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compositionComposition:CARBOPLATIN-450MG
prescription
Prescription Medicine
info
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Karplat 450 Injection 45 ml is used to treat ovarian cancer and small-cell lung cancer. It contains Carboplatin which works by stopping the cancer cells from naturally dividing and functioning. In some cases, this medicine may cause side effects such as nausea, diarrhoea, vomiting, and a low platelet count. Inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.

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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

CARBOPLATIN-450MG

Manufacturer/Marketer :

Cadila Healthcare Ltd

Consume Type :

Parenteral

Expires on or after :

Jan-28

Return Policy :

Not Returnable

About Karplat 450 Injection 45 ml

Karplat 450 Injection 45 ml is a specialised injection used to treat certain types of cancer, most notably advanced cancer of the ovaries. It is also used to treat other cancers that have spread or have not responded to other therapies. This medication is a key component of chemotherapy regimens, aimed at stopping the multiplication of cancer cells.

This medicine is not a daily treatment; instead, it is given in cycles, usually once every few weeks. This structured schedule allows your body time to recover and rebuild healthy cells between treatments. While undergoing this treatment, maintaining a balanced diet, staying physically active within your limits, and resting adequately can help your body tolerate the therapy better.

Like most chemotherapy drugs, Karplat 450 Injection 45 ml can cause side effects. Common experiences include feeling very tired, nausea, and temporary hair thinning. However, you must contact your doctor immediately if you experience serious symptoms such as high fever, unusual bleeding, or sudden shortness of breath.

Do not use Karplat 450 Injection 45 ml if you have severe kidney problems, extremely low blood cell counts, or a history of serious allergic reactions to platinum-based chemotherapy medicines. Your doctor will review your complete medical history, kidney function, and blood counts before starting treatment to ensure this medicine is safe for you. Pregnant women should not use this medicine unless specifically advised by their doctor, as it may harm an unborn baby.

It is crucial to have a detailed discussion with your doctor about your complete medical history before starting this treatment. Women who are pregnant or breastfeeding, as well as elderly individuals, require special medical supervision while using this medicine.

Uses of Karplat 450 Injection 45 ml

Karplat 450 Injection 45 ml is prescribed as part of cancer treatment regimens to help control the growth and spread of cancer cells. It is mainly used for:

  • Ovarian Cancer: Karplat 450 Injection 45 ml is widely prescribed to treat advanced ovarian cancer, helping to shrink tumours and prevent the cancer from returning after surgery or other treatments.
  • Small Cell Lung Cancer: It is used in combination with other medications to control and slow down the spread of cancer cells in the lungs.
  • Other Advanced Cancers: Doctors may prescribe this medicine to treat cancers of the head, neck, cervix, or bladder when standard treatments need additional support.

Key Benefits

Karplat 450 Injection 45 ml helps manage advanced cancers by slowing cancer growth, reducing tumour size, and improving treatment outcomes when used as part of an appropriate chemotherapy plan. It actively works to control the disease and may help reduce cancer-related discomfort while supporting a better quality of life.

  • Tumour Reduction and Symptom Relief: By shrinking tumours, Karplat 450 Injection 45 ml can significantly reduce cancer-related pain, pressure, and physical discomfort, helping you move more comfortably and feel better in your daily life.
  • Slows Cancer Progression: Karplat 450 Injection 45 ml plays an important role in slowing down or halting the progression of cancer. This control may help extend survival time and improve overall quality of life, allowing you to spend more meaningful and active time with family and friends.
Side effects of Karplat 450 Injection 45 ml
  • Managing a low platelet count (thrombocytopenia) caused by medication usage requires a multi-step approach. Here are some steps to help manage the condition:
  • Inform your doctor about your low platelet count and medication usage. They will assess the situation and guide the best course of action.
  • Your doctor may recommend adjusting or stopping the medication that is causing a low platelet count. This could involve switching to alternative medication or reducing the dosage.
  • Monitor your platelet count regularly through blood tests to track any changes. This will help the doctor determine the effectiveness of the treatment plan.
  • If an underlying condition, such as infection or inflammation, contributes to the low platelet count, your doctor will treat it.
  • In some cases, alternative treatments like platelet transfusions or medications that stimulate platelet production may be necessary.
  • Avoid risky activities and certain medications; eat a balanced diet with plenty of water to reduce bleeding risk and boost overall health.
  • If you experience severe bleeding or bruising, seek emergency medical attention immediately.
  • Include iron-rich foods like dark leafy vegetables, lean red meat, legumes and fish in your diet.
  • Consume vitamin C-rich foods as they aid iron absorption.
  • Limit tea, cocoa, and coffee as these can slow iron absorption.
  • Exercise regularly; however, do not overdo it.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
  • Avoid loud noises using ear protection aids like earplugs.
  • Take breaks from noisy environments.
  • Consult the doctor if you experience hearing problems; the doctor will monitor your condition and recommend suitable treatment measures.
  • Drink more fluids as dehydration can decrease blood flow to kidneys and increase BUN levels.
  • Eat less protein and stop protein supplements as high protein diet may increase BUN levels.
  • Severe cases may require kidney transplant or dialysis.

