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compositionComposition:TOFACITINIB-11MG
prescription
Prescription Medicine
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Jakmac-ER Tablet is used to treat rheumatoid arthritis, psoriatic arthritis, and ulcerative colitis. It contains Tofacitinib which works by lowering inflammation and symptoms associated with arthritis. In some cases, this medicine may cause side effects such as diarrhoea, headache, upper respiratory tract infection, nausea, and vomiting. Before taking this medicine, inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.

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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

TOFACITINIB-11MG

Manufacturer/Marketer :

Macleods Pharmaceuticals Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Jakmac-ER Tablet

Jakmac-ER Tablet is a prescription medicine used to manage moderate to severe autoimmune inflammatory conditions, including rheumatoid arthritis, psoriatic arthritis, and ankylosing spondylitis. It is also prescribed to treat moderate to severe ulcerative colitis, an inflammatory bowel disease. By targeting key inflammatory pathways in the body, this medicine helps reduce painful swelling and prevents further damage to your joints and tissues.

To achieve the best results, you must take Jakmac-ER Tablet consistently every day exactly as prescribed by your doctor. It is typically taken once or twice daily, and you can take it either with or without food. Along with taking your medicine regularly, adopting a balanced, anti-inflammatory diet and incorporating gentle physical exercise can significantly improve your mobility and overall treatment outcomes.

While taking Jakmac-ER Tablet , you may experience some common, mild side effects such as headaches, diarrhoea, or cold-like symptoms. However, because this medicine affects your immune system, it is crucial to consult your doctor immediately if you develop any signs of serious infections, unusual bruising, high fever, or shingles.

Talk to your doctor before starting this medicine if you have a history of tuberculosis, chronic infections, liver damage, kidney issues, or heart problems. Do not take this if you currently have a severe active infection, severe liver problems, or if you are allergic to any of its ingredients.

This medicine can interact with other drugs that suppress your immune system or certain medications processed by your liver, which can increase the risk of severe side effects or reduce how well the treatment works. You should avoid drinking excess alcohol, stop smoking, and consult your doctor before starting treatment if you are pregnant, planning a pregnancy, breastfeeding, or are an older adult.

Uses of Jakmac-ER Tablet

The following are the common conditions for which Jakmac-ER Tablet may be prescribed:

  • Rheumatoid Arthritis: Helps reduce joint pain, stiffness, and swelling in adults when other standard therapies have not worked well.
  • Psoriatic Arthritis: Lowers active joint inflammation and helps improve physical function in daily activities.
  • Ankylosing Spondylitis: Targets inflammation in the spine to reduce chronic back pain and stiffness.
  • Ulcerative Colitis: Reduces chronic inflammation in the lining of the large intestine to help achieve and maintain symptom-free periods.
     

Key Benefits

Jakmac-ER Tablet helps control excessive immune system activity that causes inflammation in autoimmune conditions. By reducing ongoing inflammation, it helps relieve symptoms, improve daily function, and lower the risk of long-term damage associated with these diseases.

Key benefits include:

  • Easier Daily Movement: By reducing inflammation in the joints, Jakmac-ER Tablet helps restore flexibility, making daily tasks like walking, bending, and reaching much more comfortable.
  • Long-Term Control Over Flares: Regular use helps keep your immune system from overreacting, which reduces the frequency and severity of painful symptom flare-ups.
  • Improved Bowel Comfort: For those managing ulcerative colitis, this medicine helps calm gut inflammation, leading to fewer urgent bathroom trips, less cramping, and healthier digestion.
     
