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compositionComposition:MEXILETINE-150MG
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Prescription Medicine
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Jollimex 150 Capsule is used to treat life-threatening arrhythmias (irregular heartbeats) such as ventricular arrhythmia. It contains Mexiletine, which reduces heart muscle cells' sensitivity to electrical impulses. Thus, it slows down electrical conduction in the heart muscle, helping restore regular heart rhythm. In some cases, Jollimex 150 Capsule may cause common side effects such as stomach pain, insomnia (difficulty sleeping), dyspepsia (indigestion), dizziness, tremors (involuntary shaking), chest discomfort, or headache.

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Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

MEXILETINE-150MG

Manufacturer/Marketer :

Jolly Healthcare

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Jollimex 150 Capsule

Jollimex 150 Capsule is used to treat life-threatening arrhythmias (irregular heartbeats) such as ventricular arrhythmia. Arrhythmia is a condition in which your heart beats irregularly, too fast, or too slow.

Jollimex 150 Capsule contains Mexiletine, which works by reducing the sensitivity of heart muscle cells to electrical impulses. Thus, it slows down electrical conduction in the heart muscle. Therefore, it helps restore regular heart rhythm.

In some cases, Jollimex 150 Capsule may cause common side effects such as stomach pain, difficulty sleeping, indigestion, dizziness, tremors (involuntary shaking), chest discomfort or headache. Most of these side effects do not require medical attention and gradually resolve over time. However, if the side effects persist, please consult your doctor.

If you are allergic to Mexiletine, local anaesthetics, or other medicines, please tell your doctor. If you are pregnant or breastfeeding, it is advised to inform your doctor before taking Jollimex 150 Capsule . Jollimex 150 Capsule is not recommended for children and adolescents below 18 years of age.

Uses of Jollimex 150 Capsule

Jollimex 150 Capsule is used in the treatment of ventricular arrhythmia (irregular heartbeats). The detailed use of Jollimex 150 Capsule is as follows:

  • Treatment of ventricular arrhythmia (irregular heartbeats): Jollimex 150 Capsule is used in the treatment of ventricular arrhythmia (irregular heartbeats) by stabilizing the heart rhythm and reducing abnormal electrical activity, by blocking sodium channels in the heart, which helps to normalize the heartbeat.

Key Benefits

  • Jollimex 150 Capsule contains Mexiletine, which is used to treat life-threatening arrhythmias (irregular heartbeats) such as ventricular arrhythmia.
  • It decreases the sensitivity of heart muscle cells to electrical impulses.
  • Thus, it slows down electrical conduction in the heart muscle. Thereby, it helps restore regular heart rhythm.
Side effects of Jollimex 150 Capsule
  • Eat slowly and chew your food well to avoid swallowing air, which can make stomach pain worse.
  • Instead of going long periods without eating, try having smaller meals or snacks throughout the day to stop too much stomach acid from building up and causing pain.
  • Stay away from fatty, fried, or spicy foods. Instead, eat more healthy, fibre-rich foods.
  • Drink plenty of water to help with digestion and avoid soda or alcohol, which can make stomach pain worse.
  • Try to manage stress with relaxation techniques, and see a doctor if stress leads to chronic stomach pain.
  • Try antacids or medications like proton pump inhibitors to protect your stomach.
Here are the steps to manage medication-triggered tremors or involuntary shaking:
  • Notify your doctor immediately if you experience tremors or involuntary shaking after taking medication or adjusting your medication regimen.
  • Your doctor may adjust your medication regimen or recommend alternative techniques like relaxation, meditation, or journaling to alleviate tremor symptoms.
  • Your doctor may direct you to practice stress-reducing techniques, such as deep breathing exercises, yoga, or journaling.
  • Regular physical activity, such as walking or jogging, can help reduce anxiety and alleviate tremor symptoms.
  • Your doctor may recommend lifestyle changes, such as avoiding caffeine, getting enough sleep, and staying hydrated, to help manage tremors.
  • Maintain regular follow-up appointments with your doctor to monitor tremor symptoms and adjust treatment plans as needed.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
  • Uncoordinated muscle movements need immediate medical attention.
  • Observe your movements and try to understand and control the particular movement.
  • Regularly do strengthening exercises to improve blood flow throughout the body and avoid involuntary movements.
  • Implement massage techniques to enhance blood flow to organs.
  • Take a balanced diet and quit smoking.
  • Practice yoga and meditation to improve thought processes and reduce uncontrolled and involuntary movements.
Here are the 7 steps to manage Dizziness caused by medication:
  • Inform your doctor about dizziness symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Follow your doctor's instructions for taking medication, and take it at the same time every day to minimize dizziness.
  • When standing up, do so slowly and carefully to avoid sudden dizziness.
  • Avoid making sudden movements, such as turning or bending quickly, which can exacerbate dizziness.
  • Drink plenty of water throughout the day to stay hydrated and help alleviate dizziness symptoms.
  • If you're feeling dizzy, sit or lie down and rest until the dizziness passes.
  • Track when dizziness occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.
Managing depression as a side effect of medication: a comprehensive guide.
  • Remember, managing depression as a side effect of medication requires patience, persistence, and collaboration with your healthcare team.
  • Tell your doctor about your depression symptoms to adjust medication.
  • Consult a therapist or counsel for emotional support.
  • Engage in regular exercise to release endorphins (neurotransmitters).
  • Practice stress-reducing techniques like meditation and deep breathing.
  • Build a support network of friends, family, and support groups.
  • Establish a consistent sleep schedule.
  • Eat a nutritious diet rich in fruits, vegetables, and whole grains.
  • Limit or avoid alcohol and recreational substances.
  • Keep a mood journal to track symptoms and progress.

