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compositionComposition:KETOCONAZOLE-200MG
prescription
Prescription Medicine
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Ketafung Tablet is an antifungal medicine used in the treatment of fungal infections such as blastomycosis, coccidioidomycosis, paracoccidioidomycosis, and histoplasmosis (lung infection caused by Histoplasma fungus). This medicine works by inhibiting the growth and multiplication of fungal cells that are responsible for the growth of infection-causing fungi.

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Written By Veda Maddala , M Pharmacy
Reviewed By Santoshini Reddy G , M Pharmacy
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More about the Product

Composition :

KETOCONAZOLE-200MG

Manufacturer/Marketer :

East West Pharma India Pvt Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Ketafung Tablet

Ketafung Tablet is a prescription medication used to treat serious, systemic fungal infections that affect internal organs. It is prescribed when other alternative antifungal treatments are not suitable or cannot be tolerated by the patient. This medication works by stopping the growth of the fungus causing the infection.

It is crucial to take it exactly as prescribed by your doctor, usually once daily, and at the same time each day to maintain a steady level of the medicine in your body. For proper absorption, this tablet should be taken with food or an acidic beverage, as stomach acid is required for it to dissolve correctly. Making simple lifestyle adjustments, such as avoiding alcohol during treatment, will help support your body's recovery.

While taking this medicine, you may experience mild side effects such as nausea, mild stomach discomfort, or headaches. However, you must contact your doctor immediately if you notice serious signs of liver damage, such as yellowing of your skin or eyes, severe abdominal pain, or unusually dark urine.

Before starting this medication, talk to your doctor if you have a history of liver disease, heart rhythm conditions, or adrenal gland issues. Do not take this if you have active liver disease or if you are taking certain medications that can cause serious heart rhythm problems when combined with it.

This medicine can interact significantly with other drugs, including common cholesterol-lowering pills and certain sedatives, which can increase the risk of severe side effects. Avoid alcohol while taking this medicine because the combination increases the risk of liver damage.

If you are pregnant, breastfeeding, or an elderly patient, you must consult your doctor to discuss whether this medication is safe for you. The safety and effectiveness of Ketafung Tablet in children have not been well established. It should only be used in children if prescribed by a doctor after carefully considering the benefits and risks.

Uses of Ketafung Tablet

Your doctor may recommend this medicine to help manage the following conditions:

  • Systemic fungal infections: It helps treat deep-seated fungal infections inside the body, such as blastomycosis, coccidioidomycosis, and histoplasmosis, by stopping the spread of the fungus.
  • Severe fungal infections resistant to other therapies: It is used when alternative antifungal treatments are unavailable or cannot be tolerated, helping to clear stubborn infections from the body.
  • Cushing's syndrome: It may reduce the production of cortisol (a stress hormone). Use it only under specialist supervision. 

Key Benefits

When taken consistently as directed, this medicine may provide the following health benefits:

  • Treats serious fungal infections: It helps treat serious fungal infections that cannot be effectively treated with topical medicines.
  • Relieves infection symptoms: It may help reduce symptoms such as persistent fever, tiredness, and discomfort caused by the fungal infection as it clears the infection.
  • Alternative treatment option: It may be used when other systemic antifungal medicines are not suitable or cannot be tolerated, as advised by your doctor.
Side effects of Ketafung Tablet
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.

Directions for Use

  • Ketafung Tablet can be taken with or without food.
  • Your doctor will decide the dose and duration depending on your condition.
  • Swallow the medicine as a whole with a glass of water.
  • Do not crush, chew, or break Ketafung Tablet as it may affect the way the medication is absorbed.

How Ketafung Tablet Works

This medicine contains Ketafung Tablet , which is an antifungal. It works by targeting the protective outer layer of the fungal cells, known as the cell membrane. It blocks the production of a key substance called ergosterol, which the fungus needs to keep its cell membrane strong and intact. Without this crucial substance, holes develop in the fungal cell membrane, causing the cell's contents to leak out. This action weakens the fungus, stops it from multiplying, and ultimately leads to the destruction of the infection-causing fungal cells.
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Alcohol

Unsafe

Avoid consumption of alcohol while taking Ketafung Tablet as it may increase the risk of liver damage and cause adverse effects.

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Pregnancy

Consult your doctor

Ketafung Tablet is a Category C pregnancy drug and is given to pregnant women only if the doctor thinks the benefits outweigh the risks.

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Breast Feeding

Unsafe

Ketafung Tablet may be excreted in breast milk. Therefore, it is recommended to avoid breastfeeding while taking Ketafung Tablet .

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Driving

Caution

Ketafung Tablet may cause dizziness or drowsiness. Therefore, drive only if you alert after taking Ketafung Tablet .