Directions for Use

  • Follow your doctor's instructions on the dosage and timing of this medication to ensure safety.
  • Karplat 450 Injection 45 ml will be administered by the doctor or healthcare professional.
  • Do not self-administer.

How Karplat 450 Injection 45 ml Works

Karplat 450 Injection 45 ml works by targeting cells that grow and divide rapidly, which is a main characteristic of cancer cells. Once injected into the bloodstream, Carboplatin enters the cancer cells and binds directly to their DNA. By damaging the DNA structure, it prevents cancer cells from copying themselves and growing. As the cancer cells are unable to repair their DNA or multiply, they eventually die. However, because carboplatin also affects some normal rapidly dividing cells, such as hair roots and blood-producing bone marrow cells, it may cause side effects such as hair loss and changes in blood cell counts.
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Alcohol

Caution

You are recommended to avoid alcohol consumption while taking Karplat 450 Injection 45 ml. It could lead to avoiding unpleasant side effects.

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Pregnancy

Unsafe

Karplat 450 Injection 45 ml should not be used during pregnancy because it causes harm to the fetus (newborn baby). Both women of childbearing potential and men must use an effective contraception method while taking Karplat 450 Injection 45 ml and at least six months afterwards. Please consult your doctor about any concerns regarding this.

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Breast Feeding

Unsafe

Karplat 450 Injection 45 ml should not be taken during breastfeeding as it passes into the breastmilk and may harm the nursing baby. It is contraindicated in breastfeeding mothers. Please consult your doctor about any concerns regarding this.

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Driving

Caution

Karplat 450 Injection 45 ml may affect your reactions and your ability to drive. Possible side effects of chemotherapy with Karplat 450 Injection 45 ml may occur, such as nausea and vomiting. If you are affected by these side effects, you should not drive and/or operate machines that require you to be alert.

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Liver

Caution

If you have had a history or evidence of any liver-related diseases, please consult the doctor before taking Karplat 450 Injection 45 ml. Your doctor will weigh the benefits and any potential risks before prescribing it to you.

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Kidney

Caution

If you have had a history or evidence of any kidney-related diseases, please consult the doctor before taking Karplat 450 Injection 45 ml. Your doctor will weigh the benefits and any potential risks before prescribing it to you.

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Children

Unsafe

Efficacy and safety have not been established. Please consult your doctor. Your doctor will weigh the benefits and potential risks before prescribing them.

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Heart

Caution

Karplat 450 Injection 45 ml should be administered with caution, especially if you have a history of heart problems. Please inform your doctor about any existing heart problems before receiving Karplat 450 Injection 45 ml.

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Geriatrics

Caution

Karplat 450 Injection 45 ml should be administered with caution in elderly patients due to an increased risk of side effects. Dose adjustment may be required based on their health condition.

What if I have taken an overdose of Karplat 450 Injection 45 ml

Since this medicine is prepared and given by trained healthcare professionals, an accidental overdose is highly unlikely. However, if you suspect an error or experience severe side effects immediately after an infusion, inform your medical team or seek emergency medical attention right away.

Diet & Lifestyle Advise

  • Stay hydrated: Drink plenty of fluids, especially water, before and after your infusion to help support your kidneys and flush the medicine from your body.
  • Eat small frequent meals: Eat small, bland meals five to six times a day instead of three large meals to help manage nausea and maintain your strength.
  • Choose safe foods: Avoid raw or undercooked foods, and wash all fruits and vegetables thoroughly to protect yourself from infections when your immune system is weak.
  • Protect health: Use a soft-bristled toothbrush and avoid flossing vigorously to protect your gums from bleeding.
  • Prevent infections: Wash your hands frequently with soap and water, and avoid crowded areas or close contact with anyone who is sick.
health query

Have a query?