Directions for Use

  • Jollimex 150 Capsule can be taken with food to prevent stomach upset or as advised by the doctor.
  • Follow your doctor’s instructions on the dosage and timing of this medication to ensure safety.
  • Swallow Jollimex 150 Capsule as a whole with a glass of water.
  • Do not chew, crush, or break it.

How Jollimex 150 Capsule Works

Jollimex 150 Capsule contains Mexiletine, which works by reducing the sensitivity of heart muscle cells to electrical impulses. Thus, it slows down electrical conduction in the heart muscle. Therefore, it helps restore regular heart rhythm.
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Alcohol

Unsafe

You are recommended to avoid consumption of alcohol while taking Jollimex 150 Capsule as it may worsen dizziness or drowsiness.

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Pregnancy

Consult your doctor

Limited data are available on the effect of Jollimex 150 Capsule in pregnancy. Hence, if you are pregnant or planning pregnancy, inform your doctor before taking Jollimex 150 Capsule .

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Breast Feeding

Consult your doctor

If you are breastfeeding, please inform your doctor before taking Jollimex 150 Capsule . Mexiletine may be excreted in breast milk. Therefore, if your doctor prescribes Jollimex 150 Capsule , you will be advised to choose an alternate method of feeding your baby.

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Driving

Unsafe

Jollimex 150 Capsule may cause dizziness, drowsiness or blurred vision in some people. Therefore, avoid driving if you experience such side effects after taking Jollimex 150 Capsule .

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Liver

Caution

Jollimex 150 Capsule should be used with caution in patients with mild to moderate liver dysfunction and is not recommended for patients with severe liver disease. Therefore, inform your doctor if you have any liver problems before taking Jollimex 150 Capsule .

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Kidney

Unsafe

Jollimex 150 Capsule is not recommended for patients with severe kidney disease. Therefore, inform your doctor if you have any kidney disease before taking Jollimex 150 Capsule .

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Children

Unsafe

Jollimex 150 Capsule is not recommended for children and adolescents below 18 years of age.

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Heart

Safe if prescribed

Jollimex 150 Capsule is used for serious heart rhythm disorders but should be avoided without prescription. It can alter cardiac electrical activity and require close monitoring due to potential side effects.

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Geriatrics

Safe if prescribed

Jollimex 150 Capsule should be avoided in geriatric patients unless prescribed. Older adults may be more sensitive to its cardiac and nervous system effects, requiring close medical supervision.

What if I have taken an overdose of Jollimex 150 Capsule

Please do not exceed the recommended dose, as it might cause an overdose. Signs and symptoms of an overdose of Jollimex 150 Capsule may include confusion, drowsiness, nausea, feeling lightheaded, seizures, loss of consciousness, and a worsening irregular heartbeat. Seek immediate medical attention if you observe any symptoms or think you have taken too much. Do this even if there are no signs of discomfort or poisoning.