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Liver

Unsafe

Ketafung Tablet is contraindicated in patients with chronic or acute liver disease. Therefore, inform your doctor if you have any Liver diseases/conditions.

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Kidney

Consult your doctor

If you have any concerns regarding the use of Ketafung Tablet in patients with kiver diseases/conditions, consult a doctor.

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Children

Consult your doctor

Ketafung Tablet is not recommended for children below 2 years of age. For children above 2 years, it is recommended to use only if the doctor has determined that benefits outweigh risks.

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Heart

Caution

If you have any concerns regarding the use of Ketafung Tablet in patients with heart diseases/conditions, consult a doctor.

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Geriatrics

Caution

Ketafung Tablet should be used with caution in elderly patients. Please consult your doctor before use.

What if I have taken an overdose of Ketafung Tablet

If you accidentally take more than your prescribed dose, seek emergency medical attention. Symptoms of an overdose may include severe nausea, vomiting, or dizziness.

Diet & Lifestyle Advise

  • Avoid alcohol: Do not drink alcohol during treatment, as it can increase the risk of serious liver damage.
  • Take with an acidic drink if advised: If you take medicines that reduce stomach acid (such as antacids or H2 blockers), ask your doctor or pharmacist whether you should take Ketafung Tablet with an acidic drink, such as cola, to help improve absorption.
  • Rest and stay hydrated: Get enough rest and drink plenty of fluids to support your recovery from the infection.
  • Maintain good hygiene: Wash towels, clothing, and other personal items regularly to help prevent the infection from spreading or coming back.
     
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How Soon It Starts Working

  • The time required for Ketafung Tablet to start to work: Ketafung Tablet ideally shows its action within 1 hour after administration.
  • The time for which the effects of Ketafung Tablet last: The effect of Ketafung Tablet lasts for 8 hours.

What if you forget to take Ketafung Tablet

If you miss a dose, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and resume your regular schedule. Do not take a double dose to make up for a missed one.

Storage

• Store the tablets at room temperature, ideally between 20°C and 25°C (68°F and 77°F).

Drug Warnings

  • Attend regular check-ups: Your doctor may perform liver function tests before and during treatment. If you have certain heart conditions or risk factors, your doctor may also recommend an electrocardiogram (ECG) before starting treatment.
  • Use only as prescribed: Do not use this medicine to treat mild fungal infections of the skin or nails unless your doctor specifically recommends it.
  • Check before taking other medicines: Talk to your doctor or pharmacist before starting any new prescription medicines, over-the-counter medicines, herbal products, or vitamin supplements, as Ketafung Tablet can interact with many medicines.
  • Important safety warning: It is associated with a risk of serious, potentially life-threatening liver damage. It is generally prescribed only when other suitable antifungal treatments are not appropriate or have not been effective. Your doctor will monitor your liver function before and during treatment.
  • Complete the full course: The duration of treatment depends on the type and severity of the fungal infection. Continue taking this medicine for the full course prescribed by your doctor, even if you start feeling better.

Drug-Drug Interactions

verifiedApollotooltip
  • Sedatives: Medicines such as alprazolam and oral midazolam may build up in the body when taken with Ketafung Tablet , increasing the risk of excessive drowsiness, slowed breathing, and other serious side effects.
  • Cholesterol-lowering medicines (statins): Taking Ketafung Tablet with simvastatin or lovastatin can greatly increase the risk of muscle damage (myopathy) and muscle breakdown (rhabdomyolysis). These medicines should generally not be used together.
  • Acid-reducing medicines: Medicines such as omeprazole, pantoprazole, ranitidine, or antacids can reduce the absorption of medicine, making it less effective. Your doctor may advise you on how to take these medicines safely.
KetoconazoleTicagrelor
Critical
KetoconazoleLurasidone
Critical

Drug-Drug Interactions

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KetoconazoleTicagrelor
Critical
How does the drug interact with Ketafung Tablet:
Co-administration of ticagrelor with Ketafung Tablet can cause severe bleeding.

How to manage the interaction:
Taking Ticagrelor with Ketafung Tablet is not recommended as it can cause an interaction, it can be taken if prescribed by the doctor. However, if you experience any unusual bleeding or bruising, swelling, vomiting, blood in your urine or stools, headache, dizziness, or weakness, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
KetoconazoleLurasidone
Critical
How does the drug interact with Ketafung Tablet:
Using Lurasidone together with Ketafung Tablet may increase the risk of side effects like Parkinson's disease(It is a brain disorder that produces uncontrollable movements).

