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  3. Istamet D-IR 5/50/1000 Tablet 7's

Istamet D-IR 5/50/1000 Tablet 7's, Pack of 7 TabletS
Istamet D-IR 5/50/1000 Tablet 7's, Pack of 7 TabletS
Istamet D-IR 5/50/1000 Tablet 7's, Pack of 7 TabletS
Istamet D-IR 5/50/1000 Tablet 7's, Pack of 7 TabletS
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Composition :

DAPAGLIFLOZIN-5MG + METFORMIN-1000MG + SITAGLIPTIN-50MG

Manufacturer/Marketer :

Sun Pharmaceutical Industries Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Istamet D-IR 5/50/1000 Tablet

Istamet D-IR 5/50/1000 Tablet is an antidiabetic medicine used to treat Type II Diabetes. In type 2 diabetes, the pancreas does not produce enough insulin, or the body is unable to use insulin effectively. As a result, blood sugar levels become elevated.

Istamet D-IR 5/50/1000 Tablet contains Dapagliflozin, Sitagliptin, and Metformin. It works by removing excess sugar from the body through urine, increasing the levels of certain natural substances that lower blood sugar when it is high, reducing sugar production by cells in the liver, and delaying sugar absorption from the intestines.

Take Istamet D-IR 5/50/1000 Tablet as advised by your doctor. Istamet D-IR 5/50/1000 Tablet may cause certain side effects such as vomiting, nausea, abdominal pain, headache and stomach upset. Most of these side effects do not need medical attention and resolve over time. If these side effects persist or worsen, please consult your doctor.

Do not take Istamet D-IR 5/50/1000 Tablet if you are allergic to any of its components. Inform your doctor about your medical history and the medicines you are taking, including herbs and supplements, before starting the treatment with Istamet D-IR 5/50/1000 Tablet. Let your doctor know if you are pregnant or breastfeeding before taking Istamet D-IR 5/50/1000 Tablet. It is not recommended for use in children below 18 years of age.

Uses of Istamet D-IR 5/50/1000 Tablet

Istamet D-IR 5/50/1000 Tablet is used in the treatment of Type II Diabetes Mellitus. The detailed uses of Istamet D-IR 5/50/1000 Tablet are as follows:
• Type 2 Diabetes Management: Istamet D-IR 5/50/1000 Tablet is used to improve blood sugar control in adults with type 2 diabetes. It combines three agents that work together to reduce glucose production, enhance insulin response, and promote glucose excretion through urine.
• Cardiovascular and Kidney Protection: Istamet D-IR 5/50/1000 Tablet helps lower the risk of heart failure and diabetic kidney disease by improving vascular function, reducing albuminuria, and supporting healthy blood pressure levels.
• Weight and Metabolic Control: Istamet D-IR 5/50/1000 Tablet supports weight loss and improves metabolic health by reducing excess glucose and enhancing insulin sensitivity, making it beneficial for overweight or obese diabetic patients.
• HbA1c Reduction and Glycemic Stability: Istamet D-IR 5/50/1000 Tablet effectively lowers HbA1c levels and helps maintain steady blood sugar throughout the day, reducing the risk of hypoglycemia and long-term complications.

Directions for Use

  • Take Istamet D-IR 5/50/1000 Tablet with food to reduce stomach upset or gastrointestinal side effects.
  • Follow your doctor's instructions on the dosage and timing of this medication to ensure safety.
  • Swallow the medicine as a whole with a glass of water.
  • Do not crush, break, or chew it.