Side effects of Jakmac-ER Tablet
  • Practice good hygiene by washing hands frequently when touching any wounds.
  • Apply creams or lotions to the dry skin and moisturize it.
  • Wear the proper clothing and footwear when working outside.
  • Cover the wounds with bandage and change it daily.
  • Avoid baths at swimming pools, lakes and rivers.
Managing Medication-Triggered UTIs: A Comprehensive Approach:
  • Inform your doctor about the medication you're taking and the UTI symptoms you're experiencing.
  • Your doctor may adjust your medication regimen or consider alternative medications or dosages that may reduce the risk of UTIs.
  • Drink plenty of water (at least 8-10 glasses a day) to help flush out bacteria. Avoid sugary drinks and caffeine, which can exacerbate UTI symptoms.
  • Urinate when you feel the need rather than holding it in. This can help prevent bacterial growth and reduce the risk of UTIs.
  • Consider cranberry supplements: Cranberry supplements may help prevent UTIs by preventing bacterial adhesion.
  • Monitor UTI symptoms and report any changes to your doctor.
  • If antibiotics are prescribed, take them as directed and complete the full course.
  • Drink a lot of water to control diarrhoea and prevent dehydration.
  • Avoid spicy, fatty, or high-fiber foods that may irritate the colon.
  • Reduce stress through methods such as deep breathing or meditation.
  • Include probiotics or supplements containing live bacteria to maintain the health of the gut.
  • Quit smoking since smoking makes colitis symptoms worse.
  • See your doctor right away if you experience extreme inflammation, bleeding stools, or abdominal pain.
Here are the steps to manage the medication-triggered Common Cold:
  • Inform your doctor about the common cold symptoms you're experiencing due to medication.
  • Your doctor may adjust your treatment plan, which could include changing your medication, adding new medications, or offering advice on managing your symptoms.
  • Practice good hygiene, including frequent handwashing, avoiding close contact with others, and avoiding sharing utensils or personal items.
  • Drink plenty of fluids, such as warm water or soup, to help thin out mucus.
  • Get plenty of rest and engage in stress-reducing activities to help your body recover. If your symptoms don't subside or worsen, consult your doctor for further guidance.
  • To promote overall health, drink plenty of water and consume hydrating foods like watermelon and leafy greens.
  • Support gut health with probiotic-rich foods such as yoghurt and sauerkraut.
  • Eat antioxidant-rich foods like berries and green tea, while limiting sugary drinks, alcohol, and processed foods.
  • Additionally, reduce stress through relaxation techniques like deep breathing and meditation.
  • Skin rash caused by allergies is due to irritants or allergens. Therefore, avoid contact with such irritants.
  • Consult your doctor for proper medication and apply an anti-itch medication. Follow the schedule and use the medication whenever needed.
  • Protect your skin from extreme heat and try to apply wet compresses.
  • Soak in the cool bath, which gives a soothing impact to the affected area.

Directions for Use

  • Jakmac-ER Tablet can be taken with or without food.
  • It is recommended to take Jakmac-ER Tablet 1-2 times a day, depending on your medical condition, or as prescribed by your doctor.
  • Swallow Jakmac-ER Tablet as a whole with a glass of water.
  • Do not crush, chew, or break it.

How Jakmac-ER Tablet Works

Jakmac-ER Tablet contains tofacitinib, a Janus kinase (JAK) inhibitor that helps reduce inflammation caused by an overactive immune system. Jakmac-ER Tablet works by blocking Janus kinase (JAK) pathways inside immune cells. These pathways transmit signals that stimulate the production of inflammatory proteins. By blocking these signals, Jakmac-ER Tablet reduces the immune system's excessive inflammatory response and helps prevent it from attacking healthy tissues. Together, these actions help reduce inflammation, relieve symptoms such as pain, swelling, and stiffness, protect joints from further damage, and promote healing of the intestinal lining in conditions such as ulcerative colitis.
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Alcohol

Caution

It is not known if alcohol interacts with Jakmac-ER Tablet , so please consult a doctor.

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Pregnancy

Unsafe

Jakmac-ER Tablet must not be taken during pregnancy. If you are a woman of child-bearing potential, use effective contraception during the treatment with Jakmac-ER Tablet and for 4 weeks after discontinuation.

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Breast Feeding

Unsafe

Avoid breastfeeding while taking Jakmac-ER Tablet . Please consult a doctor if you have any concerns.

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Driving

Safe

Jakmac-ER Tablet generally does not affect your ability to drive. However, drive or operate machinery only if you are alert.

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Liver

Caution

Dose adjustment may be needed in patients with liver impairment. Please consult your doctor if you have a liver impairment or any concerns regarding this. Jakmac-ER Tablet is not recommended for patients with severe liver problems.

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Kidney

Caution

Dose adjustment may be needed in patients with kidney impairment. Please consult your doctor if you have kidney impairment or any concerns regarding this.

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Children

Unsafe

Jakmac-ER Tablet is not recommended for children below 18 years as safety and effectiveness were not established.

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Heart

Caution

No serious side effects were observed. But it requires careful consideration and monitoring due to increased risks of heart-related problems, particularly in patients with existing cardiovascular risk factors.

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Geriatrics

Caution

No serious adverse effects were observed; however, it requires careful consideration and caution due to the increased risk of certain adverse events, particularly infections.