How to manage the interaction:
While lurasidone and Ketafung Tablet is not recommended as it may lead to an interaction, they can be used if prescribed by a doctor. However, consult a doctor if you have any abnormal muscle activity, fits, heat intolerance or heat stroke, dizziness, lightheadedness, headache, flushing, fainting, or heart palpitations. Do not discontinue any medications without consulting a doctor.
KetoconazoleConivaptan
Critical
How does the drug interact with Ketafung Tablet:
Using conivaptan together with Ketafung Tablet may significantly increase the blood levels of conivaptan, which may increase the risk of side effects.

How to manage the interaction:
Taking Ketafung Tablet with Conivaptan is not recommended as it can cause an interaction, but it can be taken if prescribed by the doctor. However, if you experience difficulty swallowing, trouble speaking, muscle weakness, trouble controlling body movements, confusion, mood changes, seizures(fits), consult the doctor immediately. Do not discontinue any medication without consulting a doctor.
KetoconazoleZiprasidone
Critical
How does the drug interact with Ketafung Tablet:
Taking Ketafung Tablet with Ziprasidone can increase the risk of irregular heart rhythm.

How to manage the interaction:
Taking Ziprasidone with Ketafung Tablet is not recommended, it can be taken together if prescribed by a doctor. However, consult a doctor if you experience sudden dizziness, lightheadedness, fainting, breathing difficult. Do not discontinue any medications without consulting a doctor.
KetoconazoleIsavuconazole
Critical
How does the drug interact with Ketafung Tablet:
Co-administration of Ketafung Tablet and Isavuconazole can significantly increase the blood levels of Isavuconazole, which may increase the risk of side effects.

How to manage the interaction:
Taking Isavuconazole with Ketafung Tablet is not recommended as it can cause an interaction, it can be taken if prescribed by the doctor. However, if you experience symptoms like nausea, stomach pain, headache while on therapy with these drugs, consult the doctor. Do not discontinue any medication without consulting a doctor.
KetoconazoleVoclosporin
Critical
How does the drug interact with Ketafung Tablet:
When Voclosporin is taken with Ketafung Tablet, it can increase the risk of serious side effects.

How to manage the interaction:
Taking Ketafung Tablet with Voclosporin is not recommended, it can be taken if prescribed by the doctor. However, if you experience any unusual symptoms, consult the doctor immediately.
KetoconazoleTriazolam
Critical
How does the drug interact with Ketafung Tablet:
When Triazolam is taken with Ketafung Tablet, it can increase the risk of drowsiness and slowed breathing.

How to manage the interaction:
Taking Triazolam with Ketafung Tablet is not recommended as it can cause an interaction, it can be taken if prescribed by the doctor. Do not stop using any medications without talking to a doctor.
KetoconazoleSilodosin
Critical
How does the drug interact with Ketafung Tablet:
Coadministration of Silodosin with Ketafung Tablet may lead to side effects including extremely low blood pressure, and increased heart rate.

How to manage the interaction:
Taking Ketafung Tablet with Silodosin together is not recommended as it can result in an interaction, but it can be taken if a doctor has advised it. However, consult a doctor immediately if you experience any symptoms such as dizziness, lightheadedness, fainting, headache, flushing, nasal congestion, heart palpitation. Do not discontinue any medications without consulting a doctor.
KetoconazoleCisapride
Critical
How does the drug interact with Ketafung Tablet:
When Cisapride is taken with Ketafung Tablet, it can increase the chance of a serious abnormal heart rhythm.

How to manage the interaction:
Taking Cisapride with Ketafung Tablet is not recommended as it can cause an interaction, it can be taken if prescribed by the doctor. However, if you experience sudden dizziness, lightheadedness, fainting, breathing difficulty, or rapid heartbeat, consult the doctor immediately. Do not stop any medications without a doctor's advice.
KetoconazoleLomitapide
Critical
How does the drug interact with Ketafung Tablet:
When Lomitapide is taken with Ketafung Tablet, it may increase the risk of side effects.

How to manage the interaction:
Taking Ketafung Tablet with Lomitapide is not recommended as it can cause an interaction, but it can be taken if prescribed by the doctor. However, if you experience symptoms such as fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, vomiting, dark urine, light stools, and skin or eye yellowing, decreased hunger, consult the doctor immediately. Do not stop using any medications without talking to the doctor.

Drug-Food Interactions

verifiedApollotooltip
  • Alcohol: Drinking alcohol while taking this medicine increases the risk of severe liver damage. 
KETOCONAZOLE-200MGGrapefruit and Grapefruit Juice
Moderate

Drug-Food Interactions

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KETOCONAZOLE-200MGGrapefruit and Grapefruit Juice
Moderate
Common Foods to Avoid:
Grapefruit Juice, Grapefruit

How to manage the interaction:
Consumption of grapefruit or its juice with Ketafung Tablet may result in side effects such as joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of hunger, dark urine, light colored stools, and yellowing of the skin or eyes. Avoid consuming grapefruit, grapefruit juice, or any supplements that include grapefruit extract while taking Ketafung Tablet.