Diet & Lifestyle Advise

  • Maintain a low-salt diet and minimize eating processed foods as they contain more sodium. Try to replace salt with spices or herbs to add flavour to the food.
  • Do regular exercise as it helps lower blood pressure and keeps blood vessels and the heart in good condition.
  • Quit smoking as smoking increases blood pressure and heart rate.
  • Eat a balanced and healthy diet that includes plenty of vegetables, fruits, and low-fat or fat-free products.
health query

Have a query?

How Soon It Starts Working

  • The time required for Jollimex 150 Capsule to start to work: Jollimex 150 Capsule ideally shows its action within 1 hour after administration. 
  • The time for which the effects of Jollimex 150 Capsule last: The effect of Jollimex 150 Capsule lasts for 10 to 12 hours.

What if you forget to take Jollimex 150 Capsule

If you miss a dose of Jollimex 150 Capsule , take it as soon as you remember. If it is almost time for next dose, skip the missed dose and continue with the regular dosing schedule. Do not take a double dose to make up for the missed dose.

Storage

• Store in a cool and dry place away from sunlight.• Keep Jollimex 150 Capsule out of reach and sight of children.• Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.

Drug Warnings

  • If you are allergic to Jollimex 150 Capsule , any local anaesthetics, or any other medications, please inform your doctor.
  • If you are pregnant or breastfeeding, it is advised to inform your doctor before taking Jollimex 150 Capsule .
  • Jollimex 150 Capsule is not recommended for children and adolescents below 18 years of age.
  • Avoid intake of alcohol with Jollimex 150 Capsule as it may worsen dizziness or drowsiness.
  • Jollimex 150 Capsule may cause dizziness, drowsiness or blurred vision in some people. Therefore, drive only if you are alert after taking Jollimex 150 Capsule .
  • Inform your doctor if you have a genetic problem with an enzyme in your body called CYP2D6, which breaks down (metabolises) certain medicines in your body too slowly, because a different dose may be applicable to you.
  • If you start to smoke or quit smoking while taking Jollimex 150 Capsule , inform your doctor, as smoking impacts the mexiletine blood levels, and your dose may need to be adjusted accordingly.

Drug-Drug Interactions

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Drug-Drug Interaction: Inform your doctor if you are taking medicines used to treat heart problems (amiodarone, verapamil, propranolol), anticonvulsants (phenytoin), antidepressants (fluvoxamine), a medicine used to treat stomach ulcers and gastric acid reflux (omeprazole), opioid analgesics (morphine), antacids, anticholinergic agents (atropine), anti-asthma drugs (theophylline), a medicine used to prevent and treat nausea and vomiting (metoclopramide), caffeine-containing medications, antibiotics (ciprofloxacin or rifampicin), antidiabetic drug (metformin), blood thinner medicines (warfarin), or muscle relaxants (tizanidine).

Drug-Food Interaction: You are recommended to reduce caffeine intake by half while taking Jollimex 150 Capsule as it can increase caffeine levels in the blood. Also, limit or avoid alcohol intake while taking Jollimex 150 Capsule as it may worsen dizziness and drowsiness.

Drug-Disease Interaction: Avoid taking Jollimex 150 Capsule if you have sinus syndrome (a type of heart rhythm disorder), long QT syndrome (an inherited heart condition), or heart problems, which can cause ankle swelling, shortness of breath or some types of heart rhythm disorders. If you have low or high electrolyte blood levels, abnormal blood counts, seizures (fits), or kidney, liver, or heart problems, please inform your doctor before taking Jollimex 150 Capsule .

MexiletineArbutamine
Critical
MexiletineTramadol
Severe

Drug-Drug Interactions

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MexiletineArbutamine
Critical
How does the drug interact with Jollimex 150 Capsule:
Co-administration of Arbutamine with Jollimex 150 Capsule can increase the risk or severity of irregular heart rhythms.

How to manage the interaction:
Taking Jollimex 150 Capsule with Arbutamine is generally avoided as it can result in an interaction, it can be taken if your doctor has advised it. However, if you experience chest tightness, blurred vision or nausea, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
MexiletineTramadol
Severe
How does the drug interact with Jollimex 150 Capsule:
Co-administration of tramadol with Jollimex 150 Capsule can increase the risk or severity of seizures(fits).