What if I have taken an overdose of Jakmac-ER Tablet

If you accidentally take more than your prescribed dose of Jakmac-ER Tablet , seek immediate medical attention or call a poison control centre right away. Do this even if you do not feel any symptoms of illness.

Diet & Lifestyle Advise

  • Anti-inflammatory diet: Focus on eating a diet rich in anti-inflammatory foods, such as olive oil, leafy green vegetables, and fish rich in omega-3 fatty acids, to support your joints and gut health.
  • Protect your joints: Keep active with low-impact physical activities like swimming, walking, or stationary cycling. This helps maintain joint flexibility and muscle strength without putting too much strain on your joints.
  • Manage gut triggers: If you are taking this medicine for ulcerative colitis, keep a food journal to identify and avoid foods that trigger your symptoms (such as highly spiced, greasy, or high-fibre foods during active flares).
  • Practise strict hand hygiene: Since Jakmac-ER Tablet dampens your immune system, wash your hands frequently with soap and water, and avoid close contact with people who have contagious illnesses like the cold or flu.
  • Schedule non-live vaccinations: Talk to your doctor about keeping your vaccinations up to date, such as the flu or pneumonia vaccines, ensuring you only receive non-live versions while on this treatment.
     
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How Soon It Starts Working

  • The time required for Jakmac-ER Tablet to start to work: The time required for Jakmac-ER Tablet to show its action is unknown.
  • The time for which the effects of Jakmac-ER Tablet last: The duration of action for Jakmac-ER Tablet is clinically unknown.

What if you forget to take Jakmac-ER Tablet

If you miss a dose of Jakmac-ER Tablet , take it as soon as you remember. However, if your next scheduled dose is only a few hours away, skip the missed dose and return to your regular schedule. Do not take two doses at the same time to make up for a missed one.

Storage

•Store Jakmac-ER Tablet tablets at controlled room temperature, ideally between 20°C and 25°C (68°F to 77°F). •Keep the tablets in their original blister pack or bottle to protect them from light and moisture. Do not store them in humid environments like the bathr

Drug Warnings

  • Complete recommended screening tests: Your doctor should screen you for tuberculosis (TB) and perform blood tests before you start Jakmac-ER Tablet .
  • Avoid live vaccines during treatment: Do not receive live vaccines, such as certain shingles vaccines or the nasal spray influenza vaccine, unless your doctor advises otherwise, as your immune system may be weakened.
  • Attend regular monitoring appointments: Keep all scheduled blood tests so your doctor can monitor your blood cell counts, liver function, kidney function, and cholesterol levels throughout treatment.
  • Watch for signs of infection or shingles: Contact your doctor immediately if you develop fever, persistent cough, unexplained skin rashes, or painful blisters on one side of your body.
  • Seek emergency medical care for serious symptoms: Stop taking Jakmac-ER Tablet and get immediate medical attention if you experience sudden chest pain, difficulty breathing, swelling or pain in one leg, or symptoms suggestive of a blood clot.
     

Drug-Drug Interactions

verifiedApollotooltip
  • Other immunosuppressants: Taking Jakmac-ER Tablet with medicines such as cyclosporine, azathioprine, tacrolimus, or biologic therapies can greatly increase the risk of serious infections and is generally not recommended.
  • Medicines affecting liver enzymes: Strong CYP3A4 inhibitors (such as ketoconazole) may increase Jakmac-ER Tablet levels, while strong CYP3A4 inducers (such as rifampicin) may reduce its effectiveness. Your doctor may adjust your dose if necessary.
     
TofacitinibVedolizumab
Severe
TofacitinibStreptozocin
Severe

Drug-Drug Interactions

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TofacitinibVedolizumab
Severe
How does the drug interact with Jakmac-ER Tablet:
Taking Vedolizumab with Jakmac-ER Tablet may increase the risk of infection.

How to manage the interaction:
Taking Jakmac-ER Tablet with Vedolizumab together can possibly result in an interaction, but it can be taken if your doctor has advised it. However, consult the doctor immediately if you experience symptoms such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination.Do not stop using any medications without a doctor's advice.
TofacitinibStreptozocin
Severe
How does the drug interact with Jakmac-ER Tablet:
Taking Jakmac-ER Tablet with Streptozocin may increase the risk of infection.

