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compositionComposition:GLIMEPIRIDE-1MG+METFORMIN-1000MG+SITAGLIPTIN-50MG
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Istamet G-IR 50/1000/1 Tablet is an antidiabetic medicine used to treat type II diabetes. It works by reducing the sugar production by cells in the liver, delaying sugar absorption from the intestine, increasing the amounts of certain natural substances that lower blood sugar and stimulating beta cells in the pancreas that produce insulin, which helps to remove sugar from the blood. Inform your doctor if you are pregnant, breastfeeding, taking other medicines or have pre-existing medical conditions.

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Written By Dr. Lakshmithulasi Yarragunta , PharmD (PB)
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

GLIMEPIRIDE-1MG+METFORMIN-1000MG+SITAGLIPTIN-50MG

Manufacturer/Marketer :

Sun Pharmaceutical Industries Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Istamet G-IR 50/1000/1 Tablet

Istamet G-IR 50/1000/1 Tablet is an oral medicine prescribed to help adults manage type 2 diabetes. Its primary medical purpose is to lower high blood sugar levels when single or double-drug treatments are no longer sufficient. By keeping your blood sugar in a safe range, this medicine helps prevent severe long-term complications.

For this medication to work best, you must take it consistently and exactly as prescribed. It is usually taken daily with meals to reduce the chances of experiencing an upset stomach. Combining this medication with healthy lifestyle choices, such as a balanced diet and regular physical activity, will significantly improve your overall results.

While taking Istamet G-IR 50/1000/1 Tablet , some people may experience mild side effects like an upset stomach, mild nausea, or low blood sugar. If you experience severe side effects, such as intense abdominal pain, persistent vomiting, or signs of liver damage, contact your doctor immediately. Do not ignore these symptoms, as they require prompt medical evaluation.

Do not take this medicine if you have severe kidney disease, liver failure, or diabetic ketoacidosis. Before starting this treatment, always tell your doctor if you have a history of heart failure, pancreas problems, or thyroid disorders. This allows your doctor to make sure the medicine is safe for your specific health profile.

This medicine can interact with alcohol and certain prescription medicines. The metformin component increases the risk of a rare but serious condition called lactic acidosis, particularly with excessive alcohol intake or reduced kidney function. The glimepiride component may increase the risk of low blood sugar, and drinking alcohol can make this risk more unpredictable. If you are pregnant, breastfeeding, or elderly, talk to your doctor or pharmacist before using this medicine, as special precautions may be needed.

Uses of Istamet G-IR 50/1000/1 Tablet

Istamet G-IR 50/1000/1 Tablet is used in the treatment of Type II Diabetes Mellitus. The detailed uses of Istamet G-IR 50/1000/1 Tablet are as follows:

  • Type 2 Diabetes Mellitus: Istamet G-IR 50/1000/1 Tablet is used to improve blood sugar control in adults with type 2 diabetes when diet, exercise, and other single or dual-component medicines do not provide adequate control.

Key Benefits

  • Helps lower and control high blood sugar by the combined action of three medicines that work in different ways.
  • Keeps blood sugar within a healthy range, helping you feel better in your day-to-day life.
  • Reduces symptoms of high blood sugar, such as tiredness, excessive thirst, and frequent urination.
  • Provides long-term blood sugar control when taken regularly along with a healthy diet and exercise.
  • Helps reduce the risk of diabetes-related complications, including kidney damage, nerve damage, vision problems, and heart disease.
  • Supports better overall health by helping maintain stable blood sugar levels over time.
  • Combines three diabetes medicines into one tablet, making your treatment simpler and more convenient.
  • Improves treatment adherence by reducing the number of tablets you need to take each day, making it easier to follow your prescribed treatment plan.
Side effects of Istamet G-IR 50/1000/1 Tablet
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
  • Drink water or other clear fluids.
  • To prevent worsening of pain, limit intake of tea, coffee, or alcohol.
  • Include bland foods like rice, toast, crackers, and rice in your diet.
  • Avoid lying down immediately after eating as it may cause indigestion or heartburn.
  • Avoid acidic and spicy food as it may cause indigestion.
  • If you experience low blood sugar levels, inform your doctor. They will assess the severity and make recommendations for the next actions.
  • Your doctor will assess your symptoms, blood sugar levels, and overall health before recommending the best course of action, which may include treatment, lifestyle modifications, or prescription adjustments.
  • Follow your doctor's instructions carefully to manage the episode and adjust your treatment plan.
  • Make medication adjustments as recommended by your doctor to prevent future episodes.
  • Implement diet and lifestyle modifications as your doctor advises to manage low blood sugar levels.
  • Monitor your blood sugar levels closely for patterns and changes.
  • Track your progress by recording your blood sugar levels, food intake, and physical activity.
  • Seek further guidance from your doctor if symptoms persist or worsen so that your treatment plan can be revised.