How Soon It Starts Working

The time required for Karplat 450 Injection 45 ml to start to work: Karplat 450 Injection 45 ml ideally shows its action within 15 minutes to an hour after administration. The time for which the effects of Karplat 450 Injection 45 ml last: The effect of Karplat 450 Injection 45 ml lasts for 24 to 36 hours.

What if you forget to take Karplat 450 Injection 45 ml

Because this medication is given on a strict clinical schedule, missing an appointment can affect your treatment progress. If you miss an appointment for your infusion, contact your clinic or doctor immediately to reschedule.

Storage

•The concentrated solution is stored by healthcare professionals at room temperature, ideally between 68°F to 77°F (20°C to 25°C). • It must be kept in its original packaging to protect it from light, and it should never be frozen.

Drug Warnings

  • Watch the injection site: If you feel any burning, coldness, pain, or notice swelling where the needle is placed during your infusion, tell your nurse immediately.
  • Get regular blood tests: You must complete all scheduled blood tests before each treatment cycle. Your doctor needs these results to verify that your kidneys and blood counts are healthy enough for the next dose.
  • Be careful during the infection-risk period: Karplat 450 Injection 45 ml can lower your white blood cell counts, usually reaching their lowest levels around 2 to 3 weeks after an infusion. During this period, your risk of infections may be higher. Follow your doctor's advice, avoid contact with people who are unwell, and report any fever or signs of infection immediately.
  • Avoid live vaccines: Do not receive any 'live' vaccines (such as the measles, mumps, rubella, or yellow fever vaccines) while using this medicine, as your weakened immune system may not be able to handle them.
  • Report hearing changes early: Karplat 450 Injection 45 ml may cause hearing problems that can worsen with repeated treatments. Tell your doctor if you notice ringing in your ears, difficulty hearing, or any changes in your hearing, even if they seem mild. Early reporting helps your doctor monitor and manage this side effect.
  • Use reliable birth control and discuss fertility: This medicine can cause severe harm to an unborn baby. Both men and women should use highly effective birth control during treatment and for several months afterwards. Karplat 450 Injection 45 ml may also affect fertility in some patients. If you wish to have children in the future, discuss fertility preservation options such as sperm banking or egg/embryo preservation with your doctor before starting treatment. 

Drug-Drug Interactions

verifiedApollotooltip

Inform your doctor if you are taking any medicines, as some treatments may increase the risk of side effects. 

  • Strong antibiotics (such as aminoglycosides): May increase the risk of kidney damage or hearing loss when used alongside Karplat 450 Injection 45 ml.
  • Water pills (loop diuretics): May increase the risk of hearing problems and dehydration.
  • Other chemotherapy medicines: May further lower your blood cell counts, increasing the risk of infection or bleeding.
CarboplatinSorafenib
Critical
CarboplatinClozapine
Severe

Drug-Drug Interactions

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CarboplatinSorafenib
Critical
How does the drug interact with Karplat 450 Injection 45 ml:
Co-administration of Sorafenib with Karplat 450 Injection 45 ml can increase the risk or severity of serious side effects.

How to manage the interaction:
Taking Sorafenib with Karplat 450 Injection 45 ml together is not recommended as it can cause an interaction, consult a doctor before taking it. However if you experience any unusual symptoms, consult the doctor. Do not stop using any medications without consulting a doctor.
CarboplatinClozapine
Severe
How does the drug interact with Karplat 450 Injection 45 ml:
Taking Karplat 450 Injection 45 ml with Clozapine may enhance the risk of serious infection.

How to manage the interaction:
Co-administration of Karplat 450 Injection 45 ml with clozapine can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you experience fever, chills, diarrhea, sore throat, muscular pains, shortness of breath, blood in phlegm(mucous secretion), red or irritated skin, body sores, or discomfort or burning during urination, consult a doctor immediately. Do not discontinue any medications without consulting a doctor.
CarboplatinEtanercept
Severe
How does the drug interact with Karplat 450 Injection 45 ml:
Taking Karplat 450 Injection 45 ml with etanercept may increase the risk of serious infections.

How to manage the interaction:
Co-administration of Karplat 450 Injection 45 ml and etanercept can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience fever, chills, diarrhea, sore throat, muscular pains, shortness of breath, blood in phlegm (mucous secretion), red or irritated skin, body sores, or discomfort or burning during urination, consult a doctor immediately. Do not discontinue any medications without consulting a doctor.
CarboplatinTofacitinib
Severe
How does the drug interact with Karplat 450 Injection 45 ml:
Co-administration of Karplat 450 Injection 45 ml with tofacitinib can increase the risk of serous infections.