How to manage the interaction:
Although taking Streptozocin and Jakmac-ER Tablet together can evidently cause an interaction, it can be taken if your doctor has suggested it. However, consult the doctor immediately if you experience symptoms such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination. Do not discontinue any medications without consulting your doctor.
TofacitinibTelithromycin
Severe
How does the drug interact with Jakmac-ER Tablet:
When Jakmac-ER Tablet is taken with Telithromycin, it can slow down the way the body breaks down Jakmac-ER Tablet.

How to manage the interaction:
Taking Jakmac-ER Tablet with Telithromycin together can possibly result in an interaction, but it can be taken if your doctor has advised it. Do not discontinue any medications without first consulting your doctor.
TofacitinibKetoconazole
Severe
How does the drug interact with Jakmac-ER Tablet:
Coadministration of Ketoconazole and Jakmac-ER Tablet may increase the blood levels and effects of Jakmac-ER Tablet which may lead to side effects (low blood cell counts, anemia, serious infections, and elevated blood lipid levels).

How to manage the interaction:
Although taking Ketoconazole and Jakmac-ER Tablet together can result in an interaction, it can be taken if a doctor has prescribed it. However, if you experience symptoms like paleness, exhaustion, dizziness, fainting, fever, chills, diarrhea, sore throat, muscular pains, shortness of breath, blood in the phlegm, weight loss, red or irritated skin, body sores, or discomfort or burning when urinating, consult a doctor. Do not stop using any medications without a doctor's advice.
TofacitinibMelphalan
Severe
How does the drug interact with Jakmac-ER Tablet:
Taking Jakmac-ER Tablet with Melphalan may increase the risk of serious infection.

How to manage the interaction:
Although taking Jakmac-ER Tablet and Melphalan together can cause an interaction, it can be taken if your doctor has suggested it. However, consult the doctor immediately if you experience symptoms such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination. Do not stop using any medications without a doctor's advice.
TofacitinibAmprenavir
Severe
How does the drug interact with Jakmac-ER Tablet:
Taking Jakmac-ER Tablet with amprenavir may increase the blood levels of Jakmac-ER Tablet and may increase the risk of infections

How to manage the interaction:
There may be a possibility of interaction between Jakmac-ER Tablet and Amprenavir, but it can be taken if prescribed by a doctor. However consult your doctor if you experience fatigue, dizziness, fainting, fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, weight loss, red or inflamed skin, body sores, and pain or burning during urination. Do not stop using any medications without a doctor's advice.
TofacitinibDocetaxel
Severe
How does the drug interact with Jakmac-ER Tablet:
Taking Jakmac-ER Tablet with Docetaxel may increase the risk of infection.

How to manage the interaction:
Although there is a possible interaction between Jakmac-ER Tablet and Docetaxel, you can take these medicines together if prescribed by your doctor. However, consult the doctor immediately if you experience symptoms such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination. Do not stop using any medications without first talking to your doctor.
TofacitinibTemsirolimus
Severe
How does the drug interact with Jakmac-ER Tablet:
Taking Jakmac-ER Tablet with Temsirolimus may increase the risk of infection.

How to manage the interaction:
Although there is a possible interaction between Jakmac-ER Tablet and Temsirolimus, you can take these medicines together if prescribed by your doctor. However, consult the doctor immediately if you experience symptoms such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination. Do not discontinue any medications without consulting your doctor.
TofacitinibIdarubicin
Severe
How does the drug interact with Jakmac-ER Tablet:
Taking Idarubicin and Jakmac-ER Tablet can increase the risk of developing serious infections.

How to manage the interaction:
Although there is an interaction, Idarubicin can be taken with Jakmac-ER Tablet, if prescribed by the doctor. However, if you experience fever, chills, diarrhea, sore throat, muscle aches, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning when you urinate, consult a doctor. Do not discontinue any medications without a doctor's advice.
TofacitinibLevamisole
Severe
How does the drug interact with Jakmac-ER Tablet:
When Jakmac-ER Tablet and levamisole are used together, there is a higher chance of getting serious infections.

How to manage the interaction:
Although taking Levamisole and Jakmac-ER Tablet together can evidently cause an interaction, it can be taken if your doctor has suggested it. If you notice any of these symptoms - infection, fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, weight loss, pain or burning during urination - contact your doctor right away. Do not stop using any medications without first talking to your doctor.

Drug-Food Interactions

verifiedApollotooltip
  • Alcohol: Jakmac-ER Tablet can be taken with or without food. However, excessive alcohol intake may increase the risk of liver problems, so discuss alcohol consumption with your doctor.
     