Directions for Use

  • Take Istamet G-IR 50/1000/1 Tablet with food to reduce stomach upset or gastrointestinal side effects.
  • Recommended to take it once daily in the morning or as advised by your doctor.
  • Swallow the medicine as a whole with a glass of water.
  • Do not crush, break, or chew it.

How Istamet G-IR 50/1000/1 Tablet Works

The three active ingredients in Istamet G-IR 50/1000/1 Tablet work together in different ways to control blood sugar, providing comprehensive management of type 2 diabetes. Glimepiride works by stimulating your pancreas to release more of your body's natural insulin, especially after meals. Insulin helps move sugar from your bloodstream into your body's cells, where it is used for energy. Metformin mainly works by reducing the amount of sugar produced by your liver. It also improves your body's sensitivity to insulin, allowing your muscles and other tissues to use glucose more effectively. Sitagliptin works by blocking an enzyme called DPP-4, which increases the levels of natural hormones known as incretins. These hormones help your pancreas release more insulin when blood sugar is high and reduce the amount of sugar released by the liver after meals.
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Alcohol

Unsafe

Alcohol increases the impact of metformin on lactate metabolism. Hence, you should not consume excessive amounts of alcohol, either temporarily or permanently, while taking Istamet G-IR 50/1000/1 Tablet .

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Pregnancy

Caution

There are no adequate studies on the effect of Istamet G-IR 50/1000/1 Tablet in pregnancy. If you are pregnant or planning pregnancy, inform your doctor before taking Istamet G-IR 50/1000/1 Tablet .

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Breast Feeding

Caution

Istamet G-IR 50/1000/1 Tablet is generally not recommended in breastfeeding. Hence, if you are breastfeeding, inform your doctor before using Istamet G-IR 50/1000/1 Tablet .

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Driving

Safe

Istamet G-IR 50/1000/1 Tablet usually does not affect your ability to drive or operate machinery.

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Liver

Caution

Istamet G-IR 50/1000/1 Tablet may cause lactic acidosis due to metformin accumulation. The risk increases with hepatic insufficiency. Your doctor may adjust the dose of this medicine or prescribe a suitable alternative based on your condition.

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Kidney

Caution

Renal impairment also increases the risk of lactic acidosis. Hence, Istamet G-IR 50/1000/1 Tablet should be used cautiously if you have kidney problems. Your doctor may adjust the dose of this medicine or prescribe a suitable alternative based on your condition.

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Children

Unsafe

Istamet G-IR 50/1000/1 Tablet is not recommended for children below 18 years, as the safety and effectiveness have not been established.

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Heart

Caution

Take Istamet G-IR 50/1000/1 Tablet with caution, especially if you have a history of heart disease. Inform your doctor before receiving the Istamet G-IR 50/1000/1 Tablet if you have a history of heart diseases/conditions. Your doctor will prescribe only if the benefits outweigh the risks.

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Geriatrics

Caution

Istamet G-IR 50/1000/1 Tablet should be used with caution in elderly patients. Please consult your doctor before use.