Medicinal Benefits

  • Istamet D-IR 5/50/1000 Tablet is a combination of three antidiabetic medicines: Sitagliptin, Dapagliflozin, and Metformin, used in the management of Type 2 Diabetes Mellitus, along with proper diet and exercise.
  • Sitagliptin is a dipeptidyl peptidase-4 (DPP-4) inhibitor that helps increase insulin release and decrease glucagon levels in the body, lowering blood sugar levels when they are high.
  • Dapagliflozin, a sodium-glucose co-transporter 2 (SGLT2) inhibitor, works by removing excess glucose through the urine, thereby lowering blood sugar levels.
  • Metformin is a biguanide which reduces the amount of sugar produced by the liver and delays glucose absorption from the intestine.
  • It improves the body’s sensitivity to insulin, promoting better glucose uptake by muscles and tissues.
  • The combined effect of these three drugs offers multi-targeted control of blood sugar levels, especially in patients not controlled by single or dual therapy.
  • Istamet D-IR 5/50/1000 Tablet helps manage blood glucose levels and prevents diabetes-related complications, such as eye problems, nerve problems, and kidney impairment.

How Istamet D-IR 5/50/1000 Tablet Works

Istamet D-IR 5/50/1000 Tablet contains Dapagliflozin, Sitagliptin, and Metformin. Dapagliflozin removes excess sugar from the body via urine. Sitagliptin works by increasing the amounts of certain natural substances that lower blood sugar when it is high. Metformin works by reducing the sugar production by cells in the liver and delaying sugar absorption from the intestines.

Storage

Store in a cool and dry place away from sunlight

What if I have taken an overdose of Istamet D-IR 5/50/1000 Tablet

Please do not exceed the recommended dose, as it might cause an overdose. Signs and symptoms of an overdose of Istamet D-IR 5/50/1000 Tablet may include low blood sugar, stomach pains, feeling or being sick (nausea or vomiting), feeling dizzy and worried. Seek immediate medical attention if you observe these symptoms or think you might have taken too much. Do this even if there are no signs of discomfort or poisoning.

Drug Warnings

  • Istamet D-IR 5/50/1000 Tablet should be avoided if you are allergic to any of the components in it.
  • Before starting treatment, inform your doctor about your medical history and the medications you are taking, including any herbs and supplements. This can help prevent unwanted effects.
  • Istamet D-IR 5/50/1000 Tablet is not recommended for use in patients with severe liver or kidney disease.
  • Consult your doctor if you are pregnant or breastfeeding.
  • It is not recommended for use in children below 18 years of age.
  • Avoid drinking alcohol while on Istamet D-IR 5/50/1000 Tablet as it increases the risk of hypoglycemia and lactic acidosis (when the lactic acid increases in the body, which impacts the functioning of various organs in the body).

Drug-Drug Interactions

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SitagliptinGatifloxacin
Critical
DapagliflozinGatifloxacin
Critical

Drug-Drug Interactions

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SitagliptinGatifloxacin
Critical
How does the drug interact with Istamet D-IR 5/50/1000 Tablet:
Co-administration of Istamet D-IR 5/50/1000 Tablet with Gatifloxacin may sometimes affect blood glucose levels. Both high blood glucose and, less frequently, low blood glucose have been reported.

How to manage the interaction:
Taking Istamet D-IR 5/50/1000 Tablet with Gatifloxacin is not recommended as it can lead to a possible interaction, However, it can be taken if advised by the doctor. Consult the prescriber if you experience symptoms such as nervousness, confusion, headache, dizziness, drowsiness, tremors, nausea, hunger, weakness, perspiration, palpitation, rapid heartbeat, increased urination, increased thirst, and increased hunger. Maintaining blood glucose levels is advised. Do not stop using any medications without a doctor's advice.
DapagliflozinGatifloxacin
Critical
How does the drug interact with Istamet D-IR 5/50/1000 Tablet:
Co-administration of Istamet D-IR 5/50/1000 Tablet with Gatifloxacin may sometimes affect blood glucose levels. Both low blood glucose and, less frequently, high blood glucose have been reported.

How to manage the interaction:
Although there is a possible interaction, Gatifloxacin can be taken with Istamet D-IR 5/50/1000 Tablet if prescribed by the doctor. Consult the prescriber if you experience symptoms such as nervousness, confusion, headache, dizziness, drowsiness, tremor, nausea, hunger, weakness, perspiration, palpitation, rapid heartbeat, increased urination, increased thirst, and increased hunger. Maintaining blood glucose levels is advised. Do not discontinue the medication without consulting a doctor.
MetforminMetrizamide
Critical
How does the drug interact with Istamet D-IR 5/50/1000 Tablet:
Co-administration of Istamet D-IR 5/50/1000 Tablet with Metrizamide together can cause the risk of lactic acidosis (when the body produces too much lactic acid ).