TOFACITINIB-11MGGrapefruit and Grapefruit Juice
Moderate

Drug-Food Interactions

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TOFACITINIB-11MGGrapefruit and Grapefruit Juice
Moderate
Common Foods to Avoid:
Grapefruit, Grapefruit Juice

How to manage the interaction:
Consuming grapefruit products while taking Jakmac-ER Tablet can increase the risk of side effects. Avoid consuming grapefruit products while being treated with Jakmac-ER Tablet, as it can lead to an interaction.

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Habit Forming

No

Therapeutic Class

[ANTIRHEUMATICS, DISEASE MODIFYING ANTIRHEUMATIC DRUGS (DMARDs)]

FAQs

Jakmac-ER Tablet is used to treat rheumatoid arthritis, psoriatic arthritis, and ulcerative colitis.
Jakmac-ER Tablet works by blocking Janus kinase enzyme, thereby lowers inflammation and symptoms associated with rheumatoid and psoriatic arthritis.
Hypertension/high blood pressure could be a side-effect of Jakmac-ER Tablet . Consult your doctor before taking Jakmac-ER Tablet if you have high blood pressure or if you are taking anti-hypertensive medicines.
Diarrhoea might be a side-effect of Jakmac-ER Tablet . Eat non-spicy meals and drink plenty of fluids to prevent dehydration if you experience diarrhoea. If you find blood in stools (tarry stools) or if you experience severe diarrhoea, consult your doctor. Do not take anti-diarrheal medicine on your own.
Jakmac-ER Tablet might impair fertility in females of reproductive potential. It is not known if the effect is reversible. Therefore, talk to a doctor before starting Jakmac-ER Tablet if you are trying to become pregnant or if you have any concerns regarding this.
Jakmac-ER Tablet affects the immune system and might lower the ability of the immune system to fight infections. Inform your doctor if you have an active infection, if you have a condition that increases the chance of having infections, if you are taking immunosuppressants, medicines that affect the immune system or corticosteroids.
Jakmac-ER Tablet is not recommended for patients with severe liver impairment. Dose adjustment may be needed in patients with mild to moderate liver impairment. Please consult the doctor if you have liver problems.
Jakmac-ER Tablet may increase the risk of cancer by changing the way the immune system works. Inform the doctor if you ever had any type of cancer.
Jakmac-ER Tablet may begin working within 2-8 weeks after starting the treatment.
Jakmac-ER Tablet should not be taken along with tocilizumab as it might increase the risk of infections. Before starting Jakmac-ER Tablet , inform the doctor if you are taking tocilizumab.
Prior to starting Jakmac-ER Tablet , active or latent tuberculosis test, CBC (complete blood count), LFT (liver function test), and lipid profile tests should be done.
No, Jakmac-ER Tablet is not a steroid. It belongs to a group of medicines known as JAK inhibitors, which specifically target and block certain inflammatory signals inside cells. Talk to your doctor to learn more.
You can receive non-live vaccines, such as the standard flu shot, while taking Jakmac-ER Tablet . However, you should avoid live vaccines because your immune system is less active and you could develop an infection from the vaccine itself. Talk to your doctor or pharmacist before getting any vaccine.
It is not recommended to take Jakmac-ER Tablet during pregnancy, as it may cause harm to an unborn baby. If you are pregnant, planning to become pregnant, or breastfeeding, talk to your doctor to discuss safer treatment options.
Alcohol does not directly interfere with how Jakmac-ER Tablet works, but both substances are processed by the liver. Consuming alcohol while on this medication can increase the risk of liver damage, so it is best to limit your intake. Talk to your doctor for personalised advice.
Because Jakmac-ER Tablet can affect your immune system and how your body heals, you may need to temporarily stop taking it before and after a planned surgical procedure. Talk to your doctor and surgeon to create a safe plan.
Since Jakmac-ER Tablet lowers your ability to fight germs, watch closely for a fever, chills, persistent cough, burning when you urinate, or extreme tiredness. If you experience any of these symptoms, contact your doctor immediately for medical advice. Do not stop taking Jakmac-ER Tablet on your own unless your doctor tells you to do so.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Country of origin

India

Manufacturer/Marketer address

Atlanta Arcade, Marol Church Road, Andheri (East), Mumbai - 400059, India.
Other Info - JAK0033
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