adequately managed by diet, exercise, and other single or dual-drug diabetes therapies.

Key Benefits

  • Helps control high blood sugar through the combined action of three medicines that work in different ways.
  • Provides comprehensive blood sugar control throughout the day, including after meals.
  • Simplifies diabetes treatment by combining three medicines into a single tablet, making it easier to follow your prescribed treatment.
  • Helps maintain stable blood sugar levels, reducing daily fluctuations that can affect your energy and well-being.
  • Supports long-term diabetes management when used regularly along with a healthy diet and exercise.
  • Reduces the risk of diabetes-related complications, such as kidney disease, nerve damage, and vision problems.
  • Helps protect the heart and blood vessels, lowering the risk of cardiovascular complications such as heart attack and stroke.
  • Promotes better overall health and quality of life by helping keep blood sugar within your target range.

Directions for Use

  • Take Isryl-Trio 2 mg Tablet 10's with food to reduce stomach upset or gastrointestinal side effects.
  • Recommended to take it once daily in the morning or as advised by your doctor.
  • Swallow the medicine as a whole with a glass of water.
  • Do not crush, break, or chew it.

How Isryl-Trio 2 mg Tablet 10's Works

Isryl-Trio 2 mg Tablet 10's combines three active ingredients namely, Glimepiride, metformin, and dapaglifloxin. Glimepiride: This component works by stimulating the pancreas to release more insulin, which is the natural hormone that helps your body process sugar. Metformin: This ingredient reduces the amount of sugar produced by your liver and makes your muscles more sensitive to insulin, helping your body use the sugar in your bloodstream more efficiently. Dapagliflozin: This active helper works through your kidneys. It prevents your kidneys from absorbing sugar back into your bloodstream, allowing the excess sugar to leave your body through your urine.
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Alcohol

Unsafe

Alcohol increases the impact of metformin on lactate metabolism. Hence, you should not consume excessive amounts of alcohol, either temporarily or permanently, while taking Isryl-Trio 2 mg Tablet 10's.

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Pregnancy

Consult your doctor

There are no adequate studies on the effect of Isryl-Trio 2 mg Tablet 10's in pregnancy. If you are pregnant or planning pregnancy, inform your doctor before taking Isryl-Trio 2 mg Tablet 10's.

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Breast Feeding

Consult your doctor

Isryl-Trio 2 mg Tablet 10's is generally not recommended in breastfeeding. Hence, if you are breastfeeding, inform your doctor before using Isryl-Trio 2 mg Tablet 10's.

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Driving

Caution

Isryl-Trio 2 mg Tablet 10's usually does not affect your ability to drive or operate machinery.

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Liver

Caution

Isryl-Trio 2 mg Tablet 10's may cause lactic acidosis due to metformin accumulation. The risk increases with hepatic insufficiency. Your doctor may adjust the dose of this medicine or prescribe a suitable alternative based on your condition.

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Kidney

Caution

Renal impairment also increases the risk of lactic acidosis. Hence, Isryl-Trio 2 mg Tablet 10's should be used cautiously if you have kidney problems. Your doctor may adjust the dose of this medicine or prescribe a suitable alternative based on your condition.

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Children

Unsafe

Isryl-Trio 2 mg Tablet 10's is not recommended for children below 18 years as the safety and effectiveness were not established.

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Heart

Caution

Take Isryl-Trio 2 mg Tablet 10's with caution, especially if you have a history of heart disease. Inform your doctor before receiving the Isryl-Trio 2 mg Tablet 10's if you have a history of heart diseases/conditions. Your doctor will prescribe only if the benefits outweigh the risks.

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Geriatrics

Caution

Isryl-Trio 2 mg Tablet 10's should be used with caution in elderly patients. Please consult your doctor before use.

What if I have taken an overdose of Isryl-Trio 2 mg Tablet 10's

If you take too much of this medicine, you may experience severe low blood sugar or a dangerous build-up of acid in your blood. If you suspect an overdose, seek emergency medical care immediately or call your local poison control center.