What if I have taken an overdose of Istamet G-IR 50/1000/1 Tablet

If you take more than your prescribed dose, seek immediate emergency medical care or call a poison control center right away. An overdose can cause severe low blood sugar (hypoglycemia) or a life-threatening chemical buildup in the blood called lactic acidosis. Symptoms may include extreme weakness, confusion, rapid breathing, or loss of consciousness.

Diet & Lifestyle Advise

  • Focus on a diet rich in high-fiber vegetables, whole grains, and lean proteins, while avoiding simple sugars, sweetened drinks, and processed carbohydrates.
  • Engage in regular, moderate physical exercise, such as walking, swimming, or cycling, for at least 150 minutes per week to help your body use insulin more efficiently.
  • Check your blood sugar levels regularly at home and keep a log of the readings to share with your healthcare team during visits.
  • Always carry a fast-acting source of sugar, such as glucose tablets, fruit juice, or hard candies, to quickly treat sudden episodes of low blood sugar.
  • Stay well-hydrated throughout the day by drinking plenty of water, which helps your kidneys function properly.
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Have a query?

How Soon It Starts Working

The time required for Istamet G-IR 50/1000/1 Tablet to start to work: Istamet G-IR 50/1000/1 Tablet ideally shows its action within 2 to 3 hours after administration.

The time for which the effects of Istamet G-IR 50/1000/1 Tablet last: The effect of Istamet G-IR 50/1000/1 Tablet lasts for 24 hours.

What if you forget to take Istamet G-IR 50/1000/1 Tablet

If you miss a dose, take it with food as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and resume your regular dosing schedule. Do not take two doses at the same time to make up for a missed one, as this can cause your blood sugar to drop dangerously low.

Storage

• Store Istamet G-IR 50/1000/1 Tablet below 30°C in a cool, dry place away from moisture, heat, and direct sunlight.

Drug Warnings

  • Check your blood sugar more frequently if you are ill, traveling, under unusual stress, or when your doctor is gradually increasing your dose.
  • Be prepared to recognize the early warning signs of low blood sugar, such as sweating, trembling, anxiety, and blurred vision, so you can treat them immediately.
  • Carry a medical ID card or wear a medical alert bracelet indicating that you have type 2 diabetes and are taking oral diabetes medications.
  • Inform all healthcare providers, including your dentist or surgeons, that you take Istamet G-IR 50/1000/1 Tablet , as you may need to pause this medication temporarily before surgical procedures or scans that use contrast dyes.
  • Avoid excessive alcohol intake, as alcohol can unpredictably affect your blood sugar levels and dramatically increase your risk of lactic acidosis.

Drug-Drug Interactions

verifiedApollotooltip
  • May increase the risk of low blood sugar when combined with other diabetes therapies, such as insulin, or certain blood pressure medications like beta-blockers.
  • Medicines like water pills (diuretics), thyroid drugs, or steroids may raise your blood sugar, making Istamet G-IR 50/1000/1 Tablet less effective.
  • Certain pain relievers and antibiotics may increase the levels of this medicine in your body, raising the risk of side effects.
No Drug - Drug interactions found in our data. We may lack specific data on this medicine and are actively working to update our database. Consult your doctor for personalized advice

Drug-Drug Interactions

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Drug-Food Interactions

verifiedApollotooltip
  • Alcohol: Limit or avoid alcohol while taking this medicine. Alcohol may increase the risk of lactic acidosis associated with the metformin component and can also make low blood sugar caused by the glimepiride component more likely or more difficult to recognize. Talk to your doctor about whether alcohol is safe for you.
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

No

Therapeutic Class

[ANTIDIABETICS]