How to manage the interaction:
Although there is an interaction, Karplat 450 Injection 45 ml can be taken with tofacitinib if prescribed by the doctor. However, If you experience fever, chills, diarrhea, sore throat, muscular pains, breathing difficulty, blood in phlegm(mucous secretion), red or irritated skin, body sores, or discomfort or burning during urination, consult a doctor immediately. Do not discontinue any medications without consulting your doctor.
CarboplatinTopotecan
Severe
How does the drug interact with Karplat 450 Injection 45 ml:
When Karplat 450 Injection 45 ml is used with topotecan, it may increase the risk of side effects.

How to manage the interaction:
Co-administration of Karplat 450 Injection 45 ml with clozapine can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you experience any unusual symptoms, consult the doctor. Do not discontinue any medications without consulting your doctor.
CarboplatinBacitracin
Severe
How does the drug interact with Karplat 450 Injection 45 ml:
Taking Karplat 450 Injection 45 ml and bacitracin can increase the risk of nephrotoxicity(kidney damage).

How to manage the interaction:
Co-administration of Karplat 450 Injection 45 ml and bacitracin can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you experience any unusual symptoms consult the doctor. Do not discontinue any medications without a doctor's advice.
CarboplatinCladribine
Severe
How does the drug interact with Karplat 450 Injection 45 ml:
Using cladribine and Karplat 450 Injection 45 ml together can increase the risk of serious infections.

How to manage the interaction:
Co-administration of Karplat 450 Injection 45 ml and cladribine can possibly result in an interaction, but it can be taken if your doctor has advised it. However, If you experience fever, chills, diarrhea, sore throat, muscular pains, shortness of breath, blood in phlegm, red or inflamed skin, body sores, or discomfort or burning during urination, consult a doctor immediately. Do not discontinue any medications without consulting a doctor.
CarboplatinThalidomide
Severe
How does the drug interact with Karplat 450 Injection 45 ml:
Taking Karplat 450 Injection 45 ml with thalidomide can increase the risk of blood clots.

How to manage the interaction:
Co-administration of Karplat 450 Injection 45 ml with thalidomide can possibly result in an interaction, but it can be taken if your doctor has advised it. However, If you experience chest pain, breathing difficulty, coughing up blood, and pain, redness, or swelling in an arm or leg, sudden loss of vision, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.
CarboplatinInfliximab
Severe
How does the drug interact with Karplat 450 Injection 45 ml:
Taking Infliximab with Karplat 450 Injection 45 ml can increase the risk or severity of developing serious infections.

How to manage the interaction:
Co-administration of Infliximab with Karplat 450 Injection 45 ml can result in an interaction, but it can be taken if your doctor has advised it. If you have any of these symptoms like fever, chills, diarrhoea, sore throat, muscle pain, difficulty breathing, pain or burning when you pee, consult a doctor immediately. Do not stop using any medications without a doctor's advice.
CarboplatinCertolizumab
Severe
How does the drug interact with Karplat 450 Injection 45 ml:
Using Karplat 450 Injection 45 ml with Certolizumab can increase the risk of developing serious infections.

How to manage the interaction:
Taking Karplat 450 Injection 45 ml with Certolizumab together can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning sensation when you urinate, consult a doctor. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

verifiedApollotooltip
  • No clinically significant food interactions are known with Karplat 450 Injection 45 ml when used as directed.
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

No

Therapeutic Class

[CHEMOTHERAPY]