How to manage the interaction:
Taking tramadol with Jollimex 150 Capsule can possibly result in an interaction, it can be taken if your doctor has advised it. Avoid activities requiring mental focus such as driving or operating dangerous machinery. Do not discontinue any medications without consulting a doctor.
MexiletineAminophylline
Severe
How does the drug interact with Jollimex 150 Capsule:
Co-administration of aminophylline with Jollimex 150 Capsule can increase the blood levels of aminophylline and increase the risk of serious side effects.

How to manage the interaction:
Taking Aminophylline with Jollimex 150 Capsule can result in an interaction, it can be taken if a doctor has advised it. However, if you experience any symptoms such as nausea, vomiting, sleeplessness, restlessness, irregular heartbeats, or difficulty breathing, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
MexiletineIopamidol
Severe
How does the drug interact with Jollimex 150 Capsule:
Co-administration of iopamidol with Jollimex 150 Capsule can increase the risk or severity of fits. The risk increases in the elderly, patients undergoing alcohol or drug withdrawal, who have a history of fits or head trauma.

How to manage the interaction:
Although taking iopamidol and Jollimex 150 Capsule together can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience symptoms such as pale, headache, rapid heart rate, shortness of breath, lightheadedness; or fatigue, consult a doctor immediately. Do not discontinue any medications without consulting a doctor.
MexiletineDroperidol
Severe
How does the drug interact with Jollimex 150 Capsule:
Co-administration of droperidol with Jollimex 150 Capsule can increase the risk or severity of irregular heart rhythms. The risk increases in patients with a history of heart illness or electrolyte imbalance.

How to manage the interaction:
Although taking droperidol and Jollimex 150 Capsule together can result in an interaction, it can be taken if your doctor has advised it. However, if you experience symptoms such as weakness, tiredness, drowsiness, confusion, muscle pain, cramps, dizziness, nausea, vomiting, fainting, shortness of breath, or heart palpitations, consult a doctor immediately. Do not discontinue any medications without consulting a doctor.
MexiletineRasagiline
Severe
How does the drug interact with Jollimex 150 Capsule:
Co-administration of rasagiline with Jollimex 150 Capsule can increase blood levels of rasagiline.

How to manage the interaction:
Taking rasagiline with Jollimex 150 Capsule can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience any symptoms such as drowsiness, dizziness, lightheadedness, blood pressure changes, nausea, vomiting, hallucinations, or abnormal behaviour, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
MexiletineChlorpheniramine
Severe
How does the drug interact with Jollimex 150 Capsule:
Co-administration of chlorpheniramine with Jollimex 150 Capsule may cause the side effects of Jollimex 150 Capsule.

How to manage the interaction:
Although taking chlorpheniramine and Jollimex 150 Capsule together can possibly result in an interaction, it can be taken if your doctor has advised it. Do not discontinue any medications without consulting a doctor.
MexiletineTheophylline
Severe
How does the drug interact with Jollimex 150 Capsule:
Co-administration of theophylline with Jollimex 150 Capsule can increase the effect of Jollimex 150 Capsule. This can increase the risk or severity of side effects.

How to manage the interaction:
Taking theophylline with Jollimex 150 Capsule can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience any symptoms such as nausea, vomiting, diarrhea, loss of appetite, headache, tremor, confusion, restlessness, insomnia, seizures, heart palpitations, and/or irregular heartbeat, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
MexiletineBupropion
Severe
How does the drug interact with Jollimex 150 Capsule:
Co-administration of bupropion with Jollimex 150 Capsule can increase the risk or severity of seizures (fits).

How to manage the interaction:
Although taking bupropion and Jollimex 150 Capsule together can result in an interaction, it can be taken if a doctor has advised it. Refrain from engaging in tasks which require mental alertness. Do not discontinue any medications without consulting a doctor.
MexiletineMetrizamide
Severe
How does the drug interact with Jollimex 150 Capsule:
Co-administration of metrizamide with Jollimex 150 Capsule can increase the risk or severity of fits. The risk increases in the elderly, patients undergoing alcohol or drug withdrawal, who have a history of fits or head trauma.