Diet & Lifestyle Advise

  • Choose complex carbohydrates: Focus on whole grains, vegetables, and legumes, which release sugar slowly into your bloodstream, preventing sudden blood sugar spikes.
  • Stay active: Aim for at least 150 minutes of moderate exercise, like brisk walking, per week. Physical activity helps your body use insulin more effectively.
  • Stay hydrated: Drink plenty of water throughout the day. Because one of the active ingredients helps remove sugar through urine, staying hydrated prevents dehydration and supports kidney health.
  • Practice daily foot care: Inspect your feet daily for cuts, blisters, or redness. Diabetes can reduce blood flow and nerve sensitivity in your feet, making early detection of injuries vital.
  • Monitor your blood sugar: Keep a regular log of your blood glucose levels as advised by your doctor to track how well your treatment plan is working.
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Have a query?

How Soon It Starts Working

The time required for Isryl-Trio 2 mg Tablet 10's to start to work: Isryl-Trio 2 mg Tablet 10's ideally shows its action within few hours after administration. 

The time for which the effects of Isryl-Trio 2 mg Tablet 10's last: The duration of action for Isryl-Trio 2 mg Tablet 10's is clinically unknown.

What if you forget to take Isryl-Trio 2 mg Tablet 10's

If you miss a dose of Isryl-Trio 2 mg Tablet 10's, take it with food as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and resume your normal schedule. Do not take two doses at the same time to make up for a missed one.

Storage

• Store Isryl-Trio 2 mg Tablet 10's tablets at room temperature, ideally between 20°C to 25°C (68°F to 77°F).

Drug Warnings

  • Always carry a quick-acting source of sugar, such as glucose tablets, fruit juice, or hard candy, in case you experience sudden symptoms of low blood sugar.
  • Ensure your kidney function is checked by your doctor via routine blood tests before starting and periodically during your treatment with Isryl-Trio 2 mg Tablet 10's.
  • Be aware that this medicine can cause your urine to test positive for glucose; inform any healthcare professional performing lab tests that you are taking this medication.
  • Limit your intake of alcohol while taking this medicine, as alcohol can dramatically increase the risk of severe low blood sugar and lactic acidosis.
  • If you are scheduled for a major surgery or an imaging test that requires contrast dye, talk to your doctor, as you may need to temporarily stop taking Isryl-Trio 2 mg Tablet 10's.
  • Pay close attention to sudden dizziness when standing up, which can occur due to mild blood pressure drops caused by increased urination.

verifiedApollotooltip
  • Diuretics (water pills): Taking these with Isryl-Trio 2 mg Tablet 10's may increase the risk of dehydration and low blood pressure.
  • Insulin or other sulfonylureas: Combining these can significantly increase your risk of experiencing low blood sugar (hypoglycemia).
  • Heart and blood pressure medicines (like ACE inhibitors or beta-blockers): These may alter how your body responds to sugar or mask the physical warning signs of low blood sugar.
  • Corticosteroids: These medications can raise blood sugar levels, potentially reducing the effectiveness of Isryl-Trio 2 mg Tablet 10's.

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  • Alcohol: Avoid heavy drinking or routine alcohol consumption, as it severely increases the risk of lactic acidosis and dangerously low blood sugar levels.