How to manage the interaction:
Taking Istamet D-IR 5/50/1000 Tablet with Metrizamide is generally avoided as it can possibly result in an interaction, it can be taken if a doctor has advised it. However, if you experience headaches, muscle cramps or pain, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
MetforminIopanoic acid
Critical
How does the drug interact with Istamet D-IR 5/50/1000 Tablet:
Co-administration of Iopanoic acid with Istamet D-IR 5/50/1000 Tablet can increase the risk of side effects.

How to manage the interaction:
Taking Istamet D-IR 5/50/1000 Tablet with Iopanoic acid is not recommended, please consult your doctor before taking it.
MetforminIodixanol
Critical
How does the drug interact with Istamet D-IR 5/50/1000 Tablet:
Co-administration of Iodixanol with Istamet D-IR 5/50/1000 Tablet can increase the risk of side effects.

How to manage the interaction:
Taking Istamet D-IR 5/50/1000 Tablet with Iodixanol is not recommended, please consult a doctor before taking it. Do not discontinue the medications without consulting a doctor.
MetforminIoversol
Critical
How does the drug interact with Istamet D-IR 5/50/1000 Tablet:
Co-administration of Ioversol with Istamet D-IR 5/50/1000 Tablet can increase the risk of side effects.

How to manage the interaction:
Taking Istamet D-IR 5/50/1000 Tablet with Ioversol is not recommended, please consult your doctor before taking it.
MetforminIopentol
Critical
How does the drug interact with Istamet D-IR 5/50/1000 Tablet:
Co-administration of Iopentol with Istamet D-IR 5/50/1000 Tablet can increase the risk of side effects.

How to manage the interaction:
Taking Istamet D-IR 5/50/1000 Tablet with Iopentol is not recommended, please consult your doctor before taking it.
MetforminIobenzamic acid
Critical
How does the drug interact with Istamet D-IR 5/50/1000 Tablet:
Co-administration of Istamet D-IR 5/50/1000 Tablet and Iobenzamic acid can increase the risk of lactic acidosis (when the body produces too much lactic acid).

How to manage the interaction:
Taking Istamet D-IR 5/50/1000 Tablet with Iobenzamic acid is generally avoided as it can result in an interaction, please consult your doctor before taking it.
MetforminIocarmic acid
Critical
How does the drug interact with Istamet D-IR 5/50/1000 Tablet:
Co-administration of Istamet D-IR 5/50/1000 Tablet and Iocarmic acid can increase the risk of lactic acidosis (when the body produces too much lactic acid).

How to manage the interaction:
Taking Istamet D-IR 5/50/1000 Tablet with Iocarmic acid is generally avoided as it can result in an interaction. please consult your doctor before taking it.
MetforminIotroxic acid
Critical
How does the drug interact with Istamet D-IR 5/50/1000 Tablet:
Co-administration of Iotroxic acid with Istamet D-IR 5/50/1000 Tablet can increase the risk of side effects.

How to manage the interaction:
Taking Istamet D-IR 5/50/1000 Tablet with Iotroxic acid is not recommended, please consult your doctor before taking it.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Try doing 30 minutes of moderate-intensity physical activity or one hour and 15 minutes of high-intensity exercise weekly.
  • Include whole-grain foods, fruits and veggies, and other fibre-enriched foods.
  • Add omega-3 fatty acid-containing oils for daily cooking.
  • Avoid too much stress, as it may elevate your blood sugar level. To control stress-related blood sugar changes, you can adopt stress management techniques like mindfulness, meditation, or yoga.
  • Weight loss gradually to achieve a healthy body mass index (18.5 to 24.9).
  • Keep your blood pressure as normal (140/90) as possible, as it reduces the risk of cardiovascular diseases in diabetes patients.
  • Avoid smoking and alcohol consumption while on treatment with Istamet D-IR 5/50/1000 Tablet.
  • Take short, frequent meals, and avoid prolonged fasting when taking Istamet D-IR 5/50/1000 Tablet.