How to manage the interaction:
Although taking metrizamide and Jollimex 150 Capsule together can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience symptoms such as paleness, headache, rapid heart rate, shortness of breath, lightheadedness; or fatigue, consult a doctor immediately. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

verifiedApollotooltip
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

No

Therapeutic Class

[ANTIARRHYTHMICS]

FAQs

Jollimex 150 Capsule is used to treat life-threatening arrhythmias (irregular heartbeats) such as ventricular arrhythmia. Arrhythmia is a condition in which your heart beats irregularly, too fast, or too slow.
Jollimex 150 Capsule contains Mexiletine which works by blocking certain electrical signals in the heart. Thereby, it helps to stabilize the heart rhythm.
Jollimex 150 Capsule may cause blurred or double vision in some people. Therefore, drive only if your vision is clear after taking Jollimex 150 Capsule .
If you take more than the recommended dose of Jollimex 150 Capsule , it may be very harmful to your health. Therefore, you are advised to take Jollimex 150 Capsule in the dose and for the duration prescribed by your doctor. However, if you have irregular heartbeats (faster or slower), low blood pressure, nausea, fits, or hallucinations, contact your doctor immediately.
The side effects of Jollimex 150 Capsule include dizziness, headache, stomach pain, chest discomfort, insomnia (difficulty sleeping) and tremor. If these side effects persist or worsen, please consult your doctor.
No, Jollimex 150 Capsule is not a beta blocker. It is a sodium channel blocker and belongs to the class of medicines called antiarrhythmics. It blocks the fast sodium channels in heart, and thus, helps in treating ventricular arrhythmia (abnormal electrical activity). It blocks specific electrical signals in the heart and stabilizes the heart rhythm.
Jollimex 150 Capsule may lower heart rate. Also, it may also cause irregular heartbeats, palpitations, decrease in blood pressure and atrial fibrillation (abnormal heart rhythm). Thus, you will be hospitalized probably when you start using Jollimex 150 Capsule . Your doctor will monitor you carefully during this time and for as long as you continue to take Jollimex 150 Capsule .
Yes, Jollimex 150 Capsule may cause liver damage. This may occur within a few weeks after starting Jollimex 150 Capsule and is more likely to happen in patients with heart failure. Patients with impaired liver function are monitored carefully. Also, in patients with liver problems, Jollimex 150 Capsule stays for more time in body. Inform your doctor if you notice symptoms such as dark or tea-colored urine, fatigue (overtiredness), loss of appetite for several days or longer, or pain and tenderness on the right side of the abdomen. If your skin or the white part of your eyes turn yellow (jaundice), consult your doctor immediately.
You are recommended not to stop taking Jollimex 150 Capsule suddenly without consulting your doctor as it may cause arrhythmias to recur which could be harmful for you. It is advised to stop Jollimex 150 Capsule gradually over 1-2 weeks. The treatment duration differs from person to person and though no exact guide is available, withdrawal of Jollimex 150 Capsule should be attempted after a suitable arrhythmia-free period.
Yes, Jollimex 150 Capsule should be taken with food or antacids to avoid stomach upset. Take it at the same time every day. Also, drink enough water while sitting in an upright position.

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While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Reference

  1. Electronic Medicines Compendium (EMC). Product Patient Information Leaflet (PIL). Cheshire, UK: Datapharm; 2025. [Accessed on 02 Jun. 2026]Check here
  2. MedlinePlus. A607064 Patient Information Monograph. Bethesda, MD: U.S. National Library of Medicine (NLM); 2025. [Accessed on 02 Jun. 2026]Check here
  3. Drugs.com Clinical Review Team. Mexiletine Clinical Drug Monograph. Auckland, NZ: Drugs.com; 2026. [Accessed on 02 Jun. 2026]Check here
  4. Drugs and Lactation Database (LactMed®) [Internet]. 2006. [Accessed on 11 Jul. 2023]Check here
  5. CiplaMed CiplaMed. [Accessed on 11 Jul. 2023]Check here
  6. M L Datta-Chaudhari, T D O'Brien. Prophylactic use of mexiletine in the elderly with acute myocardial infarction. NIH National Library of Medicine. National Center for Biotechnology Information. PubMeg.gov. February 1990. [Accessed on 1st June 2022]Check here
  7. CANA AE FARMAKEFTIKA ERGASTIRIA. Electronic Medicines Compendium (EMC). [Revised in August 2021] [Accessed on 1st June 2022]Check here

Country of origin

India

Manufacturer/Marketer address

D-50, Basement, Shanti Path, Jawahar Nagar,Jaipur, Rajasthan, India(302004)
Other Info - JOL0076
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