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Habit Forming

No

Therapeutic Class

[ANTIFUNGALS - ORAL]

FAQs

Ketafung Tablet belongs to a class of drugs called antifungals indicated to treat various systemic fungal infections such as blastomycosis (infection caused by Blastomyces fungus), chromomycosis (chronic infection of the skin and subcutaneous tissue), Coccidioidomycosis (infection caused by Coccidioides fungus), paracoccidioidomycosis (infection caused by Paracoccidioides fungus) and histoplasmosis (lung infection caused by Histoplasma fungus).
Ketafung Tablet works by destroying fungal cell membranes that are essential for their survival as they prevent the entry of unwanted substances into the cells and stop the leakage of cell contents. Thus, kills fungi and treats the fungal infection.
Ketafung Tablet is not recommended to treat fungal meningitis (fungal infection spreads to the brain and spinal cord) as it poorly penetrates into the cerebrospinal fluid. Therefore, inform your doctor if you have fungal meningitis so that appropriate medication may be prescribed.
You are recommended to avoid foods containing chocolate and caffeine such as cocoa beans, tea, coffee, cola and energy drinks while taking Ketafung Tablet as it may increase the adverse effects of caffeine such as drowsiness, nervousness or nausea.
You are not recommended to take Ketafung Tablet with simvastatin (lipid-lowering drug) as co-administration of these medicines may cause muscle problems. Therefore, please consult a doctor before taking Ketafung Tablet with other medicines.
No, you are not recommended to stop taking Ketafung Tablet without consulting your doctor as it may cause recurring infection. Therefore, take Ketafung Tablet for as long as your doctor has prescribed it and if you experience any difficulty while taking Ketafung Tablet , please consult your doctor.
No, you should not take it with antacids. Antacids reduce stomach acid, which this medicine needs to dissolve and absorb. Take antacids at least two hours before or two hours after taking this medication, or talk to your doctor.
Your doctor will order regular blood tests to monitor your liver function, as this medication can cause serious liver damage. These tests help ensure the medicine is safe for your body to process.
No, you should avoid alcohol completely while taking this medication. Both alcohol and this medicine are processed by the liver, and combining them significantly increases the risk of severe liver damage.
No, it is generally not recommended during pregnancy unless your doctor decides the benefits outweigh the potential risks to the unborn baby. Talk to your doctor if you are pregnant or planning to become pregnant.
Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed one and continue with your normal schedule. Do not double the dose to catch up.
No, oral tablets of Ketafung Tablet are not recommended for mild skin or nail infections due to the risk of serious side effects like liver damage. Your doctor will prescribe safer, alternative treatments for these conditions.
If you have low stomach acid or take acid-reducing medications, your doctor may advise you to take it with an acidic drink, such as a cola beverage, to help your body absorb the medicine.
Watch for symptoms such as unusual tiredness, loss of appetite, persistent nausea, dark urine, pale stools, or yellowing of the skin and eyes. If you notice any of these, contact your doctor right away.

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While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Reference

  1. U.S. Food and Drug Administration (FDA). 018533S040Lbl [FDA Prescribing Information]. Silver Spring, MD: FDA; 2024. [Accessed on 02 Jun. 2026]Check here
  2. Drugs.com Clinical Review Team. Ketoconazole Clinical Drug Monograph. Auckland, NZ: Drugs.com; 2026. [Accessed on 02 Jun. 2026]Check here
  3. Ketoconazole cream [Prescribing Information]. 2014. [Accessed on 10 Jun. 2025]Check here
  4. Ketoconazole [Summary of Product Characteristics]. 2023. [Accessed on 10 Jun. 2025]Check here
  5. Ketoconazole Ketoconazole. 2026. [Accessed on 01 Apr. 2026]Check here
  6. Ketoconazole 2% w/w Shampoo - Summary of Product Characteristics (SmPC) - (emc) [Internet]. Medicines.org.uk. 2021 [Accessed on 31 Oct 2025]Check here
  7. Ketoconazole (Topical Route) Description and Brand Names - Mayo Clinic [Internet]. Mayoclinic.org. 2021 [Accessed on 31 Oct 2025]Check here

Country of origin

India

Manufacturer/Marketer address

16Th Floor, Godrej Bkc, Plot C, G Block, Bandra-Kurla Complex, Bandra (East), Mumbai 400 051, India.
Other Info - KET0056
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