Habit Forming

No

Therapeutic Class

ANTIDIABETICS

Istamet D-IR 5/50/1000 Tablet Substitute

Substitutes safety advice

Product Substitutes

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Alcohol

Unsafe

Alcohol increases the impact of metformin on lactate metabolism. Hence, you should not consume excessive amounts of alcohol, either temporarily or permanently, while taking Istamet D-IR 5/50/1000 Tablet.

bannner image

Pregnancy

Consult your doctor

There are no adequate studies on the effect of Istamet D-IR 5/50/1000 Tablet in pregnancy. If you are pregnant or planning pregnancy, inform your doctor before taking Istamet D-IR 5/50/1000 Tablet.

bannner image

Breast Feeding

Caution

Istamet D-IR 5/50/1000 Tablet is generally not recommended in breastfeeding. Hence, if you are breastfeeding, inform your doctor before using Istamet D-IR 5/50/1000 Tablet.

bannner image

Driving

Safe

Istamet D-IR 5/50/1000 Tablet usually does not affect your ability to drive or operate machinery.

bannner image

Liver

Caution

Use Istamet D-IR 5/50/1000 Tablet with caution, as lactic acidosis can occur due to metformin accumulation. The risk increases with hepatic insufficiency. Your doctor may adjust the dose of this medicine or prescribe a suitable alternative based on your condition.

bannner image

Kidney

Caution

Renal impairment also increases the risk of lactic acidosis. Hence, Istamet D-IR 5/50/1000 Tablet should be used with caution if you have kidney problems. Your doctor may adjust the dose of this medicine or prescribe a suitable alternative based on your condition.

bannner image

Children

Unsafe

Istamet D-IR 5/50/1000 Tablet is not recommended for children below 18 years as the safety and effectiveness were not established.

Have a query?

FAQs

Istamet D-IR 5/50/1000 Tablet is used to treat type II diabetes mellitus, a condition wherein the body doesn't use insulin effectively, which causes unusual blood glucose levels.

Istamet D-IR 5/50/1000 Tablet is a combination medicine containing Sitagliptin that enhances glucose-mediated insulin secretion, thereby reducing fasting and post-prandial blood sugar concentrations. Dapagliflozin helps remove excess sugar from the body via urine. Metformin helps reduce the sugar production by cells in the liver and delays sugar absorption from the intestines.

If you forget to take Istamet D-IR 5/50/1000 Tablet, take it as soon as you remember. However, if it's time for the next dose, avoid taking it and do not double-dose to make up the missed dose. Taking an overdose might cause your sugar level to fall rapidly.

Istamet D-IR 5/50/1000 Tablet may cause certain side effects such as vomiting, nausea, abdominal pain, headache and allergic reactions. If these side effects persist or worsen, please consult your doctor.

Country of origin

India

Manufacturer/Marketer address

Sun Pharmaceutical Industries Ltd., Sun House, Cts No. 201 B/1, Western Express Highway, Goregaon (E), Mumbai 400063
Other Info - IST0057

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Author Details

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jul 17, 2025 | 2:53 PM IST

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Reference

  1. https://www.accessdata.fda.gov/drugsatfda_docs/label/2012/022044s022lbl.pdf
  2. https://medlineplus.gov/druginfo/meds/a606023.html
  3. https://www.accessdata.fda.gov/drugsatfda_docs/label/2020/202293s020lbl.pdf
  4. https://www.drugs.com/metformin.html
  5. https://www.nhs.uk/medicines/sitagliptin/about-sitagliptin/#:~:text=Sitagliptin%20is%20prescribed%20for%20people,is%20only%20available%20on%20prescription.

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