FAQs

Istamet G-IR 50/1000/1 Tablet is an antidiabetic medicine used to treat type II diabetes.
Istamet G-IR 50/1000/1 Tablet is a combination medicine containing Sitagliptin that enhances glucose-mediated insulin secretion, thereby reducing fasting and post-prandial blood sugar concentrations. Metformin helps reduce the sugar production by cells in the liver and delays sugar absorption from the intestines. Glimepiride works by stimulating beta cells in the pancreas that produce insulin.
If you forget to take Istamet G-IR 50/1000/1 Tablet , take it as soon as you remember. However, if it is time for the next dose, avoid taking it and do not double-dose to make up the missed dose. Taking an overdose might cause your sugar level to fall rapidly.
You should limit or completely avoid alcohol while taking this medicine. Alcohol increases the risk of experiencing dangerously low blood sugar and can trigger a rare but serious medical condition called lactic acidosis. Talk to your doctor about safe limits.
If you experience signs of low blood sugar like shaking, sweating, or dizziness, eat or drink a fast-acting sugar source immediately. This could be half a cup of fruit juice, non-diet soda, or three to four glucose tablets. If your symptoms do not improve, contact your doctor or seek emergency medical help.
Some components of this medicine may help keep your weight stable or support mild weight loss, while other components can occasionally cause minor weight gain. How your body reacts depends on your individual metabolism and lifestyle. Talk to your doctor or pharmacist to learn more.
This medicine is generally not recommended for use during pregnancy or while breastfeeding. Proper blood sugar control is vital during this time, but doctors usually prefer using alternative treatments like insulin. Talk to your doctor if you are pregnant or planning to become pregnant.
Yes, this medicine is designed to work alongside healthy lifestyle habits, not replace them. Maintaining a balanced diet and exercising regularly are crucial for managing type 2 diabetes and helping this medicine work effectively. Talk to your doctor or a registered dietitian for personalized guidance.
Taking this medicine with a meal, particularly your first main meal of the day, helps protect your stomach lining and significantly reduces common side effects like nausea, gas, or diarrhea. It also helps manage blood sugar spikes after eating.
This medicine does not directly damage the kidneys. However, the metformin component is removed from the body through the kidneys. If your kidney function becomes significantly reduced, metformin can build up in the body and increase the risk of a rare but serious condition called lactic acidosis. Your doctor will check your kidney function before starting treatment and monitor it regularly during therapy to ensure the medicine remains safe for you.
This medicine begins lowering your blood sugar shortly after you take your first dose. However, it can take several weeks of consistent daily use, combined with diet and exercise, to see the full benefits in your long-term blood sugar tests. Talk to your doctor for regular progress checks.
Regular kidney function tests help your doctor make sure this medicine remains safe and effective. Healthy kidneys remove the metformin component from your body. If your kidney function declines, your doctor may adjust your treatment or recommend an alternative medicine to reduce the risk of complications.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Reference

  1. U.S. Food and Drug Administration (FDA). 022044S022Lbl [FDA Prescribing Information]. Silver Spring, MD: FDA; 2024. [Accessed on 02 Jun. 2026]Check here
  2. MedlinePlus. A606023 Patient Information Monograph. Bethesda, MD: U.S. National Library of Medicine (NLM); 2025. [Accessed on 02 Jun. 2026]Check here
  3. Drugs.com Clinical Review Team. Metformin Clinical Drug Monograph. Auckland, NZ: Drugs.com; 2026. [Accessed on 02 Jun. 2026]Check here
  4. Janumet 50 mg/1000 mg film-coated tablets- Summary of Product Characteristics (SmPC) - (emc) [Internet]. Medicines.org.uk. 2025 [Accessed on 26th Aug 2025]Check here
  5. Janumet 50 mg/1000 mg film-coated tablets- Patient Information Leaflet (PIL) - (emc) [Internet]. Medicines.org.uk. 2025 [Accessed on 26th Aug 2025]Check here
  6. Kesavadev J, Pillai PBS, Shankar A, Krishnan G, Jothydev S. Sitagliptin 100 mg vs glimepiride 1-3 mg as an add-on to insulin and metformin in type 2 diabetes (SWIM). Endocr Connect. 2017. [Accessed on June 15, 2024]Check here

Country of origin

India

Manufacturer/Marketer address

Plot No 107/108,Namli Block , Ranipool, East Sikkim 737135
Other Info - IST0062
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