FAQs

Karplat 450 Injection 45 ml is used to treat ovarian cancer and small-cell lung cancer.
Karplat 450 Injection 45 ml contains 'Carboplatin'. Carboplatin works by breaching the cellular wall and binding to the cell’s DNA, preventing the cell from dividing and functioning normally, which eventually kills the cell.
Yes, Karplat 450 Injection 45 ml can cause low neutrophils levels, a type of white blood cells that help fight infections. If your white blood cells become low, you can be at higher risk for infections. Tell your doctor if you develop a fever or believe you have an infection.
Karplat 450 Injection 45 ml should be administered under the supervision of a qualified physician experienced in the use of cancer chemotherapeutic agents.
Before you receive treatment with Karplat 450 Injection 45 ml, tell your doctor about all of your medical conditions. You should not receive Karplat 450 Injection 45 ml if you are allergic to carboplatin or any contents in Karplat 450 Injection 45 ml. It should not be employed in patients with severe bone marrow depression or significant bleeding.
If not given an inappropriate dose, Karplat 450 Injection 45 ml can cause toxic effects, although not everyone gets it. So, Karplat 450 Injection 45 ml is prescribed by a doctor experienced in the use of medications to treat cancer only.
Avoid taking Karplat 450 Injection 45 ml if you are pregnant because Karplat 450 Injection 45 ml can cause harmful effects on the unborn baby. Females should follow effective birth control methods during treatment and at least six months after the final dose of Karplat 450 Injection 45 ml.
Karplat 450 Injection 45 ml is administered to you through an intravenous (IV) infusion. A healthcare professional usually gives it in a medical facility.
Karplat 450 Injection 45 ml is not cell cycle specific. It works by forming DNA adducts, which leads to cell death. This mechanism of action is not specific to any particular phase of the cell cycle, meaning it can affect cells at various stages of their life cycle.
Yes, Karplat 450 Injection 45 ml is FDA approved. It was approved on 3 March 1989.
Yes, Karplat 450 Injection 45 ml is a platinum-containing compound medication that works by stopping or slowing the growth of cancer cells.
Karplat 450 Injection 45 ml may cause side effects, including neuropathy (tingling and numbness) in the hands and feet, hearing loss, temporary hair loss, and constipation. Weight gain is rare but possible. While leukemia is not typically associated with Karplat 450 Injection 45 ml, the long-term use of any chemotherapy drug can increase the risk of secondary cancers. It's important to discuss any side effects with your doctor to manage them effectively.
Karplat 450 Injection 45 ml is not a vesicant, and it does not cause blistering or tissue damage if it leaks out of the vein. It is also not cardio-toxic, so it does not specifically target the heart. Additionally, Carboplatin is not an anthracycline, as it does not belong to that class of platinum-containing compounds.
Yes, sometimes the doctor may suggest Karplat 450 Injection 45 ml to treat breast cancer based on your health situation. It is often given in combination with other chemotherapy drugs for optimal results.
Karplat 450 Injection 45 ml is not available in pill form; It is available in two primary dosage forms: injection and powder for injection.
The common side effects of the Karplat 450 Injection 45 ml are nausea, vomiting, diarrhoea, constipation, sores in the mouth and throat, pain, burning, or tingling in the hands or feet, pain, itching, redness, swelling, blisters, or sores in the place where the medication was injected, hair loss, pain, weakness, loss in ability to taste food. However, these symptoms vanish as your body adjusts to the medication. If these symptoms become worse, please consult a doctor for relief.
The efficacy and safety of Karplat 450 Injection 45 ml have yet to be established for using children. Please consult your doctor. The doctor will help determine whether the potential benefits outweigh the possible risks and make the appropriate recommendation.
Hair thinning or temporary hair loss is a common side effect of this medicine. In most cases, your hair will begin to grow back gradually after you complete your entire treatment plan. Talk to your doctor for advice on managing hair loss.
This medicine can make you feel extremely tired, dizzy, or weak. It is highly recommended to arrange for a family member or friend to drive you home after your appointment. Talk to your doctor about when it is safe for you to drive.
Yes, this medication can put stress on your kidneys. Your healthcare team will run blood tests before every treatment cycle to monitor how well your kidneys are working. Drinking plenty of water helps protect your kidneys during treatment. Talk to your doctor if you experience decreased urination.
No, this medicine can cause severe birth defects. Both male and female patients must use reliable, highly effective birth control methods during treatment and for a specified time after the final dose. Talk to your doctor immediately if a pregnancy occurs.
Focus on small, frequent meals consisting of bland, easy-to-digest foods like crackers, toast, or rice to help prevent nausea. Staying hydrated with water and clear broths is also highly important. Talk to your doctor or a clinical dietitian for personalised nutrition advice.
Yes, repeated treatment with Karplat 450 Injection 45 ml may sometimes cause hearing changes, including ringing in the ears or reduced hearing ability. Inform your doctor about any new hearing symptoms during treatment so they can monitor your condition and provide appropriate advice.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Country of origin

India

Manufacturer/Marketer address

Zydus Tower, Satellite Cross Roads, Ahmedabad 380015, Gujarat, India.
Other Info - KAR0253
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