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[ANTIDIABETICS]

FAQs

Isryl-Trio 2 mg Tablet 10's is used for the treatment of Type II Diabetes.
Isryl-Trio 2 mg Tablet 10's contains Dapagliflozin, Metformin, and Glimepiride, which work by increasing the amounts of certain natural substances that lower blood sugar when it is high.
Please consult your doctor if you have concerns and for more information on this.
If you forget to take Isryl-Trio 2 mg Tablet 10's, take it as soon as you remember. However, if it is time for the next dose, avoid taking it and do not double dose to make up for the missed dose. Taking an overdose might cause your sugar level to fall down rapidly.
No, it is highly recommended to take Isryl-Trio 2 mg Tablet 10's with your first main meal of the day. Taking it with food helps reduce common stomach-related side effects such as nausea, indigestion, or abdominal discomfort. Talk to your doctor or pharmacist if you struggle to take it with meals.
Some of the active components in Isryl-Trio 2 mg Tablet 10's, specifically dapagliflozin and metformin, may help with modest weight loss as they encourage the removal of excess sugar through urine and improve how your body uses insulin. However, this medicine is not a weight loss product and should only be used to manage Type 2 diabetes. Talk to your doctor to learn more.
If you experience symptoms like shakiness, sweating, dizziness, or a fast heartbeat, consume 15 to 20 grams of fast-acting sugar immediately (such as fruit juice, non-diet soda, or glucose tablets). Check your blood sugar after 15 minutes, and if it remains low, repeat the process. Talk to your doctor if you experience frequent low blood sugar episodes.
No, you should avoid or heavily limit alcohol while taking Isryl-Trio 2 mg Tablet 10's. Alcohol increases your risk of developing severe low blood sugar and a rare but life-threatening condition called lactic acidosis. Talk to your doctor or pharmacist about safe lifestyle choices while on this medication.
This medicine is generally not recommended during pregnancy or while breastfeeding. Other blood sugar-lowering medications, such as insulin, are typically preferred during these periods. Talk to your doctor to discuss safer alternatives for managing your blood sugar during pregnancy.
The active components in Isryl-Trio 2 mg Tablet 10's begin lowering your blood sugar within a few hours of your first dose. However, it may take several weeks of consistent use, alongside diet and lifestyle modifications, to see a stable improvement in your long-term blood sugar levels. Talk to your doctor if you do not notice an improvement.
Yes, one of the active ingredients in Isryl-Trio 2 mg Tablet 10's helps your body eliminate excess sugar through your urine, which can increase the risk of genital yeast infections or urinary tract infections due to the presence of sugar in the urinary tract. Maintaining good personal hygiene and staying hydrated can help lower this risk. Talk to your doctor if you experience symptoms like itching, redness, or burning.
Lactic acidosis is a rare but very serious condition caused by a build-up of lactic acid in the blood, which can occur due to one of the ingredients in Isryl-Trio 2 mg Tablet 10's. The risk is higher in people with severe kidney or liver issues, or those who consume excessive alcohol. If you experience symptoms like unusual muscle pain, trouble breathing, or extreme tiredness, seek medical help immediately. Talk to your doctor about your risk factors.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Reference

  1. U.S. Food and Drug Administration (FDA). 202293S020Lbl [FDA Prescribing Information]. Silver Spring, MD: FDA; 2024. [Accessed on 02 Jun. 2026]Check here
  2. Drugs.com Clinical Review Team. Metformin Clinical Drug Monograph. Auckland, NZ: Drugs.com; 2026. [Accessed on 02 Jun. 2026]Check here
  3. Rx Farma Limited. Electronic Medicines Compendium (EMC). [Revised in July 2022] [Accessed on 5th September 2024]Check here
  4. Brown & Burk UK Limited. Electronic Medicines Compendium (EMC). [Revised in December 2020] [Accessed on 5th September 2024]Check here
  5. AstraZeneca UK Limited. Electronic Medicines Compendium (EMC). [Revised in November 2022] [Accessed on 5th September 2024]Check here
  6. CDSCO. Dapagliflozin… 5 mg/5 mg/10 mg/10 mg + Metformin HCL (extended release) …. 500mg/1000mg/500mg/1000mg. October 2017. [Accessed on 5th September 2024]Check here

Country of origin

India

Manufacturer/Marketer address

Systopic Laboratories Pvt. Ltd., 101, Pragati Chambers, Commercial Complex, Ranjit Nagar, New Delhi-110008.
Other Info - ISR0019
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